scholarly journals THE ASSOCIATION OF INSULIN RESISTANCE WITH BODY MASS INDEX AND BODY FAT PERCENTAGES IN NON-DIABETIC OBESE WOMEN

2018 ◽  
Vol 1 (1) ◽  
pp. 13-16
Author(s):  
Ekrem Orbay ◽  
Bahadır Han Demiral ◽  
Sabah Tüzün ◽  
Can Öner
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Obese Women

scholarly journals Body mass index and waist circumference are better predictors of insulin resistance than total body fat percentage in middle-aged and elderly Taiwanese

Medicine ◽  
2017 ◽  
Vol 96 (39) ◽  
pp. e8126 ◽  
Author(s):  
Yiu-Hua Cheng ◽  
Yu-Chung Tsao ◽  
I-Shiang Tzeng ◽  
Hai-Hua Chuang ◽  
Wen-Cheng Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Middle Aged ◽  
Fat Percentage ◽  
Total Body Fat ◽  
Total Body

scholarly journals Responses of Serum Androgen and Insulin Resistance to Metformin and Pioglitazone in Obese, Insulin-Resistant Women with Polycystic Ovary Syndrome

2005 ◽  
Vol 90 (3) ◽  
pp. 1360-1365 ◽  
Author(s):  
C. Ortega-González ◽  
S. Luna ◽  
L. Hernández ◽  
G. Crespo ◽  
P. Aguayo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Weight ◽  
Insulin Sensitivity ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Polycystic Ovary ◽  
Obese Women ◽  
Ovary Syndrome ◽  
Waist To Hip Ratio

Severe insulin resistance is a key abnormality in obese women with polycystic ovary syndrome (PCOS). The purpose of this study was to evaluate whether pioglitazone decreases insulin resistance (IR) and hyperandrogenism to the same extent as metformin in obese women with PCOS who have not received any previous treatment. Fifty-two women with PCOS were randomly allocated to receive either pioglitazone (30 mg/d, n = 25) or metformin (850 mg three times daily, n = 27) and were assessed before and after 6 months. Body weight, body mass index, and waist to hip ratio increased significantly (P ≤ 0.05) after pioglitazone treatment but not after metformin treatment. Fasting serum insulin concentration (P < 0.001 for both drugs) and the area under the insulin curve during a 2-h oral glucose tolerance test decreased after pioglitazone (P < 0.002) or metformin (P < 0.05) treatment. IR (homeostasis model of assessment-IR index) decreased and insulin sensitivity (elevation of the quantitative insulin sensitivity check index and the fasting glucose to insulin ratio) increased (P ≤ 0.008) after treatment with either drug. Hirsutism (P < 0.05) and serum concentrations of free testosterone (P < 0.02) and androstenedione (P < 0.01) declined to a similar extent after treatment with the drugs. Treatment with pioglitazone or metformin was associated with the occurrence of pregnancy (n = 5 and n = 3, respectively). These results suggest that pioglitazone is as effective as metformin in improving insulin sensitivity and hyperandrogenism, despite an increase in body weight, body mass index, and the waist to hip ratio associated with pioglitazone.

Analysis of Body Mass Index, Waist Circumference, and Body Fat in Predicting Insulin Resistance of Polycystic Ovary Syndrome

2017 ◽  
Vol 23 (7) ◽  
pp. 6807-6810
Author(s):  
Achmad Kemal Harzif ◽  
Dwiyanarsi Yusuf ◽  
Melisa Silvia ◽  
Budi Wiweko ◽  
Andon Hestiantoro
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Body Fat ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Body mass index is a reliable predictor of insulin resistance than body fat percentage

2021 ◽  
Vol 11 (7) ◽  
pp. 1
Author(s):  
John Lyngdoh ◽  
Merrycka Sangma ◽  
Raj Sarkar ◽  
Donboklang Lynser ◽  
Happy Chutia ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Reliable Predictor

scholarly journals Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men

2003 ◽  
Vol 88 (10) ◽  
pp. 4673-4676 ◽  
Author(s):  
Hideki Urakawa ◽  
Akira Katsuki ◽  
Yasuhiro Sumida ◽  
Esteban C. Gabazza ◽  
Shuichi Murashima ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Body Fat ◽  
Plasma Levels ◽  
Infusion Rate ◽  
Glucose Infusion ◽  
Glucose Infusion Rate ◽  
Total Fat

Abstract To investigate the direct relationship of oxidative stress with obesity and insulin resistance in men, we measured the plasma levels of 8-epi-prostaglandin F2α (PGF2α) in 14 obese and 17 nonobese men and evaluated their relationship with body mass index; body fat weight; visceral, sc, and total fat areas, measured by computed tomography; and glucose infusion rate during a euglycemic hyperinsulinemic clamp study. Obese men had significantly higher plasma concentrations of 8-epi-PGF2α than nonobese men (P < 0.05). The plasma levels of 8-epi-PGF2α were significantly correlated with body mass index (r = 0.408; P < 0.05), body fat weight (r = 0.467; P < 0.05), visceral (r = 0.387; P < 0.05) and total fat area (r = 0.359; P < 0.05) in all (obese and nonobese) men. There was also a significant correlation between the plasma levels of 8-epi-PGF2α and glucose infusion rate in obese men (r = −0.552; P < 0.05) and all men (r = −0.668; P < 0.01). In all subjects, the plasma levels of 8-epi-PGF2α were significantly correlated with fasting serum levels of insulin (r = 0.487; P < 0.01). In brief, these findings showed that the circulating levels of 8-epi-PGF2α are related to adiposity and insulin resistance in men. Although correlation does not prove causation, the results of this study suggest that obesity is an important factor for enhanced oxidative stress and that this oxidative stress triggers the development of insulin resistance in men.

scholarly journals Features of the hormonal profile in obese reproductive-age women

2020 ◽  
Vol 5 (3) ◽  
pp. 77-84
Author(s):  
N. V. Artymuk ◽  
O. A. Tachkova ◽  
N. A. Sukhova
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Dehydroepiandrosterone Sulfate ◽  
Reproductive Age ◽  
Obese Women ◽  
Women Of Reproductive Age ◽  
Hormonal Profile ◽  
Reproductive Age Women

Aim. To assess the hormonal profile features in obese reproductive-age women. Materials and Methods. We consecutively enrolled 163 women of reproductive age (140 women with body mass index ≥ 30 kg/m2 and 23 women with normal body mass index) who have been admitted to Podgorbunskiy Regional Emergency Medicine Hospital. All patients of both groups underwent general and gynecological examination. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone, free triiodothyronine, total and free thyroxine, cortisol, leptin, immunoreactive insulin, and progesterone were assessed on days 5-6 and 21-22 of the menstrual cycle. Results. Obese women of reproductive age were characterised by higher values of LH, LH/ FSH ratio, testosterone, estradiol, estrone, leptin, IRI and by lower levels of FSH and progesterone compared with normal weight women. A direct correlation was found between the level of leptin and estrone (r = 0.21, p = 0.014), insulin resistance (r = 0.18, p = 0.039), triglycerides (r = 0.20, p = 0.030), and low-density lipoprotein cholesterol (r = 0.22, p = 0.016). There was a statistically significant inverse correlation between the level of leptin and high-density lipoprotein cholesterol (r = -0.18, p = 0.043). A direct correlation was established between insulin and LH (r = 0.24, p = 0.030), testosterone (r = 0.32, p = 0.037), dehydroepiandrosterone sulfate (r = 0.56, p = 0.003), insulin resistance (r = 0.95, p < 0.001), cholesterol (r = 0.20, p = 0.024), triglycerides (r = 0.29, p < 0.001). Conclusion. Obese women of reproductive age have certain hormonal features that underlie menstrual and reproductive disorders in these patients.

scholarly journals Insulin Resistance in Obese Women: Does it Affect Fertility?

2020 ◽  
pp. 151-155
Author(s):  
Satrio B. Purnomo ◽  
Bobby I. Utama ◽  
Yusrawati ◽  
Ori John ◽  
Muhammad Iqbal
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Pearson Correlation ◽  
Sampling Technique ◽  
Reproductive Age ◽  
Obese Women ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Obese Female

Objective: To know the correlation of insulin resistance with body mass index in obesity women infertility.Method: This research used a cross-sectional study design. This study was conducted on February 2017 until January 2019 at Obstetric and Gynecology Division of RSUP Dr. M. Djamil and Ibnu Sina Hospital in Padang. The population of the study were all patients were obese in women of reproductive age with infertility complaints with a total sample of 27 people. The sampling technique was consecutive sampling. Data analysis was done by univariate and bivariate using Pearson correlation test.Results: We found that less than half of the respondents experienced insulin resistance with HOMA-IR values > 2,5 (22.2%) and more than half of respondents did not experience insulin resistance with HOMA-IR values < 2,5 (77.8%). There was a correlation of insulin resistance with body mass index in obese female infertility (p<0,05) with strong relationship strength. Conclusions: There was a correlation of insulin resistance with body mass index in obese female infertility.Keywords: infertility, insulin resistance, obesity   Abstrak Tujuan: Mengetahui korelasi resistensi insulin dengan indeks massa tubuh pada infertilitas perempuan obesitas.Metode: Penelitian ini menggunakan desain potong lintang. Penelitian dilakukan di Poliklinik Bagian Obstetri dan Ginekologi RSUP Dr. M. Djamil Padang dan RS Islam Ibnu Sina Padang sejak bulan Februari 2017 – Januari 2019. Populasi pada penelitian ini adalah semua pasien yang mengalami obesitas pada perempuan usia reproduksi dengan keluhan infertilitas dengan jumlah sampel sebanyak 27 orang. Teknik pengambilan sampel dengan consecutive sampling. Analisis data dilakukan secara univariat dan bivariat dengan menggunakan uji korelasi pearson. Hasil: Hasil penelitian diketahui kurang dari separuh responden mengalami resistensi insulin dengan nilai HOMA-IR > 2,5 (22,2%) dan lebih dari separuh responden tidak mengalami resistensi insulin dengan nilai HOMA-IR < 2,5 (77,8%). Terdapat korelasi resistensi insulin dengan indeks massa tubuh pada infertilitas perempuan obesitas (p<0,05) dengan kekuatan hubungan kuat.Kesimpulan: Terdapat korelasi resistensi insulin dengan indeks massa tubuh pada infertilitas perempuan obesitas.Kata kunci: infertilitas, obesitas, resistensi Insulin.

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