scholarly journals Effectiveness of pregabalin and gabapentin in patients with neuropathic pain

Ból ◽  
2020 ◽  
Vol 21 (3) ◽  
pp. 1-15
Author(s):  
Magdalena Kocot-Kępska ◽  
Magdalena Mańka-Matłok
Keyword(s):  
Clinical Trials ◽  
Neuropathic Pain ◽  
Depressive Disorders ◽  
Pain Treatment ◽  
Current Knowledge ◽  
Epidemiological Data ◽  
The Elderly ◽  
Effective Management ◽  
Inappropriate Use

Effective and safe treatment of patients with neuropathic pain (NP), despite the emergence of new clinical trials, remains a challenge for clinicians. A review of epidemiological data from around the world suggests the prevalence of NP at the level of 6.9–10% in the entire population, more often in women and in the elderly [1, 2]. Chronic NP is associated with a reduced quality of life of patients. In this group of patients, anxiety, and depressive disorders as well as sleep disorders are more common [3]. Hence, effective management of patients with NP is an important problem that requires further research. The aim of the article is to present the current knowledge about pregabalin and gabapentin, their mechanisms of action, effectiveness in patients with NP, the potential risk of side effects and the risk of inappropriate use, as well as to indicate their place in the standards of neuropathic pain treatment in the light of current clinical trials.

scholarly journals Poly(lactic-co-glycolic acid) nanomaterial-based treatment options for pain management: a review

Nanomedicine ◽  
2020 ◽  
Vol 15 (19) ◽  
pp. 1897-1913
Author(s):  
Thuỳ Linh Phạm ◽  
Dong Woon Kim
Keyword(s):  
Neuropathic Pain ◽  
Glycolic Acid ◽  
Pain Treatment ◽  
Treatment Options ◽  
New Drugs ◽  
Effective Management ◽  
Chronic Neuropathic Pain ◽  
The Public ◽  
Therapeutic Outcomes

Neuropathic pain is one of the most intense types of chronic pain; it constitutes a pervasive complaint throughout the public health system. With few effective treatments, it remains a significant challenge. Commercially available drugs for neuropathic pain are still limited and have disappointing efficacy. Therefore, chronic neuropathic pain imposes a tremendous burden on patients’ quality of life. Recently, the introduction and application of nanotechnology in multiple fields has accelerated the development of new drugs. This review highlights the application of poly(lactic-co-glycolic acid) nanomaterial-based vehicles for drug delivery and how they improve the therapeutic outcomes for neuropathic pain treatment. Finally, future developments for pain research and effective management are presented.

scholarly journals Magnesium for Pain Treatment in 2021? State of the Art

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1397
Author(s):  
Véronique Morel ◽  
Marie-Eva Pickering ◽  
Jonathan Goubayon ◽  
Marguérite Djobo ◽  
Nicolas Macian ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Clinical Trials ◽  
Neuropathic Pain ◽  
Pain Treatment ◽  
State Of The Art ◽  
Chronic Neuropathic Pain ◽  
Level Of Evidence ◽  
Post Operative Pain ◽  
Reduce Pain Intensity

Background: Magnesium (Mg) is commonly used in clinical practice for acute and chronic pain and has been reported to reduce pain intensity and analgesics consumption in a number of studies. Results are, however, contested. Objectives: This review aims to investigate randomised clinical trials (RCTs) on the effectiveness of Mg treatment on pain and analgesics consumption in situations including post-operative pain, migraine, renal pain, chronic pain, neuropathic pain and fibromyalgia. Results: The literature search identified 81 RCTs (n = 5447 patients) on Mg treatment in pain (50 RCTs in post-operative pain, 18 RCTs in migraine, 5 RCTs in renal pain, 6 RCTs in chronic/neuropathic pain, 2 RCTs in fibromyalgia). Conclusion: The level of evidence for the efficacy of Mg in reducing pain and analgesics consumption is globally modest and studies are not very numerous in chronic pain. A number of gaps have been identified in the literature that need to be addressed especially in methodology, rheumatic disease, and cancer. Additional clinical trials are needed to achieve a sufficient level of evidence and to better optimize the use of Mg for pain and pain comorbidities in order to improve the quality of life of patients who are in pain.

scholarly journals Elderly and drugs: risks and necessity of rational use

2010 ◽  
Vol 46 (4) ◽  
pp. 617-632 ◽  
Author(s):  
André de Oliveira Baldoni ◽  
Farah Maria Drumond Chequer ◽  
Elisa Raquel Anastácio Ferraz ◽  
Danielle Palma de Oliveira ◽  
Leonardo Régis Leira Pereira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Effects ◽  
Elderly Population ◽  
Adverse Drug Events ◽  
The Elderly ◽  
External Factors ◽  
Access To Information ◽  
Inappropriate Use ◽  
The World

In recent decades, the world has undergone a demographic transformation with a rapid growth of the elderly population, resulting in an increased demand for funds to maintain their health and drug consumption. Pharmacokinetic and pharmacodynamic changes occurring in the elderly can interfere directly in the adverse effects of drugs and increase the risk of intoxication. In addition, there are external factors interfering with the pharmacotherapy of the elderly, such as inappropriate use and the lack of access to information. Many therapeutic classes of drugs should be used with caution or avoided in the elderly population, such as anti-inflammatory and some anti-hypertensive drugs, diuretics and digitalis. If not managed carefully, these medicines can affect the safety and quality of life in the elderly. Thus, the aim of this review was to identify drugs that should be used with caution in elderly patients in order to avoid intoxication and/or adverse drug events.

scholarly journals The Effective Management of Caries

2013 ◽  
Vol 2 (3) ◽  
pp. 5-5
Author(s):  
Ario Santini
Keyword(s):  
Old Age ◽  
The Elderly ◽  
Ageing Population ◽  
Effective Management ◽  
Factors Associated ◽  
Dental Profession ◽  
The Uk ◽  
Changing Demographics ◽  
Tooth Retention

Increased life expectancy is causing an explosion of the ageing population that will continue for the foreseeable future. Improved quality of life at old age will demand tooth retention and, consequently, the need for appropriate restorative care. Retaining teeth and maintaining them in spite of the multitude of risk factors associated with old age is a multifaceted challenge. The dental profession must be ever sensitive to the special needs of the elderly patient in order to render a service that is sensitive and caring. As the healthcare system as a whole adjusts to the changing demographics of the UK population, it is essential that dental professions effectively manage caries across the generations.

scholarly journals Dorsal Root Ganglion (DRG) and Chronic Pain

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Amnon A. Berger ◽  
Yao Liu ◽  
HarLee Possoit ◽  
Anna C. Rogers ◽  
Warner Moore ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Pain ◽  
Neuropathic Pain ◽  
Dorsal Root ◽  
Randomized Trials ◽  
Pain Treatment ◽  
Common Condition ◽  
Significant Morbidity ◽  
Chronic Neuropathic Pain

Context: Chronic neuropathic pain is a common condition, and up to 11.9% of the population have been reported to suffer from uncontrolled neuropathic pain. Chronic pain leads to significant morbidity, lowered quality of life, and loss of workdays, and thus carries a significant price tag in healthcare costs and lost productivity. dorsal root ganglia (DRG) stimulation has been recently increasingly reported and shows promising results in the alleviation of chronic pain. This paper reviews the background of DRG stimulation, anatomical, and clinical consideration and reviews the clinical evidence to support its use. Evidence Acquisition: The DRG span the length of the spinal cord and house the neurons responsible for sensation from the periphery. They may become irritated by direct compression or local inflammation. Glial cells in the DRG respond to nerve injury, producing inflammatory markers and contribute to the development of chronic pain, even after the resolution of the original insult. While the underlying mechanism is still being explored, recent studies explored the efficacy of DRG stimulation and neuromodulation for chronic pain treatment. Results: Several reported cases and a small number of randomized trials were published in recent years, describing different methods of DRG stimulation and neuromodulation with promising results. Though evidence quality is mostly low, these results provide evidence to support the utilization of this technique. Conclusions: Chronic neuropathic pain is a common condition and carries significant morbidity and impact on the quality of life. Recent evidence supports the use of DRG neuromodulation as an effective technique to control chronic pain. Though studies are still emerging, the evidence appears to support this technique. Further studies, including large randomized trials evaluating DRG modulation versus other interventional and non-interventional techniques, are needed to further elucidate the efficacy of this method. These studies are also likely to inform the patient selection and the course of treatment.

scholarly journals Probiotics as a Treatment for “Metabolic Depression”? A Rationale for Future Studies

2021 ◽  
Author(s):  
Oliwia Gawlik-Kotelnicka ◽  
Dominik Strzelecki
Keyword(s):  
Clinical Trials ◽  
Depressive Disorders ◽  
Metabolic Diseases ◽  
Current Knowledge ◽  
Experimental Studies ◽  
Secondary Outcome ◽  
Low Grade ◽  
Intestinal Dysbiosis ◽  
Study Population ◽  
Meta Analyses

Depression and metabolic diseases often coexist having several features in common, e.g., chronic low-grade inflammation and intestinal dysbiosis. Different microbiota interventions have been proposed to be used as a treatment for these disorders. In the paper we review the efficacy of probiotics in depressive disorders, obesity, metabolic syndrome and its liver equivalent based on the published experimental studies, clinical trials and meta-analyses. Probiotics seem to be effective in reducing depressive symptoms when administered in addition to antidepressants. Additionally, probiotics intake may ameliorate some of the clinical components of metabolic diseases. However, standardized methodology regarding probiotics clinical trials has not been established yet. In this narrative review we discuss current knowledge on the recently used methodology with its strengths and limitations and propose criteria that may be implemented to create a new study of the effectiveness of probiotics in depressive disorders comorbid with metabolic abnormalities. We put across our choice on type of study population, probiotics genus, strains, dosages and formulations, intervention period, as well as primary and secondary outcome measures.

scholarly journals Deteksi Dini Gangguan Kognitif dan Depresi Pada Lansia

2020 ◽  
Vol 4 (4) ◽  
pp. 673-678
Author(s):  
Resti Rahmadika Akbar ◽  
Dian Ayu Hamama Pitra ◽  
Mutiara Anissa ◽  
Yuri Haiga ◽  
Rahma Triyana
Keyword(s):  
Brain Function ◽  
Job Loss ◽  
Depressive Disorders ◽  
Cognitive Disorders ◽  
The Elderly ◽  
Abstract Thinking ◽  
Social Changes ◽  
Risk Of Disease ◽  
Physical Changes

Increasing the number of elderly people needs to be followed by programs that can maintain the quality of life of the elderly. The ratio of elderly dependence on the productive population is increasing. For that, we need a program so that physical and social changes in the elderly do not reduce the independence of the elderly. Physical changes in the form of cognitive disorders namely decreased brain function so that activities related to the ability of attention, concentration, calculation, decision making, reasoning, and abstract thinking. Social changes in the form of job loss, loneliness, risk of disease, can be a trigger for depressive disorders in the elderly. The purpose of this activity is for all parties to have a role in the early detection of cognitive disorders and depression as well as the elderly who have symptoms can be treated early

scholarly journals Untreated Depressive Symptoms Significantly Worsen Quality of Life of the Elderly and may Lead to the Misdiagnosis of Dementia: A Cross-Sectional Study

2020 ◽  
Author(s):  
Viktor Voros ◽  
Sandor Fekete ◽  
Tamas Tenyi ◽  
Zoltan Rihmer ◽  
Ilona Szili ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Depressive Disorders ◽  
Early Recognition ◽  
The Elderly ◽  
Screening Tools ◽  
Adequate Treatment

Abstract Background: Several studies demonstrated the role of depressive mood and cognitive impairment in the background of elevated mortality and decreased Quality of Life (QoL) of the elderly.Methods: In the framework of the ICT4Life project self-administered questionnaires and clinical screening tools were used to assess QoL, depressive symptoms and cognitive functions of 60 elderly over the age of 65.Results: Males found to be depressed and cognitively declined more frequently; and had higher scores on the depression and lower on the QoL scales. Depressed elderly had lower cognitive levels and their QoL was significantly poorer than that of the non-depressed subjects. Depressive disorders were detected in a quarter of the elderly, and the majority of them did not receive adequate antidepressant medication.Conclusions: Close correlation between depression and cognitive impairment was confirmed, as well as the key role of depression in the background of QoL decline. Results also highlighted the problems of recognition and adequate treatment of depression and cognitive decline in elderly, which can be further complicated by the common symptoms of depressive pseudo-dementia. Early recognition of depressive symptoms is important not only to treat the underlying mood disorder, but also to improve QoL of the elderly.

scholarly journals State-of-the-Art Dermatophyte Infections: Epidemiology Aspects, Pathophysiology, and Resistance Mechanisms

2021 ◽  
Vol 7 (8) ◽  
pp. 629
Author(s):  
Nilce M. Martinez-Rossi ◽  
Nalu T. A. Peres ◽  
Tamires A. Bitencourt ◽  
Maíra P. Martins ◽  
Antonio Rossi
Keyword(s):  
Trichophyton Rubrum ◽  
Fungal Infections ◽  
Current Knowledge ◽  
Epidemiological Data ◽  
Resistance Mechanisms ◽  
Broad Perspective ◽  
Adverse Conditions ◽  
Fungal Biology ◽  
Adaptive Mechanisms

The burden of fungal infections is not widely appreciated. Although these infections are responsible for over one million deaths annually, it is estimated that one billion people are affected by severe fungal diseases. Mycoses of nails and skin, primarily caused by fungi known as dermatophytes, are the most common fungal infections. Trichophyton rubrum appears to be the most common causative agent of dermatophytosis, followed by Trichophyton interdigitale. An estimated 25% of the world’s population suffers from dermatomycosis. Although these infections are not lethal, they compromise the quality of life of infected patients. The outcome of antidermatophytic treatments is impaired by various conditions, such as resistance and tolerance of certain dermatophyte strains. The adage “know your enemy” must be the focus of fungal research. There is an urgent need to increase awareness about the significance of these infections with precise epidemiological data and to improve knowledge regarding fungal biology and pathogenesis, with an emphasis on adaptive mechanisms to tackle adverse conditions from host counteractions. This review outlines the current knowledge about dermatophyte infections, with a focus on signaling pathways required for fungal infection establishment and a broad perspective on cellular and molecular factors involved in antifungal resistance and tolerance.

The importance of pain treatment in the elderly to ensure quality of life, independence and autonomy. Case report

2020 ◽  
Vol 3 ◽  
Author(s):  
Ana Julia Taborda Machado ◽  
Daniel Benzecry de Almeida ◽  
Lais Kozminski da Costa Akcelrud Durao ◽  
Luci Mara França Correia
Keyword(s):  
Quality Of Life ◽  
Case Report ◽  
Pain Treatment ◽  
The Elderly
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