scholarly journals Rapid Transformational Therapy (RTT): An Emerging Non-invasive Therapeutic Modality

2021 ◽  
Vol 7 (2) ◽  
pp. 13-14
Author(s):  
Savitha Raveendran ◽  
Chandrasekaran Kaliaperumal
Keyword(s):  
Therapeutic Modality ◽  
Non Invasive

P04.22 Tumor treating fields in high-grade glioma patients: A retrospective single-center study

2021 ◽  
Vol 23 (Supplement_2) ◽  
pp. ii23-ii23
Author(s):  
R Lucaciu ◽  
B Suchorska ◽  
M Wettig ◽  
S Jung ◽  
M Scholz
Keyword(s):  
Promoter Methylation ◽  
Daily Life ◽  
Methylation Status ◽  
Mgmt Promoter Methylation ◽  
Therapeutic Modality ◽  
High Grade ◽  
Newly Diagnosed ◽  
Non Invasive ◽  
Tumor Treating Fields ◽  
Mgmt Promoter

Abstract BACKGROUND Tumor-treating fields (TTFields) are a modern anti-mitotic, non-invasive therapy for the treatment of patients with recurrent and newly diagnosed glioblastoma multiforme (GBM). In Europe, Optune® recieved in 2015 the CE certification. TTFields are a low-intensity (1–3 V/cm) approved therapeutic modality using a non-invasive application of intermediate frequency (200 kHz) alternating electric fields through four transducer arrays directly applied to the skin. The EF-14 study has shown that the addition of TTFields to temozolomide chemotherapy in patients with newly diagnosed GBM significantly improved overall survival (OS) and progression-free survival (PFS) without additional adverse events, apart from mild to moderate skin irritations (Stupp et al., JAMA 2017). MATERIAL We retrospectively analyzed data from TTFields-treated patients (2015–2020) that were treated at our department. Patient characteristics such as MGMT promoter methylation status, age, and diagnosis, as well as treatment duration and TTFields therapy usage, were evaluated for this study. RESULTS 29 patients were treated with TTFields therapy between 2015 and 2020 at our hospital. Most patients received TTFields as primary treatment together with temozolomide maintenance therapy. In detail, 48% of patients were diagnosed with newly diagnosed GBM, 41% received TTFields therapy after tumor recurrence and 10% were diagnosed with other high-grade gliomas. In summary, patients could integrate TTFields therapy into their daily life and showed high adherence to the therapy.Particularly, one of our patients (with MGMT-promoter methylation positive) receives TTFields therapy now for almost 1229 days (approx. 41 months) and is still on therapy. Additionally, this patient shows a high usage rate of 86% indicating well integration of the therapy into daily life. CONCLUSION Taken together, our data provided the outcomes of using TTFields together with chemotherapy in the treatment of recurrent and newly diagnosed GBM in our department. Therapy with TTFields has been showing to provide significant clinical benefit for GBM patients.

scholarly journals Pulmonary Delivery of Biological Drugs

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1025
Author(s):  
Wanling Liang ◽  
Harry W. Pan ◽  
Driton Vllasaliu ◽  
Jenny K. W. Lam
Keyword(s):  
Pulmonary Delivery ◽  
High Specificity ◽  
Therapeutic Modality ◽  
Systemic Delivery ◽  
Biological Drugs ◽  
Onset Of Action ◽  
Non Invasive ◽  
Inhalation Devices ◽  
Rapid Absorption ◽  
Immense Potential

In the last decade, biological drugs have rapidly proliferated and have now become an important therapeutic modality. This is because of their high potency, high specificity and desirable safety profile. The majority of biological drugs are peptide- and protein-based therapeutics with poor oral bioavailability. They are normally administered by parenteral injection (with a very few exceptions). Pulmonary delivery is an attractive non-invasive alternative route of administration for local and systemic delivery of biologics with immense potential to treat various diseases, including diabetes, cystic fibrosis, respiratory viral infection and asthma, etc. The massive surface area and extensive vascularisation in the lungs enable rapid absorption and fast onset of action. Despite the benefits of pulmonary delivery, development of inhalable biological drug is a challenging task. There are various anatomical, physiological and immunological barriers that affect the therapeutic efficacy of inhaled formulations. This review assesses the characteristics of biological drugs and the barriers to pulmonary drug delivery. The main challenges in the formulation and inhalation devices are discussed, together with the possible strategies that can be applied to address these challenges. Current clinical developments in inhaled biological drugs for both local and systemic applications are also discussed to provide an insight for further research.

An enhanced chemotherapeutic effect facilitated by sonication of MSN

2017 ◽  
Vol 46 (35) ◽  
pp. 11875-11883 ◽  
Author(s):  
Yi Ding ◽  
Ziyi Song ◽  
Qian Liu ◽  
Shaohua Wei ◽  
Lin Zhou ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Therapeutic Modality ◽  
Sonodynamic Therapy ◽  
Non Invasive ◽  
Chemotherapeutic Effect

Sonodynamic therapy (SDT) is a non-invasive therapeutic modality for cancer treatment.

scholarly journals Focused Ultrasound Effects on Osteosarcoma Cell Lines

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Valentina Agnese ◽  
Viviana Costa ◽  
Gian Luca Scoarughi ◽  
Cristiano Corso ◽  
Valeria Carina ◽  
...  
Keyword(s):  
Cell Lines ◽  
Focused Ultrasound ◽  
Acoustic Power ◽  
High Intensity Focused Ultrasound ◽  
Acoustic Energy ◽  
Therapeutic Modality ◽  
Osteosarcoma Cell ◽  
Non Invasive ◽  
Focal Area ◽  
The Impact

MRI guided Focused Ultrasound (MRgFUS) has shown to be effective therapeutic modality for non-invasive clinical interventions in ablating of uterine fibroids, in bone metastasis palliative treatments, and in breast, liver, and prostate cancer ablation. MRgFUS combines high intensity focused ultrasound (HIFU) with MRI images for treatment planning and real time thermometry monitoring, thus enabling non-invasive ablation of tumor tissue. Although in the literature there are several studies on the Ultrasound (US) effects on cell in culture, there is no systematic evidence of the biological effect of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) treatment on osteosarcoma cells, especially in lower dose regions, where tissues receive sub-lethal acoustic power. The effect of MRgFUS treatment at different levels of acoustic intensity (15.5-49 W/cm2) was investigated on Mg-63 and Saos-2 cell lines to evaluate the impact of the dissipation of acoustic energy delivered outside the focal area, in terms of cell viability and osteogenic differentiation at 24 h, 7 days, and 14 days after treatment. Results suggested that the attenuation of FUS acoustic intensities from the focal area (higher intensities) to the “far field” (lower intensities) zones might determine different osteosarcoma cell responses, which range from decrease of cell proliferation rates (from 49 W/cm2to 38.9 W/cm2) to the selection of a subpopulation of heterogeneous and immature living cells (from 31.1 W/cm2to 15.5 W/cm2), which can clearly preserve bone tumor cells.

scholarly journals Obstructive Sleep Apnea: An overview

2015 ◽  
Vol 7 (1) ◽  
pp. 19-22
Author(s):  
Mala Ram Manohar ◽  
Juhi Talesra
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Lifestyle Modification ◽  
Upper Airway ◽  
Therapeutic Modality ◽  
Oral Appliances ◽  
Upper Airway Surgery ◽  
Non Invasive ◽  
Obstructive Sleep ◽  
Short Time

Abstract Obstructive sleep apnea, is a common disorder that is characterized by repetitive partial or complete cessation of air flow, associated with oxy-hemoglobin desaturation and increased effort to breath. Treatment of obstructive sleep apnea can be divided into four general categories. These include: lifestyle modification, upper airway surgery, oral appliances, and continuous positive airway pressure (CPAP). Although the CPAP provides the most reliable therapeutic modality, it is the most cumbersomeone. Many patients, particularly young non-apneic snorers, find it unappealing, difficult to tolerate, and unacceptable. The only other non-invasive alternative, which can producefavourable results within a short time, is oral appliances. How to cite this article Manohar MR, Talesra J. Obstructive Sleep Apnea: An overview. CODS J Dent 2015;7:19-22

scholarly journals The Hanger Reflex: An Inexpensive and Non-invasive Therapeutic Modality for Dystonia and Neurological Disorders

2020 ◽  
Vol 60 (11) ◽  
pp. 525-530
Author(s):  
Takashi ASAHI ◽  
Takuto NAKAMURA ◽  
Michi SATO ◽  
Yuki KON ◽  
Hiroyuki KAJIMOTO ◽  
...  
Keyword(s):  
Neurological Disorders ◽  
Therapeutic Modality ◽  
Non Invasive

scholarly journals The Photomodulation Activity of Metformin Against Oral Microbiome

2019 ◽  
Vol 10 (3) ◽  
pp. 241-250
Author(s):  
Shima Afrasiabi ◽  
Maryam Pourhajibagher ◽  
Abbas Bahador
Keyword(s):  
Antibiotic Resistance ◽  
Photodynamic Therapy ◽  
Cancer Patients ◽  
Inflammatory Diseases ◽  
Systemic Disease ◽  
Oral Microbiome ◽  
Therapeutic Modality ◽  
Antidiabetic Drug ◽  
Non Invasive ◽  
Supporting Structures

Periodontitis is one of the most common inflammatory diseases of the periodontium, which results in the inflammatory destruction of supporting structures around teeth and is closely associated with the development of systemic disease. Due to a wide variety of antibiotic resistance periodontopathic bacteria, photodynamic therapy (PDT) is a non-invasive adjunctive therapeutic modality that is capable of destroying the whole range of microbes. Metformin (Metf) is an antidiabetic drug, and recent studies suggest that cancer patients who receive Metf and are exposed to radiotherapy and chemotherapy show better outcomes. Our surveys in this review introduce Metf as a potent stimulus in increasing the efficacy of PDT in the induction of destruction in microbial cells.

Coronary flow responses to exercise training: further evidence of the benefit of an underutilized therapeutic modality

2005 ◽  
Vol 109 (3) ◽  
pp. 265-266
Author(s):  
Thomas H. Marwick
Keyword(s):  
Exercise Training ◽  
Vascular Function ◽  
Coronary Flow ◽  
Small Animal ◽  
Therapeutic Modality ◽  
Favourable Effect ◽  
Flow Measurements ◽  
Beneficial Effects ◽  
Non Invasive ◽  
Flow Reserve

Inactivity is associated with endothelial dysfunction and the development of cardiovascular disease. Exercise training has a favourable effect in the management of hypertension, heart failure and ischaemic heart disease. These beneficial effects are probably mediated through improvements of vascular function and, in this issue of Clinical Science, Hägg and co-authors propose a coronary artery effect. The use of a Doppler technique for non-invasive assessment of coronary flow reserve in a small animal model is an exciting aspect of this study. If feasible in the hands of other investigators, the availability of sequential coronary flow measurements in animal models may help improve our understanding of the mechanisms of disorders of the coronary circulation.

X-ray microtomography

1988 ◽  
Vol 46 ◽  
pp. 998-999
Author(s):  
H.W. Deckman ◽  
B.F. Flannery ◽  
J.H. Dunsmuir ◽  
K.D' Amico
Keyword(s):  
Computed Tomography ◽  
Internal Structure ◽  
Imaging Technique ◽  
Three Dimensional ◽  
Tissue Structure ◽  
Individual Element ◽  
X Ray ◽  
Non Invasive ◽  
Panoramic Imaging ◽  
Three Dimensional Images

We have developed a new X-ray microscope which produces complete three dimensional images of samples. The microscope operates by performing X-ray tomography with unprecedented resolution. Tomography is a non-invasive imaging technique that creates maps of the internal structure of samples from measurement of the attenuation of penetrating radiation. As conventionally practiced in medical Computed Tomography (CT), radiologists produce maps of bone and tissue structure in several planar sections that reveal features with 1mm resolution and 1% contrast. Microtomography extends the capability of CT in several ways. First, the resolution which approaches one micron, is one thousand times higher than that of the medical CT. Second, our approach acquires and analyses the data in a panoramic imaging format that directly produces three-dimensional maps in a series of contiguous stacked planes. Typical maps available today consist of three hundred planar sections each containing 512x512 pixels. Finally, and perhaps of most import scientifically, microtomography using a synchrotron X-ray source, allows us to generate maps of individual element.

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