The Association between Plasma Cholesterol, High-Density-Lipoprotein Cholesterol, Triglycerides and Uric Acid in Ethanol Consumers

1985 ◽  
Vol 22 (1) ◽  
pp. 62-66 ◽  
Author(s):  
J K Allen ◽  
M A Adena
Keyword(s):  
Uric Acid ◽  
Alcohol Consumption ◽  
High Density Lipoprotein ◽  
Cholesterol Synthesis ◽  
Plasma Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Epidemiological Data ◽  
High Density ◽  
The Relationship

The relationship between the concentrations of plasma cholesterol, high-density-lipoprotein (HDL) cholesterol, triglycerides and uric acid has been studied in relation to alcohol consumption in men attending a health-screening centre. Although it has been suggested that these metabolites are associated with each other by environmental factors, including ethanol consumption, the only correlation we have found between the variables which is statistically significantly related to alcohol consumption is that between total cholesterol and uric acid. A comparison of these correlations with epidemiological data suggests that assessment of cardiovascular risk is best done by using plasma cholesterol and uric acid levels, corrected for alcohol consumption. The correlation between HDL-cholesterol and the remaining fractions of plasma cholesterol is constant over all levels of alcohol consumption, and therefore the division of cholesterol between these fractions is apparently independent of both alcohol consumption and cholesterol synthesis.

scholarly journals Is There Any Association Between Uric Acid to High-density Lipoprotein Cholesterol Ratio and Erectile Dysfunction?

2021 ◽  
Author(s):  
Dilay Karabulut ◽  
Mustafa Gürkan Yenice
Keyword(s):  
Uric Acid ◽  
Erectile Dysfunction ◽  
High Density Lipoprotein ◽  
Roc Curve ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Roc Curve Analysis ◽  
Cholesterol Ratio ◽  
Group 3

Objective: Elevated uric acid (UA) and low levels of high-density lipoprotein (HDL) cholesterol are associated with cardiovascular events and mortality. Erectile dysfunction (ED) has been considered an early marker of cardiovascular disease (CVD). Therefore, this study aimed to investigate the uric acid/ HDL ratio (UHR) as a nowel marker in patients with ED. Materials and Methods: The study included 147 patients with a mean age of 50 years (range 32-76 years). Retrospective analyses were performed on the patients who were admitted to urology outpatient clinics. The laboratory parameter results were retrieved from the hospital medical records, and the UHR value was calculated. Patients were categorized into three groups according to the International Index of Erectile Function (IIEF) score. UHR was compared between groups, and its predictive value was evaluated using regression analysis and ROC curve analysis. Results: Age was found to be significantly different in all three groups (Groups 1-2, p=0.001; Groups 1-3, p=0.000; Groups 2-3, p=0.001). It was observed that the degree of ED increased with age. The values of UA and HDL were similar in all groups (p>0.05). In contrast, the UHR value was statistically significantly higher 0.15 (0.083-0.288, p =0.047) in the moderate-severe ED (Group 3). ROC curve analyses revealed that UHR predicted severe ED (IIEF 5-11) with 42.9% sensitivity and 87.3% specificity (AUC:0.66, CI 95% 0.538-0.781, p=0.019). Conclusion: UHR may serve as a severe ED indicator in patients admitted to the cardiology outpatient clinic since it has a significant association with a low IIEF score.

scholarly journals Alcohol Intake and Incident Myocardial Infarction: The Role of High-density Lipoprotein Cholesterol (P18-020-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Shue Huang ◽  
Zhe Huang ◽  
Gregory Shearer ◽  
Shanshan Li ◽  
Shuohua Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Alcohol Consumption ◽  
High Density Lipoprotein ◽  
Lower Risk ◽  
Alcohol Intake ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Penn State

Abstract Objectives The aim of this study is to test the hypothesis that the lower risk of myocardial infarction (MI) associated with alcohol intake is through its effect on raising high-density lipoprotein (HDL) cholesterol. Methods This study included 81,827 Chinese men and women (mean age: 51 ± 12 yr.) from the Kailuan Study who were free of cardiovascular disease in 2006 (at baseline) and were followed up to Dec. 2016. At baseline, alcohol consumption was assessed via a questionnaire and the concentration of HDL cholesterol was measured. Incident MI at follow up was a first MI event, confirmed by medical record review. Multivariable Cox regression was used to model the association between habitual alcohol intake and risks of MI, adjusting for potential covariates including age, sex, education, monthly income, occupation, smoking status, physical activity, body mass index, waist circumferences, hypertension, diabetes and total cholesterol. Mediated effect through HDL cholesterol was assessed using a causal mediating analysis (SAS macro). Results During an average of 9.6 years of follow-up, we documented 1095 incident cases. The adjusted hazard ratio (HR) for MI was 0.64 (95% confidence interval (CI), 0.54–0.76) for current alcohol drinkers compared with never or former. The ratio changed very slightly, to 0.65 (95% CI, 0.55–0.76) after further adjustment of HDL cholesterol concentration. Mediation analysis showed that HDL cholesterol concentrations mediated a small, non-significant proportion (1.8%) of the effect of alcohol on MI. Conclusions Alcohol consumption was associated with a lower risk for MI incidence in a large Chinese cohort. Our results suggest that the benefits associated with moderate alcohol consumption is not related to the effects of alcohol on HDL cholesterol. Funding Sources Start-up grant from Penn State College of Health and Human Development, and Penn State CyberScience Seed Grant Program.

scholarly journals Association of Air Pollution Exposures With High-Density Lipoprotein Cholesterol and Particle Number

2017 ◽  
Vol 37 (5) ◽  
pp. 976-982 ◽  
Author(s):  
Griffith Bell ◽  
Samia Mora ◽  
Philip Greenland ◽  
Michael Tsai ◽  
Ed Gill ◽  
...  
Keyword(s):  
Air Pollution ◽  
Confidence Interval ◽  
High Density Lipoprotein ◽  
Black Carbon ◽  
Particle Number ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Pollution Exposure ◽  
The Relationship

Objective— The relationship between air pollution and cardiovascular disease may be explained by changes in high-density lipoprotein (HDL). Approach and Results— We examined the cross-sectional relationship between air pollution and both HDL cholesterol and HDL particle number in the MESA Air study (Multi-Ethnic Study of Atherosclerosis Air Pollution). Study participants were 6654 white, black, Hispanic, and Chinese men and women aged 45 to 84 years. We estimated individual residential ambient fine particulate pollution exposure (PM 2.5 ) and black carbon concentrations using a fine-scale likelihood-based spatiotemporal model and cohort-specific monitoring. Exposure periods were averaged to 12 months, 3 months, and 2 weeks prior to examination. HDL cholesterol and HDL particle number were measured in the year 2000 using the cholesterol oxidase method and nuclear magnetic resonance spectroscopy, respectively. We used multivariable linear regression to examine the relationship between air pollution exposure and HDL measures. A 0.7×10 − 6 m − 1 higher exposure to black carbon (a marker of traffic-related pollution) averaged over a 1-year period was significantly associated with a lower HDL cholesterol (−1.68 mg/dL; 95% confidence interval, −2.86 to −0.50) and approached significance with HDL particle number (−0.55 mg/dL; 95% confidence interval, −1.13 to 0.03). In the 3-month averaging time period, a 5 μg/m 3 higher PM 2.5 was associated with lower HDL particle number (−0.64 μmol/L; 95% confidence interval, −1.01 to −0.26), but not HDL cholesterol (−0.05 mg/dL; 95% confidence interval, −0.82 to 0.71). Conclusions— These data are consistent with the hypothesis that exposure to air pollution is adversely associated with measures of HDL.

scholarly journals High density lipoprotein cholesterol and alcohol consumption: are they related?

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
MR Santos ◽  
A Pereira ◽  
JA Sousa ◽  
F Mendonca ◽  
JP Monteiro ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Moderate Alcohol Consumption ◽  
Beneficial Effects ◽  
Quartile Group

Abstract Funding Acknowledgements Type of funding sources: None. OnBehalf GENEMACOR Introduction High density lipoprotein cholesterol (HDL-C) is known to be inversely related to coronary artery disease (CAD). Previous observational studies have consistently reported that individuals with moderate alcohol consumption have a lower risk of cardiovascular disease compared with that of nondrinkers and heavy drinkers. The beneficial effects of moderate drinking appear to be mediated in large part by alcohol-induced increases in HDL-C concentrations. Objective To evaluate if a moderate alcohol consumption (30-50g a day) is associated with higher levels of HDL-C in coronary patients. Materials and methods 1676 patients selected from GENEMACOR study population, with at least one > 75% coronary stenosis by angiography (median age 53.3 ± 7.9 years, 78.6% male, median HDL 43.0 ± 11.1 mg/dL). Population was divided according to the HDL level quartiles (1st quartile HDL < 35.3 mg/dL; 2nd quartile HDL 35.3 – 42 mg/dL; 3rd quartile HDL 42 – 49 mg/dL; 4th quartile HDL > 49 mg/dL). Population of the 1st and 4th quartiles (825 patients, median age of 53.3 ± 8.0 years and 78.7% male) were adjudicated and prospectively followed-up by 5.0 ± 4.2 years. X2 and T student tests were used to analyze the demographic, laboratorial, angiographic and anthropometric characteristics of the population. Results 420 (50.9%) patients were included in the 1st quartile group (median age 53.2 ± 7.9 years, 85.7% men) and 405 (49.1%) patients were included in the 4th quartile group (median age 53.4 ± 8.0 years, 71.4% men). The mean HDL level was higher in the population with moderate alcohol consumption (mean HDL 43.7 ± 15mg/dL in patients with alcohol consumption <30g/day, mean HDL 48.8 ± 16mg/dL in patients with moderate alcohol consumption and mean HDL 41.6 ± 15mg/dL in patients with alcohol consumption >50g/day). From 104 (median age 51.9 ± 7.9 years, 96.2% male) patients with a moderate alcohol consumption, 62.5% vs 37.5% were in 4th HDL quartile, p 0.01. Conclusion We conclude that in our population, a moderate alcohol consumption is associated with higher levels of HDL-C. However, even if there is a causal association between alcohol consumption and higher HDL cholesterol levels, it is suggested that efforts to reduce coronary heart disease risks concentrate on the control of another risk factors.

scholarly journals Investigating the relationship between serum uric acid to high‐density lipoprotein ratio and metabolic syndrome

2021 ◽  
Author(s):  
Farzaneh Yazdi ◽  
Mohammad Hassan Baghaei ◽  
Amir Baniasad ◽  
Ahmad Naghibzadeh‐Tahami ◽  
Hamid Najafipour ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
High Density Lipoprotein ◽  
Serum Uric Acid ◽  
Density Lipoprotein ◽  
High Density ◽  
The Relationship

scholarly journals High Density Lipoprotein Cholesterol Efflux Capacity and Atherosclerosis in Cardiovascular Disease: Pathophysiological Aspects and Pharmacological Perspectives

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 574
Author(s):  
Maria Pia Adorni ◽  
Nicoletta Ronda ◽  
Franco Bernini ◽  
Francesca Zimetti
Keyword(s):  
High Density Lipoprotein ◽  
Cholesterol Efflux ◽  
Current Knowledge ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Current Evidence ◽  
Endocrine Disorders ◽  
Lifestyle Modifications ◽  
Cholesterol Efflux Capacity

Over the years, the relationship between high-density lipoprotein (HDL) and atherosclerosis, initially highlighted by the Framingham study, has been revealed to be extremely complex, due to the multiple HDL functions involved in atheroprotection. Among them, HDL cholesterol efflux capacity (CEC), the ability of HDL to promote cell cholesterol efflux from cells, has emerged as a better predictor of cardiovascular (CV) risk compared to merely plasma HDL-cholesterol (HDL-C) levels. HDL CEC is impaired in many genetic and pathological conditions associated to high CV risk such as dyslipidemia, chronic kidney disease, diabetes, inflammatory and autoimmune diseases, endocrine disorders, etc. The present review describes the current knowledge on HDL CEC modifications in these conditions, focusing on the most recent human studies and on genetic and pathophysiologic aspects. In addition, the most relevant strategies possibly modulating HDL CEC, including lifestyle modifications, as well as nutraceutical and pharmacological interventions, will be discussed. The objective of this review is to help understanding whether, from the current evidence, HDL CEC may be considered as a valid biomarker of CV risk and a potential pharmacological target for novel therapeutic approaches.

Performance of commercially-available cholesterol self-tests

2021 ◽  
pp. 000456322199239
Author(s):  
Steef Kurstjens ◽  
Eugenie Gemen ◽  
Selina Walk ◽  
Tjin Njo ◽  
Johannes Krabbe ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Diagnostic Performance ◽  
Plasma Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Cholesterol Concentration ◽  
Limited Information ◽  
Plasma Cholesterol Concentration ◽  
Lipid Panel ◽  
Better Regulation

Background Hypercholesterolemia (plasma cholesterol concentration ≥5.2 mmol/L) is a risk factor for cardiovascular disease and stroke. Many different cholesterol self-tests are readily available at general stores, pharmacies and web shops. However, there is limited information on their analytical and diagnostic performance. Methods We included 62 adult patients who required a lipid panel measurement (cholesterol, high-density lipoprotein (HDL), triglycerides and LDLcalc) for routine care. The performance of five different cholesterol self-tests, three quantitative meters ( Roche Accutrend Plus, Mission 3-in-1 and Qucare) and two semi-quantitative strip tests ( Veroval and Mylan MyTest), was assessed according to the manufacturers’ protocol. Results The average plasma cholesterol concentration was 5.2 ± 1.2 mmol/L. The mean absolute relative difference (MARD) of the five cholesterol self-tests ranged from 6 ± 5% ( Accutrend Plus) to 20 ± 12% ( Mylan Mytest). The Accutrend Plus cholesterol meter showed the best diagnostic performance with a 92% sensitivity and 89% specificity. The Qucare and Mission 3-in-1 are able to measure HDL concentrations and can thus provide a cholesterol:HDL ratio. The Passing-Bablok regression analyses for the ratio showed poor performance in both self-tests ( Mission 3-in-1: y = 1.62x–1.20; Qucare: y = 0.61x + 1.75). The Accutrend Plus is unable to measure the plasma high-density lipoprotein concentration. Conclusions/interpretation: The Accutrend Plus cholesterol meter (Roche) had excellent diagnostic and analytic performance. However, several of the commercially-available self-tests had considerably poor accuracy and diagnostic performance and therefore do not meet the required qualifications, potentially leading to erroneous results. Better regulation, standardization and harmonization of cholesterol self-tests is warranted.

scholarly journals Prevalence and Predictors of Dyslipidemia in Children and Adolescents in Yazd Greater Area, Yazd, Iran

2021 ◽  
Keyword(s):  
High Density Lipoprotein ◽  
Children And Adolescents ◽  
Lifestyle Modification ◽  
Age Groups ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cluster Sampling ◽  
Cross Sectional

Background: Dyslipidemia, a genetic and multifactorial disorder of lipoprotein metabolism, is defined by elevations in levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non–HDL-C), triglyceride, or some combination thereof, as well as lower levels of high-density lipoprotein (HDL) cholesterol. Objectives: This study aimed to investigate the prevalence and predictors of dyslipidemia in children and adolescents in the Yazd Greater Area, Yazd, Iran. Methods: This cross-sectional study was conducted as a part of the national project implemented in Yazd Greater Area, Yazd, Iran. The sampling was performed using a multi-stage cluster sampling method on three age groups of girls and boys (6-9, 10-14, and 15-18 years old). Out of the total 1,035 children and adolescents who participated in this study, only 784 participants remained in the study until the end. Data collection was performed using lifestyle questionnaires including Kiddie-SADS-Present and Lifetime Version. Results: The prevalence of high triglyceride was estimated at 1.4% and 4.2% in 6-9 and 10-18 years old children and adolescents, respectively. The prevalence of high cholesterol, LDL, and HDL was 3.2%, 3.2%, and 25.6%, respectively. The prevalence of dyslipidemia in the total population of children and adolescents in terms of demographic variables was 64.6% and 57.3% in boys and girls, respectively (P=0.038). Gender and increase in body mass index were significantly associated with dyslipidemia with OR=1.35; 95% CI: 1.01-1.81 and OR=13.781; 95% CI: 3.78- 46.43, respectively. However, after adjustment for other factors, only an increase in BMI was significantly associated with dyslipidemia (OR=16.08; 95% CI: 4.49-57.59). Conclusions: Overweight and obese adolescents had a higher concentration of serum blood triglycerides, compared to other adolescents. Weight control, lifestyle modification, and diet are three ways to reduce lipid disorders in adolescents.

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