Development of a combined solution of pyrimidine nucleotides with vitamin B6

2021 ◽  
pp. 6228-6234
Author(s):  
M. S. Almakaiev ◽  
N. V. Dvinskikh ◽  
L. G. Almakaieva ◽  
Olga V. Kryvanych
Keyword(s):  
Ph Value ◽  
Stable Solution ◽  
Impurity Content ◽  
Nerve Fibers ◽  
Buffer System ◽  
Pyrimidine Nucleotides ◽  
Combined Solution ◽  
Total Impurity Content ◽  
Active Substances ◽  
Optimal Ph

Pyrimidine nucleotides, namely uridine monophosphate and cytidine monophosphate, play an important role in the cellular metabolism of nerve fibers. The combination of these nucleotides with pyridoxine hydrochloride (vitamin В6) in one dosage form will allow us to fully implement the strategy of the complex neurotropic pharmacotherapy in neuropathies of various origins. To develop a stable solution, an important step at the stage of the composition development is to study the compatibility of active substances (active pharmaceutical ingredients - APIs) in solution. Samples of binary solutions and solutions containing all active substances were prepared and examined. The API interaction was determined by various parameters – changes in color, transparency, рН, the total impurity content, etc. Based on a comprehensive study of the processes of the API dissolution the optimal pH limits of the solution required for the stable existence of a combination of substances with different pH values of the medium have been substantiated and experimentally confirmed. As a result of the research, the optimal pH value of the solution recommended is 4.0-4.8. In the composition of substances the amount of water can be in an adsorbed or crystallized, or combined form. This fact should be taken into account in order to correctly calculate the actual amounts of initial ingredients when preparing the solution. The nature of the water component of APIs was clarified when studying the phase composition of samples on a powder diffractometer. The studies conducted have allowed us to determine the directions of further research for developing the composition of an injection drug. This research is in choosing the optimal buffer system and excipients-antioxidants.

Synthesis and Characterization of BaCe0.8Y0.2O2.9 Nanopowder by Sol-Gel Auto-Ignited Method

2007 ◽  
Vol 280-283 ◽  
pp. 661-664 ◽  
Author(s):  
Jing Tao Ma ◽  
Xu Ping Lin ◽  
Bao Qing Zhang ◽  
Jiu Lin Wang
Keyword(s):  
Solid Oxide Fuel Cells ◽  
Ph Value ◽  
Sol Gel ◽  
Ceramic Powder ◽  
Solid Oxide ◽  
Synthesis And Characterization ◽  
Nanocrystalline Ceramic ◽  
Optimal Ph ◽  
Nitrate Solutions

A sol-gel auto-ignited synthesis, which is a hybrid of sol-gel and auto-ignited techniques, was applied to preparation of homogeneous and stoichiometric BaCe0.8Y0.2O2.9 nanocrystalline ceramic powder as solid electrolyte used in solid oxide fuel cells at 1000°C. Optimal pH value for the mixed citrate-nitrate solutions was determined by calculation. The DTA-TG and XRD were used to investigate the thermal decomposition of the gel precursor. The structure and phase present of the nanocrystalline BaCe0.8Y0.2O2.9 powders were characterized by XRD, BET and SEM techniques.

scholarly journals PENGGUNAAN KERTAS AKTIF BERBASIS OLEORESIN AMPAS JAHE EMPRIT (Zingiber officinale var. amarum) TERHADAP KUALITAS BUAH STROBERI (Fragaria x ananassa) SELAMA PENYIMPANAN

2016 ◽  
Vol 31 (1) ◽  
pp. 59 ◽  
Author(s):  
Sakinah Ummu Zahroh ◽  
Rohula Utami ◽  
Godras Jati Manuhara
Keyword(s):  
Nutritional Value ◽  
Ph Value ◽  
Zingiber Officinale ◽  
Fragaria X Ananassa ◽  
Anova Analysis ◽  
Total Acid ◽  
Acid Titration ◽  
High Production ◽  
Active Substances

<div class="WordSection1"><p><em>Strawberries (Fragaria x ananassa) are one of the horticultural commodities which have a high production and nutritional value. However, strawberries susceptible to loss of quality during postharvest. Changes in the quality of strawberries among others physical, chemical, and microbiological. Therefore, strawberries are required handling during storage with packaging. Active paper packaging based on oleoresin of ginger dreg 2% containing active substances that inhibit the growth of microbes. This research uses current active paper packaging based on oleoresin ginger dreg as a packaging of strawberries. The purpose of this research was to determine the effect of using active paper packaging based on oleoresin of ginger dreg on the quality of strawberries during 12 days of storage at 10 ± 2 ºC. Results of ANOVA analysis with 5% significance shows that the use of active paper packaging based on oleoresin ginger dreg effect on weight loss strawberries for 12 days of storage, color of red on the 3rd, 9th, and 12th day of storage, total acid titration on the 12th day of storage, total dissolved solids on 9th and 12th day of storage, and vitamin C on the 12th day of storage. The hardness and pH value are not affected by the current active paper packaging based on oleoresin ginger dreg during 12 days of storage. Total microbial of strawberries with active paper laying variation has a total microbial lower than strawberries control.</em></p></div>

scholarly journals MAGNETIC NANOPARTICLES IN BIOCATALYSIS

2021 ◽  
pp. 66-72
Author(s):  
Александрина Михайловна Сульман ◽  
Ольга Валентиновна Гребенникова ◽  
Анастасия Евгеньевна Филатова
Keyword(s):  
Magnetic Nanoparticles ◽  
Horseradish Peroxidase ◽  
Kinetic Parameters ◽  
Magnetic Particles ◽  
Ph Value ◽  
Co Precipitation ◽  
Optimal Ph

В работе изучены свойства ферментативных систем на основе иммобилизованной на магнитные частицы пероксидазы корня хрена (HRP). Магнитные наночастицы FeO были синтезированы методом соосаждения. Затем на их поверхность двумя способами была иммобилизована пероксидаза корня хрена путем ковалентной сшивки. Для этого, в первом случае, FeO последовательно обрабатывали тетраэтоксисиланом, 3-аминопропилтриэтоксисиланом, глутаровым диальдегидом и HRP. Во втором, перед иммобилизацией HRP на поверхность носителя были последовательно нанесены 3-аминопропилтриэтоксисилан, глутаровым диальдегидом и HRP. Активность синтезированных биокатализаторов оценивалась спектрофотометрически в реакции окисления 2,2'-азино-бис(3-этилбензотиазолин-6-сульфонат) аммония пероксидом водорода. В работе также были рассчитаны кинетические параметры K и V для всех типов катализаторов, в том числе для нативной HRP. Среди всех биокаталитических систем лучшие значения, по сравнению с нативным ферментом (K = 4 ммоль/л и V = 12.6∙10, ммоль/л∙с) , были получены для первого типа биокатализатора (K = 5 ммоль/л и V = 2.5∙10, ммоль/л∙с). Было также определено, что оптимальным значением рН является 7.2. The synthesis of biocatalytic systems based on horseradish peroxidase immobilized on magnetic particles was investigated. The method of co-precipitation was used to obtain magnetic nanoparticles. Two types of magnetic particles were studied: untreated and pretreated with tetraethoxysilane. The basic kinetic parameters KM and Vm were calculated for all types of biocatalysts. The optimal pH value was determined for the biocatalyst that showed the greatest activity during oxidation

scholarly journals Nasal decongestants in the treatment of nasal obstruction

2021 ◽  
pp. 120-124
Author(s):  
K. A. Nikitin ◽  
S. V. Baranskaya
Keyword(s):  
Nasal Obstruction ◽  
Nasal Mucosa ◽  
Ph Value ◽  
Nasal Congestion ◽  
Pathological Process ◽  
Buffer System ◽  
Nasal Breathing ◽  
Structural Problems ◽  
Nasal Decongestants ◽  
Nasal Valve Collapse

Nasal congestion is one of the most common symptoms of common colds and rhinitis, due to an inflammatory reaction, vasodilation, increased nasal blood flow and vascular permeability. Nasal obstruction is often a multifactorial problem, in addition to infectious causes, it can be caused by a combination of anatomical aberrations, swelling of the nasal mucosa and enlargement of the turbinates. Anatomical and structural problems, such as nasal septum deviation and nasal valve collapse, are usually treated surgically. Drug therapy of nasal obstruction is aimed at reducing edema and inflammation of the nasal mucosa. Pharmacotherapy of nasal obstruction is aimed at reducing inflammation and/or swelling of the mucous membrane. Decongestants are widely prescribed to relieve symptoms. The drugs used have different mechanisms of action and include systemic and topical drugs. This article discusses decongestants as a treatment for nasal obstruction. When applied topically, the drugs of this group act directly on the α2 and α1-adrenergic receptors of the nasal cavity, causing vasoconstriction, a decrease in the volume of the nasal conch, an increase in nasal patency, and relieving the symptoms of obstruction. The existing risk of developing side effects, both systemic and local, is reduced with atopic exposure and proper dosing of the drug used. Preferably, the use of drugs with low bioavailability. The suppression of the ciliated epithelium can be caused not only by the pathological process, but also by the composition of drugs. The value is given to the acidity of the buffer system. The optimal pH value of intranasal agents is about 6 (neutral range). The combination with anticholinesterase substances reduces the production of pathological discharge. The use of multi-component medicines allows you to restore nasal breathing and suppress excessive nasal secretion. One of the effective and safe drugs of topical action is Xylometazoline, as a monocomponent agent or in combination with ipratropium bromide.

RESEARCH OF MICROBIOLOGICAL SYNTHESIS OF FATS IN BEET MOLASSES SOLUTIONS

2020 ◽  
Author(s):  
С.О. СЕМЕНИХИН ◽  
О.В. ФЕДОСЕЕВА ◽  
М.В. БАБАКИНА ◽  
Н.М. ДАИШЕВА
Keyword(s):  
Ph Value ◽  
Matter Content ◽  
Biologically Active ◽  
Dry Matter Content ◽  
Microbiological Synthesis ◽  
Vital Activity ◽  
Beet Molasses ◽  
Initial Ph ◽  
First Time ◽  
Active Substances

Проведены исследования обработки растворов свекловичной мелассы 4 штаммами микроорганизмов с целью обогащения растворов жирами. Выявлено влияние начального значения рН, а также оптимального содержания сухих веществ в растворах мелассы, обеспечивающие эффективную жизнедеятельность микроорганизмов с синтезом биологически активных веществ. Установлено, что штаммы R. glutinis Y-332, C. curvatus Y-2236 и U. isabellina F-526 в растворах мелассы с начальным значением рН 8,5 синтезировали жиры в количестве 0,015 0,017 и 0,007 г/г сахаров соответственно штамм R. toruloides Y-334 в растворе мелассы с начальным значением рН 7,0 синтезировал жиры в количестве 0,004 г/г сахаров. Впервые получены экспериментальные данные, позволившие оценить эффективность микробиологического синтеза жиров в растворах мелассы без дополнительного внесения биогенных веществ, а также без поддержания оптимальной рН среды 4 видов микроорганизмов. Обосновано, что штаммы R. glutinis Y-332 и C. curvatus Y-2236 являются наиболее перспективными для обогащения растворов свекловичной мелассы жирами. Research aimed at treatment of beet molasses solutions with 4 strains of microorganisms in order to enrich the solutions with fats has beed established. The influence of the initial pH value, as well as the optimal dry matter content in molasses solutions, which ensure the effective vital activity of microorganisms with the synthesis of biologically active substances, is revealed. It was established that the strains of R. glutinis Y-332, C. curvatus Y-2236 and U. isabellina F-526 in molasses solutions with an initial pH of 8,5 synthesize fats in an amount of 0,015 0,017 and 0,007 g/g of sugars, respectively and the strain of R. toruloides Y-334 in molasses solution with an initial pH value of 7,0 synthesizes fats in an amount of 0,004 g/g of sugars. For the first time, it was obtained the experimental data that made possible to evaluate effectiveness of microbiological synthesis of fats in molasses solutions without nutrient addition, as well as without maintaining the optimal pH of the environment for 4 types of microorganisms. It is proved that R. glutinis strain Y-332 and C. curvatus strain Y-2236 are the most promising strains for enriching beet molasses solutions with fats.

The Use of the Direct Reading Spectrometer with dc Arc Excitation and Total Sample Combustion in the Analysis of High Purity Materials

1971 ◽  
Vol 25 (1) ◽  
pp. 60-64 ◽  
Author(s):  
B. S. Cooper ◽  
D. J. Hobbs
Keyword(s):  
High Purity ◽  
Impurity Content ◽  
Total Sample ◽  
Direct Reading ◽  
Linear Relationships ◽  
Total Impurity Content ◽  
Ultra Trace ◽  
Spectrometer Calibration ◽  
Dc Arc ◽  
Ppm Level

When a dc arc is used for trace analysis on a spectrometer, calibration curves with a pronounced toe due to spectral background are found. For analysis of high purity materials it is most important that linear relationships should be established to ultra-trace levels when total impurity content is specified within the ppm level. A solution to this problem is outlined and the linear relationships obtained for copper, bismuth, and cadmium in high purity silver to 0.1 ppm are shown. An electronic circuit is described that enables these background corrections to be made.

TiO2 Photo-Catalysis Degradation of COD and Chroma for Chemical Wastewater Treatment

2013 ◽  
Vol 777 ◽  
pp. 82-85
Author(s):  
Chang Ying Hu ◽  
Jin Long Zuo ◽  
Han Jun Xie
Keyword(s):  
Wastewater Treatment ◽  
Ph Value ◽  
Degradation Products ◽  
Initial Concentration ◽  
Emulsion Method ◽  
Photo Catalysis ◽  
Optimal Dosing ◽  
Micro Emulsion ◽  
Catalysis Efficiency ◽  
Optimal Ph

In this study, TiO2 nanoparticles composites were prepared by the micro emulsion method. Used the chemical wastewater as degradation products to evaluate the degradation performance of TiO2 photo-catalysis. The results indicated that TiO2 had photo-catalysis efficiency under the light, the optimal dosing of TiO2 was 1g/L, optimal pH value was 10, and COD of initial concentration was 1000 mg/L.

Characterisation of Norway spruce hemicelluloses extracted by pressurised hot-water extraction (ASE) in the presence of sodium bicarbonate

Holzforschung ◽  
2011 ◽  
Vol 65 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Tao Song ◽  
Andrey Pranovich ◽  
Bjarne Holmbom
Keyword(s):  
Sodium Bicarbonate ◽  
Norway Spruce ◽  
Ph Value ◽  
Hot Water ◽  
Water Extraction ◽  
Extraction Time ◽  
Plain Water ◽  
Hot Water Extraction ◽  
Ph Conditions ◽  
Optimal Ph

Abstract Ground spruce sapwood was extracted with pressurised hot water with addition of different amounts of sodium bicarbonate (NaHCO3) to find optimal pH conditions for extraction of hemicelluloses, especially of galactoglucomannans (GGMs). The extractions were carried out in an accelerated solvent extractor (ASE) at 170°C. When extraction was carried out with 2.5 mM NaHCO3 during 60–100 min extraction time (end-pH 3.9), more than 60% of the total extracted substances were hemicellulose-derived carbohydrates. Under these conditions, approximately 80% of the extracted carbohydrates were from GGMs (13% b.o. wood). At higher concentrations of NaHCO3, the yield of carbohydrates, especially those derived from GGMs, decreased. Hydrolytic depolymerisation of hemicelluloses occurring during extraction with plain water was largely inhibited in the presence of 2.5–5 mM NaHCO3. The hydrolytic deacetylation of GGM was diminished at low NaHCO3 concentrations but increased dramatically at higher NaHCO3 concentrations. It can be concluded that 2.5–5 mM NaHCO3 giving an end-pH value of 4 is better for GGM isolation than plain water.

scholarly journals The Proliferation Rule of Microcystis Aeruginosa Under Different Initial pH Conditions and its Influence on the pH Value of the Environment

2021 ◽  
Author(s):  
Sijie Wei ◽  
Guanjie Zhuang ◽  
Lirijian Cheng ◽  
Shoubing Wang
Keyword(s):  
Microcystis Aeruginosa ◽  
Ph Value ◽  
Control Strategies ◽  
Scientific Basis ◽  
Cyanobacterial Blooms ◽  
Ph Values ◽  
Inoculation Density ◽  
Initial Ph ◽  
Ph Conditions ◽  
Optimal Ph

Abstract This study investigated the characteristics of the proliferation process of Microcystis aeruginosa and its changes to environmental pH values under different initial pH values and different initial inoculation densities. The results showed that although the initial pH value or the initial inoculation density was different, the pH values of the culture systems fluctuated up and down throughout the proliferation of M. aeruginosa, both on a daily and hourly time scale, and then tended to stabilize around the same value of 10.0 at the end of proliferation. The optimal pH value for the proliferation of M. aeruginosa was 9.56. This study creatively proposes that the period when the environmental pH value starts to rise rapidly toward 9.0 could be selected as an early warning period for a cyanobacterial outbreak, and the environmental pH value could be adjusted to below 8.0 to delay the outbreak. These results provide a scientific basis for further understanding the mechanism of cyanobacterial blooms and formulating pH-based control strategies.

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