Clinical Study of 340 Cases of Hepatocellular Carcinoma in the Third Department of Internal Medicine, Kansai Medical University

Tamaka Shvasa is described as a most difficult to cure (Yapya) among all diseases in Ayurveda. In present study Tamaka Shvasa is correlated with Bronchial Asthma because of its symptomatology is much similar with Tamaka Shvasa. In modern medical science, steroids and bronchodilators are mainly used for its management, but they cause certain side effects. Present study was undertaken to provide safe and effective remedy for Tamaka Shvasa through Ayurvedic medicaments. Shirishadi tablet was given as internal medicine for 30 days. Upto 60% relief was found in signs and symptoms of Tamaka Shvasa.

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NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis

Gastroenterology Research and Practice ◽

10.1155/2010/367694 ◽

2010 ◽

Vol 2010 ◽

pp. 1-10 ◽

Cited By ~ 39

Author(s):

Shin Maeda

Keyword(s):

Hepatocellular Carcinoma ◽

Signaling Pathways ◽

Inflammatory Cell ◽

Prognostic Markers ◽

Tumor Promotion ◽

Neoplastic Cell ◽

Nuclear Factor ◽

Tlr Signaling ◽

The Third

Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide. The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets. It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-κB, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion. The cross-talk between an inflammatory cell and a neoplastic cell, which is instigated by the activation of NF-κB and JNKs, is critical for tumor organization. JNKs also regulate cell proliferation and act as oncogenes, making them the main tumor-promoting protein kinases. TLRs play roles in cytokine and hepatomitogen expression mainly in myeloid cells and may promote liver tumorigenesis. A better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC.

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Assessment of Dietary Habits, Physical Activity and Lifestyle in Medical University Students

Sustainability ◽

10.3390/su13063572 ◽

2021 ◽

Vol 13 (6) ◽

pp. 3572

Author(s):

Lavinia-Maria Pop ◽

Magdalena Iorga ◽

Iulia-Diana Muraru ◽

Florin-Dumitru Petrariu

Keyword(s):

Physical Activity ◽

Medical Students ◽

Fast Food ◽

Dietary Habits ◽

Healthy Life ◽

Related Data ◽

The Third ◽

Health Related ◽

Medical University ◽

Busy Schedule

A busy schedule and demanding tasks challenge medical students to adjust their lifestyle and dietary habits. The aim of this study was to identify dietary habits and health-related behaviours among students. A number of 403 students (80.40% female, aged M = 21.21 ± 4.56) enrolled in a medical university provided answers to a questionnaire constructed especially for this research, which was divided into three parts: the first part collected socio-demographic, anthropometric, and medical data; the second part inquired about dietary habits, lifestyle, sleep, physical activity, water intake, and use of alcohol and cigarettes; and the third part collected information about nutrition-related data and the consumption of fruit, vegetables, meat, eggs, fish, and sweets. Data were analysed using SPSS v24. Students usually slept M = 6.71 ± 1.52 h/day, and one-third had self-imposed diet restrictions to control their weight. For both genders, the most important meal was lunch, and one-third of students had breakfast each morning. On average, the students consumed 1.64 ± 0.88 l of water per day and had 220 min of physical activity per week. Data about the consumption of fruit, vegetables, meat, eggs, fish, sweets, fast food, coffee, tea, alcohol, or carbohydrate drinks were presented. The results of our study proved that medical students have knowledge about how to maintain a healthy life and they practice it, which is important for their subsequent professional life.

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Platelet counts during pregnancy in Chinese women

Journal of Laboratory Medicine ◽

10.1515/labmed-2019-0142 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Li-Xia Zhang ◽

Ning Dong ◽

Rui-Xia Yang ◽

Ang Li ◽

Xuan-Mei Luo ◽

...

Keyword(s):

Chinese Women ◽

Third Trimester ◽

Bleeding Events ◽

Common Cause ◽

Platelet Counts ◽

The Third ◽

Uncomplicated Pregnancy ◽

Gestational Thrombocytopenia ◽

The Mean ◽

Medical University

AbstractObjectivesGestational thrombocytopenia (GT) is the most common cause of thrombocytopenia during pregnancy. However, the occurrence and severity of thrombocytopenia throughout pregnancy in Chinese women are not fully defined.MethodsWe analyzed platelet counts in Chinese women who received prenatal care and/or delivered at the First Affiliated Hospital with Nanjing Medical University between January 2, 2018 and July 19, 2018 in China. These platelet counts were compared with those of nonpregnant women in the same study period.ResultsThe platelet counts of all women continued to decrease significantly each trimester (p < 0.0001). The mean platelet counts of the 818 women who had pregnancy-related complications were lower than those of the 796 women who had uncomplicated pregnancies during the third trimester (p = 0.047). At the time of delivery, platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy (26.7% vs. 19.7%, p = 0.03).ConclusionsPlatelet counts decrease throughout pregnancy in Chinese women and platelet counts less than 150 × 109/L were more common in women with pregnancy-related complications than in women with uncomplicated pregnancy. The pregnant women should be paid more attention for thrombocytopenia to avoid the occurrence of bleeding events.

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The occurrence rate and clinical application of Osteo-line on the femur neck

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02289-6 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Mingchen Zou ◽

Haotian Wu ◽

Shuangquan Yao ◽

Dong Ren ◽

Song Liu ◽

...

Keyword(s):

Clinical Application ◽

Visual Inspection ◽

Occurrence Rate ◽

Control Group ◽

Leg Length ◽

X Ray ◽

The Third ◽

Femur Neck ◽

Medical University ◽

Experimental Group

Abstract Background This study was done to observe the incidence of Osteo-line on the femur neck and to explore the clinical application of Osteo-line in osteotomy. Methods Eighty-nine adult femur specimens were selected to observe the incidence of Osteo-line on the femur neck. From August 2015 to January 2019, a total of 278 patients who completed unilateral hip arthroplasty at the Third Hospital of Hebei Medical University were retrospectively included. Patients who accepted osteotomy via Osteo-line on the femur neck were defined as the experimental group (n = 139), and patients who accepted osteotomy via traditional method (The femoral distance 1.5 cm above the trochanter was retained for osteotomy by visual inspection.) were defined as the control group (n = 139). According to the postoperative pelvic X-ray, Photoshop was used to evaluate the leg length discrepancy (LLD) by the CFR-T-LT method. Results Among the 89 specimens, the incidence of anterior Osteo-line was 75.28%, and the incidence of posterior Osteo-line was 100%. According to the clinical application results, the incidence of anterior Osteo-line on the femur neck was 80%, and the incidence of posterior Osteo-line was 100%. The Osteo-line was clearer than those on the femoral specimens. Twenty-six cases had LLD greater than 1 cm (9.29%), including 2 cases in the experimental group and 24 cases in the control group. The average postoperative LLD in the experimental group (0.19 ± 0.38 mm) was significantly shorter than in the control group (0.54 ± 0.51 mm)(P = 0.005). Conclusion The incidence of Osteo-line on the femur neck was high, and patients who accepted osteotomy via Osteo-line on the femur neck can achieve shorter postoperative LLD than the control group.

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The Third Generation of Real-Time Virtual Sonography for Navigation in the Treatment of Hepatocellular Carcinoma

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2011.05.602 ◽

2011 ◽

Vol 37 (8) ◽

pp. S136

Author(s):

Y. Eso ◽

A. Sakamoto ◽

S.G. Kim ◽

S. Saito ◽

H. Nishikawa ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Real Time ◽

Third Generation ◽

The Third

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Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

Canadian Journal of Gastroenterology and Hepatology ◽

10.1155/2017/6238106 ◽

2017 ◽

Vol 2017 ◽

pp. 1-11 ◽

Cited By ~ 2

Author(s):

Naz Fatima ◽

Tasleem Akhtar ◽

Nadeem Sheikh

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Cancer ◽

Antitumor Effect ◽

Gut Permeability ◽

Gut Flora ◽

Effective Barrier ◽

The Third ◽

Oncogenic Pathways ◽

Novel Approach ◽

Genetic Modifications

Hepatocellular carcinoma is one of the fatal malignancies and is considered as the third leading cause of death. Mutations, genetic modifications, dietary aflatoxins, or impairments in the regulation of oncogenic pathways may bring about liver cancer. An effective barrier against hepatotoxins is offered by gut-liver axis as a change in gut permeability and expanded translocation of lipopolysaccharides triggers the activation of Toll-like receptors which stimulate the process of hepatocarcinogenesis. Prebiotics, nondigestible oligosaccharides, have a pivotal role to play when it comes to inducing an antitumor effect. A healthy gut flora balance is imperative to downregulation of inflammatory cytokines and reducing lipopolysaccharides induced endotoxemia, thus inducing the antitumor effect.

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miR-34a Inhibits Cell Proliferation by Targeting SATB2 in Hepatocellular Carcinoma

BioMed Research International ◽

10.1155/2018/2863902 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 6

Author(s):

Gang Wu ◽

Zhixi Li ◽

Youyu Wang ◽

Xueming Ju ◽

Rui Huang

Keyword(s):

Hepatocellular Carcinoma ◽

Cell Proliferation ◽

Hepg2 Cells ◽

Hepatoma Cell ◽

Luciferase Reporter ◽

Hepatoma Cell Line ◽

Novel Therapy ◽

The Third ◽

Direct Target

Hepatocellular carcinoma (HCC) is the most common type of malignancy of the liver and has been reported as the third most frequent cause of cancer associated death worldwide. Accumulating evidence showed that the expression of miR-34a was abnormal in HCC patients; however, the role of miR-34a in HCC is not clear. In this study, we have observed low expression of the miR-34a in both HCC tissues and hepatoma cell line as compared to normal control. Further to investigate the role of miR-34a in HCC development, HepG2 cells were transfected with miR-34a mimic. Following transfection, miR-34a expression was significantly increased, which further repressed proliferation of HepG2 cells. Bioinformatics, Luciferase Reporter, RT-qPCR, and western blotting assays indicated that special AT-rich sequence-binding protein-2 (SATB2) is a direct target of miR-34a in HCC cells. There was a negative correlation between the expression levels of SATB2 and miR-34a. Investigation into the molecular mechanism indicated that miR-34a regulated cell proliferation through inhibiting SATB2. Therefore, the results of the present study may improve understanding regarding the role of miR-34a in regulating cell proliferation and contribute to the development of novel therapy of HCC.

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