An Overview: 1, 3, 4- oxadiazole and its uses

2021 ◽  
pp. 389-392
Author(s):  
Anuja S. Patil. ◽  
Shrinivas K. Mohite
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compound ◽  
Heterocyclic Compounds ◽  
Functional Group ◽  
Biological Activities ◽  
Anti Inflammatory ◽  
Anti Hiv

Heterocyclic compounds show various potent biological activity. Every heterocyclic compound has different structure, different functional group and designed for different biological activities. Oxadiazole is one of those heterocyclic compounds possess various biological activity. The structure is simple contain carbon, nitrogen, oxygen, hydrogen. It shows various type of biological activities such as anti- convulsant, anti- microbial, anti- tumor, anti-helminth, anti- HIV, anti- Alzheimer, insecticidal, pesticidal, anti- inflammatory. This review gives a glance on oxadiazole compound, its different derivatives and its biological uses.

scholarly journals 3,4-dihydro-2H-1,3-benzoxazines and their oxo-derivatives chemistry and bioactivities

2020 ◽  
pp. 1-1 ◽  
Author(s):  
El-Din Sharaf
Keyword(s):  
Biological Activity ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Anti Inflammatory ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Significant Class

3,4-Dihydro-2H-1,3-benzoxazines derivatives are a significant class of heterocycles with a particular awareness due to their remarkable biological activities in humans, plant as well as in animals and also, they are naturally occurrence. Because of alteration in the benzoxazines skeleton, beside their comparative chemical simplicity and accessibility, make these compounds to be suitable sources of other bioactive compounds. Resulting in the discovery of a wide set of these compounds that have a broad biological activity such as antifungal, antibacterial, anti-HIV, anticancer, anticonvulsant, anti-inflammatory and so on. Subsequently, this review herein gives a brief overview of derivatives of 3,4-dihydro-2H-1,3-benzoxazines monomers and their oxo-derivatives chemistry and bioactivities.

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

2020 ◽  
Vol 24 (5) ◽  
pp. 473-486 ◽  
Author(s):  
Ligia S. da Silveira Pinto ◽  
Thatyana R. Alves Vasconcelos ◽  
Claudia Regina B. Gomes ◽  
Marcus Vinícius N. de Souza
Keyword(s):  
Side Effects ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Present Review ◽  
Pharmacological Properties ◽  
Important Group ◽  
Wide Range ◽  
Anti Inflammatory

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

AN UPDATE ON THE SYNTHESIS OF BENZOXAZOLES

2017 ◽  
Vol 10 (10) ◽  
pp. 48 ◽  
Author(s):  
Jyothi M ◽  
Ramchander Merugu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Activity ◽  
Biological Activities ◽  
Starting Material ◽  
Bioactive Molecules ◽  
Living Systems ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Benzoxazoles being structurally similar to bases adenine and guanine interact with biomolecules present in living systems. These compounds possess antimicrobial, central nervous system activities, antihyperglycemic potentiating activity, analgesic, and anti-inflammatory activity. It can also be used as starting material for other bioactive molecules. Modifications in structure and the biological profiles of new generations of benzoxazoles were found to be more potent with enhanced biological activity. Considering all these, we have prepared this review and discussed the synthesis and biological activities of benzoxazoles.

scholarly journals Dittrichia Viscosa L. Greuter: Phytochemistry and Biological Activity

2008 ◽  
Vol 3 (11) ◽  
pp. 1934578X0800301
Author(s):  
Alejandro F. Barrero ◽  
M. Mar Herrador ◽  
Pilar Arteaga ◽  
Julieta V. Catalán
Keyword(s):  
Biological Activity ◽  
Mediterranean Region ◽  
Biological Activities ◽  
Dittrichia Viscosa ◽  
The Mediterranean ◽  
Anti Inflammatory

Dittrichia viscosa is a plant widely distributed in the Mediterranean region. This species and its components present a broad range of biological activities (for example, anti-inflammatory, antifungal, antiulcer, antiviral, antiparasitic), which are reviewed. Extracts of the species are particularly rich in terpenoids, in particular eudesmane acids, notably ilicic acid (45) and α-costic acid (44). Flavonoids are also abundant, especially during flowering.

scholarly journals Bioactivities and Future Perspectives of Chaetoglobosins

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Jinhua Chen ◽  
Wenzhou Zhang ◽  
Qingfeng Guo ◽  
Weijiang Yu ◽  
Yongna Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Large Class ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Chaetomium Globosum ◽  
Future Perspectives ◽  
Anti Inflammatory ◽  
Anti Hiv ◽  
Fungal Secondary Metabolites

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

Synthesis and Biological Activities of Sulfonated Polysaccharides Having Pentofuransidic Structures

2007 ◽  
Vol 342-343 ◽  
pp. 721-724
Author(s):  
Byung Won Kang ◽  
T. Yoshida ◽  
Jong Baek Lee ◽  
S.J. Jeon ◽  
H.D. Choi
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
Anticoagulant Activity ◽  
Polymer Backbone ◽  
Molecular Weights ◽  
The Relationship ◽  
Anti Hiv

In order to elucidate the relationship between the structure and biological activity such as anti-HIV and blood anticoagulant activity, sulfonated polysaccharides and amino-polysaccharides having pentofuranosidic structures were synthesized. These sulfonated polysaccharides had potent anti-HIV activity in spite of low molecular weights, and which was dependent on the degree of sulfonation. For the blood anticoagulant activity, the conformation of polymer backbone and sulfamide group plays an important role on the interactions with the blood anticoagulant factor.

A Review: Therapeutic and Biological Activity of Benzothiazole Derivatives

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Suresh Choudhary ◽  
G Jeyabalan ◽  
Naresh Kalra
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
New Products ◽  
Therapeutic Agents ◽  
Present Review ◽  
Benzothiazole Derivatives ◽  
Anti Inflammatory

The Benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess interesting biological activities, such as antitumor, antimicrobial, anthelmintic, antileishmanial, anticonvulsant and anti-inflammatory. The present review focuses on the benzothiazoles with potential activities that are now in development. The synthesized benzothiazole derivatives could be considered as lead molecule for the development of therapeutic agents.

An Overview on Pyranocoumarins: Synthesis and Biological Activities

2020 ◽  
Vol 23 (24) ◽  
pp. 2679-2721 ◽  
Author(s):  
Evangelia-Eirini N. Vlachou ◽  
Konstantinos E. Litinas
Keyword(s):  
Organic Compounds ◽  
Antifungal Agents ◽  
Biological Activities ◽  
Biological Properties ◽  
Pyran Ring ◽  
Naturally Occurring ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Antibacterial And Antifungal ◽  
Anti Hiv

Pyrano- and dipyranocoumarins are classes of naturally occurring organic compounds with very interesting biological activities. This review focuses on the synthetic strategies for the synthesis of pyranocoumarins and dipyranocoumarins and the biological properties of those compounds. The synthesis involves the formation of the pyran ring, at first, from a coumarin or the formation of pyranone moiety from an existing pyran. Pyranocoumarins and dipyranocoumarins present anti-HIV, anti-cancer, neuroprotective, antidiabetic, antibacterial, antifungal, anti-inflammatory activities. Especially khellactones and calanolides are usually potent and selective in anti-HIV activity. Decursin and decursinol derivatives are effective as anticancer, neuroprotective, antidiabetic, antibacterial, and antifungal agents.

Overview of Coumarins and its Derivatives: Synthesis and Biological Activity

2020 ◽  
Vol 17 ◽  
Author(s):  
Tanvi Sahni ◽  
Sunita Sharma ◽  
Diksha Verma ◽  
Pardeep Kaur
Keyword(s):  
Biological Activity ◽  
Pharmaceutical Industry ◽  
Schiff Bases ◽  
Enzyme Inhibitors ◽  
Biological Activities ◽  
Anti Inflammatory

Abstract: Coumarin is a heterocyclic scaffold and its derivatives namely Schiff bases, esters, and hydrazides, etc, play an important role in the field of agrochemical and pharmaceutical industry due to its structure. Over the years, various biological activities like antifungal, antimicrobial, anti-viral, anti-cancerous, anti-tumor, anti-inflammatory, anti-filarial, enzyme inhibitors, anti-aflatoxigenic, analgesics, antioxidant and Oestrogenic, etc had been analyzed. This review covers the latest literature and knowledge on the synthetic procedures for various coumarin and its derivatives, biological and pharmacological applications.

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