scholarly journals Pulmonary Function Impairment among Stone Cutting Workers in North Gujarat

2021 ◽  
Vol 11 (6) ◽  
pp. 39-46
Author(s):  
Vidhya Solanki ◽  
Karishma Barot ◽  
Priyanka Chaudhari
Keyword(s):  
Pulmonary Function ◽  
Work Experience ◽  
Pulmonary Function Tests ◽  
Primary Objective ◽  
Construction Sites ◽  
Significant Difference ◽  
Function Impairment ◽  
Secondary Objective ◽  
Stone Cutting ◽  
North Gujarat

Background: Pulmonary problems are a major cause of morbidity & mortality all over the world. It has been found that lung functions are mostly affected in workers exposed to affect majorly in granite, marble, various other rocks and sand dust exposed workers. Objective:The primary objective of the study was to find out the prevalence of pulmonary function impairment among stone cutting workers at various construction sites in North Gujarat and the secondary objective was to find the effectiveness of Physiotherapy measures among those workers. Methods: A total of 408 male stone cutting worker participated in this study around various construction sites in the vicinity of North Gujarat from September to December 2019. After assessing pulmonary function tests, workers with impairment were treated with Deep breathing exercise and advice personal protective measures like face masks, cession of smoking and water spraying before cutting. Results: The data was collected from all the stone cutting workers. The average age was 31.43 ± 9.18 years and the average duration of work experience as stone cutter was 12.32± 6.11. A total of 50.24 % participant complaints of chronic cough, 10.29% of chest pain and 31.61% of participants reported wheezes. Data Analysis showed after 3 months of Physiotherapeutic intervention there was significant difference in FEV1 FVC and FEV1/FVC. Conclusion:The present study shows that there was a high prevalence of pulmonary functions impairment among stone cutting worker in North Gujarat and Physiotherapy measures can be used as an adjacent to minimize this problem. Key words: Stone cutting workers, Pulmonary Function impairment, Pulmonary Function test, North Gujarat.

scholarly journals Lung Volume Reduction Surgery in Patients with Heterogenous Emphysema: Selecting Perspective

2019 ◽  
Vol 7 (24) ◽  
pp. 4389-4392
Author(s):  
Nguyen Truong Giang ◽  
Trung Nguyen Ngoc ◽  
Nguyen Van Nam ◽  
Nguyen Viet Nhung ◽  
Ta Ba Thang ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Lung Volume ◽  
Pulmonary Function Tests ◽  
Volume Reduction ◽  
Military Hospital ◽  
Lung Volume Reduction Surgery ◽  
Lung Volume Reduction ◽  
Function Tests ◽  
Significant Difference ◽  
Preoperative Factor

BACKGROUND: Lung volume reduction surgery (LVRS) was introduced to alleviate clinical conditions in selected patients with heterogenous emphysema. Clarifying the most suitable patients for LVRS remained unclear. AIM: This study was undertaken to specifically analyze the preoperative factor affecting to LVRS. METHODS: The prospective study was conducted at 103 Military Hospital between July 2014 and April 2016. Severe heterogenous emphysema patients were selected to participate in the study. The information, spirometry, and body plethysmographic pulmonary function tests in 31 patients who underwent LVRS were compared with postoperative outcomes (changing in FEV1 and CAT scale). RESULTS: Of the 31 patients, there was statistically significant difference in the outcome of functional capacity, lung function between two groups (FEV1 ≤ 50% and > 50%) (∆FEV1: 22.46 vs 18.32%; p = 0.042. ∆CAT: 6.85 vs 5.07; p = 0.048). Changes of the FEV1 and CAT scale were no statistically significant differences in three groups residual volume. Patients with total lung capacity < 140% had more improved than others (∆FEV1: 23.81 vs 15.1%; p = 0.031). CONCLUSION: Preoperative spirometry and body plethysmographic pulmonary function tests were useful measures to selected severe heterogenous emphysema patients for LVRS. Patients with FEV1 ≤ 50%, TLC in the range of 100-140% should be selected.

scholarly journals Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Minmin Yin ◽  
Haibao Wang ◽  
Xianwei Hu ◽  
Xiaoshu Li ◽  
Guanghe Fei ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Grey Matter ◽  
Inferior Frontal Gyrus ◽  
Structural Alteration ◽  
Functional Impairments ◽  
Copd Patients ◽  
Significant Difference ◽  
Function Impairment ◽  
Different Levels

Abstract Background To explore patterns of brain structural alteration in chronic obstructive pulmonary disease (COPD) patients with different levels of lung function impairment and the associations of those patterns with cognitive functional deficits using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) analyses based on high-resolution structural MRI and diffusion tensor imaging (DTI). Methods A total of 115 right-handed participants (26 severe, 29 moderate, and 29 mild COPD patients and a comparison group of 31 individuals without COPD) completed tests of cognitive (Montreal Cognitive Assessment [MoCA]) and pulmonary function (forced expiratory volume in 1 s [FEV1]) and underwent MRI scanning. VBM and TBSS analyses were used to identify changes in grey matter density (GMD) and white matter (WM) integrity in COPD patients. In addition, correlation analyses between these imaging parameter changes and cognitive and pulmonary functional impairments were performed. Results There was no significant difference in brain structure between the comparison groups and the mild COPD patients. Patients with moderate COPD had atrophy of the left middle frontal gyrus and right opercular part/triangular part of the inferior frontal gyrus, and WM changes were present mainly in the superior and posterior corona radiata, corpus callosum and cingulum. Patients with severe COPD exhibited the most extensive changes in GMD and WM. Some grey matter (GM) and WM changes were correlated with MoCA scores and FEV1. Conclusions These findings suggest that patients with COPD exhibit progressive structural impairments in both the GM and the WM, along with impaired levels of lung function, highlighting the importance of early clinical interventions.

scholarly journals Pulmonary function parameters among marble industry workers in Lahore, Pakistan

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 938
Author(s):  
Imran Maqsood Butt ◽  
Tajammal Mustafa ◽  
Shahnaz Rauf ◽  
Anjum Razzaq ◽  
Javaria Anwer
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Work Experience ◽  
Pulmonary Function Tests ◽  
Significant Risk ◽  
Exposed Group ◽  
Dust Particles ◽  
Continuous Exposure ◽  
Healthy Individuals ◽  
Marble Dust

Background: Occupational contact with dust particles is a well-known phenomenon, particularly in developing countries of the world. Crystalline silica present in marble dust is the main etiology of a rising prevalence of obstructive lung diseases in marble stone workers, who are in direct contact with marble dust in the surrounding environment during their regular work.  The purpose of this study was to compare the pulmonary function parameters of workers in marble workshops and age matched healthy individuals in the Lahore District of Pakistan. Methods: The study included 164 male individuals, 82 individuals working in marble workshops and 82 healthy individuals from the same community. Data were collected through in-person interviews using a structured questionnaire after obtaining written consent. A Spiro Lab spirometry for pulmonary function tests was used to identify any change in the lung function parameters. FVC% (forced vital capacity), FEV 1 (forced expiratory volume in first second) and FEV1 / FVC ratio were evaluated. Results: Mean age in the exposed group (marble workers) and non-exposed group (healthy individuals) were 29.92 ± 6.19 and 30.58 ± 6.37 years, respectively. The mean years of work experience of the exposed group was 11.92 ± 5.67 years. A statistically insignificant difference was observed between marble exposed workers & healthy individuals from the demographic variables. Lung function parameters in marble workers exhibited a highly significant (P < 0.001) decrease in FVC%, FEV1 & FEV1 / FVC ratio when compared to healthy individuals. Seventy-one percent of marble workers had abnormal pulmonary parameters whereas 34% of workers had restrictive pulmonary impairment. Marble workers who had worked for more than 15 years had a highly significant risk of developing abnormal pulmonary function (P < 0.001). Conclusion: Continuous exposure to marble dust deteriorates the lung function of marble workers.

Pulmonary toxicity in patients receiving docetaxel chemotherapy

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e13532-e13532
Author(s):  
U. Kefeli ◽  
P. F. Yumuk ◽  
B. Ceyhan ◽  
F. Dane ◽  
B. Eroglu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Pulmonary Function ◽  
Cumulative Dose ◽  
Pulmonary Toxicity ◽  
Pulmonary Function Tests ◽  
Post Treatment ◽  
Function Tests ◽  
Significant Difference ◽  
Docetaxel Treatment ◽  
Docetaxel Chemotherapy

e13532 Background: Docetaxel is used widely as monotherapy or in combination for the treatment of various types of cancers. Although rarely observed, pulmonary toxicity can be seen with docetaxel. This side effect had been reported mostly in non-small cell lung cancer patients receiving docetaxel. We aimed to investigate the pulmonary toxicity in patients receiving docetaxel chemotherapy other than lung cancer. Methods: 34 patients were investigated prospectively to demonstrate the pulmonary toxicity of docetaxel. Pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) scans were applied to all patients before chemotherapy and 14 - 21 days after completion of treatment. We used a HRCT scoring system that was based on the previous studies. All HRCT images were reviewed by two different observers. Results: We have seen no pulmonary symptoms that may reflect pulmonary toxicity in 34 patients. There were statistically significant differences between pre- and post-treatment values of FEV1 (L/sec) (p<0.05), FEV1/FVC (%) (p<0.05), FEF25–75 (L/sec) (p<0.01), FEF25–75 (%) (p<0,01), DLCO (mL/mmHg/min) (p<0.001), DLCO (%) (p<0.001), DLCO/VA (DLCO/L) (p<0.05), and DLCO/VA (%) (p<0.05). Also, there was a statistically significant difference between the pre- and post-treatment HRCT scores. The differences between pre- and post- treatment values of pulmonary function tests were not correlated with the number of docetaxel cycles and cumulative dose. There was a statistical relationship between number of docetaxel cycles (r =0.468, p<0.0001), docetaxel cumulative dose (r=0,596, p<0.0001) and HRCT scores after completion of docetaxel treatment. Conclusions: Although we have shown that docetaxel treatment causes a decline in PFTs and worsens HRCT scores, the symptoms of patients were not consistent with these differences. Therefore, it should be noted that the negative effects of docetaxel on PFTs and HRCT scores should be investigated by increasing the number of patients. No significant financial relationships to disclose.

Randomized phase II trial of budesonide versus placebo in high-risk population with screening-detected lung nodules: Update on secondary endpoints

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 1518-1518
Author(s):  
B. Bonanni ◽  
A. Guerrieri-Gonzaga ◽  
D. Radice ◽  
D. Serrano ◽  
C. Varricchio ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Smoking Status ◽  
Primary Objective ◽  
Systemic Absorption ◽  
High Risk Population ◽  
Double Blind ◽  
Significant Difference ◽  
Secondary Endpoints

1518 Background: Lung cancer phase II chemoprevention trials have not focused so far on the peripheral lung. CT discovers small, undetermined peripheral nodules, which may be preinvasive lesions. In a recent phase II trial the glucocorticoid Budesonide reduced peripheral nodules at spiral CT. Methods: We performed a randomized, double-blind, placebo-controlled, phase IIb clinical trial of inhaled budesonide in current (CS) or former smokers (FS) with CT-detected peripheral nodules. Primary endpoint: shrinkage effect on nodules. Secondary endpoints: decrease in size/number of the target lesions, modulation of tumor markers in sputum and plasma, toxicity, effect on pulmonary function. Two hundred and two subjects received 800μg budesonide (B) twice daily or placebo (P) for 1 year. CT scans at 0 and 12 months (mts), and clinical evaluation + serum/plasma collection at 0, 3, 6, and 12 months were performed. Subjects were stratified according to gender, smoking habits (CS vs. FS), and nodule characteristics (solid vs. non-solid). Results: Preliminary data had shown no shrinkage of the nodules in the B treated arm in a per subject analysis (primary objective). We present now results on serum markers (ultrasensitive C-reactive protein, CRP), emphysema and pulmonary function. As compared to baseline, CRP median levels show at 12 months a nonsignificant (p = 0.85) reduction: -0.25 ± 0.63 (B) vs. -1.16 ± 0.97 (P). 12-month values are significantly (p = 0.01) associated with baseline values and smoking status, with higher mean values at 12 months in FS (B 2.1 ± 2.0 vs. P 3.4 ± 1.9). Emphysema values at 12 months are significantly higher (p = 0.0022) in the B (+ 0.29 ± 0.06) versus P arm (+ 0.12 ± 0.07). This difference is not correlated to sex (p = 0.7062) and smoking status (p = 0.8044). As regards spirometry, no significant difference on FEV 1% and DLC/VA appears between arms at 12 months: median FEV 1% values 3.7 ± 1.0 for B versus 2.9 ± 1.0 for P (p = 0.6221); median DLC/VA increase of 0.3 ± 1.9 (B) versus decrease of -3.8 ± 1.6 (P) (p = 0.4191). Conclusions: A significant effect of B on ultrasensitive-CRP and pulmonary function has not been shown. CRP results may indicate the lack of systemic absorption of B. Emphysema appears slightly worse in the B arm, particularly in FS; this is worth further investigation. No significant financial relationships to disclose.

Ozone and high ventilation effects on pulmonary function and endurance performance

1983 ◽  
Vol 55 (3) ◽  
pp. 805-812 ◽  
Author(s):  
W. C. Adams ◽  
E. S. Schelegle
Keyword(s):  
Pulmonary Function ◽  
Minute Ventilation ◽  
Pulmonary Function Tests ◽  
Endurance Performance ◽  
Subjective Symptoms ◽  
Adult Males ◽  
Long Distance ◽  
Function Impairment ◽  
Respiratory Discomfort ◽  
Exercise Induced

Ozone (O3) toxicity is potentiated by exercise-induced expired minute ventilation (VE) for a given exposure, which may also impair endurance performance. Ten healthy, well-trained long-distance runners were exposed on six occasions for 1 h to O3 concentrations of 0, 0.20, or 0.35 parts per million (ppm), during exercise simulating either training or competition, with mean VE = 77.5 1 X min -1. Standard pulmonary function tests, subjective symptoms, and periodic observations of exercise ventilatory response and respiratory metabolism were obtained. Statistical analyses revealed no significant exercise mode effect for pulmonary function, but a significant O3 effect for forced vital capacity and expiratory volume at 1 s was observed. Altered exercise ventilatory pattern response was noted, but there was no significant O3 effect on exercise oxygen uptake, heart rate, VE, or alveolar ventilation. Subjective symptoms increased with O3 concentration. Statistically significant pulmonary function impairment observed at 0.20 ppm O3 suggests that endurance athletes may be more susceptible to the effects of a given O3 concentration than normal young adult males as a result of sustained high mean VE incurred during training and competition. Three subjects were unable to complete both the training and competitive simulations at 0.35 ppm O3. Performance decrements appeared to be the result of physiologically induced respiratory discomfort rather than decrements in pulmonary gas exchange and/or oxygen transport and delivery.

Creation and evaluation of a cancer chemotherapy order review guide for use at a community hospital

2017 ◽  
Vol 25 (1) ◽  
pp. 25-43 ◽  
Author(s):  
Alexandra P Punke ◽  
JA Waddell
Keyword(s):  
Cancer Chemotherapy ◽  
Literature Search ◽  
Community Hospital ◽  
Dose Calculation ◽  
Primary Objective ◽  
Hospital Pharmacists ◽  
Detailed Explanation ◽  
Significant Difference ◽  
Secondary Objective ◽  
To Receive

The proper evaluation of cancer chemotherapy orders is necessary for patients to receive safe and effective treatment. The chemotherapy treatment setting is evolving resulting in hospital pharmacists without extensive oncology training or experience now being responsible for evaluation of chemotherapy orders. The primary objective was to create a step-by-step chemotherapy order evaluation guide with a detailed explanation for each step. The secondary objective was to evaluate non-oncology trained pharmacists' ability to accurately review simulated chemotherapy orders post-education using the guide. A two-page chemotherapy order evaluation guide was created based on an accepted method of chemotherapy order review consisting of the following eight steps: regimen verification, clinical trial protocol verification, body surface area calculation, dose calculation, laboratory values, emesis prophylaxis, adjunctive or supportive care measures, and pharmacy labels. A literature search was performed for each step. A detailed explanation for each step was written as a separate component from the guide to encompass the literature search information and current guidelines in a more comprehensive manner. Non-oncology trained community hospital pharmacists were educated on use of the guide for approximately 30 min. The guide was evaluated using timed simulated chemotherapy orders pre- and post-education consisting of a general chemotherapy order and a carboplatin dosing order. Nineteen pharmacists were tested with simulated chemotherapy orders. A significant difference was detected between the pre- and post-education for both the general chemotherapy (p = 0.00032) order and carboplatin dosing order (p = 0.031).

Needling Versus Liquid Nitrogen Cryotherapy for the Treatment of Pedal Warts

2014 ◽  
Vol 104 (4) ◽  
pp. 394-401 ◽  
Author(s):  
Daniel J. Cunningham ◽  
Jessica T. Brimage ◽  
Reza N. Naraghi ◽  
Virginia M. Bower
Keyword(s):  
Human Papillomavirus ◽  
Liquid Nitrogen ◽  
Primary Objective ◽  
Local Inflammation ◽  
Cell Mediated Immune Response ◽  
Significant Difference ◽  
Secondary Objective ◽  
To Receive ◽  
Group 1

Background We hypothesized that needling of a pedal wart creates local inflammation and a subsequent cell-mediated immune response (CMIR) against human papillomavirus. The primary objective of this study was to investigate whether needling to induce a CMIR against human papillomavirus is an effective treatment for pedal warts compared with liquid nitrogen cryotherapy. A secondary objective was to investigate whether the CMIR induced by needling is effective against satellite pedal warts. Methods Eligible patients with pedal warts were randomly allocated to receive either needling or liquid nitrogen cryotherapy. Only the primary pedal wart was treated during the study. Follow-up was 12 weeks, with outcome assessments made independently under blinded circumstances. Results Of 37 patients enrolled in the study, 18 were allocated to receive needling and 19 to receive liquid nitrogen cryotherapy. Regression of the primary pedal wart occurred in 64.7% of the needling group (11 of 17) and in 6.2% of the liquid nitrogen cryotherapy group (1 of 16) (P =  .001). No significant relationship was found between needling of the primary pedal wart and regression of satellite pedal warts (P = .615) or complete pedal wart regression (P = .175). There was no significant difference in pain, satisfaction, or cosmesis between the two groups. Conclusions The regression rate of the primary pedal wart was significantly higher in the needling group compared with the liquid nitrogen cryotherapy group.

scholarly journals Use of positive pressure in the bariatric surgery and effects on pulmonary function and prevalence of atelectasis: randomized and blinded clinical trial

2014 ◽  
Vol 27 (suppl 1) ◽  
pp. 26-30 ◽  
Author(s):  
Letícia BALTIERI ◽  
Laisa Antonela SANTOS ◽  
Irineu RASERA-JUNIOR ◽  
Maria Imaculada Lima MONTEBELO ◽  
Eli Maria PAZZIANOTTO-FORTI
Keyword(s):  
Bariatric Surgery ◽  
Pulmonary Function ◽  
Postoperative Period ◽  
Pulmonary Function Tests ◽  
Optimal Time ◽  
Positive Pressure ◽  
Time Of Application ◽  
Significant Difference ◽  
Blinded Study ◽  
Postoperative Respiratory Complications

BACKGROUND: In surgical procedures, obesity is a risk factor for the onset of intra and postoperative respiratory complications. AIM: Determine what moment of application of positive pressure brings better benefits on lung function, incidence of atelectasis and diaphragmatic excursion, in the preoperative, intraoperative or immediate postoperative period. METHOD: Randomized, controlled, blinded study, conducted in a hospital and included subjects with BMI between 40 and 55 kg/m2, 25 and 55 years, underwent bariatric surgery by laparotomy. They were underwent preoperative and postoperative evaluations. They were allocated into four different groups: 1) Gpre: treated with positive pressure in the BiPAP mode (Bi-Level Positive Airway Pressure) before surgery for one hour; 2) Gpos: BIPAP after surgery for one hour; 3) Gintra: PEEP (Positive End Expiratory Pressure) at 10 cmH2O during the surgery; 4) Gcontrol: only conventional respiratory physiotherapy. The evaluation consisted of anthropometric data, pulmonary function tests and chest radiography. RESULTS: Were allocated 40 patients, 10 in each group. There were significant differences for the expiratory reserve volume and percentage of the predicted expiratory reserve volume, in which the groups that received treatment showed a smaller loss in expiratory reserve volume from the preoperative to postoperative stages. The postoperative radiographic analysis showed a 25% prevalence of atelectasis for Gcontrol, 11.1% for Gintra, 10% for Gpre, and 0% for Gpos. There was no significant difference in diaphragmatic mobility amongst the groups. CONCLUSION: The optimal time of application of positive pressure is in the immediate postoperative period, immediately after extubation, because it reduces the incidence of atelectasis and there is reduction of loss of expiratory reserve volume.

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