Review analysis on phytochemical and biological activity studies on plants of Aquilegia L.

About 60-70 species of the Aquilegia L. genus used in Western and Eastern traditional medicine grown in the England, Scotland, Wales, Siberia and Canada. The Aquilegia L. genus is used to treat a variety of diseases, in particular, digestive organs dysfunctions as stomach ulcer, liver disease, as well as cancer, lung disease and rheumatic diseases.The phytochemical studies of Aquilegia L. genus have been started since the 1960s and currently 57 natural compounds isolated from 16 plant species. These include labdane diterpene - 2 (3.5%), cycloartane - 13 (22.8%), flavonoids - 22 (38.5%), alkaloids and nitrogen-containing compounds - 10 (17.5%) and phenolic acids, fatty acids. From these 19 new natural compounds belonging to cycloartane glycosides, labdane diterpene, flavoalkaloids and nitrile nitrogen compound have been identified. The presence of fla-voalkaloid can consider a specific characterization of Aqiulegia species.Antioxidative, hepatoprotective, antibacterial and anti-cancer activities of various extracts and some isolated pure compounds of few species have been studied.In Mongolia, there are five species of plants including A.sibirica Lam, A.viridiflora Pall, A.glandulosa Fisch, A.ganboldii Kamelin & Gubanov, A.turczaninovii Kamelin & Gubanov and their phytochemical and biological activity have not been studied yet. Удвалын (Aquilegia L.) төрлийн ургамлуудын химийн бүрдэл ба биологийн идэвхийн судалгааны тойм Хураангуй: Өрнө, дорнын анагаах ухаанд хэрэглэгддэг Удвалын төрлийн 60-70 орчим зүйл ургамал манай дэлхийн ихэвчлэн Англи, Шотланд, Уэльс, Сибирь, Канадын сэрүүн бүс нутгаар тархан ургадаг. Удвалын төрлийн ургамлууд нь олон төрлийн өвчнийг анагаахад ач тустай хэмээн уламжлалт анагаах ухаанд ходоодны шархлаа, хорт хавдар, элэгний өвчин, уушигны өвчин, хэрэх өвчний үед хэрэглэдэг.Удвалын төрлийн ургамлуудын фитохимийн судалгаа 1960-аад оны үеэс хийгдэж эхэлсэн бөгөөд одоогоор 16 зүйл ургамлаас 57 бага молекулт нэгдлийг ялгасан ба тэдгээрээс лабданы дитерпен - 2 (3.5%), циклоартанен - 13 (22.8%), флавоноид - 22 (38.5%), алкалоид ба нитрилийн уламжлалын нэгдэл - 10 (17.5%) болон фенолын хүчил, тосны хүчлийн ангиллын нэгдлүүд байна. Эдгээр нэгдлээс тритерпений ангиллын циклоартанений гликозидууд, лабданы дитерпен, нитрилийн уламжлалын азот агуулсан нэгдэл, флавоалкалоид зэрэг 19 байгалийн шинэ нэгдлийг ялгаж бүтэц байгууламжийг тогтоосон бөгөөд Удвалын зүйл ургамалд флавоалкалоид агуулагддаг онцлогтой.Мөн Удвалын зарим зүйл ургамлын төрөл бүрийн ханд, цэвэр нэгдлүүдийн антиоксидант, элэг хамгаалах, бактерийн эсрэг, хорт хавдрын эсрэг зэрэг биологийн идэвх судлагдсан байна.Манай оронд Удвалын төрлийн ургамлуудаас Сибирь удвал, Ногоон удвал, Шүүсэвчит удвал, Ганболдын удвал, Турчаниновын удвал зэрэг 5 зүйл ургамал ургадаг бөгөөд тэдгээрийн фитохими, биологийн идэвхийн судалгаа хараахан хийгдээгүй. Түлхүүр үгс: Удвал, флавоалкалоид, тритерпеноид, флавонол, биологийн идэвх

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STEROID CONJUGATES AS POTENTIAL ANTI-CANCER AGENTS

Russian Journal of Biotherapy ◽

10.17650/1726-9784-2019-19-1-22-52 ◽

2020 ◽

Vol 19 (1) ◽

pp. 22-52

Author(s):

V. A. Zolottsev ◽

A. S. Latysheva ◽

V. S. Pokrovsky ◽

I. I. Khan ◽

R. L. M. Almanza ◽

...

Keyword(s):

Biological Activity ◽

Natural Compounds ◽

The Past ◽

Anti Cancer ◽

Steroid Conjugates

The review is dedicated to results of investigations of steroid conjugates published predominantly over the past decade. It consists of three parts in which the data concerning biological activity of steroid conjugates with known drugs, steroid dimers, and steroid conjugates with some natural compounds, their fragments and related derivatives and analogs, are discussed. The structures of 231 steroid conjugates and their anti-cancer properties are presented.

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2,3-Dehydroderivatives of Silymarin Flavonolignans: Prospective Natural Compounds for the Prevention of Chronic Diseases

Proceedings ◽

10.3390/proceedings2019011021 ◽

2019 ◽

Vol 11 (1) ◽

pp. 21 ◽

Cited By ~ 2

Author(s):

Kateřina Valentová ◽

David Biedermann ◽

Vladimír Křen

Keyword(s):

Biological Activity ◽

Chronic Diseases ◽

Biological Activities ◽

Natural Compounds ◽

Oxidation Products ◽

Radical Scavengers ◽

Silybum Marianum ◽

Fruit Extract ◽

Anti Cancer

Silybum marianum fruit extract silymarin displays various biological activities, which are attributed mostly to its major component silybin. However, silymarin contain several other isomeric flavonolignans (isosilybin, silychristin, silydianin) and their oxidation products, the 2,3-dehydroflavonolignans (2,3-dehydrosilybin, 2,3-dehydrosilychristin, 2,3-dehydrosilydianin). The latter compounds were found to be 1-2 orders of magnitude more efficient radical scavengers, reducing, chelating, cytoprotective, anti-aging, anti-cancer and anti-angiogenic agents than the parent flavonolignans. Although 2,3-dehydroflavonolignans occur in silymarin as minorities, they seem to be responsible for the majority of the biological activity and therefore have potential for the prevention of chronic diseases.

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Review analysis on phytochemical study of Heracleum L.

Bulletin of Institute of Chemistry and Chemical Technology, Mongolian Academy of Sciences ◽

10.5564/bicct.v0i8.1479 ◽

2020 ◽

pp. 55-62

Author(s):

Nomuun Ts ◽

Odontuya G

Keyword(s):

Biological Activity ◽

Kidney Disease ◽

Traditional Medicine ◽

Plant Species ◽

Natural Compounds ◽

Molecular Structures ◽

Phytochemical Study ◽

Review Analysis ◽

Coumarin Compounds ◽

Phytochemical Studies

Heracleum L. genus are used in traditional medicine area for the treatment of many disorders such as dissolving gallstones, kidney disease, gynecopathy, adenitis, anthrax, and stopping haemorrhage. The phytochemical studies of Heracleum L.genus have been started since the 1982s and currently 111 natural compounds isolated from 23 plant species. These includes coumarin - 71 (64%), flavonoid - 14 (12.6%), iridoid - 2 (1.8%), lignan - 3(2.7%), lipid - 7 (6.3%), polyacetylene - 3 (2.7%),phenylpropanoid - 1 (0.9%), and other class of compounds - 10 (9%). From these, 28 new natural compounds belonging to coumarins, iridoids and phenylpropanoid have been isolated and their molecular structures were elucidated. This genus is rich of coumarin compounds by phytochemical study. There are two specific Heracleum species, namely H.sibiricum L., and H.dissectum Ldb. that grow in Mongolia, although their phytochemistry and biological activity studies have not been performed yet. Балдарганы (Heracleum L.) төрлийн ургамлуудын химийн бүрэлдэхүүний судалгааны тойм Хураангуй: Балдарганы төрлийн ургамлуудыг олон төрлийн өвчнийг анагаахад тустай хэмээн уламжлалт анагаах ухаанд цөсний чулууг задлах, бөөрний өвчин, эмэгтэйчүүдийн өвчин, булчирхайн үрэвсэл, боом, хатиг анагаах, цус алдалтыг зогсооход хэрэглэдэг. Балдарганы төрлийн ургамлуудын химийн бүрэлдэхүүн, найрлагыг 1982 оноос судалж эхэлсэн бөгөөд одоогоор 23-н зүйл ургамлаас 111 хоёрдогч метаболитыг ялгасан ба эдгээр нь кумарин - 71 (64%), флавоноид - 14 (12.6%), иридоид - 2 (1.8%), лигнан - 3 (2.7%), липид - 7 (6.3%), фенилпропаноид - 1 (0.9%), полиацетилен - 3 (2.7%) болон бусад ангиллын нэгдлүүд - 10 (9%) юм. Эдгээрээс фенолт нэгдлийн ангиллын кумарин, фенилпропаноид, терпеноидын ангиллын иридоид зэрэг 28-н байгалийн шинэ нэгдлийг ялгаж бүтэц байгууламжийг тогтоожээ. Химийн судалгааны дүнд энэ төрлийн ургамалд кумарин зонхилон агуулагддаг байна. Манай оронд Балдарганы төрлийн ургамлуудаас Цуулбар балдаргана, Сибирь балдаргана гэсэн 2 зүйл ургадаг бөгөөд тэдгээрийн фитохими, биологийн идэвхийн судалгаа төдийлөн сайн хийгдээгүй байна. Түлхүүр үг: Балдаргана, кумарин, флавоноид, иридоид, фенилпропаноид

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ANTI-CANCER COMPOUNDS ISOLATED FROM SOFT CORAL SINULARIA CRUCIATA - ALCYONIIDAE

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2012.1.11 ◽

2012 ◽

pp. 84-89

Author(s):

Quoc Hung Vo ◽

Nguyen Phuong Nhi Doan ◽

Dinh Quynh Phu Nguyen ◽

Thi Dieu Tram Ho ◽

Thi Hoai Nguyen

Keyword(s):

Mass Spectrometry ◽

Soft Coral ◽

Normal Phase ◽

Ionization Mass ◽

Medical Field ◽

Bioactive Substances ◽

Anti Cancer ◽

The World ◽

Pure Compounds ◽

Layer Chromatography

Objectives: Nowadays, bioactive substances isolated from marine organisms which are abundant and varied in Vietnamese sea attracted more and more the attention of scientists in the world and Vietnam as well. We have studied on soft coral Sinularia cruciata – Alcyoniidae, which has never been studied in Vietnam before, to find substances which are useful in medical field, especially in anti-cancer therapy. Materials and method: Specimens of soft coral Sinularia cruciata were collected from Con Co, Quang Tri province in May 2011. Pure compounds were isolated by using Thin Layer Chromatography; Column Chromatography normal phase and inverse phase; Shephadex LH 20. Structures of them were determined by spectral data of Nuclear Magnetic Resonance (NMR), Electrospray Ionization Mass Spectrometry (ESI-MS). Results & Conclusion: Structures of 4 compounds were identified: (1) 5.8-epidioxycholest-6-en-3-ol (2) Cholesterol (3) 1-O-hexadecyl-glycerol (Chimyl alcohol) (4) Glycerol 1-O-octadecyl ether (Batyl alcohol). The substance (1) was demonstrated to have strong anti-cancer effects in previous study. Key words Sinularia cruciata, Alcyoniidae, 5,8-epidioxycholest-6-en-3-ol, soft coral, cancer.

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Role of Resveratrol in Modulating microRNAs in Human Diseases: From Cancer to Inflammatory Disorder

Current Medicinal Chemistry ◽

10.2174/0929867326666191212102407 ◽

2020 ◽

Vol 28 (2) ◽

pp. 360-376 ◽

Cited By ~ 7

Author(s):

Atefeh Amiri ◽

Maryam Mahjoubin-Tehran ◽

Zatollah Asemi ◽

Alimohammad Shafiee ◽

Sarah Hajighadimi ◽

...

Keyword(s):

Molecular Mechanisms ◽

Antioxidant Activities ◽

Natural Compounds ◽

Therapeutic Effects ◽

Inflammatory Disorder ◽

Inflammatory Disorders ◽

Therapeutic Modalities ◽

Anti Cancer ◽

Current Therapies ◽

Anti Inflammatory

: Cancer and inflammatory disorders are two important public health issues worldwide with significant socio.economic impacts. Despite several efforts, the current therapeutic platforms are associated with severe limitations. Therefore, developing new therapeutic strategies for the treatment of these diseases is a top priority. Besides current therapies, the utilization of natural compounds has emerged as a new horizon for the treatment of cancer and inflammatory disorders as well. Such natural compounds could be used either alone or in combination with the standard cancer therapeutic modalities such as chemotherapy, radiotherapy, and immunotherapy. Resveratrol is a polyphenolic compound that is found in grapes as well as other foods. It has been found that this medicinal agent displays a wide pharmacological spectrum, including anti-cancer, anti-inflammatory, anti-microbial, and antioxidant activities. Recently, clinical and pre-clinical studies have highlighted the anti-cancer and anti-inflammatory effects of resveratrol. Increasing evidence revealed that resveratrol exerts its therapeutic effects by targeting various cellular and molecular mechanisms. Among cellular and molecular targets that are modulated by resveratrol, microRNAs (miRNAs) have appeared as key targets. MiRNAs are short non-coding RNAs that act as epigenetic regulators. These molecules are involved in many processes that are involved in the initiation and progression of cancer and inflammatory disorders. Herein, we summarized various miRNAs that are directly/indirectly influenced by resveratrol in cancer and inflammatory disorders.

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Natural Compounds and Drug Discovery: Can Cnidarian Venom Play a Role?

Central Nervous System Agents in Medicinal Chemistry ◽

10.2174/1871524919666190227234834 ◽

2019 ◽

Vol 19 (2) ◽

pp. 114-118

Author(s):

Gian Luigi Mariottini ◽

Irwin Darren Grice

Keyword(s):

Biological Activity ◽

Marine Species ◽

Natural Compounds ◽

Therapeutic Agents ◽

Industrial Applications ◽

Bioactive Molecules ◽

Sea Anemones ◽

Therapeutic Approaches ◽

Ongoing Research ◽

Biological Compounds

Natural compounds extracted from organisms and microorganisms are an important resource for the development of drugs and bioactive molecules. Many such compounds have made valuable contributions in diverse fields such as human health, pharmaceutics and industrial applications. Presently, however, research on investigating natural compounds from marine organisms is scarce. This is somewhat surprising considering that the marine environment makes a major contribution to Earth's ecosystems and consequently possesses a vast storehouse of diverse marine species. Interestingly, of the marine bioactive natural compounds identified to date, many are venoms, coming from Cnidarians (jellyfish, sea anemones, corals). Cnidarians are therefore particularly interesting marine species, producing important biological compounds that warrant further investigation for their development as possible therapeutic agents. From an experimental aspect, this review aims to emphasize and update the current scientific knowledge reported on selected biological activity (antiinflammatory, antimicrobial, antitumoral, anticoagulant, along with several less studied effects) of Cnidarian venoms/extracts, highlighting potential aspects for ongoing research towards their utilization in human therapeutic approaches.

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Natural and Nature-Derived Products Targeting Human Coronaviruses

Molecules ◽

10.3390/molecules26020448 ◽

2021 ◽

Vol 26 (2) ◽

pp. 448

Author(s):

Konstantina Vougogiannopoulou ◽

Angela Corona ◽

Enzo Tramontano ◽

Michael N. Alexis ◽

Alexios-Leandros Skaltsounis

Keyword(s):

Natural Products ◽

Antiviral Agents ◽

Critical Perspective ◽

Human Coronavirus ◽

State Of Emergency ◽

Pharmacological Agents ◽

Pure Compounds ◽

Total Plant ◽

Human Coronaviruses ◽

The 1960S

The ongoing pandemic of severe acute respiratory syndrome (SARS), caused by the SARS-CoV-2 human coronavirus (HCoV), has brought the international scientific community before a state of emergency that needs to be addressed with intensive research for the discovery of pharmacological agents with antiviral activity. Potential antiviral natural products (NPs) have been discovered from plants of the global biodiversity, including extracts, compounds and categories of compounds with activity against several viruses of the respiratory tract such as HCoVs. However, the scarcity of natural products (NPs) and small-molecules (SMs) used as antiviral agents, especially for HCoVs, is notable. This is a review of 203 publications, which were selected using PubMed/MEDLINE, Web of Science, Scopus, and Google Scholar, evaluates the available literature since the discovery of the first human coronavirus in the 1960s; it summarizes important aspects of structure, function, and therapeutic targeting of HCoVs as well as NPs (19 total plant extracts and 204 isolated or semi-synthesized pure compounds) with anti-HCoV activity targeting viral and non-viral proteins, while focusing on the advances on the discovery of NPs with anti-SARS-CoV-2 activity, and providing a critical perspective.

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The Occurrence and Biological Activity of Tormentic Acid—A Review

Molecules ◽

10.3390/molecules26133797 ◽

2021 ◽

Vol 26 (13) ◽

pp. 3797

Author(s):

Marta Olech ◽

Wojciech Ziemichód ◽

Natalia Nowacka-Jechalke

Keyword(s):

Biological Activity ◽

Plant Species ◽

Current Knowledge ◽

In Vivo Studies ◽

Natural Sources ◽

Anti Cancer ◽

Biochemical Mechanisms ◽

Tormentic Acid

This review focuses on the natural sources and pharmacological activity of tormentic acid (TA; 2α,3β,19α-trihydroxyurs-2-en-28-oic acid). The current knowledge of its occurrence in various plant species and families is summarized. Biological activity (e.g., anti-inflammatory, antidiabetic, antihyperlipidemic, hepatoprotective, cardioprotective, neuroprotective, anti-cancer, anti-osteoarthritic, antinociceptive, antioxidative, anti-melanogenic, cytotoxic, antimicrobial, and antiparasitic) confirmed in in vitro and in vivo studies is compiled and described. Biochemical mechanisms affected by TA are indicated. Moreover, issues related to the biotechnological methods of production, effective eluents, and TA derivatives are presented.

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