COLON TARGETING APPROACHES: PAST, PRESENT AND FUTURE

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (03) ◽  
pp. 5-17
Author(s):  
S Bisht ◽  
H Bajaj ◽  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Proximal Colon ◽  
Local Drug Delivery ◽  
Gi Tract ◽  
Systemic Delivery ◽  
Colon Targeting ◽  
Release System ◽  
System Pressure ◽  
Fecal Content

The colon specific drug delivery system is gaining importance not only for local drug delivery of drugs but also for the systemic delivery of protein & peptide drugs. Colon was considered as black-box as most of the drugs are absorbed from upper part of the GI tract. Colon targeting was aimed mainly because of less enzymatic activity and longer transit time. It also has drawbacks like less water content and presence of fecal content. To achieve successful colon targeted drug delivery, a drug needs to be protected from degradation, release and absorption in the upper portion of the GI tract and then to be ensured controlled release in the proximal colon. The various approaches that can be exploited to target the release of drug to the colon including formulation approaches through pH sensitive system are microbial triggered systems i.e., prodrugs and polysaccharide based system, timed release system, osmotically controlled drug system, pressure dependent release system, programmed pulsatile release system and others.

scholarly journals A Prototype Therapeutic Capsule Endoscope for Ultrasound-Mediated Targeted Drug Delivery

2018 ◽  
Vol 03 (02) ◽  
pp. 1840001 ◽  
Author(s):  
Fraser Stewart ◽  
Antonella Verbeni ◽  
Yongqiang Qiu ◽  
Ben F. Cox ◽  
Jan Vorstius ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Crohn’S Disease ◽  
Side Effects ◽  
Capsule Endoscopy ◽  
Targeted Drug Delivery ◽  
Capsule Endoscope ◽  
Proof Of Concept ◽  
Gi Tract ◽  
Preliminary Results ◽  
Targeted Drug

The prevalence of gastrointestinal (GI) diseases such as Crohn’s disease, which is chronic and incurable, are increasing worldwide. Treatment often involves potent drugs with unwanted side effects. The technological–pharmacological combination of capsule endoscopy with ultrasound-mediated targeted drug delivery (UmTDD) described in this paper carries new potential for treatment of these diseases throughout the GI tract. We describe a proof-of-concept UmTDD capsule and present preliminary results to demonstrate its promise as an autonomous tool to treat GI diseases.

A new approach to local drug delivery bubbling under the surface

2019 ◽  
Vol 11 (503) ◽  
pp. eaay3582
Author(s):  
Eoin O’Cearbhaill
Keyword(s):  
Drug Delivery ◽  
Minimally Invasive ◽  
Targeted Drug Delivery ◽  
Local Drug Delivery ◽  
New Approach ◽  
Targeted Drug

Ultrasound is coupled with a needle-based minimally invasive electrode to enhance targeted drug delivery to superficial tumors.

Design and synthesis of aptamer AS1411-conjugated EG@TiO2@Fe2O3 nanoparticles as a drug delivery platform for tumor-targeted therapy

2020 ◽  
Vol 44 (37) ◽  
pp. 15871-15886 ◽  
Author(s):  
Nahid Mansouri ◽  
Razieh Jalal ◽  
Batool Akhlaghinia ◽  
Khalil Abnous ◽  
Roya Jahanshahi
Keyword(s):  
Drug Delivery ◽  
Targeted Therapy ◽  
Sustained Release ◽  
Targeted Drug Delivery ◽  
Fe2o3 Nanoparticles ◽  
Ph Responsive ◽  
Release System ◽  
Design And Synthesis ◽  
Delivery Platform ◽  
Targeted Drug

AS1411@GMBS@EG@TiO2@Fe2O3 nanoparticle is an effective and safe pH-responsive sustained release system for targeted drug delivery into nucleolin-positive cells.

scholarly journals Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

2018 ◽  
Vol 244 (6) ◽  
pp. 433-444 ◽  
Author(s):  
Rebecca M Haley ◽  
Horst A von Recum
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Delivery ◽  
Local Drug Delivery ◽  
Future Research ◽  
Systemic Delivery ◽  
Number Of Patients ◽  
Long Term Treatment ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Inflammatory processes are increasingly being identified at the core of many different disease states (e.g. heart disease, cancer, diabetes). As such, anti-inflammatory strategies available through drug delivery have undergone renewed interest. Due to the systemic side effects of steroidal drugs, non-steroidal anti-inflammatory drugs are often preferred for long-term treatment of inflammation in a variety of applications. While non-steroidal anti-inflammatory drugs are generally safe, there are some serious side effects that can be associated with their usage, particularly when given systemically or orally. Due to the high number of patients taking non-steroidal anti-inflammatory drugs, the reduction or elimination of these side effects, such as is possible through local drug delivery, could have a very powerful effect on patient quality of life. This review comments on a sampling of existing methods for localized or targeted delivery of non-steroidal anti-inflammatory drugs, with the goal of helping future research groups to focus on bettering methods shown to be effective and filling the gaps of knowledge in this field. Additionally, commentary is made on the field as a whole, and the standardization issues that arise from its expansiveness and diversity. Impact statement This work provides an overview of research currently being done exploring potential drug delivery device strategies for NSAIDs as an alternative to systemic delivery. Commentary on this field is made in an attempt to aid future experimental design, enabling researchers to determine the drugs and delivery vehicles which are most advantageous for them to pursue, as well as suggestions to standardize the reporting of such future research.

scholarly journals Primary and Novel Approaches in Colon Targeted Drug Delivery System: A Review

2015 ◽  
Vol 3 (02) ◽  
pp. 37-57
Author(s):  
Komal . ◽  
Ujjwal Nautiyal ◽  
Ramandeep , Anita Devi Singh ◽  
Anita Devi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Local Treatment ◽  
Systemic Delivery ◽  
Colonic Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoeabiasis , colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the colon i.e. drug release and absorption should not occur in the stomach as well as the small intestine, and neither the bioactive agent should be degraded in either of the dissolution sites but only released and absorbed once the system reaches the colon. Different approaches are designed based on prodrug formulation, pHsensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The efficiency of drug delivery system is evaluated using different in vitro and in vivo release studies. This review article discusses, in brief, introduction to targeted drug delivery system, anatomy and physiology of the colon and approaches utilized in the colon targeted drug delivery system.

scholarly journals Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems

2021 ◽  
Vol 2 (3) ◽  
pp. 626-647
Author(s):  
Yubia De Anda-Flores ◽  
Elizabeth Carvajal-Millan ◽  
Alma Campa-Mada ◽  
Jaime Lizardi-Mendoza ◽  
Agustin Rascon-Chu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Gi Tract ◽  
Colonic Delivery ◽  
Drug Degradation ◽  
Non Invasive ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multiple barriers along the GI tract and affect encapsulation efficiency, drug protection, and release mechanisms upon arrival in the colon. Also, there is information disclosed about the size of the nanoparticles that are usually involved in the mechanisms of diffusion through the barriers in the GI tract, which may influence early drug degradation and release in the digestive tract.

scholarly journals Potential application of Colonic drug delivery system in prevention and treatment of Colorectal Cancer

2021 ◽  
Vol 001 (03) ◽  
Author(s):  
Mudassir Ansari ◽  
Kavita Singh
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Drug Distribution ◽  
Gi Tract ◽  
Colonic Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Colorectal cancer (CRC) is the second leading cause of cancer related deaths in USA. The current regimen used to treat colorectal cancer has many side effects and have higher drug distribution in other tissues. Physical activity and diet play major role in prevention of Colon cancer which is briefly discussed in this paper. Colon targeted drug delivery system (CoDDS) is found to be a promising approach to target the drug specifically to colon. This review provides the description of various colon targeted approaches that can be used to treat CRC. Factors to be consider while designing CoDDS include pH of GIT, Transit time of GI tract and Microbiota of colon. This review will discuss the staging and standard treatments modalities for CRC.

scholarly journals Chrono pharmacotherapy: A pulsatile Drug Delivery

2015 ◽  
Vol 1 (1) ◽  
pp. 25
Author(s):  
Huma Hameed ◽  
Arwa Khalid ◽  
Fazala Khalid ◽  
Rabeea Khan ◽  
Akhtar Rasul
Keyword(s):  
Drug Delivery ◽  
Circadian Rhythms ◽  
Antihypertensive Drugs ◽  
Systemic Delivery ◽  
Night Time ◽  
Colon Targeting ◽  
Therapeutic Outcomes ◽  
Zero Order Release ◽  
Pulsatile Drug Delivery ◽  
Pulsatile Delivery

Chronopharmacotherapy refers to a treatment in which controlled drug delivery is achieved according to circadian rhythms of disease by enhancing therapeutic outcomes and minimizing side effects. Colon targeting has gained great importance not only for the treatment of local diseases such as Crohn’s disease, inflammatory bowel disease and ulcerative colitis but also very important in systemic delivery of proteins/peptides, antiasthmatic drugs, antidiabetic agents and antihypertensive drugs, which mostly show their efficacy based on circadian rhythms of the body.Colon drug delivery is one of the difficult approaches to achieve the targeted and desired outcomes through pulsatile drug delivery by avoiding dose dumping.The main reasonbehind the use of pulsatile delivery is provision ofconstant drug release where a zero-order release is notpreferred. Chronopharmacotherapy in colon targeting play its role bymany systems such ascapsular systems, pulsatile system and osmotic systems, which are based on use of rupturable membranes and biodegradable polymers.The objective of this review article is to provide latest knowledge about drugs with chrono-pharmacological behavior entails night time dosing specially to the colon.

scholarly journals Orodental Local Drug Delivery

2015 ◽  
Vol 6 (2) ◽  
pp. 41-46 ◽  
Author(s):  
Nandita Ahanthem ◽  
Nikhat Gazge
Keyword(s):  
Drug Delivery ◽  
Drug Dosage ◽  
Oral Route ◽  
Local Drug Delivery ◽  
Systemic Delivery ◽  
Rapid Repair ◽  
First Pass Metabolism ◽  
First Pass ◽  
Pass Metabolism ◽  
Systemic Drug

ABSTRACT Oral mucosal diseases are the most common diseases affecting humans and these can be treated with the use of various drugs. These drugs can be administered via many routes to produce its pharmacological bioeffects. One such site is the oral cavity, where both local and systemic deliveries of drug can take place. Oral route has been the most convenient and commonly employed route of drug delivery. The oral mucosa's accessibility, excellent blood supply, bypass of hepatic first pass metabolism, rapid repair, and permeability profile make it an attractive site for local and systemic drug deliveries. Local drug delivery allows topical treatment of various oral mucosal diseases, as it provides a more targeted and efficient drug-delivery option than systemic delivery. This review highlights various methods of drug delivery and important aspects of mucoadhesive drug delivery and drug dosage for treatment of orodental diseases. How to cite this article Ahanthem N, Basavaraju SM, Pachipulusu B, Gazge N. Orodental Local Drug Delivery. J Health Sci Res 2015;6(2):41-46.

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