Role of Nutrition in Body Weight Gain and Early Onset of Puberty and Sexual Maturity in (HF X Kankrej) Crossbred Heifers

Author(s):  
Arjan Dhami ◽  
Kamlesh Hadiya ◽  
Dinesh Chaudhari ◽  
Pravin Lunagariya ◽  
Nilesh Sarvaiya ◽  
...  
2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Anju Balakrishnan ◽  
Deborah A Howatt ◽  
Hong Lu ◽  
Mark J Graham ◽  
Adam E Mullick ◽  
...  

Background and Objective The renin angiotensin system plays a critical role in atherosclerosis. Inhibition of angiotensinogen (AGT) or renin prevents atherosclerosis. AGT inhibition also ablates diet induced obesity. The purpose of this study was to compare the effects of AGT and renin inhibition on established atherosclerosis and obesity. Methods and Results To determine the role of AGT, male LDL receptor -/- mice were fed a saturated fat-enriched diet for 12 weeks to establish atherosclerosis (N=80). Body weight increased about 1 g/week in the 12-week duration. Twenty mice were then terminated to assess baseline atherosclerosis, and the remaining mice were randomly grouped to administer either control- or AGT-antisense oligonucleotides (ASO) (50 mg/kg/week ip; N=20/group) for 12 weeks. To determine the role of renin inhibition, male LDL receptor -/- mice were fed the same fat-enriched diet for 16 weeks (N=55). Mean body weight gain was about 1 g/week. Twenty-one mice were terminated to assess baseline atherosclerosis, and the remaining mice were randomly grouped to infuse either PBS (N=24) or aliskiren (12.5 mg/kg/d; N=10) for 12 weeks. Inhibition of AGT or renin significantly decreased systolic blood pressure. Atherosclerotic lesions were quantified in the aortic arch. Inhibition of either AGT or renin attenuated the rogression of atherosclerosis as compared to their relative controls (P=0.047 and P≤0.001, respectively), whereas neither mode of inhibition regressed atherosclerosis compared to their respective baseline. Renin inhibition did not influence the fat diet-induced body weight gain. Surprisingly, inhibition of AGT not only abolished body weight gain, but also led to pronounced loss of body weight (baseline versus 12-week injection of AGT-ASO: 36.0±0.8 versus 32.2±0.9 g; P<0.001). Echo MRI analyses demonstrated that the lower body weight in mice administered AGT-ASO was attributed to less fat mass, while lean mass was comparable between control-ASO and AGT-ASO groups. Conclusions Inhibition of either AGT or renin attenuated the continued development of atherosclerosis. Inhibition of AGT also profoundly reduced body weight. This highlights a disparity between the two modes of RAS inhibition.


1972 ◽  
Vol 52 (4) ◽  
pp. 761-766 ◽  
Author(s):  
J. D. SUMMERS ◽  
W. F. PEPPER ◽  
E. T. MORAN Jr.

Leghorn-type pullets were fed 14 and 20% protein corn–soya diets to 8 weeks of age. The birds on the low protein diet were significantly smaller and consumed less feed than the higher protein-fed birds. At 20 weeks of age pullets fed the low protein starting diet were still significantly smaller than the 20% protein-fed chicks even though similar diets were fed during the growing period. A corn–feathermeal diet resulted in reduced feed intake and body weight gain when fed ad libitum from 8 to 24 weeks as compared with dietary treatments. None of the starting or growing treatments had any effect on hen house performance except for a reduced body weight of those pullets fed the feathermeal diet. The data suggest that a low protein starting diet, followed by a corn–feathermeal (amino acid imbalanced) diet can be fed ad libitum and still achieve reduced weight gain and delayed sexual maturity without any adverse effect on hen house performance.


2003 ◽  
Vol 27 (1) ◽  
pp. 191-201
Author(s):  
Tahani S. S. AL-Azawi

Cyproheptadine hydrochloride is a very high potent histamine and serotonine antagonist. This study was conducted to investigate the role of cyproheptadine on feed intake, body weight gain, feed conversion ratio, serum total protein, cholesterol and glucose. Red blood cells (RBC), Hemoglobin (Hb), Packed Cell Volume (PCV) and differential leukocytic count in blood of chickens were also estimated. A total of 60 one-day-old Fabro chicks were randomly divided into 2 groups. One group was received cyproheptadine at a rate of 10 ug / 100g body weight daily for eight weeks and the second group was used as a control.  The results revealed that cyproheptadine could stimulate feed intake and improve body weight gain in chickens. Erythrocyte count, hemoglobin content and PCV where increased significantly in these chickens accompanied by an increase in percentage of lymphocytes with a significant decrease in percentage of heterophiles and H / L ratio. This drug also reduces the total protein, cholesterol and glucose in serum.


2018 ◽  
Vol 26 (10) ◽  
pp. 257-272
Author(s):  
Abbas Abed Sharhan ◽  
Kareem H. Rasheed

       This study was conducted to demonstrate the role of  alcoholic extract from ficus carica leaves in the treatment  of  hypothyroidism disease which induced by carbimazole drug. Forty  male rats were divided into five  groups,  eight  for each . group I selected as negative control  and administered orally with normal saline alone, group II served as positive control and treated by carbimazole anti-thyroid  drug for six weeks ,  group  III  was treated by plant extract (500 mg /kg, bw) for six weeks, the  fourth group IV was treated by carbimazole drug (5 mg) for six week to induce hypothyroidism   and then  treated by plant extract (500 mg /kg , bw) , and the fifth V group was  treated by thyroxin drug (100 mg) for six week instead of plant extract.          The results showed  insignificant differences (P<0.05) in body weight gain in the fourth  group ( carbimazole and plant extract) when compared  with the first  group (normal saline alone), second group (carbimazole alone), third group (plant extract alone  , while the results demonstrated  that a significant  increase (P<0.05)   in body weight gain when  compared with fifth groups (carbimazole and thyroxine). While the results revealed insignificant differences (P<0.05) in the concentrations of  T3 and T4  in the fourth (carbimazole & plant extract), fifth  groups  (carbimazole & thyroxin drug ) and the  third group (plant extract alone) when compared  with the first  group ( normal saline alone ), but  there was  a significant increase (P<0.05)  when compared with the  second group (carbimazole alone) , in addition  the  results indicated a significant decrease (P<0.05) when compared  with the third  group, Furthermore, the results revealed insignificant difference (P<0.05) in TSH concentration in the fourth (carbimazole & plant extract), fifth groups (carbimazole & thyroxin drug)   and the  third group (plant extract alone) when compared  with the first  group (normal saline alone) , also the data showed a significant decrease(P<0.05) when compared with the  second group (carbimazole alone). In conclusion, it is possible to use methanolic plant extract from ficus carica leaves in the regulation of hypothyroidism due to the presence of phytochemical components that can affect the mechanism of T3 and T4 production by the thyroid gland.                          


2017 ◽  
Vol 46 (2) ◽  
pp. 121-127
Author(s):  
S Jahan ◽  
F Islam ◽  
MSA Bhuiyan ◽  
AKFH Bhuiyan

The study was aimed at investigating the productive and reproductive performances of the rural chicken in Bangladesh. A total of 200 indigenous chickens in the villages of Sherpur district in Bangladesh was used in this study to collect the data on body weight at hatch (BWH), body weight at sexual maturity (BWS), body weight gain up to sexual maturity (BSBG), body weight gain from sexual maturity to one year of age (BYSG), body weight at one year of age (BWY), age at sexual maturity (AGSX), eggs per clutch (EGC), clutches per year (CLY), hatchability (HATCH) and survivability (SURV). The data showed that cap headed (CH) chickens were good meat producer (1027.14±25.32g meat at one year of age), and Non-Descript Deshi (ND) chickens were good egg producer with 12.03±0.11 eggs per clutch and 4.15±0.07 clutches per year, respectively. The effects of village, sex and type of birds on AGSX of indigenous chickens were significant but, only the effects of chicken type on EGC were significant (P<0.01). At present study, most of growth and reproductive traits found positively correlated and this might be suggestive that selection for one trait would affect the other positively. These results could be used as a guideline for planning, conservation and improvement of indigenous chickens of Bangladesh.Bang. J. Anim. Sci. 2017. 46 (2): 121-127


Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Amrita V Pai ◽  
Samuel Woperrer ◽  
Hong Ji ◽  
Xie Wu ◽  
James Li ◽  
...  

Background and Objective: Ovarian hormone loss is associated with an increased incidence of hypertension, body weight (BW) gain and inflammation. Since BW gain is also associated with an increased incidence of hypertension, it has been difficult to separate the role of the immune system in hypertension from BW gain. Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats gain BW after ovariectomy; however, only the DS rat becomes hypertensive. In this study, we took advantage of the DS/ DR model to determine which T cell genes are associated with hypertension induced by ovarian hormone loss-independently of body weight gain. Methods and Analysis: DS and DR rats (1 month) were either ovariectomized (OVX) or subjected to sham surgery (Sham). At 4 months of age, a microarray analysis was conducted on isolated splenic T-cells from these 4 groups and differential expression was confirmed by real-time PCR. Results: In contrast to DR rats which remain normotensive, the mean arterial pressure (MAP) significantly increased by 14 mm Hg in DS rats after ovariectomy [MAP (mmHg): DS-OVX, 143 ± 3.4 vs DS-Sham, 129 ± 9.4; n=10-11/group; p=0.0002; DR-OVX, 123 ± 15 vs DR-Sham, 126 ± 4.8; n=11-12/group; ns]. Both rat strains, however, exhibited a similar 17-20% increase in BW after ovariectomy compared to sham treatment [BW (g): DS-OVX, 372 ± 34 vs. DS-Sham, 308 ± 13; n=6-7/group; p<0.05; DR-OVX, 323 ± 22 vs, DR-Sham, 276 ± 49; n=7/group; p<0.05]. Microarray analysis suggested that among many others, the genes GTP Cyclohydrolase 1 (GCH1) and Engulfment Adaptor PTB Domain Containing 1 (GULP1) were specifically associated with resistance or susceptibility to hypertension induced by ovarian hormone loss. Real-time PCR confirmed that GCH1 and GULP1 were selectively elevated by ovariectomy in DS but not DR splenic T cells. Conclusion: GCH1 and GULP1 play a role in hypertension associated with ovarian hormone loss independently of BW gain, which has implications for women with ovarian hormone deficiency due to premature ovarian failure or elective oophorectomy.


2017 ◽  
Vol 9 (2) ◽  
pp. 179-181
Author(s):  
Neha Kumari ◽  
Kusum Dash ◽  
Roopam Singh

ABSTRACT Introduction Increased body weight is a major epidemic for a developed country, and is also expanding to developing countries. It is measured as the body mass index (BMI). Control of body weight gain, where weight gain in adequate proportion is indicated, is a major challenge before, during, and after pregnancy. Aim To find out whether the increased value of BMI as measured at 20 to 24 weeks of gestation can be used to predict the development of preeclampsia. Objective To study the role of increased value of BMI in development of preeclampsia in normal pregnancies. Materials and methods A case—control retrospective study was conducted on pregnant women who attended the antenatal clinic of Bokaro General Hospital, Jharkhand, India. About 220 pregnant women, who attended the antenatal clinic, in 20 to 24 weeks of gestation, were included after proper written consent for study. Results About 220 patients were included in our study, who attended the antenatal clinic between 20th and 24th weeks of pregnancy. In our study, the maximum proportion of participants’ BMI ranges between 22 to 24 and 24 to 26 kg/m2. In our study, we found with increase of BMI value, the percentage of preeclampsia development increases. Conclusion In view of our results, counseling about body weight and its management should be known to the women before, during, and after pregnancy. How to cite this article Kumari N, Dash K, Singh R. Is Body Weight a Telltale of Preeclampsia? J South Asian Feder Obst Gynae 2017;9(2):179-181.


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