Antioxidants with Multivitamin and Mineral Supplementation Attenuates Chemotherapy or Radiotherapy-induced Oxidative Stress in Cancer Patients

Abstract Purpose Over the past several decades, research has suggested reactive oxygen species act as cofactors for cervical cancer development. The aim of this study is to evaluate the antioxidant and lipid peroxidation status in cervical cancer patients in Bangladesh. Methods From December 2017 to 2018, a cross-sectional observational study was conducted on 50 cervical cancer patients and 50 controls. Plasma levels of lipid peroxidation and total antioxidant capacity were measured. The Student’s t test was used for statistical analysis. P values less than 0.05 were taken as a level of significance. Results There was a significant reduction in total antioxidant levels in patients with cervical cancer, 972.77 ± 244.22 SD µmol equivalent to ascorbic acid/L, compared to normal controls, 1720.13 ± 150.81 SD µmol equivalent to ascorbic acid/L (P < 0.001). Levels of lipid peroxidation were found to be significantly higher in cervical cancer, 7.49 ± 2.13 SD µmol/L, than in women without cervical cancer, 3.28 ± 0.58 SD µmol/L (P < 0.001). The cervical cancer patients had significantly higher levels of oxidative stress index (0.83 ± 0.31) in comparison to controls (0.19 ± 0.04) (P < 0.001). Conclusion There was an increased oxidative stress index due to imbalance between lipid peroxidation generation and total antioxidant capacity in cervical cancer patients. Further studies are needed to explore the role of oxidative stress as a cofactor for cervical carcinogenesis.

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Oxidative Stress and Cognitive Alterations Induced by Cancer Chemotherapy Drugs: A Scoping Review

Antioxidants ◽

10.3390/antiox10071116 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1116

Author(s):

Omar Cauli

Keyword(s):

Oxidative Stress ◽

Cancer Patients ◽

Repeated Administration ◽

Caffeic Acid Phenethyl Ester ◽

Scientific Basis ◽

Clinical Settings ◽

Chemotherapy Drugs ◽

Scientific Attention ◽

The Brain ◽

Cognitive Alterations

Cognitive impairment is one of the most deleterious effects of chemotherapy treatment in cancer patients, and this problem sometimes remains even after chemotherapy ends. Common classes of chemotherapy-based regimens such as anthracyclines, taxanes, and platinum derivatives can induce both oxidative stress in the blood and in the brain, and these effects can be reproduced in neuronal and glia cell cultures. In rodent models, both the acute and repeated administration of doxorubicin or adriamycin (anthracyclines) or cisplatin impairs cognitive functions, as shown by their diminished performance in different learning and memory behavioural tasks. Administration of compounds with strong antioxidant effects such as N-acetylcysteine, gamma-glutamyl cysteine ethyl ester, polydatin, caffeic acid phenethyl ester, and 2-mercaptoethane sulfonate sodium (MESNA) counteract both oxidative stress and cognitive alterations induced by chemotherapeutic drugs. These antioxidant molecules provide the scientific basis to design clinical trials in patients with the aim of reducing the oxidative stress and cognitive alterations, among other probable central nervous system changes, elicited by chemotherapy in cancer patients. In particular, N-acetylcysteine and MESNA are currently used in clinical settings and are therefore attracting scientific attention.

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Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy

Nutrition ◽

10.1016/j.nut.2005.06.003 ◽

2006 ◽

Vol 22 (2) ◽

pp. 136-145 ◽

Cited By ~ 106

Author(s):

Giulia Gramignano ◽

Maria Rita Lusso ◽

Clelia Madeddu ◽

Elena Massa ◽

Roberto Serpe ◽

...

Keyword(s):

Quality Of Life ◽

Oxidative Stress ◽

Nutritional Status ◽

Cancer Patients ◽

Advanced Cancer ◽

Anticancer Therapy ◽

Advanced Cancer Patients ◽

Related Quality

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Roles of Superoxide dismutase(SOD) , Malondialdehyde (MDA), 8-iso-prostaglandinF2α ( 8-iso-PGF2α)as oxidative stress in development and progression of Brest cancer in Iraqi females patients

Al-Qadisiyah Journal Of Pure Science ◽

10.29350/jops.2020.25.1.1053 ◽

2020 ◽

Vol 25 (1) ◽

pp. 1-4

Author(s):

Ferdous Abbas Jabir ◽

Ahmed Sabah Shaker

Keyword(s):

Breast Cancer ◽

Oxidative Stress ◽

Cancer Patients ◽

Antioxidant Defenses ◽

Blood Levels ◽

P Value ◽

Oxygen Species ◽

Breast Cancer Patients ◽

Markers Of Oxidative Stress ◽

The Mean

Oxidative stress occurs as a result of disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses. Markers of oxidative stress were measured the markers of oxidative stress in breast cancer patients after diagnosis of breast cancer and compared these plasma blood levels controls This study was conducted to three markers of oxidative stress ;these are (SOD) enzyme ,malondialdehyde (MDA)and8-iso-prostaglandinF2α plasma of patients with breast cancer and compare with controls .In this study ; the mean MDA (ng/ml) levels for the breast cancer patients and the controls were55.91±3.31 and40.61±3.76 respectively, while the SOD (pg/ml) levels were1530.37±80.4 and1851.4 9±93.65 respectively and the 8-iso-PGF2α (ng/ml ) levels were 40.16±3.31 and 30.16±2.34 difference of the mean were statistically significant (p value <0.05).

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The effect of antioxidants in Ehrlich Ascites Cancer

Cellular and Molecular Biology ◽

10.14715/cmb/2021.67.2.4 ◽

2021 ◽

Vol 67 (2) ◽

pp. 20-24

Author(s):

Seher Yılmaz ◽

Adem Tokpınar ◽

Ece Eroğlu ◽

Şükrü Ateş ◽

Rabbia Zahid ◽

...

Keyword(s):

Oxidative Stress ◽

Cancer Patients ◽

Cell Transformation ◽

Cancer Chemoprevention ◽

Full Potential ◽

Functional Screening ◽

Molecular Oncology ◽

Underlying Mechanisms ◽

Antioxidant Supplement ◽

Antioxidant Supplements

A fundamental goal in molecular oncology is to unravel the underlying mechanisms which cause the cell transformation. In line with this approach, genome-wide functional screening approaches have revealed exciting insights into heterogeneous nature of cancer. Rapidly expanding horizons of research have unraveled myriad of pathways which play instrumental role in carcinogenesis and metastasis. Oxidative stress has also been reported to be significantly involved in cancer onset and progression. In line with this approach, oxidative stress modulating chemicals have always been sharply divided into antioxidants and oxidative stress-inducing agents. Conceptual and experimental advancements have enabled us to critically analyze full potential of these two different groups of chemicals in cancer chemoprevention. Different antioxidants are currently being analyzed in different phases of clinical trials. Although it has been reported in the literature that antioxidant supplements reduce tumor cells in some tumors or cause volume reduction in solid tumor sizes, there is no definite consensus. Therefore, an antioxidant supplement guideline based on more detailed clinical research and as a result of these is needed to achieve the best care for cancer patients and to avoid risky treatments for cancer patients.

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Pro-inflammatory cytokines and oxidative stress/antioxidant parameters characterize the bio-humoral profile of early cachexia in lung cancer patients

Oncology Reports ◽

10.3892/or.18.6.1521 ◽

2007 ◽

Cited By ~ 1

Author(s):

Nicoletta Fortunati ◽

Roberta Manti ◽

Nadia Birocco ◽

Mariateresa Pugliese ◽

Enrico Brignardello ◽

...

Keyword(s):

Oxidative Stress ◽

Lung Cancer ◽

Cancer Patients ◽

Inflammatory Cytokines ◽

Lung Cancer Patients ◽

Antioxidant Parameters ◽

And Oxidative Stress ◽

Pro Inflammatory Cytokines

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Oxidative stress and plasma lipoproteins in cancer patients

Einstein (São Paulo) ◽

10.1590/s1679-45082014rc3110 ◽

2014 ◽

Vol 12 (4) ◽

pp. 480-484 ◽

Cited By ~ 3

Author(s):

Fernanda Maria Machado Maia ◽

Emanuelly Barbosa Santos ◽

Germana Elias Reis

Keyword(s):

Oxidative Stress ◽

Lipid Profile ◽

Total Cholesterol ◽

Cancer Patients ◽

Thiobarbituric Acid ◽

Plasma Lipoproteins ◽

Cross Sectional ◽

Patients With Cancer ◽

Group 2 ◽

Group 1

Objective To evaluate the relation between oxidative stress and lipid profile in patients with different types of cancer.Methods This was an observational cross-sectional. A total of 58 subjects were evaluated, 33 males, divided into two groups of 29 patients each: Group 1, patients with cancer of the digestive tract and accessory organs; Group 2 patients with other types of cancers, all admitted to a public hospital. The plasma levels (lipoproteins and total cholesterol, HDL, and triglycerides, for example) were analyzed by enzymatic kits, and oxidative stress based on thiobarbituric acid-reactive substances, by assessing the formation of malondialdehyde.Results In general the levels of malondialdehyde of patients were high (5.00μM) as compared to 3.31μM for healthy individuals. The median values of lipids exhibited normal triacylglycerol (138.78±89.88mg/dL), desirable total cholesterol values (163.04±172.38mg/dL), borderline high LDL (151.30±178.25mg/dL) and low HDL (31.70±22.74mg/dL). Median HDL levels in Group 1 were lower (31.32mg/dL) than the cancer patients in Group 2 (43.67mg/dL) (p=0.038). Group 1 also showed higher levels of oxidative stress (p=0.027).Conclusion The lipid profile of patients with cancer was not favorable, which seems to have contributed to higher lipid peroxidation rate, generating a significant oxidative stress.

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