scholarly journals Effects of sodium valproate combined with levetiracetam in treatment of children epilepsy and its influences on serum S-100 and high mobility group box-1

2020 ◽  
Vol 7 (1) ◽  
pp. 12
Author(s):  
Huimin Li ◽  
Jinli Hao ◽  
Hua Chen ◽  
Yong Meng
Keyword(s):  
Sodium Valproate ◽  
Epileptic Seizure ◽  
Adverse Reactions ◽  
High Mobility ◽  
Epileptiform Discharge ◽  
Control Group ◽  
Study Group ◽  
Chi Square ◽  
S 100 ◽  
Hs Crp

Objective: To explore the effects of sodium valproate combined with levetiracetam in the treatment of children epilepsy, and its influences on serum S-100 and high mobility group box-1 (HMGB-1) in children with epilepsy.Methods: A total of 160 children who were diagnosed as epilepsy in Baogang Hospital of Inner Mongolia from July 2016 to October 2018 were selected as research objects. They were randomly divided into the study group (n = 80) and the control group (n = 80) by the random number table method, i.e., they were treated with sodium valproate combined with levetiracetam and sodium valproate alone, respectively. After 16 weeks of treatment, the effective rates of epileptic seizure treatment and the improvement of epileptiform discharge were evaluated, and chi-square test was used for statistical comparison. The related indicators, including serum tumor necrosis factor- (TNF-), hypersensitive C-reactive protein (hs-CRP), homocysteine (Hcy), haematocrit (HCT), erythrocyte sedimentation rate (ESR), serum S-100 and HMGB-1, were measured before and after treatment. Paired t-test was used for the comparison in the above indicators within a group before and after treatment; group t-test was used for the comparison between two groups. Chi-square test was used for the comparison in the rate of adverse reactions during treatment between two groups. The study was approved by Ethics Committee of Baogang Hospital (Approval No.: BG201606073), and all children’s guardians were required to sign informed consent forms for clinical study. There were no statistically significant differences between two groups in general clinical data (p > .05), such as sex constituent ratio, age, the course of disease, the frequency of epileptic seizure per year before treatment, the incidence of epileptiform discharge before treatment and the constituent ratio of types of epileptic seizure, etc.Results: 1) After treatment, the effective rates of epileptic seizure treatment and the improvement of epileptiform discharge in the study group were 92.5% (74/80) and 85.0% (68/80) respectively, which were both significantly higher than those in the control group [68.8% (55/80) and 58.8% (47/80)], and the differences were statistically significant (2 = 14.444, 13.635; p < .001). 2) In the study group, the levels of serum TNF-, hs-CRP and Hcy, as well as HCT and ESR after treatment were (53.1 ± 14.0) pg/ml, (5.0 ± 2.5) mg/L, (12.5 ± 3.1) μmol/L, (38.1 ± 5.1)% and (3.0 ± 0.5) mm/h respectively, which were all significantly lower than those [(107.9 ± 17.8) pg/ml, (10.1 ± 2.5) mg/L, (42.2 ± 5.8) μmol/L, (45.3 ± 4.5)% and (5.2 ± 0.6) mm/h] before treatment, and all the differences were statistically significant (t = 21.644, 12.902, 40.393, 9.468, 25.194; p < .001). In the control group, the levels of serum TNF-, hs-CRP and Hcy, as well as HCT and ESR after treatment were (60.6 ± 17.8) pg/ml, (8.2 ± 2.2) mg/L, (15.2 ± 3.1) μmol/L, (40.2 ± 3.4)% and (4.5 ± 0.6) mm/h respectively, which were all significantly lower than those [(112.4 ± 14.3) pg/ml, (9.3 ± 3.8) mg/L, (41.1 ± 2.8) μmol/L, (44.6 ± 5.5)% and (5.4 ± 0.8) mm/h] before treatment, and all the differences were statistically significant (t = 20.292, 2.241, 55.456, 3.320, 8.050; p < .05). After treatment, the above indicators in the study group were all significantly lower than those in the control group, and all the differences were statistically significant (t = 2.962, 8.595, 5.508, 3.064, 17.178; p < .05). 3) In the study group, the levels of serum S-100 and HMGB-1 after treatment were (0.65 ± 0.38) μg/L and (5.3 ± 2.4) μg/L respectively, which were significantly lower than those [(0.91 ± 0.32) μg/L and (8.1 ± 2.0) μg/L] before treatment, and the differences were statistically significant (t = 4.681, 8.020; p < .001). In the control group, the levels of serum S-100 and HMGB-1 after treatment were (0.78 ± 0.27) μg/L and (6.4 ± 2.2) μg/L respectively, which were significantly lower than those [(0.88 ± 0.25) μg/L and (7.9 ± 1.7) μg/L] before treatment, and the differences were statistically significant (t = 2.431, p = .016; t = 4.826, p < .001). After treatment, the levels of serum S-100 and HMGB-1 in the study group were significantly lower than those in the control group, and the differences were statistically significant (t = 2.495, p = .014; t = 2.840, p = .005). 4) There was no significant difference between two groups in the rate of adverse reactions, such as nausea, vomiting, poor appetite, dizziness, drowsiness, hepatic and renal injury during treatment (p > .05).Conclusions: The efficacy of sodium valproate combined with levetiracetam is obviously better than that of sodium valproate alone in the treatment of children epilepsy. The children patients’ serum S-100 and HMGB-1 are more significantly reduced, resulting in a lower rate of adverse reactions, which has a certain clinical value.

scholarly journals Maternal and fetal outcome in oligohydramnios after 34 weeks of gestation

2018 ◽  
Vol 7 (11) ◽  
pp. 4604
Author(s):  
Mahantappa A. Chiniwar ◽  
Joe Kaushik M. ◽  
Sharada B. Menasinkai
Keyword(s):  
Amniotic Fluid ◽  
Fetal Outcome ◽  
Morbidity And Mortality ◽  
Research Centre ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Perinatal Morbidity ◽  
Amniotic Fluid Index ◽  
Chi Square

Background: Oligohydramnios is one of the major causes of maternal and perinatal morbidity and mortality. It is a clinical condition characterized by Amniotic Fluid Index (AFI) ≤5 cm by sonographic assessment. The aim of present study is to know the maternal and fetal outcome in oligohydramnios after 34 weeks of gestation compared with women who had normal volume of amniotic fluid.Methods: Study was done for the period of 21 months from November 2014-July 2016 at Adichunchanagiri Institute of Medical Sciences, Hospital and Research Centre Bellur. 50 antenatal cases with > 34 weeks of gestation with AFI ≤5 cm by ultrasonographic estimation were included as study group and 50 women with normal AFI were included as control group. Maternal and fetal outcome of the women with oligohydramnios were analyzed and compared with control group.Results: Results were analyzed statistically using parameters like mean, SD, Chi Sq test, P value. Amniotic fluid was clear in 32% in study and 78% in control group, thin meconium stained in 30% in study group and 14%in control group and was thick meconium stained in 38% in study group and 8% in control group (Chi square =22.31, p<0.0001). Induction of labour was done in 54% in study group and 20% in control group. Cesarean delivery was done in 58% in study group women and 28% in control group women. Regarding the birth weight of babies 62% were < 2.5 kg in study group and 18% in control group with p<0.001. 10% of babies in study group required NICU admission and perinatal mortality was 2%.Conclusions: Due to increased perinatal morbidity and mortality and increased rate of LSCS, timely decision during labour is important to reduce perinatal morbidity and mortality.

scholarly journals Examining Metabolic Profiles in Opioid-‎Dependent Patients ‎

2020 ◽  
Vol 10 (3) ◽  
pp. 28681
Author(s):  
Nader Molavi ◽  
Amir Ghaderi ◽  
Hamid Reza Banafshe
Keyword(s):  
Control Group ◽  
Study Group ◽  
Metabolic Profiles ◽  
Opioid Use ◽  
Serum Samples ◽  
Social Burden ◽  
Study Results ◽  
Significant Difference ◽  
Hs Crp ◽  
Opioid Users

Background: Drug abuse is a social burden and a public health disorder. Previous evidence suggested numerous illicit substances (e.g., opioids, amphetamines, cocaine, & cannabis) affect immune system functions, oxidative stress mechanisms, inflammatory cytokines, and reactive oxygen species production. This study aimed to determine the extent of these metabolic parameters in opioid-dependent patients. We also compared these patients with a healthy control group. Methods: This study was conducted in Amirie Clinic, Kashan, Iran. Plasma and serum samples from 50 illicit opioid users (study group) and 50 non-opioid users (control group) were studied. Metabolic levels for MDA, NO, TAC, GSH, Insulin, HOMA-IR, and hs-CRP were assessed in both research groups (N=100). Results: There was a significant difference in the status of MDA (P=0.003), NO (P=0.01), TAC (P=0.003), GSH (P=0.001), insulin (P=0.04), HOMA-IR (P=0.02), and hs-CRP (P=0.001) between the study and control groups. Furthermore, there was a significant correlation among the duration of illicit opioid use and MDA concentrations (r=-0.424, P=0.002), as well as TAC levels (r=0.314, P=0.02). Conclusion: The study results suggested metabolic profiles were impaired in the study group, compared to the controls.  

scholarly journals Therapeutic benefit of aripiprazole-olanzapine combination in the treatment of senile Alzheimer’s disease complicated by mental disorders

2020 ◽  
Vol 19 (2) ◽  
pp. 441-446
Author(s):  
Na Zheng ◽  
Ning Wang ◽  
Ji-Min Jia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mental Disorders ◽  
Clinical Efficacy ◽  
Lower Incidence ◽  
Adverse Reactions ◽  
Study Groups ◽  
Therapeutic Benefit ◽  
Control Group ◽  
Study Group

Purpose: To determine the clinical efficacy of aripiprazole-olanzapine combination treatment in elderly Alzheimer’s disease complicated with mental disorders. Methods: Ninety-two elderly patients with Alzheimer’s disease and mental disorders who were admitted to Binzhou People's Hospital, were enrolled in the study. They were randomized into control and study groups. Control group was treated with olanzapine, while the study group was treated with aripiprazole as an adjuvant therapy in addition to olanzapine. The clinical efficacy, scores on different scales (MMSE, ADAS-cog, CDR, ADL, NPI and CMAI), and incidence of adverse reactions were determined. Results: The overall degree of response was significantly higher in the study group than in the control group (p < 0.05). There were no significant differences in MMSE, ADAS-cog, CDR, ADL, NPI and CMAI scores between the two groups before treatment (p > 0.05). The MMSE score of the study group was significantly higher than that of the control group, and the scores in the other scales in the study group were significantly lower after treatment (p < 0.05). The study group had significantly lower incidence of adverse reactions than control group (p < 0.05). Conclusion: Aripiprazole-olanzapine combination has significant therapeutic benefit in the treatment of elderly Alzheimer’s disease patients complicated with mental disorders. It promotes recovery of neurological function, as well as produces a lower incidence of adverse reactions. Keywords: Aripiprazole, Olanzapine, Alzheimer’s disease, Mental disorders

scholarly journals Topical Application of Chlorhexidine Gel with Brush-On Technique in the Tailored Treatment of Plaque Induced Gingivitis

2020 ◽  
Vol 10 (17) ◽  
pp. 6014
Author(s):  
Gianna Maria Nardi ◽  
Roberta Grassi ◽  
Guglielmo Campus ◽  
Maria Letizia Pareti ◽  
Dario Di Stasio ◽  
...  
Keyword(s):  
Topical Application ◽  
Control Group ◽  
Study Group ◽  
Gingival Index ◽  
Chi Square ◽  
Plaque Score ◽  
Tailored Treatment ◽  
Chi Square Test ◽  
Chlorhexidine Gel

Aim: This study aimed to assess the action of a chlorhexidine-based brush-on gel application in the treatment of plaque-related gingivitis. Methods: The enrollment involved consecutive patients diagnosed with plaque-induced gingivitis. Each participant’s full mouth plaque score and gingival index were recorded at the first appointment (t0) and at follow ups after 1 week (t1), 2 weeks (t2) and 3 weeks (t4). All patients were randomly sorted into two groups: A study group, who was given instruction to brush their gums daily with a chlorhexidine gel, and a control group who received a placebo gel. The two groups’ data at baseline were compared using a chi-square test, while the t-Student and Mann–Whitney tests were employed to analyze the index’s trends, both separately and compared. Results: In total, 30 patients were enrolled, 15 referring to the study group and 15 to the control group. The study group had an 87% decrease in their plaque score and an 84% decrease in their gingival index (p < 0.05). The control group displayed a reduction in plaque score and gingival index of 74% and 84%, respectively (p < 0.05). The plaque score decreased statistically more significantly in the study group than in the control group. Conclusion: Topical employment of a chlorhexidine-containing brush-on gel appears to be a useful home tool in the treatment of plaque-induced gingivitis, associated with professional debridement.

Association of CYP2B6 c.516G>T Polymorphism with Acute Lymphoblastic Leukemia Susceptibility

2014 ◽  
Vol 926-930 ◽  
pp. 1073-1076
Author(s):  
Zhong Hai Yuan ◽  
Yi Ju Hou ◽  
Chen Zhao ◽  
Yan Li
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Genomic Dna ◽  
Lymphoblastic Leukemia ◽  
Control Group ◽  
Study Group ◽  
Regression Analyses ◽  
Specific Primers ◽  
Blood Leukocytes ◽  
Chi Square ◽  
Chi Square Test

Abstract:Objective: To investigate whether any association exists between genetic polymorphism in CYP2B6 c.516G>T and individual susceptibility to acute lymphoblastic leukemia (ALL). Methods: Our study group consisted of 96 ALL patients(T-ALL 17 cases, B-ALL 79 cases) and 348 unrelated healthy newborn volunteers as a control group. Genomic DNA was extracted from peripheral blood and cord blood leukocytes. We genotyped CYP2B6 c.516G>T polymorphism by use of PCR with sequence-specific primers (PCR-SSP). The data were analyzed statistically using chi-square and logistic regression analyses. Results: The frequencies of GG genotype were 74.14%, 57.29%, 29.41% and 63.29%, and GT genotype were 23.85%, 37.50%, 64.71% and 31.65%, and TT genotype were 2.01%, 5.21%, 5.88% and 5.06% in control group, ALL, T-ALL, and B-ALL cases, respectively. Chi-square test showed a significant correlation between the CYP2B6 c.516G>T polymorphism GT genotype and ALL patients (OR=2.035, 95%CI=1.249-3.313, P=0.004); and T-ALL patients (OR=6.839, 95%CI=2.309-20.252, P=0.000); whereas and B-ALL patients (OR=1.554, 95%CI=0.906-2.667, P=0.108). Conclusions: This study revealed the CYP2B6 c.516GT genotype may be a risk factor to the development of ALL, especially T-ALL.

scholarly journals Role of High Dose Calcium in the Prevention of Preeclampsia

2016 ◽  
Vol 28 (2) ◽  
pp. 66-70 ◽  
Author(s):  
Aparna Khan ◽  
Susil Kumar Mandal ◽  
Amitava Pal
Keyword(s):  
Preterm Delivery ◽  
Final Analysis ◽  
Analysis Data ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
High Dose ◽  
Study Group ◽  
Chi Square ◽  
The Difference ◽  
Lost To Follow Up

Objectives: To assess the effect of supplementation of high dose of calcium(2gm) in prevention of preeclampsia.Materials & Methods: A randomized controlled clinical trial on 272 healthy nulliparous woman were randomly allocated into two groups by means of a computer generation randomization list. From 20 weeks of gestation until delivery who received 2gm of oral elemental calcium per day (n=127 )were assigned to high dose calcium group or the study group and 145 women were assigned to low dose calcium or control group , receiving 500 mg of calcium per day. Ten women (3.67%) were lost to follow up after randomization (4 in the study group and 6 in the control group) . Thus a total of 123 woman in the study group and 139 in the control group were included in the final analysis. Data was collected by standard questionnaire, clinical examination and investigations and statistical analysis was performed by student’s t-test, chi square tests. P<0.05 was statistically significant.Results: Preeclampsia developed in Study Group were 5.7% and Control Group 13.7% and the difference was statistically significant (Chi-squares - 4.65, df =1, p = 0.031). There were 2.43% (3 of 123 women) preterm delivery in the study group and 7.91% (11 of 39 women) in the control group. So, there was a significantly lower risk of preterm delivery in the study group ( p = 0.049). Intrauterine growth retardation (IUGR) was found in 3.25% and 9.35% of women in the study and the control groups respectively. The incidence is higher in the control group when compared to the study group (p = 0.045).Conclusion: Calcium intake is beneficial for both pregnant women and her unborn child. Daily supplementation with 2 grams of calcium during pregnancy significantly reduced the risk of preeclampsia, preterm labor and IUGR. So, high dose calcium should be supplemented to all women during pregnancy in developing countries where preeclampsia and preeclampsia related morbidities and mortality are quite high.Bangladesh J Obstet Gynaecol, 2013; Vol. 28(2) : 66-70

scholarly journals Clinical Effect of Auricular Point Sticking in Patients with Lung Cancer Receiving Chemotherapy

2021 ◽  
Vol 5 (6) ◽  
pp. 73-77
Author(s):  
Xiaorui Zhu
Keyword(s):  
Lung Cancer ◽  
Stress Response ◽  
Adverse Reactions ◽  
Clinical Effect ◽  
Clinical Symptoms ◽  
Auricular Point Sticking ◽  
Jiangxi Province ◽  
Control Group ◽  
Study Group ◽  
Auricular Point

Objective: To discuss and analyze the clinical effect of auricular point sticking in lung cancer chemotherapy. Methods: Sixty-two patients with lung cancer treated with chemotherapy in Suqian Traditional Chinese Medicine Hospital of Jiangxi Province were selected for case evaluation and analysis. The time span of the research was from June 2020 to June 2021. The patients were divided into two groups: a study group (n = 31) and a control group (n = 31) based on their medical record numbers. All the patients were treated with conventional western medicine before and after chemotherapy to prevent adverse reactions; however, the patients in the study group were also treated with auricular point sticking in addition to the former. The relevant indexes of the two groups were compared. Results: The incidence of adverse reactions was significantly lower in the study group compared to the control group (P < 0.05); the rate of symptomatic relief of the patients in the study group was higher than that of the control group (P < 0.05); the stress response indexes toward chemotherapy of the study group were better than those of the control group (P < 0.05). Conclusion: Auricular point sticking for patients with lung cancer who are receiving chemotherapy can reduce the incidence of adverse reactions, alleviate clinical symptoms, such as chest distress, asthma, and poor appetite, significantly alleviate stress response caused by chemotherapy, as well as promote the treatment effect; thus, it is worthy of promotion.

scholarly journals Clinical Study of Recombinant Human Endostatin Combined with Iressa in Targeted Treatment of Patients with Lung Adenocarcinoma with Pleural Metastasis

2021 ◽  
Vol 5 (4) ◽  
pp. 46-50
Author(s):  
Yanbing Wang
Keyword(s):  
Targeted Therapy ◽  
Lung Adenocarcinoma ◽  
Adverse Reactions ◽  
Control Group ◽  
Study Group ◽  
Short Term ◽  
Recombinant Human Endostatin ◽  
Pleural Metastasis ◽  
Pleural Metastases

Objective: To evaluate and comprehensively analyze the clinical efficacy of recombinant human endostatin combined with Iressa targeted therapy in patients with pleural metastasis of lung adenocarcinoma. Methods: The interval of the selected study period span was from January 2017 to April 2021. The sample source of the study was 42 patients with lung adenocarcinoma admitted to hospital. The random number table method was used for study grouping, and they were further divided into study groups (n = 21, 14 cases with pleural metastasis) and control group (n=21, 13 cases with pleural metastasis), all patients received systemic chemotherapy with pemetrexed and cisplatin. Patients with pleural metastases in the control group were injected with 60 mg cisplatin into the thoracic cavity. Patients in the study group were treated with Iressa (gefitinib) targeted therapy if genetic testing showed epidermal growth factor receptor (EGRF) mutations, and patients with pleural metastases were treated with pleural metastasis with Endo (recombinant human endostatin YH-16) to control pleural effusion. Two sets of related indicators were compared and analyzed. Results: Comparing the short-term disease control rate, treatment effectiveness and long-term survival rate between the two groups shows that the study group has more advantages (P<0.05). In the comparison between the two groups of serum markers and related indicators, the study group has more advantages (P<0.05), whereas in the comparison between the two groups in the incidence of adverse reactions, there is no significant difference (P>0.05). Based on statistics of the recurrence rate of pleural fluid in the two groups, the study group is significantly lower than the control group (P<0.05). Conclusion: Recombinant human endostatin combined with Iressa targeted therapy for patients with lung adenocarcinoma with pleural metastasis has significant short-term and long-term effects without serious adverse reactions. It can be fully promoted in medical institutions at all levels.

scholarly journals Relationship between Thyroid Hormone Levels and Crime Type: A Controlled Study in Prisoners

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Hasan Acar ◽  
Ayse Ulgen
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Stimulating Hormone ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Chi Square ◽  
Exact Test ◽  
Hormone Levels ◽  
Male Volunteers ◽  
Group A

Various factors cause aggression, which can be related to imbalance of T3 and T4 hormones, which can act as neurotransmitters and are reported to be elevated during aggression. This indicates changes in the hypothalamic-pituitary-thyroid axis that cause long-term changes in aggressive behaviour, especially in criminals. Moreover, mental and behavioural disorders possibly occur in individuals with impairment in thyroid hormone balance. The main rationale for this study was to asses if high T3, high T4, and low TSH hormones may have an effect on aggression-related crime tendency. Furthermore, the study aimed to measure levels of thyroid hormones in prisoners and to examine relationships of the hormone levels with crime rates. Our study was conducted in Ankara Sincan Closed Prisons. The study group consisted of 208 male volunteers who were imprisoned and the control group included 82 male volunteers who were not imprisoned. Prisoners in the study group were divided into two groups: those who committed aggression-related crime (Group A, n = 96) and prisoners convicted of other crimes (Group B, n = 112). Pulse rates, T3, T4, and thyroid-stimulating hormone (TSH) levels, and theT3/T4 ratio were measured in these prisoners. Data were analysed using the Wilcoxon rank sum test and chi-square Fisher’s exact test to test for any statistically significant differences. Results showed that toxic goitre rates, T3 and T4 values, and pulse rates were significantly higher in Group A than in the control group. Significant increase in T3 and T4 levels and the presence of toxic goitre were associated with aggression-related crime. These examinations should be performed on prisoners in general, especially those convicted of violent crimes. Additional rehabilitation and research programs should also be developed for such patients.

The Impact of Nipple Repair in the Treatment of  Lactating Nipple Injury

2020 ◽  
Author(s):  
HAIFENG GAO ◽  
jie Wang ◽  
Songtao Ding ◽  
Yan Li ◽  
Yi Zhang ◽  
...  
Keyword(s):  
Pain Relief ◽  
Recurrence Rate ◽  
Control Group ◽  
Study Group ◽  
Chi Square ◽  
Chi Square Test ◽  
Relief Rate ◽  
The Difference ◽  
Cure Rates ◽  
The Impact

Abstract Objective To explore the effect of nipple repair in the treatment of lactating nipple injury.Methods Patients with nipple lesions admitted to the Maternal and Child Health Hospital of Haidian District from December 2015 to January 2020 were retrospective control study. The patients received nipple repair was the study group, the patients did not treated with medicine or surgery was the control group. Patients in both groups continued to be exclusively breastfeed with good sucking, The method of chi-square test was adopted by using SPSS24.0 statistical software to compare the difference of healing effect of nipple injury, pain relief rate, and recurrence rate of nipple injury.Results A total of 167 patients were enrolled, including in the 81 study group and 86 in the control group. The cure rates of the nipple injury in the study group and in the control group were 54.3% (44/81) and 26.7% (23/86) (χ2 = 13.451, P = 0.001). The complete pain relief rate was 48.1% (39/81) and 23.3% (20/86) (χ2 = 14.170, P = 0.001). The recurrence rate was 36.4% (16/44) and 34.8% (8/23) (χ2 = 0.016, P = 0.898).Conclusion For patients with no improvement in nipple damage after correction of etiology, nipple repair can improve the healing environment of nipple breakage, relieve nipple pain.

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