scholarly journals The Sweet Spot: Continued Search for the Glycemic Threshold for Macrovascular Disease—A Retrospective Single Center Experience

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Andrzej Boguszewski ◽  
Andrew Teklinski ◽  
Howard Rosman ◽  
Devang Desai ◽  
Sajid Ali ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Macrovascular Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Preventive Cardiology ◽  
Lipid Disorder ◽  
Glucose Levels ◽  
Single Center Experience

Background. Atherosclerotic cardiovascular disease (ASCVD) is a common complication of diabetes mellitus and impaired fasting glucose (IFG). We hypothesized that the relation of fasting glucose levels to ASCVD is linear, with the prevalence of clinical ASCVD beginning to increase even among individuals currently categorized as normoglycemic. Methods. Patient charts were retrospectively reviewed from our Dyslipidemic Preventive Cardiology Clinic. We evaluated the prevalence of ASCVD relative to fasting glucose levels in a cross-section of patients at high risk for ASCVD. Results. In 558 dyslipidemic patients, ASCVD prevalence increased with increasing fasting glucose levels. A significantly higher prevalence of ASCVD was observed among patients with fasting glucose levels between 90 and 99 mg/dL versus lower levels. As glucose levels increased from 90 to 125 mg/dL, the prevalence of ASCVD continued to rise in parallel. Logistic regression analysis with forward likelihood ratio stepwise selection indicated that individuals with fasting blood glucose of 90–99 mg/dL were 2.6 times more likely to have ASCVD than those with lower levels of fasting blood glucose. Conclusion. Our findings suggest that the current cutoff for impaired fasting glucose of 100 mg/dL may be somewhat conservative and that a level above 90 mg/dL may be more appropriate as an ASCVD risk factor, particularly in patients with a lipid disorder.

scholarly journals Association of a Self-Paid Medically Supervised Weight Management Program with Reversal of Obesity-Associated Impaired Fasting Glucose

2021 ◽  
Vol 11 (2) ◽  
pp. 386-394
Author(s):  
Vijaya Surampudi ◽  
Xinkai Zhou ◽  
Chi-Hong Tseng ◽  
David Heber ◽  
Zhaoping Li
Keyword(s):  
Weight Loss ◽  
Blood Glucose ◽  
Retrospective Analysis ◽  
Weight Management ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Management Program ◽  
Weight Management Program ◽  
Glucose Levels

Aims: The progression of prediabetes to T2DM can be delayed through diet modification and weight management. However, the intensive lifestyle program is often not covered by medical insurance. This retrospective analysis evaluates the association of a patient self-paid weight management program on an improvement of blood sugar in overweight and obese patients with impaired fasting glucose (IFG). Methods: The medical records of 4634 patients who participated in the self-pay UCLA Weight Management Program were reviewed and 2572 patients met the criteria for this retrospective analysis to examine whether this program was associated with the reversal of IFG over 3 months among 1396 patients with normal fasting glucose (NFG) and 1176 with IFG. Results: The patients with IFG lost comparable amounts of weight (10.5 ± 1.3 kg) at three months, as did the subjects with NFG (10.1 ± 1.3 kg). Fasting blood glucose in the IFG group decreased from 108.49 ± 6.4 to 101.8 ± 9.41 mg/dL (p < 0.0001) after three months. There were also significant reductions in triglycerides, and both systolic and diastolic blood pressure in both groups in association with weight loss. Conclusion: Our medically supervised self-pay multidisciplinary weight management program was associated with reduced fasting blood glucose levels in patients with IFG over three months with comparable weight loss to patients with NFG.

scholarly journals Frequency of impaired fasting glucose in first degree relatives of Type-II diabetic patients and its association with Body Mass Index

2020 ◽  
Vol 36 (3) ◽  
Author(s):  
Alia Ali Muhammed ◽  
Azeem Taj ◽  
Muhammed Uthman Ahmed ◽  
Elsa Tabrez
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Impaired Fasting Glucose ◽  
Type Ii Diabetes ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Diabetic Patients ◽  
Type Ii ◽  
Glucose Levels ◽  
First Degree Relatives

Objectives: To determine the frequency of impaired fasting glucose in first degree relatives of people with Type-II diabetes and its association with BMI. Methods: This cross-sectional study was conducted in Diabetic clinic of Shaikh Zayed Hospital, Lahore from July to December 2017. Individuals aged ≥35 years, first degree relatives of people with Type-II diabetes, were selected and their fasting blood glucose levels were checked twice a week apart. Study participants were divided into 3 groups. Group-I were those with normal fasting blood glucose (FBS: <100mg/dl), Group-II were those with impaired fasting glucose (100-125mg/dl), considered as high risk and Group-III included those who turned out to be having frank diabetes (FBS: ≥126mg/dl). Exclusion criteria were known diabetes and pregnancy. Proportions of impaired fasting glucose levels versus BMI were compared using Chi-square test. Significance was considered at P <0.001. Results: A total of hundred subjects were included in the study with the mean age of 44.27 years. Sixty percent participants had normal FBS, 31% showed impaired FBS and 09% had frank diabetes (P <0.001). Significant association was found between impaired fasting glucose and BMI, as with increasing BMI the frequency of impaired fasting glucose increases. Conclusion: First-degree relatives of people with Type-II diabetes showed higher frequency of impaired fasting glucose and obesity was an important risk factor. doi: https://doi.org/10.12669/pjms.36.3.57 How to cite this:Ali A, Taj A, Ahmed MU, Tabrez E. Frequency of impaired fasting glucose in first degree relatives of Type-II diabetic patients and its association with Body Mass Index. Pak J Med Sci. 2020;36(3):407-411. doi: https://doi.org/10.12669/pjms.36.3.57 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Hypoglycemic Activity of Okra (Abelmoschus esculentus) in Participants with Impaired

2019 ◽  
Vol 7 (1) ◽  
pp. 626-635
Author(s):  
Czari Jo Lauren ADAP ◽  
CARLA RHOCEL T DIAZ ◽  
Paula Louise J. Victorino ◽  
Ma. Kristine HERNANDEZ MENDOZA ◽  
YANNA YVONNE CAAGBAY MACAYAN
Keyword(s):  
Insulin Resistance ◽  
Blood Glucose ◽  
Short Duration ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Abelmoschus Esculentus ◽  
Glucose Load ◽  
Experimental Phase ◽  
Control Phase ◽  
Glucose Levels

Introduction: Impaired fasting glucose (IFG) is characterized by a blood glucose level higher than normal but lower than that of diabetes level. Abelmoschus esculentus (okra) is an alternative hypoglycemic and antidiabetic plant due to its phytochemical constituents that regulate intestinal glucose absorption and prevents insulin resistance. This study determined the hypoglycemic activity of okra among IFG participants. Methodology: Subjects were random subjects with impaired fasting glucose results upon screening.  Quasi-experimental pre-test post-test was used where a standard glucose load was consumed in the control phase and powdered okra seed-peel mixed with the glucose load was consumed during the experimental phase. The blood sugar concentration was measured again every hour until three hours after consumption of the standard glucose load. In the experimental phase, the same group of participants was asked to consume 75 grams of glucose load with powdered okra peel that depends on their body weight (200 mg/kg of body mass). Fasting, 1 -hour, 2-hour and 3-hour glucose concentration were measured the same way it was done during the control phase. Results: Statistical analysis revealed that Abelmoschus esculentus has its hypoglycemic effect only during the first hour while data results for the 2nd and 3 rd hour are considered insignificant. The results proved that okra’s mechanism in lowering glucose levels is immediate yet of short duration. Discussion: Based on the data gathered, the researchers conclude that the powdered peel of Abelmoschus esculentus (okra) is effective in lowering the blood glucose levels of IFG individuals only during the first hour after the administration of oral glucose load. Abelmoschus esculentus may not be effective in lowering the blood glucose after the next hours due to the fact that its mechanism of action is immediate but of short duration. The researchers recommend future researches on the study of Abelmoschus esculentus using increased dosage of each participant and that the experiment should be performed at the same month.   Keywords: Abelmoschus esculentus, okra, impaired fasting glucose, diabetes, hypoglycaemia, insulin resistance

scholarly journals Pre-impaired Fasting Glucose State Is A Risk Factr for Endothelial Dysfunction Flow-mediated Dilation Japan (FMD-J) Study

2020 ◽  
Author(s):  
Takayuki Yamaji ◽  
Takahiro Harada ◽  
Yu Hashimoto ◽  
Yuji Takaeko ◽  
Masato Kajikawa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Large Sample Size ◽  
Clinical Trial Registry ◽  
Significant Difference

Abstract Background There is little information on the relationships of fasting blood glucose (FBG) including high normal blood glucose and impaired fasting glucose (IFG) with endothelial function. The purpose of this study was to evaluate the relationship between FBG level and flow-mediated vasodilation (FMD) in detail using a large sample size. Methods This study was a cross-sectional study. We measured FMD in 7265 subjects at 31 general hospitals. The subjects were divided into four groups based on FBG levels: <5.55 mmol/L, 5.55–6.05 mmol/L, 6.11–6.94 mmol/L, and ≥ 6.99 mmol/L or known type 2 diabetes. The subjects were also divided into six groups based on FBG levels: <5.00 mmol/L, 5.00-5.22 mmol/L, 5.27–5.50 mmol/L, 5.55–6.05 mmol/L, 6.11–6.94 mmol/L, and ≥ 6.99 mmol/L or known type 2 diabetes. Results FMD decreased in relation to increase in FBG level. There was a significant difference in FMD between the FBG of < 5.55 mmol/L group and the other three groups (6.7 ± 3.1% vs. 5.9 ± 2.8%, 5.7 ± 3.1%, and 5.1 ± 2.6%; p < 0.001, respectively). After adjustment for confounding factors, the odds of having the lowest quartile of FMD was significantly higher in the FBG of 5.27–5.50 mmol/L, 5.55–6.05 mmol/L, 6.11–6.94 mmol/L, and ≥ 6.99 mmol/L or known type 2 diabetes groups than in the FBG of < 5.00 mmol/L, group. Conclusions These findings suggest that FBG of 5.55–6.05 mmol/L and FBG of 6.11–6.94 mmol/L are similarly associated with endothelial dysfunction and that a pre-IFG state (FBG of 5.27–5.50 mmol/L) is also a risk for endothelial dysfunction compared with FBG of < 5.00 mmol/L. Clinical Trial Registry Information: http://www.umin.ac.jp (UMIN000012950, UMIN000012951, UMIN000012952, and UMIN000003409)

Effect of consumption of a carob pod inositol-enriched beverage on insulin sensitivity and inflammation in middle-aged prediabetic subjects

2016 ◽  
Vol 7 (10) ◽  
pp. 4379-4387 ◽  
Author(s):  
Celia Bañuls ◽  
Susana Rovira-Llopis ◽  
Sandra López-Doménech ◽  
Silvia Veses ◽  
Víctor M. Víctor ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Body Mass ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Middle Aged ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Carob Pod

This study assessed the effects of an inositol-enriched beverage (IEB) on blood glucose levels and inflammation status in subjects with an impaired fasting glucose (IFG) state according to body mass index (BMI).

A meal replacement regimen improves blood glucose levels in prediabetic healthy individuals with impaired fasting glucose

Nutrition ◽  
2014 ◽  
Vol 30 (11-12) ◽  
pp. 1306-1309 ◽  
Author(s):  
Daniel König ◽  
Sadaf Kookhan ◽  
Denise Schaffner ◽  
Peter Deibert ◽  
Aloys Berg
Keyword(s):  
Blood Glucose ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Healthy Individuals ◽  
Meal Replacement ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Acute Effect of Height-Adjustable Workstations on Blood Glucose Levels in Women with Impaired Fasting Glucose Levels While Working: A Pilot Study

2021 ◽  
Vol 6 (4) ◽  
Author(s):  
Amanda R. Bonikowske ◽  
Katie C. Carpenter ◽  
Steven D. Stovitz ◽  
Dipankar Bandyopadhyay ◽  
Mark A. Pereira ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Pilot Study ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Acute Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels

scholarly journals Impaired fasting glucose and impaired glucose tolerance in rural population of Bangladesh

1970 ◽  
Vol 36 (2) ◽  
pp. 47-51 ◽  
Author(s):  
MA Rahim ◽  
AK Azad Khan ◽  
Quamrun Nahar ◽  
SMK Ali ◽  
Akhtar Hussain
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Impaired Fasting Glucose ◽  
Rural Population ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Intervention Strategy

The prevalence of type 2 diabetes is rapidly rising all over the world at an alarming rate. Over the past 30 years, the increase in prevalence is rising exponentially in South Asian region, data suggest a three fold increase (from 2.0 to 7.0%) in the urbanizing population of Bangladesh within 5 years. However, the prevalence of various degrees of glucose intolerance i.e. type 2 diabetes, impaired glucose tolerance and impaired fasting glucose considered vital for prevention are still unknown in this population. The objective of the study was to estimate the prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) with their demographic and anthropometric characteristics in a reasonable large sample compare to other studies conducted in Bangladesh. A random sample of 5000 rural population aged ≥ 20 years was included in this cross sectional study. Fasting blood glucose (FBG) level was measured from 3981 individuals and 2-hr blood glucose (BG) was done on 3954 subjects, excluding known diabetic cases (n= 27). Height, weight, waist and hip circumference including blood pressure and demographic information was also collected. The prevalence of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly detected type 2 diabetes (T2DM) were 1.3%, 2.0% and 7.0% respectively. IFG, IGT, IFG+IGT were more prevalent in females than males. Age, body mass index (BMI), waist circumference (WC) and waist to hip ratio (WHR) were higher in glucose–intolerant subjects than in normal glucose tolerant (NGT) group. FBG and 2-hr BG values were correlated in NGT and DM subjects. Our data suggest that estimation of FBG value identifies more people with diabetes compared to 2-hr BG estimation. These findings need to be further examined in other settings with urban and rural populations for the justification of FBG for screening of diabetes in Bangladeshi population for development of intervention strategy for the prevention and management of abnormal glucose tolerance. The significance of IFG as a precursor of diabetes and CVD will become evident only from longitudinal studies in different ethnic groups. DOI: 10.3329/bmrcb.v36i2.6986Bangladesh Med Res Counc Bull 2010; 36: 47-51

scholarly journals Pre-impaired fasting glucose state is a risk factor for endothelial dysfunction: Flow-mediated Dilation Japan (FMD-J) study

2020 ◽  
Vol 8 (1) ◽  
pp. e001610 ◽  
Author(s):  
Takayuki Yamaji ◽  
Takahiro Harada ◽  
Yu Hashimoto ◽  
Yuji Takaeko ◽  
Masato Kajikawa ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Cross Sectional Study ◽  
Large Sample Size ◽  
Cross Sectional ◽  
Significant Difference ◽  
Registration Number

IntroductionDiabetes mellitus is associated with endothelial dysfunction. However, there is little information on the relationships of fasting blood glucose (FBG), including high normal blood glucose and impaired fasting glucose (IFG) with endothelial function. The purpose of this study was to evaluate the relationship between FBG level and flow-mediated vasodilation (FMD) using a large sample size.Research design and methodsThis study was a cross-sectional study. We measured FMD in 7265 subjects at 31 general hospitals. The subjects were divided into four groups based on FBG levels: <100, 100–109, 110–125, and ≥126 mg/dL or known diabetes. The subjects were also divided into six groups based on FBG levels: <90, 90–94, 95–99, 100–109, 110–125, and ≥126 mg/dL or known diabetes.ResultsFMD decreased in relation to increase in FBG level. There was a significant difference in FMD between the FBG of <100 mg/dL group and the other three groups (6.7±3.1% vs 5.9±2.8%, 5.7±3.1%, and 5.1±2.6%, respectively; p<0.001). After adjustment for confounding factors, the odds of having the lowest quartile of FMD were significantly higher in the FBG of 95–99, 100–104, 105–109, 110–125, and ≥126 mg/dL or known diabetes groups than in the FBG of the <90 mg/dL group.ConclusionsThese findings suggest that FBG of 100–109 mg/dL and FBG of 110–125 mg/dL are similarly associated with endothelial dysfunction and that a pre-IFG state (FBG of 95–99 mg/dL) is also a risk for endothelial dysfunction compared with FBG of <90 mg/dL.Trial registration numberUMIN000012950, UMIN000012951, UMIN000012952, and UMIN000003409.

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