scholarly journals Risk Factors for Relapse of Human Brucellosis

2015 ◽  
Vol 8 (7) ◽  
pp. 77 ◽  
Author(s):  
Mohammad Reza Hasanjani Roushan ◽  
Zahra Moulana ◽  
Zeinab Mohseni Afshar ◽  
Soheil Ebrahimpour

<p><strong>BACKGROUND &amp; PROPOSE: </strong>Brucellosis is serious disease around the world, especially in underdeveloped countries. It’s clinical manifestations is extensive.<strong> </strong>Thus diagnosis and treatment of this infection have difficulties, in among them, relapse is a great problem. This study aimed to evaluate risk factors of relapse after treatment in patients.</p><p><strong>METHODS: </strong>It is a descriptive-analytic study from 1990 to 2014, in Ayatolla Rohani hospital in Babol, Iran. We studied 980 patients with brucellosis. The studied community included patients infected with brucellosis and the required information was gathered based on their hospital files. The base for recognizing Malta fever were clinical symptoms and Para-clinical sign congruent with infection like as, titer SAT&gt;1:320 and 2-ME&gt;1:160. Patients with relapse and patients without relapse were placed separately in two groups. The data were statistically compared with Spss 16, by Chi-square and Cox –regression tests.</p><p><strong>RESULTS: </strong>Based on this study, treatment regimen is a preventive factor (P=0.000). Moreover, Based on some statistical methods, regimens no. 3 and 4 were introduce preventive factors (P=0.001) and (P=0.004). It should also be noted that findings the same statistical model, factors like gender, age, residence, professional contacts, complications and delay in treatment were also analyzed but none of them are considered as preventive factors<strong>.</strong></p><p><strong>CONCLUSION: </strong>Since the main and exact reason for Malta fever’ relapse is not recognized yet, anticipation of relapse is beneficent for treatment of infection.</p>

2018 ◽  
Vol 58 (4) ◽  
pp. 180-5
Author(s):  
Putu Diah Vedaswari ◽  
Ketut Dewi Kumara Wati ◽  
I Gusti Lanang Sidiartha ◽  
I Gusti Ayu Putu Eka Pratiwi ◽  
Hendra Santoso ◽  
...  

Background Highly active antiretroviral therapy (HAART) has been reported to improve growth, especially in the first 2 years of treatment. It is not clear whether catch up growth is maintained after 2 years of HAART. Objective To assess growth in stunted children with HIV after 3 years of HAART and analyze possible risk factors for non-reversal of stunting. Methods This study was done from May 2016 to April 2017 to follow children with HIV who started HAART between January 2009 and April 2014, and continued for 3 years. Inclusion criteria were children with HIV, aged < 18 years, compliance to the regimen, and stunting. Exclusion criteria were patients lost to follow up or who died prior to 3 years of HAART. Non-reversal of stunting was defined as HAZ ≤ -2SD after 3 years of HAART. Possible risk factors for non-reversal were analyzed using Chi-square test with P<0.05, as well as risk ratio (RR) and 95% confidence intervals (CI). Results Of 150 HIV-infected pediatric patients, 115 were on HAART and 55 (47.8%) were stunted at HAART initiation. Of the 55 stunted and HAART-treated children, 31 (56.4%) were male. Baseline median age was 3.6 years (interquartile range 0.37-8.48). Non-reversal occurred in 32 (58.2%) subjects. Multivariate Cox regression model analysis showed predictors of non-reversal after 3 years of HAART to be age >2 years (RR 16.05; 95%CI 2.89 to 89.02; P=0.002) and HIV stage III-IV (RR 8.93; 95%CI 1.47 to 54.37; P=0.017). Conclusion HAART initiation at age >2 years and HIV clinical stage III-IV at diagnosis are risk factors for non-reversal of stunting after 3 years of HAART.


2021 ◽  
pp. 96-101
Author(s):  
O. R. Trutiak ◽  
O. L. Lychkovska ◽  
R. R. Holovyn ◽  
M. I. Dats-Opoka

Bronchial asthma (BA) is a common chronic pathology of the lower respiratory tract in children. The first manifestations of the disease can begin at any age, but the clinical features, of the course, are different in different periods of childhood. Manifestations and course of asthma may disappear or progress with age. Therefore, it is likely that there are differences in the pathophysiology, inflammatory response of the body and the features of the clinic of asthma in children of different ages, which affects the diagnosis and treatment. The aim of the study was to determine the features of clinical symptoms and the influence of risk factors for asthma on its occurrence in children of different ages. Materials and methods. We analyzed the anamnesis and clinical symptoms of 57 children aged 3 to 18 years, who were treated from September 2020 to June 2021 in the Lviv Regional Children's Clinical Hospital “OHMATDYT” and in the Lviv Municipal City Children's Clinical Hospital. The age groups did not differ statistically in the severity of asthma (P> 0.05). Thus, in group 1 was 1 patient (9.09%) with mild form, 1 patient (9.09%) - moderate persistent form, 8 patients (72.73%) - with severe persistent form. Among patients of age group 2 was 1 patient (3.85%) with mild persistent form, 3 children (11.54%) - moderate and 21 children (80.77%) - with severe persistent form. In group 3 was 1 patient (5%) with a mild persistent form, 6 patients (30%) - moderate and 12 children (80%) - with a severe persistent form. The vast majority of patients were boys (84.21 ± 4.83%). All patients underwent general clinical examinations, spirometry, and allergy tests. We used the clinical-anamnestic method to perform the tasks of the work, which consisted in collecting a detailed somatic and genealogical anamnesis during the parents` questionnaire. Physical development of children was assessed using centile tables. Statistics were evaluated by calculating Student's t-test and Pearson's consistency test. Preschool children with asthma were more likely to experience shortness of breath during exercise and a wet low-yielding cough, and children of primary and secondary school age were more characterized by concomitant allergic rhinitis. Autumn was more unfavorable period for the exacerbation of clinical manifestations of asthma in children of Lviv region was period. We did not find correlation of birth weight on the timing of asthma. However, a burdensome obstetric history contributed to the early development of clinical manifestations of asthma. Preschool children were more likely to be exposed to nicotine during the antenatal period and had a shorter duration of breastfeeding, which may be a probable risk factor for asthma in preschool children. In 77% of children from different age groups were burdened with a history of allergies, with 66% of cases more pronounced in the maternal line. An analysis of physical development revealed that most preschool children were overweight. Conclusions. Asthma has features of clinical symptoms in children of different ages - shortness of breath during exercise and whooping cough are characteristic of preschool children, and concomitant chronic persistent rhinitis - for older age groups. Seasonal exacerbations are characteristic of asthma in children; in particular, the autumn period is more unfavorable, common for asthmatics in children of all ages among patients in Lviv region. Maternal smoking during pregnancy has a significant effect on the risk of developing asthma in children. Also, a burdened maternal allergy history and overweight child contributes to the development of asthma in children.


Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
B. Delia Johnson ◽  
C. Noel Bairey Merz ◽  
Ricardo Azziz ◽  
Glenn D Braunstein ◽  
Leslee J Shaw ◽  
...  

Background: Menstrual cycling irregularity is being associated with greater frequency of diabetes and adverse cardiovascular (CV) events, suggesting a mechanistic link between ovarian dysfunction, CAD risk factors, and CAD. Confirmation of this link and potential explanatory mechanism(s) have not been established. Methods: We compared 686 postmenopausal women with and without a history of irregular cycles who were undergoing coronary angiography for suspected ischemia and enrolled in the WISE study. Coronary angiography was assessed by a core laboratory, and the women were prospectively followed for a median of 5.9 years. Chi square and rank sums analyses were used to compare the women on the presence and severity of CAD, CAD risk factors, and CV events. Multivariate Cox regression, adjusting for angiographic CAD and CAD risk factors was used to define time to death, MI, stroke, and angina hospitalization. Results: Overall mean age was 62, 18% were non-white, 130 (19%) reported a history of irregular cycles, and 42% had CAD (≥ 50% stenosis). Women with irregular cycles were younger (p=0.01) but did not exhibit more diabetes, obesity, or metabolic syndrome than those with regular cycles. They became menopausal at a younger age (42 ±10 vs 46 ±8, p=0.001) and had more frequent hysterectomy or oophorectomy (both p<0.01). Women with irregular cycles had a similar adjusted prevalence and severity of angiographic CAD compared to those without irregular cycles, yet had a doubled risk for MI (6% vs. 3%, p=0.02) and higher angina hospitalization rate (34% vs. 28%, p=0.01). No differences were found for the incidence of stroke or death. The relationship was maintained in risk-adjusted models controlling for metabolic syndrome, ethnicity and angiographic CAD severity (p=0.01 for MI and p=0.01 for angina hospitalization). Conclusion: Although less commonly applied, a history of menstrual cycling irregularity may be an important clinical marker of downstream risk, which is not immediately explained by the presence or severity of CAD risk factors or angiographic CAD. Additional, non-CAD risk factors, such as hormonal, inflammatory and thrombotic variables, may play a role mechanistically in the link between menstrual irregularity and adverse events.


2004 ◽  
Vol 132 (6) ◽  
pp. 1109-1114 ◽  
Author(s):  
M. R. HASANJANI ROUSHAN ◽  
M. MOHREZ ◽  
S. M. SMAILNEJAD GANGI ◽  
M. J. SOLEIMANI AMIRI ◽  
M. HAJIAHMADI

The epidemiological features and clinical manifestations of adult cases of brucellosis admitted to the Department of Infectious Diseases, Babol Medical University, Iran from 1997 to 2002 were investigated. Of 469 cases, 267 (56·9%) were males. The mean age of cases was 36·9±15 years. Most (60·8%) were from rural areas. Two thirds of cases (306, 66·3%) presented during spring or summer. Fresh cheese (22·4%), animal husbandry (11·3%), laboratory worker (8·1%) and veterinary profession (1·5%) were the main risk factors. Forty-five families (9·6%) had two cases. Sweating, fever, and arthralgia were the most frequent clinical symptoms. Complications were documented in 105 males (39·5%) and 41 females (20·3%, P=0·0001). Peripheral arthritis was seen in 24 (9%) males and 19 (9·4%) females, with knees and hips being the most common sites of infection. Sacroiliitis and spondylitis were seen in 28 (6%) and 32 (6·8%) cases respectively with spondylitis more common in males (P=0·023). Epididymo-orchitis was seen in 29 (10·9%) males. There were three cases each of endocarditis (0·6%) and neurological complications (0·6%). Most patients with brucellosis did not have any of the known risk factors for brucellosis. Thus consumption of unsafe dairy products could be the main route of infection. The disease manifested with a diversity of clinical manifestations and complications. Complications were more frequent in males than females.


2017 ◽  
Vol 57 (2) ◽  
pp. 63
Author(s):  
Clarissa Cita Magdalena ◽  
Budi Utomo ◽  
Retno Asih Setyoningrum

Background Miliary tuberculosis (TB) is a fatal form of tuberculosis with severe clinical symptoms and complications. The mortality rate from this disease remains high, therefore, it is important to identify the risk factors for miliary TB for early detection and treatment.Objective To identify risk factors for miliary tuberculosis in children.Methods A case-control study of children aged 0-14 years with miliary TB was conducted in Dr. Soetomo Hospital from 2010 to 2015. Data were taken from medical records. Case subjects were children with miliary TB, and control subjects were children with pulmonary TB . Patients with incomplete medical records were excluded. Case subjects were identified from the total patient population; control subjects were included by purposive sampling, with case:control ratio of 1:1. Potential risk factors were age, nutritional status, BCG immunization status, and history of contact with TB patients. Statistical analyses were done with Chi-square and logistic regression tests. P values < 0.05 were considered to be statistically significant.Results A total of 72 children were analyzed, with 36 case and 36 control subjects. Nutritional status had a significant associatation with miliary TB in children (OR 3.182; 95%CI 1.206 to 8.398; P=0.018) in both bivariate and multivariate analyses. The probability of a child with moderate or severe undernutrition developing miliary TB was 76.09%. Other factors were not significantly associated with miliary TB.Conclusion Nutritional status is significantly associated with miliary TB in children, and moderate or severe undernutrition increases the risk for developing miliary TB.


2021 ◽  
Author(s):  
Yunyun Liu ◽  
Jing Li ◽  
Zhibo Cheng ◽  
Guocai Xu ◽  
Yongpai Peng ◽  
...  

Abstract Purpose. We aimed to find prognostic factors for uterine serous cancer(USC) patients in a retrospective study.Methods. 51 USC patients between 2010-2020 were enrolled. All pathological specimens were reviewd. The research protocol was approved by Institutional Review Board and all patients were informed consent before the study began. Statistics were done using SPSS 25.0, T test and chi-square analyses were used to compare differences, the overall survival(OS) was estimated with Kaplan-Meier(KM) analysis, univariate and multivariate Cox regression analyses were utilized to find prognostic factors.Results. The median overall survival(OS) and progressive free survival(PFS) were 75.94 and 63.49 months, respectively. Diagnosed with diabetes mellitus(P=0.006, HR=6.792, 95%CI=1.726-26.722) and CA125>28U/ml(P=0.006, HR=7.136, 95%CI=1.780-28.607) before surgery were independent risk factors for OS, advanced FIGO stage(P=0.001, HR=10.628, 95%CI=2.894-39.026) and DM(P=0.003, HR=6.327, 95%CI=1.875-21.354) were independent factors for PFS. Age≤52, , tumor size≥2.5cm and cervical mucosal infiltration may indicate poor prognosis but were not independent risk factors. Hypertension patients with routine medical treatment tend to survive longer, but there was no statistical differences in OS and PFS compared to patients with normal blood pressure.Conclusion. In addition to surgical and adjuvant treatments, gynecologists should focus more on the comorbid conditions of USC patiens, especially for DM.


Author(s):  
Tariq Homoud Althagafi ◽  
Mona Abdullah Alharbi ◽  
Ashjan Nasser Bamarhool ◽  
Zahra Dheya Almajed ◽  
Leen Hani Natto ◽  
...  

Neonatal sepsis is a systemic disease caused by bacterial organisms, viral infections, or fungus that causes hemodynamic abnormalities and other clinical symptoms resulting in severe complications and may progress into mortality. Parturition can be used to diagnose organisms caused by the premature onset of sepsis in some cases, but only after an average of three days of life. Clinical manifestations of infection may also diagnose the organisms caused by the early onset of sepsis. Late sepsis can refer to any incident of sepsis from delivery to discharge in high-risk newborns, and the majority of them have been hospitalized for a lengthy period. Late-onset Guillain-Barré syndrome infections generally refer to the infections that occur between one week and up to three months post-labor. The precise load fraction for newborn sepsis varies by context, with differing load estimations between nations with varying lead levels. With the diversity of treatments utilized, explaining the degree of obstetric palsy is crucial and complicated. When comparing birthing sepsis rates, it is critical to understand if a tiny figure represents a total birth rate or another rate, such as a hospital admission number. As stated, it is critical to evaluate if population estimates based on the numbers of neonatal sepsis episodes have been recorded. This article aims to review the literature regarding neonatal sepsis from different aspects including, the etiology, risk factors, and different types and onset of neonatal sepsis.


Background and Aims: Coronavirus disease 2019 (COVID-19) is an emerging disease, whose first case was reported in December 2019, and rapidly affected the world. Therefore, the present study was conducted to investigate the frequency and factors associated with morbidity and mortality due to COVID -19 in Ghaen, Iran. Materials and Methods: This retrospective descriptive-analytical study used the information sources of the portal of Shohada Ghaen Hospital, Gaen, Iran, from March 2020 to December 2021, which was collected from 1,124 patients with suspected respiratory infection referring to the hospital. Data using Chi-square and Fisher's exact test for univariate relationships. Moreover, two-way logistic regression was used to investigate the causal relationships, and P<0.05 was considered statistically significant. Results: In this study, the mean age of participants (n=1,124) was obtained at 51.6±24.5 years, and 546 (48.6%) subjects had a positive COVID-19 test by reverse transcription polymerase chain reaction, among whom 65 (11.9%) cases passed away. Clinical symptoms of body aches, coughs, diarrhea, and shortness of breath were associated with a positive COVID-19 test. It was also revealed that habitat, diabetes, cardiovascular and lung diseases, age, and job were risk factors of COVID-19 infection, and hospitalization in the ICU and age were identified as risk factors for COVID-19-caused death (P<0.05). Conclusion: In the present study, cough and shortness of breath were found to be the most frequent symptoms among patients and deceased individuals. Since these symptoms may be associated with a worse prognosis, they require the special attention of medical staff. The findings of this study also showed that the elderly were more at risk of death from this disease than other age groups, which increased the need for more education and attention to this group of society.


2021 ◽  
Vol 8 ◽  
Author(s):  
Xiaoyuan Wei ◽  
Yu Min ◽  
Jiangchuan Yu ◽  
Qianli Wang ◽  
Han Wang ◽  
...  

Background: Sepsis, as one of the severe diseases, is frequently observed in critically ill patients, especially concurrent with diabetes. Whether admission blood glucose is associated with the prognosis, and outcome of septic patients is still debatable.Methods: We retrospectively reviewed and analyzed the demographic characteristics of septic patients in the Medical Information Mart for Intensive Care III (MIMIC III, version 1.4) between June 2001 and October 2012. The Chi-square and Fisher's exact tests were used for the comparison of qualitative variables among septic patients with different glucose levels and the 30-day mortality in septic patients with diabetes or not. Univariate and stepwise multivariate Cox regression analyses were used to determine the risk factors for 30-day mortality. Kaplan-Meier analysis was conducted to reveal the different 30-day survival probabilities in each subgroup.Results: A total of 2,948 septic patients (910 cases with diabetes, 2,038 cases without diabetes) were ultimately included in the study. The 30-day mortality was 32.4% (956/2,948 cases) in the overall population without any difference among diabetic and non-diabetic septic patients (p = 1.000). Admission blood glucose levels &lt;70 mg/dl were only observed to be significantly associated with the 30-day mortality of septic patients without diabetes (hazard ratio (HR) = 2.48, p &lt; 0.001). After adjusting for confounders, age &gt;65 years (HR = 1.53, p = 0.001), the Sequential Organ Failure Assessment (SOFA) score &gt;5 (HR = 2.26, p &lt; 0.001), lactic acid &gt;2 mmol/L (Lac, HR = 1.35, p = 0.024), and platelet abnormality (&lt;100 k/ul: HR = 1.49; &gt;300 k/ul: HR = 1.36, p &lt; 0.001) were the independent risk factors for 30-day mortality in septic patients with diabetes. In non-diabetes population, age &gt;65 years (HR = 1.53, p &lt; 0.001), non-White or non-Black patients (HR = 1.30, p = 0.004), SOFA score &gt;5 (HR = 1.56, p &lt; 0.001), blood glucose &lt;70 mg/dl (HR = 1.91, p = 0.003), anion gap (AG) &gt;2 mmol/L (HR = 1.60, p &lt; 0.001), Lac (HR = 1.61, p &lt; 0.001), urea nitrogen &gt;21 mg/dl (HR = 1.45, p = 0.001), alanine aminotransferase (ALT, HR = 1.31, p = 0.009), total bilirubin &gt;1.2 mg/dl (HR = 1.20, p = 0.033), and low hemoglobin (HR = 1.34, p = 0.001) were the independent risk factors for 30-day mortality.Conclusions: Our results indicate admission blood glucose, especially in terms of &lt;70 mg/dl, is the key signaling in predicting the worse 30-day survival probability of septic patients without diabetes, which could help clinicians to make a more suitable and precise treatment modality in dealing with septic patients.


2018 ◽  
Vol 8 (1) ◽  
pp. 10-13
Author(s):  
Deepak Adhikari ◽  
Rupesh Gautam ◽  
Sweta Moktan ◽  
Mukesh Mallik ◽  
Mamita Sakhakarmi

Introduction: Contrast-enhanced Computed Tomography (CECT) is an imaging technique to diagnose many clinical manifestations. Contrast media used in CECT can lead to contrast induced nephropathy (CIN). Hence, screening of serum creatinine (SCr) level prior to CECT is commonly practiced as it is considered to be an indicator for the risk of Contrast Induced Nephropathy (CIN). But, it adds up extra cost and also increases duration for investigation. The purpose of this study is to find out, if SCr screening can be skipped among certain group by medical history related to risk factors of CIN. Methodology: A total 250 patient SCr were obtained prior to CECT over period of 4 months between June 2016 to September 2016. Duplication in the samples was avoided. A survey of medical history regarding risk factors for CIN was taken in each case. Chi square test and odds ratio was applied for data analysis. Results: In this study 68% of total (250) patients were found to have normal SCr level without any risk factors for CIN and among 3% abnormal categorized patients (SCr ≥1.5mg/dl)) 71% (5 of 7) were identified with risk factors. Conclusions: The data suggests that screening SCr prior to CECT is significant only to those patients who acquire any of the identifiable risk factors for CIN. Those patients who are not identified with any of the associated risk factors, especially for renal disease, are not mandatory to obtain SCr value. This can reduce many challenges while checking patient’s creatinine status, such as patient’s booking delays, extra cost and time, additional pricking while taking blood sample. This practice can also increase the departmental throughput and efficiency of service.


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