scholarly journals ASCORBIC ACID AND THE PROTECTIVE EFFECT IN SWISS MICE TREATED WITH GREEN TEA INFUSIONS

2015 ◽  
Vol 12 (24) ◽  
pp. 17-27
Author(s):  
Luana Taís Hartmann BACKES ◽  
Telma Elita BERTOLIN ◽  
Silvana Souza ROMAN ◽  
Janaine de Oliveira PAIVA ◽  
Vanusa MANFREDINI ◽  
...  
Keyword(s):  
Vitamin C ◽  
Protective Effect ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Control Group ◽  
Beneficial Effects ◽  
Group 4 ◽  
Group 5 ◽  
Group 2 ◽  
Experimental Group

The use of medicinal plants is expressive because it’s beneficial effects, however the dosages some times are not adjusted. The study had for objective to investigate the toxicity of the green tea and the protective effect of vitamin C. Had been used 36 mice swiss, distributed in 6 groups (n=6): Control group with 1 ml/kg of saline solution 0.9%; Experimental group 1 with extract of Camellia sinensis in 0,5% concentration; Experimental group 2 with extract of Camellia sinensis in 10% concentration; Experimental group 3 with extract of Camellia sinensis in 0,5% concentration associate with vitamin C in 40mg/mL concentration; Experimental group 4 with extract of Camellia sinensis in 10% concentration associate with vitamin C in 40mg/mL concentration and Experimental group 5 with vitamin C solution in 40mg/mL concentration. The results had been significant for corporal weight and agencies (liver, kidneys, dull and brain) in the group of bigger concentration of green tea and in the groups where vitamin C was associated, allowing itself to suggest a light toxicity in the groups that had received these treatments.

scholarly journals THE SURVIVAL RATE OF CHICK EMBRYO INFLUENCED BY NICOTINE AND ANTIOXIDANT GREEN TEA (CAMELLIA SINENSIS)

2021 ◽  
Vol 71 (6) ◽  
pp. 2029-32
Author(s):  
Maryam Shan ◽  
Shazia Muazam ◽  
Hina Shan ◽  
Fahad Atta ◽  
Zubia Iftikhar ◽  
...  
Keyword(s):  
Survival Rate ◽  
Chick Embryo ◽  
Green Tea ◽  
Camellia Sinensis ◽  
Control Group ◽  
Medical College ◽  
Group 4 ◽  
Group 3 ◽  
Group 2

Objectives: To study the effects of Nicotine on the survival rate of chick embryo and to evaluate the preventive role by the antioxidant green tea camellia sinensis. Study Design: Laboratory-based experimental study. Place and Duration of Study: Army Medical College, Rawalpindi, from Nov 2011 to Nov 2012. Methodology: A total of 75 Fayoumi fresh fertilized eggs were kept at Poultry Research Institute, Rawalpindi. Experimental solutions were injected to the eggs of four groups at forty-eight hours of incubation and the effect on the growth was recorded and compared with the control group. The control and experimental groups were observed to assess the effects of Nicotine and the role of antioxidant green tea Camellia sinensis on the survival rate and growth of chick embryo’s femur. Results: The control group (group-1) showed 100% survival rate of embryos. The experimental group-2 showed survival rate of 100% embryos and the group-3 and group-4 showed survival rate 50% and 70% of embryos, respectively. Conclusion: It was concluded that green tea decreases the oxidative stress caused by the Nicotine.

scholarly journals Effectiveness of medical treatment in overcoming the ureteral double-J stent related symptoms

2012 ◽  
Vol 6 (6) ◽  
pp. 234 ◽  
Author(s):  
Ugur Kuyumcuoglu ◽  
Bilal Eryildirim ◽  
Murat Tuncer ◽  
Gokhan Faydaci ◽  
Fatih Tarhan ◽  
...  
Keyword(s):  
The Body ◽  
Control Group ◽  
Group 4 ◽  
Double J Stent ◽  
Urinary Tract Symptoms ◽  
Stone Treatment ◽  
Group 3 ◽  
Group 5 ◽  
Group 2

Background: We investigated whether the frequency of lower urinary tract symptoms (LUTS) increased in patients in whom double-J stents were applied. We also evaluated several medical therapy protocols to treat symptoms related with ureteral stents.Materials and Methods: A total of 108 patients, in whom unilateral double-j stent was applied during ureteral stone treatment, were included. Before the double-J stent was applied, all patients completed storage components of the “International Prostate Symptom Score” (IPSSs), quality of life components of the IPSS (IPSS-QOL) and “Overactive Bladder Questionnaire” (OABq) forms and scores were calculated. After the procedure, cases were randomized into 5 groups, an antiinflammatory was given to Group 1, spasmolytic to Group 2, anticholinergic to Group 3 and α-blocker to Group 4. No additional drug was given to Group 5 as this control group. During the fourth week of the procedure, IPSSs, IPSS-QOL and OABq forms were again completed and scores were compared with the previous ones.Results: When all the cases were evaluated, the IPSSs, IPSS-QOLand OABq scores of patients in whom the double-J stent was applied were statistically significantly higher the procedure. Compared to the control group, the cases where the double-J stent was applied showed a higher IPSSs, IPSS-QOL and OABq scores and none of the medical therapies could prevent this increase.Interpretation: The frequency of LUTS increased in cases where the ureteral stent was applied and discomfort continued as long as the stent stayed in the body.

scholarly journals Zingerone Ameliorates Hepatotoxicity

2020 ◽  
Vol 11 (1) ◽  
pp. 280-284 ◽  
Author(s):  
Julietpoornamathy J ◽  
Parameswari C.S.
Keyword(s):  
The Body ◽  
Control Group ◽  
Medical Sciences ◽  
Toxic Compounds ◽  
Group 4 ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Insight Into ◽  
Group 1

In medical sciences, toxicity is an area wherein extensive studies have been carried to improve the diseases as well as to prevent. So, there is a high requirement for novel and improved alternative therapeutic strategies to manage diseases. The liver is the largest gland in the body, which executes several important mechanisms; it stores minerals and vitamins and releases them in periods of need. The main aim of this study was to give a closer insight into potent non- toxic compounds that is capable of modifying the responses. Animals were divided into five equal groups viz control (Group 1), administered with food and water ad libitum, (Group 2) administered with olive oil, (Group 3) administered with zingerone, (Group 4) administered with concanavalin A, (Group 5) administered with cyclosporine A followed by zingerone. Our results revealed significant changes in liver marker enzymes and liver histology of zingerone treated rats when compared to control rats.  A corollary, zingerone has no toxic effect on hepatocytes and was found to be safe at a dose of 10mg/kg b wt and also ameliorates hepatotoxicity.

scholarly journals Evaluation of Some Male and Female Rats’ Reproductive Hormones Following Administration of Aspartame With or Without Vitamin C or E

2021 ◽  
Vol 45 (2) ◽  
pp. 14-20
Author(s):  
Omar H Azeez
Keyword(s):  
Vitamin C ◽  
Reproductive Hormones ◽  
Female Rats ◽  
Control Group ◽  
Male And Female ◽  
Group 4 ◽  
Male And Female Rats ◽  
Group 3 ◽  
Group 2

Aspartame (ASP) is a sugar substitute. Its use rose because it has been demonstrated to have deleterious effects after being metabolized. In the presence of antioxidant vitamins C or E, the effects of ASP on reproductive hormones of adult male and female Albino Wister rats were investigated. A total of eighty male and female rats were used in this study. The rats were divided into four groups: group 1, received no treatment; group 2, received ASP at 40 mg/kg BW; group 3, received ASP at 40 mg/kg BW with vitamin C at 150 mg/kg BW; and group 4, received ASP at 40 mg/kg BW and vitamin E at 100 mg/kg BW. All treatments were given orally by gavage needle once daily for consecutive 90 days. The levels of estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone hormone (TH) were measured after 90 days in blood plasma. In comparison with the control group, ASP treatment resulted in lower levels of E2, FSH, and LH in male and female rats. When the antioxidants vitamin C or E was given, the effects of ASP were reversed, and the levels of E2, LH, and FSH were increased. The testosterone hormone was likewise significantly increased by ASP, but testosterone hormone concentrations were decreased by vitamin C or E treatments. Long-term ASP consumption caused interfering with testicular and ovarian hormonal activity, while vitamins C and E on the other hand, overcome longstanding consumption ASP's effects.

Bond Integrity of Titanium Surface to Resin Cement After Conditioning with Different Photobiomodulataion Therapy (PBT)

2021 ◽  
Vol 11 (5) ◽  
pp. 970-975
Author(s):  
Khold Al Ahdal ◽  
Laila Al Deeb ◽  
Mohammed S. Bin-Shuwaish ◽  
Rana S. Al-Hamdan ◽  
Modhi Al Deeb ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Testing Machine ◽  
Resin Cement ◽  
Control Group ◽  
Sem Images ◽  
Group 4 ◽  
Modes Of Failure ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

The aim of the present study was to evaluate the efficacy of interfacial bonding between resin cement and titanium alloy conditioned with different Photobiomodulataion Therapy (PBT) in comparison with conventional regimes. Seventy-five samples of titanium bar were segmented polished; and based on conditioning regime divided into five groups (15 each specimens). Group 1: No treatment (control), Group 2: Sand blasting with 120 µm Al2O3, Group 3: Er,Cr:YSGG (ECL), Group 4: Er:YAG laser (EYL), Group 5: Nd:YAG laser (NYL). After different conditioning regimes, resin cement was mixed and applied. All specimens were thermocycled for 500 cycles and positioned on universal testing machine for shear bond strength testing. Modes of failure was assessed by a single examiner using stereomicroscope at 40× magnification. Three pairs of specimens in each group were sputter coated and scanning electron microscope (SEM) images were taken at 1000× magnification using 20 Kv. The highest SBS values were observed in group 2 (14.25±2.29 MPa) and the lowest bond values were displayed in group 1 (6.98 ±0.59 MPa). Titanium alloy abutments conditioned with different laser prototypes ECL (11.22±1.40 MPa), EYL (9.29±1.22 MPa) and NYL (9.12 ±1.84 MPa) exhibited comparable SBS (p > 0.05). Adhesive failures were primarily dominant among all experimental groups. Photo-biomodulation in the form of ECL lasers has the potential to be used as a supplement to sandblasting procedure in conditioning of cement retained titanium alloy implant abutments.

scholarly journals FE-SEM Evaluation of Dental Specimens Prepared by Different Methods forIn VitroContamination

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Vitor Cesar Nakamura ◽  
Simony Hidee Hamoy Kataoka ◽  
Giulio Gavini ◽  
Patrícia Helena Ferrari ◽  
Silvana Cai
Keyword(s):  
Control Group ◽  
Buffer Solution ◽  
Morphological Alterations ◽  
Ultrasonic Bath ◽  
Group 4 ◽  
Cement Removal ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Objective. To evaluate through FE-SEM the cleanliness and dentinal alterations promoted by different methods of dental sample preparation.Methods. Twenty-five human single-rooted teeth were used. The teeth were cleaned and autoclaved in wet medium and randomly divided into 5 groups (), according to the preparation methods employed—control group: no solutions applied; group 1: cement removal and irrigation with 5.25% % EDTA for 4 minutes each; group 2: 17%  % NaOCl (4 minutes ultrasonic bath); group 3: cement removal and 17%     buffer solution + distilled water (10 minutes ultrasonic); group 4: 17%   NaOCl (3 minutes ultrasonic bath). Specimens were analyzed by field emission scanning electron microscope (FE-SEM), at 1500x magnification. Data were submitted to qualitative analysis according to a scoring system and submitted to Kruskal-Wallis test.Results. In ascending order, as to bind parameters, (i) cleanliness: control, group 2, group 3, group 5, and group 4, (ii) dentinal alterations: group 1, group 5, group 2, group 3, and group 4.Conclusion. The proposed protocol was suitable for subsequent microbiological contamination, because it showed less dentinal morphological alterations with increased removal of organic waste.

scholarly journals The Evaluation of Various Restoration Techniques on Internal Adaptation of Composites in Class V Cavities

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
D. Dionysopoulos ◽  
C. Papadopoulos ◽  
E. Koliniotou-Koumpia
Keyword(s):  
Room Temperature ◽  
Control Group ◽  
Class V ◽  
Group 4 ◽  
Restoration Techniques ◽  
Group 3 ◽  
Internal Adaptation ◽  
Group 5 ◽  
Group 2 ◽  
Group 1

Aim.The aim of this study was to evaluate the effect of different restoration techniques on the formation of internal microgaps between materials and dentin in class V restorations.Materials and Methods.Twenty-five extracted human premolars were prepared with standardized class V cavity outlines (3 mm × 2 mm × 2 mm). The cavities were randomly divided into 5 groups of 10 cavities each and restored according to manufacturer’s instructions: Group 1: preheating (55°C) conventional composite (Filtek Z250), Group 2: flowable composite (Filtek Flow), Group 3: Filtek Flow + Filtek Z250 light-cured separately, Group 4: Filtek Flow + Filtek Z250 light-cured simultaneously, and Group 5 (control): Filtek Z250 at room temperature (23°C). The specimens were then thermocycled and cross-sectioned through the center of the restoration. Subsequently, impressions were taken, and epoxy resin replicas were made. The internal adaptation of the materials to the axial wall was analyzed under SEM.Results.The preheated Filtek Z250 (Group 1) showed better internal adaptation than the room temperature groups(P<0.05). The combination of Filtek Flow with Filtek Z250 which was light-cured separately (Group 3) exhibited better internal adaptation than control group(P<0.05).Conclusion.Different restoration techniques exhibit different behavior regarding internal adaptation to dentin after photopolymerization.

scholarly journals Protective Effect of Morocco Carob Honey Against Lead-Induced Anemia and Hepato-Renal Toxicity

2016 ◽  
Vol 39 (1) ◽  
pp. 115-122 ◽  
Author(s):  
Aicha Fassi Fihri ◽  
Noori S. Al-Waili ◽  
Redouan El-Haskoury ◽  
Meryem Bakour ◽  
Afaf Amarti ◽  
...  
Keyword(s):  
Protective Effect ◽  
Renal Toxicity ◽  
Biological Activities ◽  
Kidney Injury ◽  
Lead Toxicity ◽  
Control Group ◽  
Daily Group ◽  
Group 4 ◽  
Group 3 ◽  
Group 2

Background/Aims: Natural honey has many biological activities including protective effect against toxic materials. The aim of this study was to evaluate the protective effect of carob honey against lead-induced hepato-renal toxicity and lead-induced anemia in rabbits. Methods: Twenty four male rabbits were allocated into four groups six rabbits each; group 1: control group, received distilled water (0.1 ml / kg.b.wt /daily); group 2: received oral lead acetate (2 g/kg.b.wt/daily); group 3: treated with oral honey (1g /kg.b.wt/daily) and oral lead (2 g/kg.b.wt/daily), and group 4: received oral honey (1 g/kg.b.wt/daily). Honey and lead were given daily during 24 days of experimentation. Laboratory tests and histopathological evaluations of kidneys were done. Results: Oral administration of lead induced hepatic and kidney injury and caused anemia during three weeks of the exposure. Treatment with honey prevented hepato-renal lead toxicity and ameliorated lead-induced anemia when honey was given to animals during lead exposure. Conclusion: It might be concluded that honey has a protective effect against lead-induced blood, hepatic and renal toxic effects.

scholarly journals Comparative Study on the Protective Effect of Zinc Nanoparticle and Zinc Supplement on Carbamazepine Induced Reproductive Damage in Male Albino Rats

2020 ◽  
pp. 140-147
Author(s):  
Auwal Balarabe Bello ◽  
Mudassir Lawal ◽  
A. Muhammad Hisbullahi
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Control Group ◽  
Albino Rats ◽  
Zinc Supplement ◽  
Ogun State ◽  
Group 4 ◽  
Sample Bottle ◽  
Group 6 ◽  
Group 5

Aim: The aim of this study is to compare the protective effect of zinc nanoparticle and zinc supplement against carbamazepine induced reproductive changes in male Albino rats. Study Design: In this experiment, 60 Male albino rats were used which are divided into six groups of 10 rats each. The first group was used as the control for the experiment and they were given distilled water. The second Group, Group 2 were administered with 20 mg/kg body weight of carbamazepine, group 3 were administered with 20 mg/kg of carbamazepine plus 10 mg/kg of zinc nanoparticle and Group 4 were administered with 20 mg/kg of carbamazepine plus 10 mg/kg of zinc supplement while group 5 were administered with 10 mg/kg of zinc nanoparticle and also group 6 were administered with 10 mg/kg of zinc supplement only. Place and Duration of Study: Department of Biochemistry, Bells University of technology, Ota, Ogun State Nigeria, the research was carried out from February to June, 2018. Methodology: Zinc nanoparticle extraction was carried out to obtained Zinc nanoparticle. A 60 male albino rats with weight ranging from 140 g - 230 g were used. They were fed with normal rat chow and were allowed to acclimatize for a period of two weeks. They were then divided into six groups according to their body weight which contained the test groups and the control group. The rats were sacrificed after two weeks of test administration. They were allowed an overnight fast (24 hours). The cervical dislocation was done, and the blood was collected from the heart, in to a lithium heparinized bottle. The testes of the rats were also collected and stored in a sample bottle containing buffer and stored, the liver, kidney and the brain were collected too. The rats liver and testes were weight and macerated in 5 times the volume of the actual organ weight using homogenate buffer (phosphate buffer). The resulting homogenate was centrifuge at 10000 rmp speed for 15 mins then it was removed from the centrifuge and the supernatant was decanted and stored below 4°C. Result: The group administered with carbamazepine only show significant decreased in the level of follicle stimulating hormone, luteinizing hormone and testosterone when compared with control group, followed by the group administered with zinc nanoparticle only. However, group 6 and group 4 that were administered with zinc supplement and zinc supplement plus carbamazepine showed a significant increase in the level of these hormones when compared with control group, while group 6 which were administered with carbamazepine and zinc nanoparticle showed no significant different when compared with control group. In addition carbamazepine alone significantly increased the level of alanine transaminase (ALT) in the liver and also the group administered with zinc nanoparticle alone significantly increased the level of aspartate transaminase (AST) with decrease in the level of ALT. However, the groups administered with zinc supplement alone and in combination with carbamazepine reduced ALT and AST levels in the liver. Conclusion: Therefore, this study suggest that, carbamazepine induced toxicity by affecting the level of sex hormones and activities of the kidney in the male albino rats, and also zinc nanoparticle have more protective effect than zinc supplement against carbamazepine toxicity.

scholarly journals NADPH Oxidase 4 Signaling in a Ventilator-induced Lung Injury Mouse Model

2021 ◽  
Author(s):  
Sang Hoon Lee ◽  
Mi Hwa Shin ◽  
Ah Young Leem ◽  
Su Hwan Lee ◽  
Kyung Soo Chung ◽  
...  
Keyword(s):  
Lung Injury ◽  
Lavage Fluid ◽  
Lung Damage ◽  
Control Group ◽  
Group 4 ◽  
Ventilator Induced Lung Injury ◽  
Cell Counts ◽  
Group 5 ◽  
Group 2

Abstract For patients with acute respiratory distress syndrome, a ventilator is essential to supply oxygen to tissues, but it may also cause lung damage. We investigated the role of NOX4 in a ventilator-induced lung injury (VILI) model.Wild-type (WT) male C57BL/6J mice and NOX4 knockout (KO) male mice were divided into five groups: (1) control group; (2) high tidal ventilation (HTV) group: WT mice + HTV; (3) NOX4 KO group; (4) NOX4 KO with HTV group; (5) NOX4 inhibitor group: WT mice + HTV + NOX4 inhibitor. In addition, the relationship between EphA2 (which is related to lung injury) and NOX4 was investigated using EphA2 KO mice, and NOX4 levels in the bronchoalveolar lavage fluid (BALF) of 38 patients with pneumonia were examined.In the NOX4 inhibitor group, cell counts and protein concentrations from BALF were significantly lower than those in the HTV group (both, p<0.001). In the NOX4 KO group and the NOX4 inhibitor group, EphA2 levels were significantly lower than those in the HTV group (p<0.001). NOX4 levels were significantly higher in patients with pneumonia and patients who received ventilator treatment in the ICU.In the VILI model, it may be possible to block VILI using NOX4 antibodies.

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