scholarly journals Insulin Resistance in Obese Women: Does it Affect Fertility?

Author(s):  
Satrio B. Purnomo ◽  
Bobby I. Utama ◽  
Yusrawati ◽  
Ori John ◽  
Muhammad Iqbal

Objective: To know the correlation of insulin resistance with body mass index in obesity women infertility.Method: This research used a cross-sectional study design. This study was conducted on February 2017 until January 2019 at Obstetric and Gynecology Division of RSUP Dr. M. Djamil and Ibnu Sina Hospital in Padang. The population of the study were all patients were obese in women of reproductive age with infertility complaints with a total sample of 27 people. The sampling technique was consecutive sampling. Data analysis was done by univariate and bivariate using Pearson correlation test.Results: We found that less than half of the respondents experienced insulin resistance with HOMA-IR values > 2,5 (22.2%) and more than half of respondents did not experience insulin resistance with HOMA-IR values < 2,5 (77.8%). There was a correlation of insulin resistance with body mass index in obese female infertility (p<0,05) with strong relationship strength. Conclusions: There was a correlation of insulin resistance with body mass index in obese female infertility.Keywords: infertility, insulin resistance, obesity   Abstrak Tujuan: Mengetahui korelasi resistensi insulin dengan indeks massa tubuh pada infertilitas perempuan obesitas.Metode: Penelitian ini menggunakan desain potong lintang. Penelitian dilakukan di Poliklinik Bagian Obstetri dan Ginekologi RSUP Dr. M. Djamil Padang dan RS Islam Ibnu Sina Padang sejak bulan Februari 2017 – Januari 2019. Populasi pada penelitian ini adalah semua pasien yang mengalami obesitas pada perempuan usia reproduksi dengan keluhan infertilitas dengan jumlah sampel sebanyak 27 orang. Teknik pengambilan sampel dengan consecutive sampling. Analisis data dilakukan secara univariat dan bivariat dengan menggunakan uji korelasi pearson. Hasil: Hasil penelitian diketahui kurang dari separuh responden mengalami resistensi insulin dengan nilai HOMA-IR > 2,5 (22,2%) dan lebih dari separuh responden tidak mengalami resistensi insulin dengan nilai HOMA-IR < 2,5 (77,8%). Terdapat korelasi resistensi insulin dengan indeks massa tubuh pada infertilitas perempuan obesitas (p<0,05) dengan kekuatan hubungan kuat.Kesimpulan: Terdapat korelasi resistensi insulin dengan indeks massa tubuh pada infertilitas perempuan obesitas.Kata kunci: infertilitas, obesitas, resistensi Insulin.

2020 ◽  
Vol 5 (3) ◽  
pp. 77-84
Author(s):  
N. V. Artymuk ◽  
O. A. Tachkova ◽  
N. A. Sukhova

Aim. To assess the hormonal profile features in obese reproductive-age women. Materials and Methods. We consecutively enrolled 163 women of reproductive age (140 women with body mass index ≥ 30 kg/m2 and 23 women with normal body mass index) who have been admitted to Podgorbunskiy Regional Emergency Medicine Hospital. All patients of both groups underwent general and gynecological examination. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone, free triiodothyronine, total and free thyroxine, cortisol, leptin, immunoreactive insulin, and progesterone were assessed on days 5-6 and 21-22 of the menstrual cycle. Results. Obese women of reproductive age were characterised by higher values of LH, LH/ FSH ratio, testosterone, estradiol, estrone, leptin, IRI and by lower levels of FSH and progesterone compared with normal weight women. A direct correlation was found between the level of leptin and estrone (r = 0.21, p = 0.014), insulin resistance (r = 0.18, p = 0.039), triglycerides (r = 0.20, p = 0.030), and low-density lipoprotein cholesterol (r = 0.22, p = 0.016). There was a statistically significant inverse correlation between the level of leptin and high-density lipoprotein cholesterol (r = -0.18, p = 0.043). A direct correlation was established between insulin and LH (r = 0.24, p = 0.030), testosterone (r = 0.32, p = 0.037), dehydroepiandrosterone sulfate (r = 0.56, p = 0.003), insulin resistance (r = 0.95, p < 0.001), cholesterol (r = 0.20, p = 0.024), triglycerides (r = 0.29, p < 0.001). Conclusion. Obese women of reproductive age have certain hormonal features that underlie menstrual and reproductive disorders in these patients.


2016 ◽  
Vol 2 (1) ◽  
pp. 13
Author(s):  
Ese ANIBOR ◽  
Efe OJIGHO ◽  
Tobore OGBATORHO

Context: Carrying angle and body mass index (BMI) varies among individuals and therefore significant in forensic medicine and anthropology.Aim: The purpose of this study was to determine whether the BMI of healthy adolescents from Abraka had an impact on the carrying angle of the elbow joint. This research was also aimed at determining the variation of carrying angle among male and female adolescents from Abraka in Nigeria.Settings and Design: The multi-stage sampling technique was employed in this cross sectional study.Methods and Materials: Three hundred and eighty-four volunteers between the ages of 10 to 19 years (mean 14years) were investigated.Statistical analysis used: The data were analyzed using the Statistical Package for the Social Sciences (SPSS 20). Pearson correlation coefficient was used to establish the relationship between carrying angle and body mass index among the adolescents. The independent t test was used to determine gender differences in carrying angle among the participants.Results: Gender had no significant effect on the mean carrying angle irrespective of the side (p>0.05). There was a weak positive correlation between right carrying angle (M=12.411, SD=1.719) and BMI (M=18.730, SD=2.613), with r=0.144 and p<0.05. It was also observed that there was a weak positive correlation between left carrying angle (M=12.480, SD=1.787) and BMI (M=18.730, SD=2.613), with r=0.017 and p<0.05.Conclusion: The BMI of adolescents in Delta State has an impact on the carrying angle of the elbow joint.  


2015 ◽  
Vol 3 (2) ◽  
pp. 47-51
Author(s):  
B.B. Karki ◽  
M.D. Bhattarai ◽  
M.R. Bajracharya ◽  
S Karki ◽  
A.R. Devkota

Background and aims: Body mass index, waist and hip circumference have been using for measurement of obesity, however practically it’s difficult to get these measures accurately because of the various reasons, so an alternative to this could be neck and wrist circumference measurement. As there is scarce report on such anthropometric studies from Nepal, we aimed to find out the correlation between neck and wrist circumference with waist circumference for obesity measure.Method: A cross sectional observational study of total 297(147 male and 150 female) participants, aged above 18 years conducted on 2013 at Kathmandu valley. Anthropometric markers of obesity were measured, including body weight, height, waist, hip, neck and wrist circumferences.Results: A strong positive Pearson correlation of neck circumference with waist circumference was found in both male and females(r=0.64 in male and r=0.86 in female). Neck circumference had strong positive correlation with waist circumference in obese female than in male(r=0.5 in male and r=0.82 in female).Similarly, neck circumference had positive correlation with body mass index(r=0.53in male and r=0.79 in female),hip(r=0.54in male and r=0.76in female), weight(r=0.59in male and r=0.77in female) except waist hip ratio(r=0.59in male and r=0.10in female). Neck circumference cutoff for abnormal waist (>=90cm for male and >=80cm for female) was 34.4cm for male and 32.5 cm for female. Similarly wrist circumference had also positive correlation with waist circumference(r=0.58 and r=0.64 in female) and with weight(r>0.6) in both sexes.Conclusion: Neck circumference which can be relatively easily measured has shown strong correlation with waist.Journal of Advances in Internal Medicine 2014;3(2):47-51.


Author(s):  
Widya Kusumawati ◽  
◽  
Lely Khulafa’ur Rosidah ◽  

ABSTRACT Background: Hormonal contraception is still a popular contraceptive method for most women. More than six million women worldwide use the injectable hormonal contraceptive method. The hormones estrogen and progesterone contained in hormonal birth control can affect the increase of sodium and fluids. This will affect the fat layer and appetite which will cause weight gain, thus impacting body mass index (BMI). This study aimed to determine the effect of hormonal contraception on BMI. Subjects and Method: This was a cross-sectional study conducted in Ngampel village, Mojoroto District, Kediri, East Java, in June – July 2019. The total of 30 women in reproductive age were selected using purposive sampling technique. The independent variable was the use of hormonal contraception. the dependent variable was BMI. The data were collected by questionnaire then analyzed using Chi Square test. Results: The use of hormonal contraception was increased the BMI among women in reproductive age. Conclusion: The use of hormonal contraception can give an effect on BMI. Sometimes, woman body should be given the opportunity to rest using non-hormonal birth control. Keywords: family planning, hormonal contraception, body mass index Correspondence: Widya Kusumawati. Dharma Husada Kediri Academy of Midwifery. Jl. Coverage No 41 A Kediri City. Email: [email protected]. Mobile: 085722223910. DOI: https://doi.org/10.26911/the7thicph.03.20


2019 ◽  
Vol 10 (1) ◽  
pp. 12
Author(s):  
Putri Engla Pasalina ◽  
Yusri Dianne Jurnalis ◽  
Ariadi Ariadi

AbstrakWanita Usia Subur (WUS) merupakan kelompok usia dengan prevalensi anemia yang cukup tinggi, di Indonesia mengalami peningkatan dari 19,7%(2007)  menjadi 22,4% (2013). Status besi WUS pranikah berdampak pada outcome maternal dan neonatal saat kehamilan. Hubungan Indeks Massa Tubuh (IMT) dan anemia masih kontroversial. Berat badan kurus merupakan indikasi rendahnya asupan mikronutrien yang berhubungan dengan anemia. Pada studi lain, berat badan berlebih/ obesitas meningkatkan resiko anemia karena peningkatan sitokin inflamasi (Interleukin-6) yang menstimulasi peningkatan hepsidin dan penurunan penyerapan besi. Tujuan penelitian ini adalah menganalisis hubungan Indeks Massa Tubuh  dengan kejadian  anemia  pada WUS  pranikah. Penelitian ini berjenis analitik observasional dengan metode pendekatan cross sectional dilakukan pada 36 WUS pranikah ( 18  anemia dan 18 tidak anemia) di Kantor Urusan Agama (KUA) Kecamatan Koto Tangah Kota Padang. Pengambilan sampel dilakukan secara consecutive sampling. Pengukuran tinggi badan menggunakan microtoice dan berat badan menggunakan timbangan pegas. Pemeriksaan hemoglobin dengan metode sianmethemoglobin di Laboratorium Biokimia Universitas Andalas. Uji Bivariat dilakukan dengan uji Chi Square.Hasil penelitian menunjukkanWUS dengan IMT berlebih merupakan persentase terbesar (66,7%) yang ditemukan pada kelompok anemia. Tidak terdapat hubungan antara IMT dengan kejadian anemia dengan nilai p 0,7 (p>0,05). Kesimpulan penelitian ini adalah tidak terdapat hubungan antara IMT dengan kejadian anemia. Kata Kunci: Indeks Massa Tubuh, Kejadian Anemia AbstractWomen of Reproductive Age (WRA) are an age group with a fairly high anemia prevalence in Indonesia, increasing from 19.7% (2007) to 22.4% (2013). Iron status of premarital women affects maternal and neonatal outcomes during pregnancy. The relationship between the Body Mass Index (BMI) and anemia is controversial. Underweight indicates of inadequate dietary intake of micronutrients associated with anemia. In other study, overweight/obesity also increase anemia risk because release of proinflammatory cytokines (Interleukin-6) and which stimulates release of hepsidin and decrease iron absorbtion. The purpose of this study was to analyze the relationship between body mass index with the incidence of anemia in premarital WRA. This research was an observational analytic type with a cross sectional approach performed on 36 premarital WRA (18 with anemia and 18 without anemia) in Koto Tangah District, Padang. Sampling was done by consecutive sampling. Body height is measured by microtoice and body weight is measured by manual scale. Hemoglobin was examined with the cyanmethemoglobin method at the Andalas University Biochemistry. Bivariate test was carried out by Chi Square test. The results showed overweight women is the highest percentage (66,7%) in anemia group. There was no relationship between BMI and the incidence of anemia (p > 0.05). The study concluded that there was no relationship between BMI and anemia. Keywords: Body Mass Index, Anemia


2020 ◽  
Vol 11 (3) ◽  
pp. 62-66
Author(s):  
Renu Yadav ◽  
Nisha Ghimire ◽  
Soumitra Mukhopadhyay ◽  
Subodh Kumar Yadav

Background: Studies have concluded that the medical students of hostels are at high risk of anemia due to inappropriate diet and their long schedules that indirectly affect their performance. Thus, concerning for the long duration of medical studies, it has become a serious medical issue. Aims and Objective: Thus, our objective is to determine the prevalence of anemia among medical students in Nobel Medical College and Teaching Hospital, Nepal. Materials and Methods: This is a descriptive cross-sectional study which was conducted and Teaching Hospital from January 2017 to December 2017 where all the subjects were selected with convenient sampling technique. The total of 150 MBBS students (male=95, female=55), age 18-25 years were included in the study who were clinically healthy. The demographic data (name, age, sex, address) and anthropometric variables (height, weight, body mass index) were recorded and hemoglobin was estimated by Sahli’s acid hematin method. Results: Only 42.1% of total were mild anemic and 11.6 % were moderately anemic. Among female, 1.8% were severely anemic, 9.1% were moderately anemic and 41.8% were mild anemic. Compared to male, anemia in female medical students was found to be more extensive. Conclusions: It has been concluded from the above study that the mild anemia is highly prevalent among medical students regardless of gender. Though the subjects are not severely affected, it is a concerned issue since the cause might be inappropriate food habit or the food facilities available at hostels.


2005 ◽  
Vol 90 (3) ◽  
pp. 1360-1365 ◽  
Author(s):  
C. Ortega-González ◽  
S. Luna ◽  
L. Hernández ◽  
G. Crespo ◽  
P. Aguayo ◽  
...  

Severe insulin resistance is a key abnormality in obese women with polycystic ovary syndrome (PCOS). The purpose of this study was to evaluate whether pioglitazone decreases insulin resistance (IR) and hyperandrogenism to the same extent as metformin in obese women with PCOS who have not received any previous treatment. Fifty-two women with PCOS were randomly allocated to receive either pioglitazone (30 mg/d, n = 25) or metformin (850 mg three times daily, n = 27) and were assessed before and after 6 months. Body weight, body mass index, and waist to hip ratio increased significantly (P ≤ 0.05) after pioglitazone treatment but not after metformin treatment. Fasting serum insulin concentration (P &lt; 0.001 for both drugs) and the area under the insulin curve during a 2-h oral glucose tolerance test decreased after pioglitazone (P &lt; 0.002) or metformin (P &lt; 0.05) treatment. IR (homeostasis model of assessment-IR index) decreased and insulin sensitivity (elevation of the quantitative insulin sensitivity check index and the fasting glucose to insulin ratio) increased (P ≤ 0.008) after treatment with either drug. Hirsutism (P &lt; 0.05) and serum concentrations of free testosterone (P &lt; 0.02) and androstenedione (P &lt; 0.01) declined to a similar extent after treatment with the drugs. Treatment with pioglitazone or metformin was associated with the occurrence of pregnancy (n = 5 and n = 3, respectively). These results suggest that pioglitazone is as effective as metformin in improving insulin sensitivity and hyperandrogenism, despite an increase in body weight, body mass index, and the waist to hip ratio associated with pioglitazone.


2004 ◽  
Vol 10 (3) ◽  
pp. 437-441
Author(s):  
S. Esmaelzadeh ◽  
N. Rezaei ◽  
M. Hajiahmadi

Todetermine the efficacy of ultrasonographic assessment of uterus size in women of reproductive age, we conducted a cross-sectional analytic study of 231 women aged 15-45 years in Babol, northern Islamic Republic of Iran. Mean uterus size was 86.6 mm x 49.6 mm x 40.6 mm overall, 72.8 mm x 42.8 mm x 32.4 mm for nulliparous women and 90.8 mm x 51.7 mm x 43.0 mm for multiparous women. Mean age was 31.7 +/- 9.6 years and mean body mass index [BMI] was 24.7 +/- 4.0 kg/m2. Uterus size was significantly associated with parity and age; but not with BMI. Our findings show a greater mean uterus size than reported by others. Ultrasonographic measurement of uterus size is valuable for predicting pathologies associated with abnormal uterine size


2021 ◽  
Vol 10 (4) ◽  
pp. 328-334
Author(s):  
Anggrita Salsabila Ramadhia ◽  
Harna Harna ◽  
Mertien Sa'pang ◽  
Nadiyah Nadiyah

Background: Adequate micronutrients intake is essential to ensure the immune function. Certain populations may have insufficient intake of micronutrients, and in situations that increase the demand for example infections, stress, and pollution that decrease the body's stores of micronutrients, putting them at risk of deficiency and may impair immunity. Several researchs related to micronutrient intake, nutritional status, sleep duration are still contradictory results in showing the relationship with immunity.Objectives: To determine the relationship between micronutrient intake, sleep duration, body mass index and the immune status of Balitbang Hukum dan HAM employees.Methods: This type of research is an observational study with a cross sectional approach. The sampling technique used was simple random sampling technique. The samples taken were 47 people.Results: Median intake of micronutrient vitamin A 1024.5 mcg, vitamin C 208.3 mg, vitamin D 1.4 mcg, vitamin E 3.5 mg, iron 5.1 mg, zinc 4.2 mg. Meanwhile, the median sleep duration was 6 hours and the median body mass index was 22.2 kg / m2. The intake of micronutrients with immune status has a p value> 0.05. Sleep duration with immune status has a p value <0.05 with a negative relationship direction. Body mass index with immune status has a p value> 0.05.Conclusion: There is no relationship between micronutrient intake and body mass index with immune status, meanwhile there is a relationship between sleep duration and immune status of Balitbang Hukum dan HAM employees.Keywords : Micronutrient intake; Sleep duration; Body mass index; Immune status


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