Climbing therapy under PK-tailored prophylaxis

2014 ◽  
Vol 34 (S 01) ◽  
pp. S13-S16 ◽  
Author(s):  
E. Schmit ◽  
D. Czepa ◽  
K. Kurnik ◽  
M. Spannagl ◽  
M. Stemberger
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Half Life ◽  
Bleeding Event ◽  
Frequency Factor ◽  
Severe Haemophilia ◽  
Factor Activity ◽  
Physical And Mental Health ◽  
Joint Health

SummaryClimbing has a low risk of injury and strengthens the entire musculature. Due to its benefits in physical and mental health as well as its high fun factor climbing is an established way of therapy. So far, the usefulness of climbing therapy has not been shown for people with haemophilia (PWH). A crucial requirement for physical activity in PWH is regular prophylaxis. As the patient’s individual pharmacokinetic (PK) response varies significantly, PK-tailored prophylaxis may decrease bleeding frequency. Case report: We describe a man (age 25 years) with severe haemophilia A who took part in an 8.5-month weekly climbing program under PK-tailored prophylaxis. Bleeding frequency, factor consumption, joint health (Haemophilia Joint Health Score, HJHS), quality of life (Haemo-QoL-A) and climbing performance (UIAA scale) were assessed before and after the training. Prior to the study, the patient was on demand treatment. The patient was started on standard prophylaxis for a 2 months period and then observed for 6.5 months under PK-tailored prophylaxis. PK-tailored prophylaxis was targeted to a trough level of 1–3%. For high-impact activities a factor activity >15%, for low-impact activities a factor activity >5% was suggested. Results: Climbing therapy was safe. The bleeding rate decreased from 14 (2012) to 1 (during the study period of 8.5 months). The one bleeding event was due to a missed infusion and was not triggered by physical activity. The elimination half-life using Bayesian statistics was determined to be 16h. Using this half-life for PK-tailored prophylaxis reduced the factor VIII consumption in comparison to standard prophylaxis. Joint health was particularly improved in the categories range of motion and swelling. Quality of life scores stayed at a high level. Climbing performance improved by 1 grade. Conclusio: The combination of PK-tailored prophylaxis with therapeutic climbing improved clinical outcome in this young adult with severe haemophilia. The tailored concept for high- and low-impact activities appeared to be safe.

scholarly journals Changes in the Health of Adolescent Athletes: A Comparison of Health Measures Collected Before and During the CoVID-19 Pandemic

2021 ◽  
Author(s):  
Timothy A. McGuine ◽  
Kevin Biese ◽  
Scott J. Hetzel ◽  
Labina Petrovska ◽  
Stephanie Kliethermes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Physical Activity ◽  
Online Survey ◽  
Depression Symptoms ◽  
Physical And Mental Health ◽  
Adolescent Athletes ◽  
Cross Sectional ◽  
Health Measures

ABSTRACT Context: In the spring of 2020, schools closed to in-person teaching and sports were cancelled to control the transmission of CoVID-19. The changes that took place to the physical and mental health among young athletes during this time remain unknown, however. Objective: Identify changes in the health (mental health, physical activity and quality of life) of athletes that occurred during the CoVID-19 pandemic. Design: Cross-sectional study. Setting: Sample recruited via social media. Patients or Other Participants: 3243 Wisconsin adolescent athletes (age=16.2±1.2 yrs., female=58% female) completed an online survey in May 2020 (DuringCoVID-19). Health measures for this cohort were compared with previously reported data for Wisconsin adolescent athletes (n=5231, age=15.7±1.2, 47% female) collected in 2016–2018 (PreCoVID-19). Main Outcome Measure(s): Demographic information included: sex, grade and sports played. Health assessments included the Patient Health Questionnaire-9 Item (PHQ-9) to identify depression symptoms, the Pediatric Functional Activity Brief Scale (PFABS) for physical activity, and the Pediatric Quality of Life Inventory 4.0 (PedsQL) for health related quality of life (HRQoL). Univariable comparisons of these variables between groups were made via t-tests or chi-square tests. Means and 95% confidence intervals (CI) for each group were estimated by survey weighted ANOVA models. RESULTS: Compared to PreCoVID-19, a larger proportion of the During-CoVID-19 participants reported rates of moderate to severe levels of depression (9.7% vs 32.9%, p<0.001). During-CoVID-19 participants reported 50% lower (worse) PFABS scores (mean:12.2 [95%CI: 11.9, 12.5] vs 24.7 [24.5, 24.9] p<0.001) and lower (worse) PedsQL total scores compared to the PreCoVID-19 participants (78.4 [78.0, 78.8] vs. 90.9 [90.5, 91.3] p<0.001). CONCLUSIONS: During the CoVID-19 pandemic, adolescent athletes reported increased symptoms of depression, decreased physical activity and decreased quality of life compared to adolescent athletes in previous years.

scholarly journals Serum Concentrations of Vitamin D, Calcium, Phosphorus and Trace Minerals in Adults and Children with Haemophilia A: Association with Disease Severity, Quality of Life, Joint Health and Functional Status

2020 ◽  
Author(s):  
Amir Abbasnezhad ◽  
Mehdi Habibi ◽  
Babak Abdolkarimi ◽  
Soodabeh Zare ◽  
Ezatollah Fazeli Moghadam ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Vitamin D ◽  
Serum Levels ◽  
Haemophilia A ◽  
Serum Concentrations ◽  
Joint Health ◽  
Adults And Children ◽  
Lower Physical Activity

Background: To investigate the serum levels of 25(OH)D and minerals in adults and children with haemophilia A, and the possible association of these factors with Pediatric Haemophilia/Haemophilia Activities List (PedHAL/HAL), Haemophilia Joint Health Score (HJHS) and Haemophilia-specific quality of life (QoL) index this case-control study was conducted. Materials and Methods: Eighty five haemophilia A patients (HP) registered in Hemophilia Society of Lorestan province were recruited. Along with HP, sex and age matched healthy controls (HCs) were recruited. Linear regression was used to evaluate the possible relation between biochemical factors and other variables. One-way analysis of variance (ANOVA) was used to compare the biochemical factors between three or more independent groups. Results: Results indicated that serum zinc, phosphorus and magnesium were significantly lower, whereas, serum level of alkaline phosphatase (ALP) was statistically higher in HP compared with HCs. Other biochemical factors including calcium and parathyroid hormone (PTH) were not different between groups. Serum 25(OH) D was lower only in children with haemophilia and not in adults. Percentage of subjects who were vitamin D deficient was higher in HP vs. HCs (57.6% vs. 35.3%), and also this rate was higher in children with haemophilia vs. adults (77.8% vs. 48.3%). Lower serum concentrations of assessed minerals and vitamin D were associated with lower physical activity, poor QoL and worst joint health, and these associations were stronger in children. Conclusion: Present study indicated that serum levels of vitamin D and minerals were low in HP, and these low levels were associated with poor QoL, lower physical activity and worst joint health.

scholarly journals Clinical, humanistic, and economic burden of severe haemophilia B in adults receiving factor IX prophylaxis: findings from the CHESS II real-world burden of illness study in Europe

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Tom Burke ◽  
Sohaib Asghar ◽  
Jamie O’Hara ◽  
Margaret Chuang ◽  
Eileen K. Sawyer ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Real World ◽  
Economic Burden ◽  
Half Life ◽  
Burden Of Illness ◽  
Indirect Costs ◽  
Factor Ix ◽  
Severe Haemophilia ◽  
Haemophilia B

Abstract Background Real-world studies of the burden of severe haemophilia B in the context of recent therapeutic advances such as extended half-life (EHL) factor IX (FIX) products are limited. We analysed data from the recent CHESS II study to better understand the clinical, humanistic, and economic burden of severe haemophilia B in Europe. Data from male adults with severe haemophilia B receiving prophylaxis were analysed from the retrospective cross-sectional CHESS II study conducted in Germany, France, Italy, Spain and the United Kingdom. Inhibitors were exclusionary. Patients and physicians completed questionnaires on bleeding, joint status, quality of life, and haemophilia-related direct and indirect costs (2019–2020). All outcomes were summarised using descriptive statistics. Results A total of 75 CHESS II patients were eligible and included; 40 patients (53%) provided self-reported outcomes. Mean age was 36.2 years. Approximately half the patients were receiving EHL versus standard half-life (SHL) prophylaxis (44% vs 56%). Most patients reported mild or moderate chronic pain (76%) and had ≥ 2 bleeding events per year (70%), with a mean annualised bleed rate of 2.4. Mean annual total haemophilia-related direct medical cost per patient was €235,723, driven by FIX costs (€232,328 overall, n = 40; €186,528 for SHL, €290,620 for EHL). Mean annual indirect costs (€8,973) were driven by early retirement or work stoppage due to haemophilia. Mean quality of life (EQ-5D) score was 0.67. Conclusions These data document a substantial, persistent real-world burden of severe haemophilia B in Europe. Unmet needs persist for these patients, their caregivers, and society.

scholarly journals Effects of top rope climbing therapy on joint health in adult haemophilia patients with severe arthropathies

2018 ◽  
Vol 5 (1) ◽  
pp. 93-102
Author(s):  
Courtney Schroeder ◽  
Richard Fw. Barnes ◽  
Lena Volland ◽  
Sonha Nguyen ◽  
Annette von Drygalski
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Musculoskeletal Disorders ◽  
Power Doppler ◽  
Physical Activities ◽  
Before And After ◽  
Suboptimal Adherence ◽  
Joint Health ◽  
And Cartilage

Abstract Background: Low impact physical activity is important for patients with haemophilic arthropathies, but is often considered boring with suboptimal adherence. There is therefore a need for physical activities that motivate patient engagement. Aims: To evaluate the benefits of top rope climbing, increasingly used in other musculoskeletal disorders, as an engaging sports discipline in haemophilia. Materials/Methods: Six adult arthropathic patients with haemophilia (PWH) completed 12 sessions of tailored top rope climbing training. Functional and clinical joint status, climbing skills, quality of life (QoL), annual bleed rate (ABR) and joint findings with musculoskeletal ultrasound/power doppler (MSKUS/PD) were assessed before and after climbing. Results: Haemophilia joint health scores, dorsiflexion in arthropathic joints and climbing skills all improved. ABRs were comparable before and during climbing, and QoL remained high. MSKUS evaluation demonstrated no detrimental effects on synovial and cartilage health, with a decrease of inflammatory PD signal in some joints. Conclusion: We conclude that top rope climbing therapy (known as “Haemophilia Vertical”) can improve joint health in PWH with arthropathies. Haemophilia Vertical therefore emerges as an innovative athletic concept to promote physical activity among PWH. Further study investigating the longer-term impact in a larger cohort is warranted.

Abstract P288: The Association Between Moderate to Vigorous Physical Activity and Health-Related Quality of Life Among Hispanic/Latino Adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Priscilla Vasquez ◽  
Ramon Durazo-Arvizu ◽  
David Marquez ◽  
Maria Argos ◽  
Melissa Lamar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Short Form ◽  
Vigorous Physical Activity ◽  
Health Study ◽  
Health Related Quality ◽  
Physical And Mental Health ◽  
Related Quality ◽  
Health Related

Background: Self-reported moderate to vigorous physical activity (MVPA) has been associated with better health-related quality of life (HRQoL), however research on quantitative MVPA in relation to HRQoL has been limited. In addition, the association of PA with physical and mental health components of HRQoL has not been examined. Hypothesis: Higher accelerometer-measured MVPA will be associated with better mental and physical HRQoL. Methods: Cross-sectional data from 12,179 adults ages 18-74 in 2008-11, who participated in HCHS/SOL and had complete data on key study variables. MVPA (minutes/week), measured by accelerometer, was grouped into 4 levels: inactive, low, moderate, and high. HRQoL was assessed using the Short-Form 12 (SF-12) questionnaire; the SF-12 mental and physical component summary (MCS; PCS) scores were computed (standardized to general US population norms with mean of 50 and standard deviation of 10; higher scores indicate better HRQoL). Multivariable linear regression models were used to derive adjusted means with 95% confidence intervals (CI) and to assess linear trends. All models were adjusted for covariates. The analyses were weighted for the study design and non-response. Results: PCS adjusted mean scores ranged from 46.8 (CI: 44.9, 48.6) among inactive persons to 51.3 (CI: 50.8, 51.8) among those with high levels of MVPA (p trend <0.001). No significant differences in MCS scores were observed across MVPA levels (p = 0.64). Conclusion: MVPA was positively associated with better self-perceived physical health-related quality of life. Our findings align with studies examining self-reported MVPA and HRQoL. Future prospective studies should evaluate whether increasing MVPA can lead to improvements in HRQoL among the US Hispanic/Latino population.

Active Longevity program as important element of rehabilitation of elderly patients in primary health care

2021 ◽  
Vol 1 (11) ◽  
pp. 50-54
Author(s):  
Ya. G. Spiryakina ◽  
N. V. Orlova ◽  
R. Kh. Bagautdinov ◽  
T. I. Bonkalo
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Elderly Patients ◽  
Depressive Disorders ◽  
Progressive Increase ◽  
Blood Cholesterol ◽  
Physical And Mental Health ◽  
Total Blood ◽  
Almost All

Progressive increase in the proportion of elderly patients in the population of many countries actualizes the issues of preserving physical and mental health, working capacity and quality of life of retirees. As a part of preventive geriatric rehabilitation, ‘the Active Longevity’ program has been operating in many cities of Russia over the past three years, one of the aspects of the program is the involvement of elderly patients in active life, including an increase in physical activity. This study included 744 patients who attended face‑to‑face physical training sessions. According to the results of the survey, 41% of pensioners noted an increase of daily physical activity, 94% reported an improvement in health and mood, the level of total blood cholesterol decreased. Almost all patients, both with and without clinical and subclinical manifestations of anxiety and depression, reported a good and very good mood immediately after exercise. Increasing physical activity in elderly patients improves the quality of life and prolongs its duration, and is also an effective method of non‑drug treatment of anxiety‑depressive disorders.

scholarly journals High School Sports During the CoVID-19 Pandemic: The Impact of Sport Participation on the Health of Adolescents

2021 ◽  
Author(s):  
Timothy A. McGuine ◽  
Kevin Biese ◽  
Scott J. Hetzel ◽  
Allison Schwarz ◽  
Claudia L. Reardon ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
High School ◽  
High School Students ◽  
Physical And Mental Health ◽  
Adolescent Athletes ◽  
School Students ◽  
School Sports ◽  
The Impact

ABSTRACTContextDuring the fall of 2020, some high schools across the US allowed their students to participate in interscholastic sports while others cancelled or postponed their sport programs due to concerns regarding CoVID19 transmission. It is unknown what effect this has had on the physical and mental health of student athletes.ObjectiveIdentify the impact of playing a sport during the CoVID19 pandemic on the health of student athletes.DesignCross-sectional study.SettingSample recruited via email.Patients or Other Participants559 Wisconsin high school athletes (age=15.7+1.2 yrs., female=44%) from 44 high schools completed an online survey in October 2020. A total of 171 (31%) athletes played (PLY) a fall sport, while 388 (69%) did not play (DNP).Main Outcome Measure(s)Demographics included: sex, grade and sports played. Assessments included the General Anxiety Disorder-7 Item (GAD-7) for anxiety, Patient Health Questionnaire-9 Item (PHQ-9) for depression, the Pediatric Functional Activity Brief Scale (PFABS) for physical activity, and the Pediatric Quality of Life Inventory 4.0 (PedsQL) for quality of life. Univariable comparisons between the two groups were made via t-tests or chi-square tests. Means for each continuous outcome measure were compared between the groups by ANOVA models that controlled for Age, Sex, Teaching method (Virtual, Hybrid, or In-person), and the % of students eligible for free lunch.RESULTSPLY group participants were less likely to report moderate to severe symptoms of anxiety (PLY=6.6%, DNP=44.1%, p<0.001) and depression (PLY=18.2%, DNP=40.4%, p<0.001). PLY athletes reported higher (better) PFABS scores (mean: [95%CI]), (PLY=23.2[22.0,24.5], DNP=16.4[15.0,17.8], p <0.001) and higher (better) PedsQL total scores (PLY=88.4[85.9,90.9], DNP=79.6[76.8,82.4], p <0.001).CONCLUSIONSAdolescent athletes who played a sport during the CoVID19 pandemic reported fewer symptoms of anxiety and depression, as well as higher physical activity and quality of life scores compared to adolescent athletes who did not play a sport.Key pointsHigh school students who played a sport during the CoVID-19 pandemic in the fall of 2020 were less likely to report anxiety and depression symptoms than athletes who did not play a sport.High school students who played a sport during the CoVID-19 pandemic in the fall of 2020 reported higher physical activity and quality of life scores compared to high school athletes who did not play a sport.Participation in high school sports may have significant physical and mental health benefits for US adolescent athletes during the CoVID-19 pandemic.

scholarly journals A cross-sectional study of the relationship between exercise, physical activity, and health-related quality of life among Japanese workers during the COVID-19 pandemic

2021 ◽  
Author(s):  
Ryosuke Sugano ◽  
Kazunori Ikegami ◽  
Hisashi Eguchi ◽  
Mayumi Tsuji ◽  
Seiichiro Tateishi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Health Related Quality ◽  
Physical And Mental Health ◽  
Japanese Workers ◽  
Related Quality ◽  
Health Related

Background: Exercise and physical activity positively affect physical and mental health, and healthy workers contribute to increased work productivity. This study aimed to investigate time spent on exercise during leisure time and physical activity, including time at work, in relation to health-related quality of life (HRQOL) among Japanese workers. Methods: An Internet-based national health survey —Collaborative Online Research on Novel-coronavirus and Work study (CoRoNaWork study)— was conducted among 33,087 Japanese workers in December 2020. After excluding invalid responses, 27,036 participants were categorized into four and five groups according to exercise time and physical activity time, respectively. Each group's scores were compared on each of the four questions on the Japanese version of the Centers for Disease Control and Prevention Health-Related Quality of Life (CDC HRQOL-4) between each group using a linear mixed model. Age-sex adjusted and multivariate models were used to compare each index of the CDC HRQOL-4.

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