Prevalencia de mucosa gástrica heterotópica cervical y su relación con síntomas de reflujo gastroesofágico. Estudio observacional

2021 ◽  
Vol 51 (2) ◽  
Author(s):  
Natalia Marina Zeytuntsian ◽  
José Tawil ◽  
Ana Adet Caldelari ◽  
Álvaro Falzone ◽  
Patricio Sheridan ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Clinical Manifestations ◽  
Heterotopic Gastric Mucosa ◽  
Extraesophageal Reflux ◽  
Cross Sectional ◽  
Reflux Symptoms ◽  
Throat Clearing ◽  
Extraesophageal Symptoms ◽  
The Mean ◽  
Upper Gastrointestinal

Introduction. The heterotopic gastric mucosal patch or inlet patch is the presence of gastric columnar mucosa outside the stomach, most frequently located in the proximal esophagus. Its manifestations vary from esophageal and extraesophageal reflux symptoms to major complications, most of them being asymptomatic. Aim. To determine the prevalence of cervical heterotopic gastric mucosa in our environment and its association with esophageal and extraesophageal reflux symptoms. Material and methods. Prospective cross-sectional and observational study; consecutive patients who came to our institution between December 2018 and October 2019 for diagnostic upper gastrointestinal videoendoscopy were included, following a questionnaire on clinical manifestations. Results. A total of 1,408 patients were included. In 89 (6.3%), a cervical heterotopic gastric mucosal patch was described. The mean age of the patients without this condition was 54.6 and 55.5 in patients with it. The esophageal symptoms of gastroesophageal reflux (heartburn, regurgitation, and chest pain) in patients with cervical heterotopic gastric mucosa was observed in 40 (44.9% / p = 0.473), 12 (13.5% / p = 0.783) and 4 (4.5% / p = 0.199) patients respectively. The presence of extraesophageal symptoms (globus, chronic cough, dysphonia, and throat clearing) in patients with cervical heterotopic gastric mucosa was: 9 (10.1% / p = 0.011); 7 (7.9% / p = 0.155); 4 (4.5% / p = 0.458) and 9 (10.1% / p = 0.036) respectively. Conclusions. A statistically significant association was found between the presence of cervical heterotopic gastric mucosal patch and symptoms of globus (p = 0.011) and throat clearing (p = 0.036). It could be interpreted that this group of patients would benefit from the research and treatment of this condition with the intention of improving their symptoms.

Celiac Disease in Kosovar Albanian Children: Evaluation of Clinical Features and Diagnosis

2020 ◽  
Vol 16 (3) ◽  
pp. 241-247
Author(s):  
Atifete Ramosaj-Morina ◽  
Alije Keka-Sylaj ◽  
Arbana Baloku Zejnullahu ◽  
Lidvana Spahiu ◽  
Virgjina Hasbahta ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Disease Onset ◽  
Clinical Manifestations ◽  
Gastrointestinal Symptoms ◽  
Dominant Mode ◽  
Primary School Children ◽  
Cross Sectional ◽  
Classical Form ◽  
Wide Range ◽  
The Mean

Background: Celiac disease is an immune-mediated disorder characterized by variable clinical manifestations, specific antibodies, HLA-DQ2/DQ8 haplotypes, and enteropathy. Objectives: The aim of this study was to present the clinical spectrum and patterns of celiac disease in Kosovar Albanian children. Methods: A cross-sectional retrospective study was performed with Albanian children aged 0-18 years, treated for celiac disease in the Pediatric Clinic, University Clinical Center of Kosovo from 2005 to 2016. Results: During the study period, 63 children were treated for celiac disease. The mean age at diagnosis was 5.5 years (SD ± 3.31). The mean age at celiac disease onset was 3.3 years (SD ± 2.02), while the mean delay from the first symptoms indicative of celiac disease to diagnosis was 2.2 years (SD ± 2.09). More than 70% of the patients were diagnosed in the first 7 years of life, mainly presented with gastrointestinal symptoms, while primary school children and adolescents mostly showed atypical symptoms (p<0.001). The classical form of celiac disease occurred in 78% of the cases. Sixty (95%) patients carried HLA-DQ2.5, DQ2.2 and/or HLA-DQ8 heterodimers, and only three of them tested negative. Conclusions: Kosovo, as the majority of developing countries, is still facing the classical form of celiac disease as the dominant mode of presentation; as a result, most children with other forms of the celiac disease remain undiagnosed. : Physicians should be aware of the wide range of clinical presentations and utilize low testing thresholds in order to prevent potential long-term problems associated with untreated celiac disease.

scholarly journals Time Intervals From Onset of Clinical Manifestations to Treatment in Patients With Cancer at Hospital General San Felipe, Tegucigalpa, Honduras

2019 ◽  
pp. 1-7
Author(s):  
José A. Sánchez ◽  
Mayra G. Handal ◽  
Juan F. Vílchez Rodriguez ◽  
Sinthia I. Mejía ◽  
Annye P. Pagoaga
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Clinical Staging ◽  
Time Interval ◽  
Pathology Report ◽  
Time Intervals ◽  
Cross Sectional ◽  
Patients With Cancer ◽  
The Mean ◽  
Mean Time

PURPOSE In cancer, clinical staging is related to outcomes, and this is linked to the evolution of the disease over time. In Honduras, cancer mortality is high, and time intervals from onset of symptoms to treatment of cancer are not known. We conducted a cross-sectional study to determine these intervals. PATIENTS AND METHODS This investigation was carried out from April 25 to August 30, 2018, and included 202 patients at the main cancer referral center in Honduras. For the purposes of the study, information was obtained from patients, their caregiver, medical records, or treatment cards. Patients older than age 18 years were included after informed consent was signed. RESULTS The mean time interval from onset of symptoms to cancer treatment was 232 days. Different intervals of time were identified, and the mean of these intervals was calculated in days as follows: 68 days from onset of symptoms to first medical evaluation; 146 days from first evaluation to oncologist consultation; 26 days from cancer specialist to the pathology report; and 86 days from the histopathologic diagnosis to the beginning of treatment. Once diagnosis was established, the average elapsed times to chemotherapy, radiotherapy, surgery, and chemoradiotherapy were 88, 102, 76, and 154 days, respectively ( P < .05, when surgery is compared against chemotherapy and radiotherapy). CONCLUSION The mean time interval from symptom presentation to treatment in patients with cancer is more than 7 months. This could explain the advanced stages of disease seen at the time of treatment in Honduras, which decrease chance of cure and increase the mortality rate of cancer). Appropriate intervention to decrease these intervals must be taken to reduce mortality.

Epidemiological Study of Henoch-Schonlein Purpura and its Characteristics in Infected Children During 2009-2016

2021 ◽  
Vol 15 (6) ◽  
pp. 1629-1633
Author(s):  
Sadegh Dehghanmehr ◽  
Reza Naghdi ◽  
Farahnaz Irandegani ◽  
Hamed Taheri ◽  
Omar Pourbalouch ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Additional Treatment ◽  
Henoch Schonlein Purpura ◽  
Cross Sectional ◽  
Cutaneous Manifestations ◽  
The Mean ◽  
Autumn And Winter ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Introduction: Due to the different complications caused by Henoch-Schonlein purpura and in order to prevent additional treatment costs for patients, we decided to investigate the clinical features of cases of Henoch-Schonlein purpura. Materials and Methods: In this descriptive cross-sectional study, 52 children in whom the diagnosis of Henoch-Schonlein purpura was confirmed were enrolled in the study from 2009 to 2016. The instruments of this research include a researcher-made questionnaire with two parts. The first part is related to demographic characteristics including age, sex and season of referral and the second part was related to morbidity such as various symptoms. Data were collected from patients’ records and interviews with families and were analyzed using SPSS V.22. Results: Out of 52 patients, 30 (57.7%) were boys and 22 (43.3%) were girls. The mean age of patients was 3.02 to 6.58 years. Autumn and winter had the most clients of Henoch-Schonlein purpura. One of the most common manifestations seen in most patients was cutaneous manifestations. There was no significant relationship between gender and clinical manifestations and seasons of the year with these manifestations (p> 0.05). The results showed that age was significantly associated with renal manifestations (P <0.05). Conclusion: The results of this study showed that the prevalence of Henoch-Schonlein purpura disease is higher in boys. Cutaneous manifestations were seen in most patients and in patients with renal manifestations, the mean age was higher and significant. Keywords: Henoch-Schonlein purpura, clinical manifestations, complications, gender, age

TROMBOSIT TERENDAH, KENAIKAN HEMATOKRIT DAN KADAR TNF-α SEBAGAI INDIKASI KEPARAHAN INFEKSI VIRUS DENGUE PADA PASIEN DD DAN DBD

2019 ◽  
Vol 10 (01) ◽  
pp. 13-22
Author(s):  
A.S. Siskayani ◽  
I Made Sumarya ◽  
N.L.P Kartika Sari
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Clinical Manifestations ◽  
Hemorrhagic Fever ◽  
Hemorrhagic Diathesis ◽  
Dengue Virus Infection ◽  
Cross Sectional ◽  
Blood Samples ◽  
Tnf Α ◽  
The Mean

Clinical manifestations of dengue virus infection vary from unspecified fever, dengue fever (DF) and dengue hemorrhagic fever (DHF). The fundamental difference in the diagnosis between DF and DHF is plasma leakage, hypotension, thrombocytopenia and hemorrhagic diathesis in DHF. The objectives of the study were to determine the lowest platelet, haematocrit increase, and TNF-α levels in DF and DHF patients as an indication of severity of dengue virus infection. The cross-sectional study was conducted by taking 54 blood samples of patients aged 26-45 years who were infected by dengue virus and grouped into two groups: DF patient group (27 blood samples) and DHF group (27 blood samples). The lowest platelets and hematocrit rise were determined by Hematology Analyzer and the TNF-α levels were determined by ELISA. The data obtained were statistically analyzed by independent Mann-Whitney test. The results showed that the lowest mean platelet counts of DF patients were significantly (p <0.01) higher than those of DHF patients. The mean hematocrit increase in DF patients was significantly (p <0.01) lower than that of the DHF patients and the mean TNF-α levels of DF patients were significantly (p <0.01) lower than the DHF patients. Based on the results of this study it can be concluded that the lowest platelets, hematocrit increase and TNF-α levels are an indication of the severity of dengue virus infection.

Clinical Manifestations and Therapeutic Findings of the Children with Glucose-6-Phosphate Dehydrogenase Deficiency Presenting Favism

2020 ◽  
Vol 20 ◽  
Author(s):  
Fariba Tarhani ◽  
Alireza Nezami ◽  
Ghobad Heidari ◽  
Babak Abdolkarimi
Keyword(s):  
G6pd Deficiency ◽  
Dehydrogenase Deficiency ◽  
Clinical Manifestations ◽  
Descriptive Study ◽  
Cross Sectional ◽  
Common Complaint ◽  
The Mean ◽  
Fava Beans ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Hydration Therapy

Aim: Favism is characterized as acute anemia, due to Glucose-6-phosphate dehydrogenase (G6PD) deficiency as a result of fava beans intake. It is associated with paleness, jaundice, and hemoglobinuria. In this study, signs, symptoms and therapeutic findings of the patients with hemolysis due to G6PD deficiency were investigated in Shahid Madani Hospital of Khorramabad, Lorestan. Methods: This is a single-center cross-sectional descriptive study that was conducted on all children with G6PD deficiencyinduced hemolysis. Results: 308 children (64.3% male and 35.7% female) were included in this study. The most common complaint was jaundice (82.5%) and the most common cause of hemolysis was the intake of fava bean (85.7%). 68% of the children were treated with hydration/fluid therapy. Blood transfusion was conducted in 36.36% of the cases and the mean of blood administered was 18.9 cc/kg. Conclusion: In this study, hydration therapy was performed in most of the children presenting favism. Also, the incorrect calculation of the amount of blood needed for transfusion has increased the frequency of blood transfusions and prolonged hospitalization time.

scholarly journals HELICOBACTER PYLORI INFECTION;

2012 ◽  
Vol 19 (02) ◽  
pp. 202-207
Author(s):  
NABIHA FAISAL ◽  
MUHAMMAD MANSOOR UL HAQ ◽  
HAFEEZULLAH SHAIKH ◽  
Pervez Ashraf ◽  
Jamila. H. Esmail
Keyword(s):  
Gastrointestinal Endoscopy ◽  
Tertiary Care ◽  
Upper Gastrointestinal Endoscopy ◽  
National Hospital ◽  
Cross Sectional ◽  
Duration Of Symptoms ◽  
Data Source ◽  
The Mean ◽  
H Pylori ◽  
Upper Gastrointestinal

Objective: To determine the frequency of H. pylori infection in dyspeptic patients undergoing endoscopy at a tertiary care centerin Karachi. Data source: Patients undergoing endoscopy at Liaquat National Hospital, Karachi. Design of study: Cross sectional descriptivestudy. Setting: Department of Gastroenterology, Liaquat National Hospital, Karachi. Period: May 2008–October 2008. Material andmethods: All adult patients with symptoms of dyspepsia for more than 1 month duration were included. Patients with upper gastrointestinalbleed, anemia or weight loss were excluded. Upper gastrointestinal endoscopy was performed in all patients and biopsy specimens two eachfrom antrum and body and one from fundus were taken for histology. Results: A total of 123 dyspeptic patients were included in the study. 76(61.8%) patients were males and 47 (38.2%) were females. H pylori was detected in mucosa of 49 (39.8%) patients. The mean age of thepatients was 41.41 ± 13.15 Years (95%CI; 39.06 to 43.75). Rate of H.pylori infection was not found statistical significant with age, gender,duration of symptoms and BMI. Conclusions: The prevalence of H pylori infection in dyspeptic patients was lower than reported in previousstudies from other centers in Pakistan. Other environmental factors should be evaluated in every patient especially who is negative for H. pyloriin our setup.

scholarly journals P-EGS10 Clinicopathology of Critically Ill Patient With Coffee Ground Vomitus Undergo Oesophagogastroduodenoscopy

2021 ◽  
Vol 108 (Supplement_9) ◽  
Author(s):  
Muhammad Hafizuddin Salleh ◽  
Abdul Rahim Samad ◽  
Mohammad Alif Yunus ◽  
Ismail Sagap
Keyword(s):  
Critically Ill ◽  
Critically Ill Patient ◽  
Upper Gastrointestinal Endoscopy ◽  
Cross Sectional ◽  
Surgical Department ◽  
Gastrointestinal Bleed ◽  
Coronary Syndrome ◽  
Coffee Ground ◽  
The Mean ◽  
Upper Gastrointestinal

Abstract Background The incidence of acute gastrointestinal bleed in Malaysia is approximately 72 per 100000, as the incidence in patients who had mechanical ventilation is 2.6%. Coffee ground vomitus is one of the presentations of upper gastrointestinal bleed, and the decision for upper gastrointestinal endoscopy in a critically ill patient with such presentation would be a dilemma as endoscopy might lead to several complications such as endotracheal tube dislodgement, transient bacteremia, cardiopulmonary event, and perforation. We studied the clinicopathology of patients who were referred to our unit with coffee ground vomitus in a critically ill condition, as it would help us further in determining the severity and outcome of the patients. Methods This was a retrospective cross-sectional study from 59 patients in the critical unit in Hospital Melaka who were referred to the surgical department for coffee ground vomitus and underwent esophagogastroduodenoscopy. The study was conducted from November 2020 till July 2021. Results The median age of the patient was 73 years old and the mean body mass index was 25.6.. The primary diagnosis of patients in the critical care was Acute Coronary Syndrome 18%, Sepsis 17%, and cerebrovascular accidents 10%. The mean systolic blood pressure was 126 and the mean pulse rate was 94. The mean hemoglobin level upon admission was 10.7 and 9.07 upon referral. Other laboratory parameters that were analyzed were urea, INR, platelet, and lactate. 51% had history of taking antiplatelet or anticoagulants. 92% of patients underwent urgent OGDS (within 24 hours of referral), and 30% of them had findings of high-risk ulcers (Forrest 1b, 2a, and 2b) which need urgent intervention.     Conclusions The data from the study would be beneficial in providing evidence for further clinical research in our center on identifying the factors that will predict the outcome of OGDS towards the patient either for endoscopic intervention or diagnostic endoscopy only.

scholarly journals Hemolytic disease of the new-born due to ABO incompatibility

2018 ◽  
Vol 5 (2) ◽  
pp. 605 ◽  
Author(s):  
Vijaya S. Kattimani ◽  
Ushakiran C. B.
Keyword(s):  
Blood Group ◽  
Total Duration ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
Treatment Modalities ◽  
Cross Sectional ◽  
Indirect Bilirubin ◽  
Abo Incompatibility ◽  
Significant Difference ◽  
The Mean

Background: Better understanding of the clinical characteristics of HDN due to ABO incompatibility helps to optimise care. The objective of this study was to investigate the clinical manifestations and outcome of treatment modalities.Methods:This study was a hospital based cross sectional study conducted in the neonatal unit of Cheluvamba hospital attached to Mysore Medical College and Research Institute. A total of 50 neonates with blood group A or B born to mothers with blood group O; with jaundice and or anemia were enrolled during the period from January 2015 to December 2015. The various maternal and neonatal parameter and their association with development of jaundice and or anemia was studied. The outcome of treatment modalities was studied.Results: Out of 50 ABO Incompatible neonates 24 (48%) were male and 26 (52%) were female. The percentage of O–A and O–B incompatible neonates were 38% (19) and 72% (31), respectively. Jaundice was detected within the first 24 hours in 6% and 18% neonates had anemia. The mean age of presentation was 2.9±0.89 days. The various maternal and neonatal factors had no significant association with development of jaundice and or anemia due to ABO Incompatibility. The mean initial Indirect Bilirubin was 21.26±3.97, initial hemoglobin was 14.3±2.31 and the mean Reticulocyte count was 16.6±5.3. Total 22 (44%) neonates had laboratory evidence of hemolysis (microspherocytosis). DCT was positive in 4 (8%) neonates. The main clinical manifestation was jaundice and was treated with phototherapy in 49 (98%) of the cases. The mean duration of phototherapy was 53.84±9.82 hours. Only one infant required exchange transfusion and on follow up had no neurological sequelae. The mean total duration of stay was 3.6±1.2 days. There was no significant difference in the HDN due to either O–A or O–B incompatibility.Conclusions:Early identification of high risk neonates with ABO Incompatibility, diagnosis and early intervention can reduce morbidity and mortality. 

A Cross-Sectional Study of Clinical Profiles and Complications Associated with Fever with Thrombocytopenia

2021 ◽  
Vol 8 (8) ◽  
pp. 445-449
Author(s):  
Melvin Dominic ◽  
Hari Hara C. Sudhan ◽  
Karthik Narayan ◽  
Ram Kirubakar Thangaraj ◽  
Abdussamad M ◽  
...  
Keyword(s):  
Platelet Count ◽  
Clinical Manifestations ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Spontaneous Bleeding ◽  
Cross Sectional ◽  
General Physical Examination ◽  
The Mean ◽  
General Physical

BACKGROUND Fever is the commonest cause of thrombocytopenia that narrows the differential diagnosis and management of fever. The complexity of thrombocytopenia and its control can also be determined through fever. Lack of proper surveillance system and limited laboratory services pose a definite challenge for a perfect diagnosis leading to case management primarily based on clinical manifestations. METHODS A cross-sectional study was conducted on 90 patients attending outpatient department of Vinayaka Missions Kirupananda Variyar Medical College & Hospitals, during the period of April 2017 to September 2017 (6 months). In patients with fever with thrombocytopenia, a careful history was recorded, general physical examination, laboratory and technical investigation reports were noted down from regular investigations. Culture sensitivity and serology were considered as primary outcome variables. The continuous data was expressed as mean ± standard deviation (SD) and for independent sample “t” test was used to compare the data. A probability value (“P” value) of ≤ 0.05 at 95 % confidence interval was considered as statistically significant using Statistical Package for the Social Sciences (SPSS). RESULTS The mean age was 44.73 ± 21.18 years in the study population. 39 (43.33 %) were males and 51 (56.67 %) were females. The average period of stay in the hospital was 8.84 ± 5.73 days; the most common chief complaint was chills & rigors seen in 65 (72.22 %) patients. The most commonly observed comorbidity in the patients was diabetes mellitus. The mean and SD of platelet count was 91522.22 ± 32265.13 per µL. 21 (23.33 %) people had dengue. The mean platelet count at discharge was 192215.19 ± 49481.85 per µL. CONCLUSIONS The commonest cause is infection, for fever with decreased platelet count. A significant number of cases of febrile thrombocytopenia were diagnosed as sepsis in the present study. KEYWORDS Infection, Dengue, Septicaemia, Petechiae / Purpura, Spontaneous Bleeding, Fever

Sign in / Sign up

Export Citation Format

Share Document