scholarly journals Exploring PubMed as a reliable resource for scholarly communications services

2019 ◽  
Vol 107 (1) ◽  
Author(s):  
Peace Ossom Williamson ◽  
Christian I. J. Minter
Keyword(s):  
Reading Program ◽  
Biomedical Literature ◽  
Public Access ◽  
High Rate ◽  
Medical Library ◽  
Scholarly Communications ◽  
Communications Services ◽  
The Difference ◽  
Almost All ◽  
Access Policies

Objective: PubMed’s provision of MEDLINE and other National Library of Medicine (NLM) resources has made it one of the most widely accessible biomedical resources globally. The growth of PubMed Central (PMC) and public access mandates have affected PubMed’s composition. The authors tested recent claims that content in PMC is of low quality and affects PubMed’s reliability, while exploring PubMed’s role in the current scholarly communications landscape.Methods: The percentage of MEDLINE-indexed records was assessed in PubMed and various subsets of records from PMC. Data were retrieved via the National Center for Biotechnology Information (NCBI) interface, and follow-up interviews with a PMC external reviewer and staff at NLM were conducted.Results: Almost all PubMed content (91%) is indexed in MEDLINE; however, since the launch of PMC, the percentage of PubMed records indexed in MEDLINE has slowly decreased. This trend is the result of an increase in PMC content from journals that are not indexed in MEDLINE and not a result of author manuscripts submitted to PMC in compliance with public access policies. Author manuscripts in PMC continue to be published in MEDLINE-indexed journals at a high rate (85%). The interviewees clarified the difference between the sources, with MEDLINE serving as a highly selective index of journals in biomedical literature and PMC serving as an open archive of quality biomedical and life sciences literature and a repository of funded research.Conclusion: The differing scopes of PMC and MEDLINE will likely continue to affect their overlap; however, quality control exists in the maintenance and facilitation of both resources, and funding from major grantors is a major component of quality assurance in PMC. This article has been approved for the Medical Library Association’s Independent Reading Program.

scholarly journals Investigating the need for scholarly communications positions in Association of Academic Health Sciences Libraries member institutions

2017 ◽  
Vol 105 (2) ◽  
Author(s):  
Kim Mears, MLIS ◽  
Sandra L. Bandy, MS, AHIP
Keyword(s):  
Online Survey ◽  
Health Sciences ◽  
Public Access ◽  
Full Time ◽  
Academic Health ◽  
Discussion List ◽  
Scholarly Communications ◽  
Time Position ◽  
Communications Services

Background: The role of health sciences librarians has expanded in the scholarly communications landscape as a result of the increase in federal public access mandates and the continued expansion of publishing avenues. This has created the need to investigate whether academic health sciences libraries should have scholarly communications positions to provide education and services exclusively related to scholarly communication topics.Methods: A nine-question online survey was distributed through the Association of Academic Health Sciences Libraries (AAHSL) email discussion list to gather preliminary findings from and opinions of directors of health sciences libraries on the need for scholarly communications positions.Results: The survey received a 38% response rate. The authors found that AAHSL members are currently providing scholarly communications services, and 46% of respondents expressed the need to devote a full-time position to this role.Discussion: Our survey reveals a juxtaposition occurring in AAHSL member libraries. While administrators acknowledge the need to provide scholarly communications services, they often experience budget challenges in providing a full-time position for these services.

Peritoneal Fluid and Plasma Fibrinolytic Activity in Women with Pelvic Inflammatory Disease

1992 ◽  
Vol 68 (02) ◽  
pp. 102-105 ◽  
Author(s):  
P J Dörr ◽  
E J P Brommer ◽  
G Dooijewaard ◽  
H M Vemer
Keyword(s):  
Pelvic Inflammatory Disease ◽  
Inflammatory Disease ◽  
Peritoneal Fluid ◽  
Fibrinolytic Activity ◽  
Degradation Products ◽  
Adhesion Formation ◽  
High Rate ◽  
Control Group ◽  
The Difference ◽  
Fibrinolytic Parameters

SummaryPrevious studies have shown that the fibrinolytic activity of peritoneum is depressed in local inflammation. We measured fibrinolytic parameters in peritoneal fluid and in plasma of 10 women with pelvic inflammatory disease (PID). Nine women, in whom laparoscopy for sterilisation was performed, served as a control group.In the peritoneal fluid of women with PID, PAI-Ag, t-PA-Ag and u-PA-Ag were many times higher than in the control group. In contrast to the antigens which may be present in inert complexes, the potentially active compounds, measured as t-PA activity and plasmin-activable scu-PA, were not significantly different in the two groups, and in none of the samples was the active enzyme tcu-PA detectable. Nevertheless, the mean peritoneal fluid TDP and FbDP concentrations were about twenty times higher in the PID group than in the control group. In plasma of PID patients, none of the parameters except u-PA-Ag differed from those in the control group. The difference between control and patient plasma u-PA-Ag was statistically significant, but too small to attach any relevance to the observation.Our data suggest that, in contrast to the classical concept of decreased fibrinolytic activity as a cause of adhesion formation, intraperitoneal fibrinolysis is enhanced in peritoneal inflammation through stimulation of the local production of t-PA and u-PA. Despite concomitant production of PAI, fibrinolysis occurs at a high rate, resulting in high levels of fibrin degradation products. Since this activated fibrinolysis does not meet the demand, therapeutic enhancement should be considered to prevent adhesions.

ATTITUDE TO OPEN ACCESS IN RUSSIAN SCHOLARLY COMMUNITY: 2018. SURVEY RESULTS AND ANALYSIS

2018 ◽  
Vol 1 (1) ◽  
pp. 6-21 ◽  
Author(s):  
I. K. Razumova ◽  
N. N. Litvinova ◽  
M. E. Shvartsman ◽  
A. Yu. Kuznetsov
Keyword(s):  
Open Access ◽  
Open Access Publishing ◽  
Scholarly Community ◽  
Research Areas ◽  
Survey Results ◽  
The Difference ◽  
Policies And Programs ◽  
The Uk ◽  
High Level ◽  
Access Policies

Introduction. The paper presents survey results on the awareness towards and practice of Open Access scholarly publishing among Russian academics.Materials and Methods. We employed methods of statistical analysis of survey results. Materials comprise results of data processing of Russian survey conducted in 2018 and published results of the latest international surveys. The survey comprised 1383 respondents from 182 organizations. We performed comparative studies of the responses from academics and research institutions as well as different research areas. The study compares results obtained in Russia with the recently published results of surveys conducted in the United Kingdom and Europe.Results. Our findings show that 95% of Russian respondents support open access, 94% agree to post their publications in open repositories and 75% have experience in open access publishing. We did not find any difference in the awareness and attitude towards open access among seven reference groups. Our analysis revealed the difference in the structure of open access publications of the authors from universities and research institutes. Discussion andConclusions. Results reveal a high level of awareness and support to open access and succeful practice in the open access publications in the Russian scholarly community. The results for Russia demonstrate close similarity with the results of the UK academics. The governmental open access policies and programs would foster the practical realization of the open access in Russia.

scholarly journals Two maize cultivars of contrasting leaf size show different leaf elongation rates with identical patterns of extension dynamics and coordination

AoB Plants ◽  
2021 ◽  
Author(s):  
Tiphaine Vidal ◽  
Hafssa Aissaoui ◽  
Sabrina Rehali ◽  
Bruno Andrieu
Keyword(s):  
Genotypic Variation ◽  
Leaf Size ◽  
High Rate ◽  
Time Interval ◽  
Extension Rate ◽  
Leaf Production ◽  
Maize Cultivars ◽  
Plant Environment ◽  
The Difference ◽  
Leaf Extension

Abstract Simulating leaf development from initiation to maturity opens new possibilities to model plant–environment interactions and the plasticity of plant architecture. This study analyses the dynamics of leaf production and extension along a maize (Zea mays) shoot to assess important modelling choices. Maize plants from two cultivars originating from the same inbred line, yet differing in the length of mature leaves were used in this study. We characterised the dynamics of the blade and sheath lengths of all phytomers by dissecting plants every 2–3 days. We analysed how differences in leaf size were built up and we examined the coordination between the emergence of organs and phases of their extension. Leaf extension rates were higher in the cultivar with longer leaves than in the cultivar with shorter leaves; no differences were found in other aspects. We found that (i) first post-embryonic leaves were initiated at a markedly higher rate than upper leaves; (ii) below ear position, sheaths were initiated at a time intermediate between tip emergence and appearance, while above the ear position, sheaths were initiated at a high rate, such that the time interval between the blade and sheath initiations decreased for these leaves; and (iii) ear position also marked a change in the correlation in size between successive phytomers with little correlation of size between upper and lower leaves. Our results identified leaf extension rate as the reason for the difference in size between the two cultivars. The two cultivars shared the same pattern for the timing of initiation events, which was more complex than previously thought. The differences described here may explain some inaccuracies reported in functional-structural plant models. We speculate that genotypic variation in behaviour for leaf and sheath initiation exists, which has been little documented in former studies.

Effect of Flaw Dimensions on Ductile Fracture Behavior of Non-Aligned Multiple Flaws in a Plate

2011 ◽  
Author(s):  
Katsumasa Miyazaki ◽  
Kunio Hasegawa ◽  
Koichi Saito
Keyword(s):  
Ductile Fracture ◽  
Flat Plate ◽  
Fracture Behavior ◽  
Maximum Load ◽  
Surface Flaws ◽  
Fracture Tests ◽  
The Difference ◽  
Almost All ◽  
Maximum Minimum

The fitness-for-service codes require the characterization of non-aligned multiple flaws for flaw evaluation, which is performed using a flaw proximity rule. Worldwide, almost all such codes provide their own proximity rule, often with unclear technical bases of the application of proximity rule to ductile or fully plastic fracture. In particular, the effect of flaw dimensions of multiple surface flaws on fully plastic fracture of non-aligned multiple flaws had not been clear. To clarify the effect of the difference of part through-wall and through-wall flaws on the behavior of fully plastic fracture, the fracture tests of flat plate specimens with non-aligned multiple part through-wall flaws were conducted. When the flaw depth a was shallow with 0.4 in ratio of a to thickness t, the maximum load Pmax occurred at penetration of multiple flaws and the effect of vertical distance of non-aligned multiple flaws H on Pmax was not so significant. However, when flaw depth was deep with 0.8 in a/t, Pmax occurred after penetration of flaws and the effect of H on Pmax could be seen clearly. It was judged that the through-wall flaw tests were appropriate for discussion of the effect of H on Pmax and the alignment rule of multiple flaws. In addition, in order to clarify the appropriate length parameter to estimate Pmax of test specimens with dissimilar non-aligned through-wall multiple flaws, the fracture tests of plate specimens were also conducted. The effect of different flaw length on Pmax was discussed with maximum, minimum and averages of dissimilar non-aligned multiple flaw lengths. Experimental results showed that the maximum length lmax would be an appropriate length parameter to estimate Pmax, when the non-aligned multiple through-wall flaws were dissimilar.

United Front: Partisans of the Leningrad Region and their connections with the Central Asian Soviet Republics

2021 ◽  
Vol 2021 (02) ◽  
pp. 214-225
Author(s):  
Sergey Kulik ◽  
Аnatoliy Kashevarov ◽  
Zamira Ishankhodjaeva
Keyword(s):  
World War Ii ◽  
Weather Conditions ◽  
Leningrad Region ◽  
World War ◽  
North West ◽  
The North ◽  
Occupied Territory ◽  
Central Asian ◽  
The Difference ◽  
Almost All

During World War II, representatives of almost all the Soviet Republics fought in partisan detachments in the occupied territory of the Leningrad Region. Among them were many representatives of the Central Asian republics: Kazakhstan, Kyrgyzstan and Uzbekistan. Many Leningrad citizens, including relatives of partisans, had been evacuated to Central Asia by that time. However, representatives of Asian workers’ collectives came to meet with the partisans. The huge distance, the difference in cultures and even completely different weather conditions did not become an obstacle to those patriots-Turkestanis who joined the resistance forces in the North-West of Russia.

A Low-Dimensional Dissimilarity Analysis of Unilateral and Bilateral Stroke-Impacted Hand Trajectories

2016 ◽  
Vol 138 (11) ◽  
Author(s):  
Jay Ryan U. Roldan ◽  
Dejan Milutinović ◽  
Zhi Li ◽  
Jacob Rosen
Keyword(s):  
Multidimensional Scaling ◽  
Healthy Subject ◽  
Motion Capture ◽  
Early Phase ◽  
Three Dimensional ◽  
High Rate ◽  
Motion Capture System ◽  
Trajectory Data ◽  
The Difference ◽  
Low Dimensional

In this paper, we propose a quantitative approach based on identifying hand trajectory dissimilarities through the use of a multidimensional scaling (MDS) analysis. A high-rate motion capture system is used to gather three-dimensional (3D) trajectory data of healthy and stroke-impacted hemiparetic subjects. The mutual dissimilarity between any two trajectories is measured by the area between them. This area is used as a dissimilarity variable to create an MDS map. The map reveals a structure for measuring the difference and variability of individual trajectories and their groups. The results suggest that the recovery of hemiparetic subjects can be quantified by comparing the difference and variability of their individual MDS map points to the points from the cluster of healthy subject trajectories. Within the MDS map, we can identify fully recovered patients, those who are only functionally recovered, and those who are either in an early phase of, or are nonresponsive to the therapy.

scholarly journals ANALYSIS OF SMES CREDIT RESTRUCTURING POLICY IN ECONOMIC RECOVERY DURING THE COVID-19 PANDEMIC

2021 ◽  
Vol 5 (2) ◽  
pp. 405
Author(s):  
Lussi Agustin ◽  
Moh. Yusron Solikin ◽  
Zunairoh .
Keyword(s):  
Financial Services ◽  
Global Economy ◽  
Empirical Studies ◽  
System Stability ◽  
Economic Recovery ◽  
Top Down ◽  
The Difference ◽  
Almost All ◽  
Industry Sectors ◽  
The Impact

Penelitian ini bertujuan untuk menganalisis seberapa maksimal proses kebijakan retrukturisasi Kredit UMKM dalam Pemulihan Ekonomi di Masa Pandemi Covid-19. Kondisi perekonomian global sedang mengalami goncangan hebat akibat mewabahnya Covid-19. Dampak dari pandemic ini sangat mempengaruhi segala aspek terutama pada kondisi Kesehatan dan perekonomian suatu negara, tidak terkecuali Indonesia. Secara keseluruhan, hampir semua sektor industry mengalami goncangan dan tidak terkecuali sektor UMKM. Maka dari itu dikeluarkanlah kebijakan retrukturisasi Kredit UMKM guna mendorong optimalisasi fungsi intermediasi pada perbankan dan menjaga stabilitas sistem keuangan serta mendukung pertumbuhan perekonomian. Program restrukturisasi kredit menjadi program dari OJK yang dapat diterapkan oleh perbankan kepada UMKM. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan menggunakan studi empiris dari penelitian terdahulu serta peraturan-peraturan terkait dengan restrukturisasi kredit yang dikeluarkan oleh Otoritas Jasa Keuangan. Hasil penelitian ini menunjukkan bahwa implementasi kebijakan restrukturisai kredit bagi UMKM sudah berjalan dan digunakan oleh para pelaku UMKM. Kemudian berdasarkan implementasinya kebijakan ini merupakan kebijakan top-down dimana memerlukan banyak Lembaga untuk bekerja sama dan keputusan berasal dari Peraturan pemerintah baru di teruskan ke Lembaga-lembaga lain di bawahnya hingga informasinya sampai dan bisa dirasakan oleh para UMKM.  This research aims to analyze the policy of restructuring SMEs Credit in Economic Recovery during the Covid-19 Pandemic. The global economy is experiencing severe shocks due to the outbreak of Covid-19. The impact of this pandemic greatly affects all aspects, especially on the health and economic condition of a country, not least Indonesia. Overall, almost all industry sectors are experiencing shocks and are no exception to the SMEs sector. Therefore, the policy of restructuring SMEs Credit was issued to encourage optimization of intermediation function in banking and maintain the financial system stability and support economic growth. Credit restructuring program becomes a program from OJK that can be applied by banks to SMEs. The method used in this research is a qualitative method using empirical studies from previous research as well as regulations related to credit restructuring issued by the Financial Services Authority. The results of this research show that the implementation of credit restructuring policy for SMEs is already running and used by SMEs. Then based on the difference in implementation of this policy is a top-down policy that requires many Institutions to cooperate and decisions derived from the new government regulations are forwarded to other institutions under it until the information reaches and can be felt by SMEs.

scholarly journals Insertions and deletions trigger adaptive walks in Drosophila proteins

2012 ◽  
Vol 279 (1740) ◽  
pp. 3075-3082 ◽  
Author(s):  
Evgeny V. Leushkin ◽  
Georgii A. Bazykin ◽  
Alexey S. Kondrashov
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequences ◽  
Molecular Adaptation ◽  
Amino Acid Substitutions ◽  
Protein Coding ◽  
Evolution Of Life ◽  
High Fraction ◽  
Adaptive Walks ◽  
The Difference ◽  
Almost All

Maps that relate all possible genotypes or phenotypes to fitness—fitness landscapes—are central to the evolution of life, but remain poorly known. An insertion or a deletion (indel) of one or several amino acids constitutes a substantial leap of a protein within the space of amino acid sequences, and it is unlikely that after such a leap the new sequence corresponds precisely to a fitness peak. Thus, one can expect an indel in the protein-coding sequence that gets fixed in a population to be followed by some number of adaptive amino acid substitutions, which move the new sequence towards a nearby fitness peak. Here, we study substitutions that occur after a frame-preserving indel in evolving proteins of Drosophila . An insertion triggers 1.03 ± 0.75 amino acid substitutions within the protein region centred at the site of insertion, and a deletion triggers 4.77 ± 1.03 substitutions within such a region. The difference between these values is probably owing to a higher fraction of effectively neutral insertions. Almost all of the triggered amino acid substitutions can be attributed to positive selection, and most of them occur relatively soon after the triggering indel and take place upstream of its site. A high fraction of substitutions that follow an indel occur at previously conserved sites, suggesting that an indel substantially changes selection that shapes the protein region around it. Thus, an indel is often followed by an adaptive walk of length that is in agreement with the theory of molecular adaptation.

BINDING OF 17-SUBSTITUTED 16-NITRILE 16,17-SECOESTRANE COMPOUNDS TO ESTROGEN RECEPTORS – „IN VITRO“ AND „IN SILICO“ STUDY

2021 ◽  
Author(s):  
Suzana S. Jovanović-Šanta ◽  
◽  
Esma Isenović ◽  
Julijana A. Petrović ◽  
Yaraslau U. Dzichenka
Keyword(s):  
Amino Acids ◽  
Estrogen Receptors ◽  
Nuclear Translocation ◽  
Binding Mode ◽  
High Rate ◽  
Dynamics Simulation ◽  
Breast Cancers ◽  
Number Of Binding Sites ◽  
Almost All

About 75% of breast cancers express estrogen receptors (ERs), which is a good base for an efficient endocrine therapy. This gives the opportunity for the treatment of patients with antiestrogens, compounds that bind to the ERs and thus compete to estradiol (E2), preventing its action in progression of estrogen-depending cancers. Here we present results of testing the effect of the modified steroids, namely 17-substituted 16-nitrile 16,17-secoestrane compounds on the E2-ER complex forming, its stability, nuclear translocation and binding to DNA. Almost all compounds in moderate to high rate induced lower forming of this complex, destabilizing it – they increased Kd of this complex and decreased number of binding sites. Complex formed in the presence of some test secosteroids could pass to the nucleus, while other compounds inhibited translocation. In the presence of some compounds binding of the formed complex E2-ER to DNA was noticed. Docking followed molecular dynamics simulation was performed to reveal binding mode of E2 to ER in the presence of test secosteroids. Amino acids important for binding process and complex stabilization were detected. Analysis of the simulation data allowed identifying key amino acids and type of binding of the secoestrane compounds, important for high affinity binding of the steroidal compounds.

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