scholarly journals The Relationship Between Left Ventricle Remodelling Types and Inflammatory Markers

2021 ◽  
Vol 41 (3) ◽  
pp. 266-273
Author(s):  
Ömer KÜMET ◽  
Berat ENGİN ◽  
Remzi SARIKAYA ◽  
Semih SÜRMEN ◽  
İmran ÖNÜR ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Inflammatory Markers ◽  
Left Ventricle Remodelling ◽  
The Relationship

Endothelial Dysfunction and Inflammatory Markers of Vascular Disease

2020 ◽  
Vol 19 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Sevket Balta
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Disease ◽  
Inflammatory Markers ◽  
Vascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Non Invasive ◽  
Von Willebrand ◽  
The Relationship ◽  
Willebrand Factor

: Vascular diseases are the main reason for morbidity and mortality worldwide. As we know, the earlier phase of vascular diseases is endothelial dysfunction in humans, the endothelial tissues play an important role in inflammation, coagulation, and angiogenesis, via organizing ligand-receptor associations and the various mediators’ secretion. We can use many inflammatory non-invasive tests (flowmediated dilatation, epicedial fat thickness, carotid-intima media thickness, arterial stiffness and anklebrachial index) for assessing the endothelial function. In addition, many biomarkers (ischemia modified albumin, pentraxin-3, E-selectin, angiopoietin, endothelial cell specific molecule 1, asymmetrical dimethylarginine, von Willebrand factor, endothelial microparticles and endothelial progenitor cells) can be used to evaluate endothelial dysfunction. We have focused on the relationship between endothelial dysfunction and inflammatory markers of vascular disease in this review.

scholarly journals Plasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Sarinnapha M. Vasunilashorn ◽  
◽  
Long H. Ngo ◽  
Simon T. Dillon ◽  
Tamara G. Fong ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Brain Barrier ◽  
Plasma Levels ◽  
Inflammatory Markers ◽  
Brain Barrier ◽  
Markers Of Inflammation ◽  
Blood Brain ◽  
Csf Levels ◽  
The Relationship

Abstract Background Our understanding of the relationship between plasma and cerebrospinal fluid (CSF) remains limited, which poses an obstacle to the identification of blood-based markers of neuroinflammatory disorders. To better understand the relationship between peripheral and central nervous system (CNS) markers of inflammation before and after surgery, we aimed to examine whether surgery compromises the blood-brain barrier (BBB), evaluate postoperative changes in inflammatory markers, and assess the correlations between plasma and CSF levels of inflammation. Methods We examined the Role of Inflammation after Surgery for Elders (RISE) study of adults aged ≥ 65 who underwent elective hip or knee surgery under spinal anesthesia who had plasma and CSF samples collected at baseline and postoperative 1 month (PO1MO) (n = 29). Plasma and CSF levels of three inflammatory markers previously identified as increasing after surgery were measured using enzyme-linked immunosorbent assay: interleukin-6 (IL-6), C-reactive protein (CRP), and chitinase 3-like protein (also known as YKL-40). The integrity of the BBB was computed as the ratio of CSF/plasma albumin levels (Qalb). Mean Qalb and levels of inflammation were compared between baseline and PO1MO. Spearman correlation coefficients were used to determine the correlation between biofluids. Results Mean Qalb did not change between baseline and PO1MO. Mean plasma and CSF levels of CRP and plasma levels of YKL-40 and IL-6 were higher on PO1MO relative to baseline, with a disproportionally higher increase in CRP CSF levels relative to plasma levels (CRP tripled in CSF vs. increased 10% in plasma). Significant plasma-CSF correlations for CRP (baseline r = 0.70 and PO1MO r = 0.89, p < .01 for both) and IL-6 (PO1MO r = 0.48, p < .01) were observed, with higher correlations on PO1MO compared with baseline. Conclusions In this elective surgical sample of older adults, BBB integrity was similar between baseline and PO1MO, plasma-CSF correlations were observed for CRP and IL-6, plasma levels of all three markers (CRP, IL-6, and YKL-40) increased from PREOP to PO1MO, and CSF levels of only CRP increased between the two time points. Our identification of potential promising plasma markers of inflammation in the CNS may facilitate the early identification of patients at greatest risk for neuroinflammation and its associated adverse cognitive outcomes.

scholarly journals The relationship between heart rate variability and inflammatory markers in cardiovascular diseases

2008 ◽  
Vol 33 (10) ◽  
pp. 1305-1312 ◽  
Author(s):  
Alexander Haensel ◽  
Paul J. Mills ◽  
Richard A. Nelesen ◽  
Michael G. Ziegler ◽  
Joel E. Dimsdale
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiovascular Diseases ◽  
Inflammatory Markers ◽  
The Relationship

scholarly journals The relationship of pro-inflammatory markers to vascular endothelial function after acute stroke

2016 ◽  
Vol 127 (6) ◽  
pp. 486-492 ◽  
Author(s):  
Sandra A Billinger ◽  
Jason-Flor V Sisante ◽  
Anna E Mattlage ◽  
Abdulfattah S Alqahtani ◽  
Michael G Abraham ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Acute Stroke ◽  
Inflammatory Markers ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Relationship Of ◽  
The Relationship

scholarly journals O21 Is hypoalbuminaemia associated with amputation-free survival in chronic limb-threatening ischaemia? A retrospective cohort study

2021 ◽  
Vol 108 (Supplement_5) ◽  
Author(s):  
A T O Nickinson ◽  
I Black ◽  
J S M Houghton ◽  
R D Sayers
Keyword(s):  
Nutritional Status ◽  
Inflammatory Markers ◽  
White Cell Count ◽  
Tissue Loss ◽  
Albumin Concentration ◽  
Free Survival ◽  
Cardiovascular Comorbidities ◽  
Operative Outcomes ◽  
One Year ◽  
The Relationship

Abstract Introduction Serum albumin is a recognised marker of nutritional status. Whilst associated with post-operative outcomes, the relationship with amputation-related outcomes in chronic limb-threatening ischaemia (CLTI) remains unclear. It is also uncertain whether any relationship may be confounded by systematic inflammation. We aimed to investigate whether hypoalbuminaemia is associated with amputation-related outcomes and evaluate its relationship with other inflammatory markers. Method A retrospective study of patients managed for CLTI at a vascular centre between 01/01/2013–31/12/2015 was undertaken. Patients were identified from local coding databases. Patient demographics and comorbidities, results of admission bloods and procedural data were recorded from electronic records. Hypoalbuminaemia was defined as albumin concentration &lt;35 g/L. One-year amputation-free survival (AFS) was the primary outcome. Cox’s proportional hazard models were calculated to compare the risk of amputation/death. Linear regression was performed to investigate the relationship between albumin and other inflammatory markers. Result 374 patients were included (mean albumin concentration = 38.8g/L [SD = 5.2]), with 72 patients being hypoalbuminaemic. No differences were observed in sex (P=0.678), age (P=0.207), history of tissue loss (P=0.057), or cardiovascular comorbidities between groups, however a greater proportion of patients with hypoalbuminaemia had COPD (P=0.002). Patients with hypoalbuminaemia had a significantly higher combined risk of 1-year amputation/death compared to those with normal albumin concentration (HR 1.94, 95% CI 1.29–2.91). White cell count and CRP concentration were significant predictors of albumin concentration (r2=0.113, P&lt;0.001). Conclusion Hypoalbuminaemia is an important prognostic biomarker of AFS in CLTI, however this association may relate to a complex relationship between nutritional status and inflammation. Take-home Message Albumin is more than just a marker of nutritional status in patients with chronic limb-threatening ischaemia.

scholarly journals THE EFFECTIVENESS OF COMBINATED ANTIHYPERTENSIVE TREATMENT IN PATIENTS WITH ESSENTIAL HYPERTENSION OF THE II-ND STAGE DEPENDING ON THE TYPE OF DAILY BLOOD PRESSURE PROFILE AND THE TYPE OF REMODELLING OF THE LEFT VENTRICLE

2020 ◽  
Vol 73 (1) ◽  
pp. 46-51
Author(s):  
Tetiana Y. Niushko ◽  
Olena K. Tarasiuk ◽  
Yulia K. Sikalo
Keyword(s):  
Blood Pressure ◽  
Left Ventricle ◽  
Antihypertensive Treatment ◽  
Blood Pressure Monitoring ◽  
Combined Therapy ◽  
Pressure Profile ◽  
Target Level ◽  
Pressure Monitoring ◽  
Blood Pressure Profile ◽  
Left Ventricle Remodelling

The aim: To evaluate the dynamics of structural and functional parameters of the heart, vessels in patients with hypertension of the II-nd stage under the influence of combined antihypertensive treatment depending on the type of the left ventricle remodelling and the profile of blood pressure (BP). Materials and methods: The study involved 110 patients with hypertension of the II-nd stage. The ambulatory blood pressure monitoring, echocardiography and Doppler examination of the shoulder arteries were performed. Initial treatment included bisoprolol, lisinopril, hydrochlorothiazide. With impossibility of BP lowering to the target level, amlodipine has been added. Results: higher levels of BP in the “non-dipper” patients have led to the development of more pronounced changes in the heart and vessels compared with “dipper” patients. Three-component therapy was effective in patients with lower BP. The prescription of amlodipine has been found to be necessary for the majority of “non-dipper” patients and for the minority of “dipper”. Combined therapy effectively controlled the BP at the level of the target and contributed to a decrease in the displays of remodelling of the heart and blood vessels. Conclusions: combined therapy used for 6 months reduces displays of disadaptive heart and vascular remodelling, diastolic, endothelial dysfunction. With the lack of efficacy of the therapy, which includes bisoprolol, lisinopril, hydrochlorothiazide, the adding of amlodipine to it can reach the target level of BP

The association between a metabolically healthy overweight/obesity phenotype and markers of inflammation among Chinese children and adolescents aged 10–18 years

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Jinyu Zhou ◽  
Ling Bai ◽  
Yangyang Dong ◽  
Rongrong Cai ◽  
Wenqing Ding
Keyword(s):  
Children And Adolescents ◽  
Inflammatory Markers ◽  
Normal Weight ◽  
Chinese Children ◽  
Metabolic Phenotypes ◽  
Tnf Α ◽  
Metabolically Healthy ◽  
Hs Crp ◽  
The Relationship ◽  
Chinese Children And Adolescents

Abstract Objectives The association between metabolically healthy overweight/obesity (MHO) and inflammatory markers remains controversial. The aim of the present study was to describe the prevalence of different metabolic phenotypes and to examine the relationship of different metabolic phenotypes with inflammatory markers among Chinese children and adolescents. Methods The study included 1,125 children and adolescents aged 10–18 years using a cross-sectional survey, and all subjects were classified into four groups based on a combination of BMI and metabolic status. In addition, the inflammatory markers we measured were high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6). Results The prevalence of metabolically healthy with normal-weight (MHNW), MHO, metabolically unhealthy with normal-weight (MUNW), and metabolically unhealthy overweight/obesity (MUO) phenotypes was 38.76, 7.11, 38.67 and 15.47%, respectively. The results of logistic regression analysis showed that the MHO was associated with the z scores of hs-CRP in Chinese children and adolescents (OR=0.57, 95% CI: 0.39–0.83). Meanwhile, multivariate adjusted regression analysis showed that the relationship between hs-CRP and MHO among the overweight/obese was consistent with the results above, but among the normal-weight, only the highest quartile of TNF-α could increase the risk of MUNW (OR=1.65, 95% CI: 1.09–2.52). Conclusions MHO phenotypes were not common in Chinese children and adolescents. Individuals with MHO had a more beneficial hs-CRP profile than those with MUO.

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