scholarly journals Preparation of ¹⁸F-NaF radiopharmaceuticals using home-made automatic synthesis module at Hanoi Irradiation Center

2019 ◽  
Vol 9 (1) ◽  
pp. 41-49
Author(s):  
Manh Thang Tran ◽  
Van Vinh Mai ◽  
Thi Tam Dam ◽  
Quang Anh Nguyen ◽  
Thi Thu Hien Le ◽  
...  
Keyword(s):  
Cation Exchange ◽  
Saline Water ◽  
Isotonic Saline ◽  
Radiochemical Yield ◽  
Clinical Tests ◽  
Skeletal Scintigraphy ◽  
Natural Distribution ◽  
Automatic Synthesis ◽  
Pet Ct

The aim of this study is to prepare 18F-NaF radiopharmaceutical using a home-madeautomatic synthesis module consisting of hardware and software which was made by a researcherteam of Hanoi Irradiation Center, HIC, Hanoi, Vietnam. Fluorine-18 isotopes produced in cyclotron KOTRON13 were transferred to the module and radioactive cation impurities were first removed by cation exchange on a carboxymethyl cation exchange (CM) cartridge, and then 18F- ion were trapped by a quaternary methyl ammonium anion exchange (QMA) cartridge. Finally, 18F- was eluated from the cartridge by isotonic saline water (NaCl 0,9% in water) in the form of 18F-NaF. Time of the preparation process was about 13 minutes. Radiochemical yield of the preparation was as high as 95.5%, in average. The qualities of the product were satisfied the criteria of the United StatesPharmacopoeia (USP38). PET/CT bone scaner (skeletal scintigraphy) pre-clinical tests using of the 18 F-NaF product showed good quality of imaging for the entire skeletal and distribution of the 18F-NaF in the kidney and the bladder agreed with it’s natural distribution.

Restaging of patients with lymphoma

2008 ◽  
Vol 47 (01) ◽  
pp. 37-42 ◽  
Author(s):  
T. Pfluger ◽  
V. Schneider ◽  
M. Hacker ◽  
N. Bröckel ◽  
D. Morhard ◽  
...  
Keyword(s):  
Low Dose ◽  
Non Hodgkin Lymphoma ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
Significant Difference ◽  
18F Fdg ◽  
Sensitivity Specificity ◽  
Fdg Pet Ct

SummaryAim: Assessment of the clinical benefit of i.v. contrast enhanced diagnostic CT (CE-CT) compared to low dose CT with 20 mAs (LD-CT) without contrast medium in combined [18F]-FDG PET/CT examinations in restaging of patients with lymphoma. Patients, methods: 45 patients with non-Hodgkin lymphoma (n = 35) and Hodgkin's disease (n = 10) were included into this study. PET, LD-CT and CECT were analyzed separately as well as side-by-side. Lymphoma involvement was evaluated separately for seven regions. Indeterminate diagnoses were accepted whenever there was a discrepancy between PET and CT findings. Results for combined reading were calculated by rating indeterminate diagnoses according the suggestions of either CT or PET. Each patient had a clinical follow-up evaluation for >6 months. Results: Region-based evaluation suggested a sensitivity/specificity of 66/93% for LD-CT, 87%/91% for CE-CT, 95%/96% for PET, 94%/99% for PET/LD-CT and 96%/99% for PET/CE-CT. The data for PET/CT were obtained by rating indeterminate results according to the suggestions of PET, which turned out to be superior to CT. Lymphoma staging was changed in two patients using PET/ CE-CT as compared to PET/LD-CT. Conclusion: Overall, there was no significant difference between PET/LD-CT and PET/CE-CT. However, PET/CE-CT yielded a more precise lesion delineation than PET/LD-CT. This was due to the improved image quality of CE-CT and might lead to a more accurate investigation of lymphoma.

scholarly journals Effects of Various Quantities of Three Irrigation Water Types on Yield and Fruit Quality of ‘Succary’ Date Palm

Agronomy ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 796
Author(s):  
Mohamed A. Mattar ◽  
Said S. Soliman ◽  
Rashid S. Al-Obeed
Keyword(s):  
Soil Water ◽  
Fruit Quality ◽  
Irrigation Water ◽  
Deficit Irrigation ◽  
Date Palm ◽  
Saline Water ◽  
Irrigation Level ◽  
Water Types ◽  
Palm Trees

A field experiment was conducted on date palm trees (Phoenix dactylifera ‘Succary’) cultivated on sandy loam soil from 2017 to 2018. This study investigated the effects of providing water of three different qualities, namely freshwater (FR) and two saline water sources: reclaimed wastewater (RW) and well-water (WE) applied through three irrigation levels representing 50% (I50), 100% (I100), and 150% (I150) of crop evapotranspiration (ETc), on the soil water and salt distribution patterns, yield, water productivity (WP), and fruit quality of the ′Succary′ date palm. The electrical conductivity (ECw) of FR, RW, and WE were 0.18, 2.06, and 3.94 dS m−1, respectively. Results showed that WE applied by the I150 treatment had the highest soil water content, followed by RW used in the I100 irrigation level and FR with I50, whereas the soil salt content was high for WE applied in the I50 level and low for FR applied by the I150 treatment. Deficit irrigation (I50) of date palms with either RW or WE reduced date yields on average 86 kg per tree, whereas the yield increased under over-irrigation (I150) with FR to 123.25 kg per tree. High WP values were observed in the I50 treatments with FR, RW, or WE (on average 1.82, 1.68, and 1.67 kg m−3, respectively), whereas the I150 treatment with each of the three water types showed the lowest WP values. Fruit weight and size were the lowest in the full irrigation (I100) with WE, whereas the I150 treatment with RW showed the highest values. There were no significant differences in either total soluble solids (TSS) or acidity values when the irrigation level decreased from 100% to 50% ETc. Compared with both I50 and I100 treatments, reduced values of both TSS and acidity were observed in the I150 treatment when ECw decreased from 3.94 to 0.18 dS m−1,. Fruit moisture content decreased with the application of saline irrigation water (i.e., RW or WE). Total sugar and non-reducing sugar contents in fruits were found to be decreased in the combination of RW and I150, whereas the 50% ETc irrigation level caused an increment in both parameters. These results suggest that the application of deficit irrigation to date palm trees grown in arid regions, either with FR or without it, can sufficiently maximize WP and improve the quality of fruits but negatively affects yield, especially when saline water is applied. The use of saline water for irrigation may negatively affect plants because of salt accumulation in the soil in the long run.

scholarly journals GMP production of 6-[18F]Fluoro-l-DOPA for PET/CT imaging by different synthetic routes: a three center experience

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Valdemar L. Andersen ◽  
Mikkel A. Soerensen ◽  
Johan Hygum Dam ◽  
Niels Langkjaer ◽  
Henrik Petersen ◽  
...  
Keyword(s):  
Radiochemical Yield ◽  
Ct Imaging ◽  
University Hospital ◽  
Dopamine Synthesis ◽  
Congenital Hyperinsulinism ◽  
Molar Activity ◽  
Time Period ◽  
Pet Ct ◽  
Synthetic Routes ◽  
Radiochemical Yields

Abstract Background The radiofluorinated levodopa analogue 6-[18F]F-l-DOPA (3,4-dihydroxy-6-18F-l-phenylalanine) is a commonly employed radiotracer for PET/CT imaging of multiple oncological and neurological indications. An unusually large number of different radiosyntheses have been published to the point where two different Ph. Eur. monographs exist depending on whether the chemistry relies on electrophilic or nucleophilic radiosubstitution of appropriate chemical precursors. For new PET imaging sites wishing to adopt [18F]FDOPA into clinical practice, selecting the appropriate production process may be difficult and dependent on the clinical needs of the site. Methods Data from four years of [18F]FDOPA production at three different clinical sites are collected and compared. These three sites, Aarhus University Hospital (AUH), Odense University Hospital (OUH), and Herlev University Hospital (HUH), produce the radiotracer by different radiosynthetic routes with AUH adopting an electrophilic strategy, while OUH and HUH employ two different nucleophilic approaches. Production failure rates, radiochemical yields, and molar activities are compared across sites and time. Additionally, the clinical use of the radiotracer over the time period considered at the different sites are presented and discussed. Results The electrophilic substitution route suffers from being demanding in terms of cyclotron operation and maintenance. This challenge, however, was found to be compensated by a production failure rate significantly below that of both nucleophilic approaches; a result of simpler chemistry. The five-step nucleophilic approach employed at HUH produces superior radiochemical yields compared to the three-step approach adopted at OUH but suffers from the need for more comprehensive synthesis equipment given the multi-step nature of the procedure, including HPLC purification. While the procedure at OUH furnishes the lowest radiochemical yield of the synthetic routes considered, it produces the highest molar activity. This is of importance across the clinical applications of the tracer discussed here, including dopamine synthesis in striatum of subjects with schizophrenia and congenital hyperinsulinism in infants. Conclusion For most sites either of the two nucleophilic substitution strategies should be favored. However, which of the two will depend on whether a given site wishes to optimize the radiochemical yield or the ease of the use.

scholarly journals Formation of ‘Crioula’ guava rootstock under saline water irrigation and nitrogen doses

2016 ◽  
Vol 20 (8) ◽  
pp. 739-745 ◽  
Author(s):  
Leandro de P. Souza ◽  
Reginaldo G. Nobre ◽  
Evandro M. da Silva ◽  
Geovani S. de Lima ◽  
Francisco W. A. Pinheiro ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Salt Stress ◽  
Experimental Design ◽  
Deleterious Effect ◽  
Saline Water ◽  
Dry Weight ◽  
Saline Water Irrigation ◽  
N Dose

ABSTRACT The objective of this research was to evaluate the growth and formation of fresh and dry weight of ‘Crioula’ guava rootstock irrigated with waters of different saline levels and nitrogen (N) doses, in an experiment conducted in plastic tubes under greenhouse conditions. The experimental design was randomized blocks, in a 5 x 4 factorial scheme with four replicates, and the treatments consisted of five levels of water electrical conductivity - ECw (0.3, 1.1, 1.9, 2.7 and 3.5 dS m-1) and four N doses (70, 100, 130 and 160% of the N dose recommended for the cultivation of guava seedlings, cv. ‘Paluma’). The dose referring to 100% corresponds to 773 mg of N dm-3. The highest growth of ‘Crioula’ guava rootstock was obtained with ECw of 0.3 dS m-1 and fertilization of 541.1 mg N dm-3 of soil; increasing N doses did not reduce the deleterious effect of the salt stress on the growth and phytomass formation of ‘Crioula’ guava rootstock; irrigation with water of up to 1.75 dS m-1, in the production of guava rootstocks, promotes acceptable reduction of 10% in growth and quality of the seedlings.

scholarly journals POSSIBILITIES OF USING CRYOSURGICAL METHOD IN TREATMENT OF DEPTH BRAIN TUMORS

2016 ◽  
Vol 175 (1) ◽  
pp. 11-17
Author(s):  
A. I. Kholyavin ◽  
V. B. Nizkovolos ◽  
B. V. Martynov ◽  
D. V. Svistov ◽  
A. D. Anichkov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Brain Tumor ◽  
Surgical Treatment ◽  
Surgical Removal ◽  
Tumor Localization ◽  
Brain Areas ◽  
Pet Ct ◽  
Stereotactic Guidance

Cryosurgical method is used in treatment of patients with glial tumors which localized in depth and functionally meaningful brain areas. These patients are generally considered as inoperable and receive conservative treatment. Their prognosis has become worse as compared to the patients whose brain tumor is available for surgical removal. The authors used a multiway stereotactic destruction of tumors by cryosurgical cannula, which is inserted in bone cutter opening using manipulator. MR-imaging and PET/CT of brain were applied for stereotactic guidance. The majority of patients who underwent this operation didn’t noticed any loss of quality of life. The rates of survival were higher than corresponding indicators for patients who were treated only by chemo- or radiation therapy and the rates were equal to the patients underwent the radical operations. Thus, the multiway stereotactic cryodestruction is a new, safe and effective method of surgical treatment for the patients with tumor localization in such areas, that their location blocked an application of traditional surgical removal by open method.

scholarly journals ARRANJO ESPACIAL E PODA NA PRODUÇÃO E QUALIDADE QUÍMICA DE MARACUJÁ IRRIGADO COM ÁGUA SALINA

Irriga ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 549-561
Author(s):  
RAFAEL RAMOS MORAIS ◽  
JOÃO PAULO SILVA MACÊDO ◽  
LOURIVAL FERREIRA CAVALCANTE ◽  
JACKSON TEIXEIRA LOBO ◽  
ANTÔNIO GUSTAVO LUNA SOUTO ◽  
...  
Keyword(s):  
Saline Water ◽  
Titratable Acidity ◽  
Solid Content ◽  
Fruit Yield ◽  
Main Stem ◽  
Planting Density ◽  
Soluble Solid Content ◽  
Soluble Solid ◽  
Solids Content

ARRANJO ESPACIAL E PODA NA PRODUÇÃO E QUALIDADE QUÍMICA DE MARACUJÁ IRRIGADO COM ÁGUA SALINA     RAFAEL RAMOS MORAIS1; JOÃO PAULO SILVA MACÊDO2; LOURIVAL FERREIRA CAVALCANTE3; JACKSON TEIXEIRA LOBO1; ANTÔNIO GUSTAVO LUNA SOUTO1 E EVANDRO FRANKLIN MESQUITA4   1 Programa de pós-graduação em Agronomia, Departamento de Fitotecnia e Ciências Ambientais do Centro de Ciências Agrárias, Universidade Federal da Paraíba, Rodovia PB 079, SN, Km 12, 58.397-000, Areia, Paraíba, Brasil, [email protected]; [email protected], [email protected]. 2 Empresa Paraibana de Pesquisa, Extensão Rural e Regularização Fundiária, Rodovia BR 230, S/N, Km 13, Morada Nova, 58.108-502, Cabedelo, Paraíba, Brasil, [email protected]. 3 Professor do Departamento de Solos e Engenharia Rural, Universidade Federal da Paraíba, Rodovia PB 079, S/N, Km 12, 58.397-000, Areia, Paraíba, Brasil, [email protected]. 4 Professor do Centro de Ciências Humanas e Agrárias, Universidade Estadual da Paraíba, Sitio Cajueiro, S/N, Zona Rural, 58.884-000, Catolé do Rocha, Paraíba, Brasil, [email protected].     1 RESUMO   Um experimento foi desenvolvido no município de Coronel Ezequiel, Estado do Rio Grande do Norte, Brasil, para avaliar os efeitos da densidade de plantio e poda da haste principal em plantas de maracujazeiro amarelo, acesso Guinezinho, sob irrigação com água salina de 3,4 dS m-1. Os tratamentos, com distância de 2,0 m entre linhas, foram distribuídos em blocos ao acaso, com quatro repetições de 12 plantas por parcela, em esquema fatorial 4 × 2, correspondente as distâncias de 3, 6, 9 e 12 m entre plantas nas linhas com e sem poda da haste principal, ao atingir o sistema de sustentação. Os componentes avaliados foram número de frutos colhidos, produção por planta, produtividade e na polpa dos frutos, os valores de sólidos solúveis, acidez titulável, pH e a relação sólidos solúveis/ acidez titulável. A interação entre os fatores estudados exerceu efeitos significativos no número de frutos colhidos, produção por planta, teor de sólidos solúveis e acidez titulável. A produtividade foi influenciada pelos dois fatores de forma isolada. O pH da polpa respondeu apenas ao espaçamento entre plantas nas linhas e a relação SS/AT não foi influenciada por nenhuma das fontes de variação estudadas. O aumento das distâncias de plantio nas linhas promove ganho de produção por planta, mas reduz a produtividade. Plantas podadas na haste principal apresentam maior produtividade. A irrigação com água de qualidade restritiva à agricultura não inibiu a capacidade produtiva do maracujazeiro amarelo acesso Guinezinho e não prejudicou a qualidade química dos frutos.   Palavras-chave: acesso Guinezinho, densidade de plantio, Passiflora edulis Sims.     MORAIS, R. R.; MACÊDO, J. P. S.; CAVALCANTE, L. F.; LOBO, J. T.; SOUTO, A. G. L.; MESQUITA, E. F. SPATIAL ARRANGEMENT AND PRUNING IN THE PRODUCTION AND CHEMICAL QUALITY OF YELLOW PASSIONFRUIT IRRIGATED WITH SALINE WATER       2 ABSTRACT   An experiment was carried out in  Coronel Ezequiel municipality, Rio Grande do Norte State, Brazil, to evaluate the effects of planting density and pruning of the main stem on yellow passion fruit plants access Guinezinho under irrigation with saline water (3.4 dS m-1). The treatments, with inter-row distance of 2 m, were distributed in randomized blocks, with four replications of 12 plants per plot, in a 4 × 2 factorial scheme, corresponding to intra-row distances of 3, 6, 9 and 12 m for plants with and without pruned main stem, upon reaching the support system. The evaluated components were number of fruit harvested, production per plant, fruit yield and in the fruit pulp, the analyzed components were soluble solid content, titratable acidity, pH and soluble solid content/ titratable acidity ratio. The interaction between the factors studied significantly affected the number of fruit harvested, production per plant, solids content and titratable acidity. The fruit yield was influenced by the two isolated factors, but the pH of the pulp responded only to the intra-row plant spacing, and the solids content/ titratable acidity ratio was not influenced by any of the sources of variation studied. Increasing the distances intra-row raises the production per plant, but reduces fruit yield. Plants pruned on the main stem have higher fruit yield. Irrigation with restrictive water quality to agriculture did not inhibit the productive capacity of yellow passion fruit access Guinezinho and did not impair the chemical quality of the fruits.   Keywords: Guinezinho access, planting density, Passiflora edulis Sims.

scholarly journals PET-Specific Parameters and Radiotracers in Theoretical Tumour Modelling

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Matthew Jennings ◽  
Loredana G. Marcu ◽  
Eva Bezak
Keyword(s):  
Gene Expression ◽  
In Silico ◽  
Tumour Growth ◽  
Patient Specific ◽  
Computational Techniques ◽  
Accurate Information ◽  
Pet Ct ◽  
Ct Data ◽  
Specific Management

The innovation of computational techniques serves as an important step toward optimized, patient-specific management of cancer. In particular,in silicosimulation of tumour growth and treatment response may eventually yield accurate information on disease progression, enhance the quality of cancer treatment, and explain why certain therapies are effective where others are not.In silicomodelling is demonstrated to considerably benefit from information obtainable with PET and PET/CT. In particular, models have successfully integrated tumour glucose metabolism, cell proliferation, and cell oxygenation from multiple tracers in order to simulate tumour behaviour. With the development of novel radiotracers to image additional tumour phenomena, such as pH and gene expression, the value of PET and PET/CT data for use in tumour models will continue to grow. In this work, the use of PET and PET/CT information inin silicotumour models is reviewed. The various parameters that can be obtained using PET and PET/CT are detailed, as well as the radiotracers that may be used for this purpose, their utility, and limitations. The biophysical measures used to quantify PET and PET/CT data are also described. Finally, a list ofin silicomodels that incorporate PET and/or PET/CT data is provided and reviewed.

Impact of total variation regularized expectation maximization reconstruction on the image quality of 68Ga-PSMA PET: a phantom and patient study

2021 ◽  
pp. 20201356
Author(s):  
Feng-Jiao Yang ◽  
Shu-Yue Ai ◽  
Runze Wu ◽  
Yang Lv ◽  
Hui-Fang Xie ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Image Quality ◽  
Total Variation ◽  
Expectation Maximization ◽  
Image Noise ◽  
Psma Pet ◽  
Pet Ct ◽  
Digital Pet ◽  
The Impact

Objectives: To investigate the impact of total variation regularized expectation maximization (TVREM) reconstruction on the image quality of 68Ga-PSMA-11 PET/CT using phantom and patient data. Methods: Images of a phantom with small hot sphere inserts and 20 prostate cancer patients were acquired with a digital PET/CT using list-mode and reconstructed with ordered subset expectation maximization (OSEM) and TVREM with seven penalisation factors between 0.01 and 0.42 for 2 and 3 minutes-per-bed (m/b) acquisition. The contrast recovery (CR) and background variability (BV) of the phantom, image noise of the liver, and SUVmax of the lesions were measured. Qualitative image quality was scored by two radiologists using a 5-point scale (1-poor, 5-excellent). Results: The performance of CR, BV, and image noise, and the gain of SUVmax was higher for TVREM 2 m/b groups with the penalization of 0.07 to 0.28 compared to OSEM 3 m/b group (all p < 0.05). The image noise of OSEM 3 m/b group was equivalent to TVREM 2 and 3 m/b groups with a penalization of 0.14 and 0.07, while lesions’ SUVmax increased 15 and 20%. The highest qualitative score was attained at the penalization of 0.21 (3.30 ± 0.66) for TVREM 2 m/b groups and the penalization 0.14 (3.80 ± 0.41) for 3 m/b group that equal to or greater than OSEM 3 m/b group (2.90 ± 0.45, p = 0.2 and p < 0.001). Conclusions: TVREM improves lesion contrast and reduces image noise, which allows shorter acquisition with preserved image quality for PSMA PET/CT. Advances in knowledge: TVREM reconstruction with optimized penalization factors can generate higher quality PSMA-PET images for prostate cancer diagnosis.

Sign in / Sign up

Export Citation Format

Share Document