scholarly journals A Systematic Study on TRIZ to Prepare the Innovation of 3DPVS

2021 ◽  
Author(s):  
Haobo Yuan
Keyword(s):  
Cell Culture ◽  
Systematic Study ◽  
Conceptual Development ◽  
Concept Generation ◽  
Scaffold Design ◽  
Comprehensive Overview ◽  
Design Studies ◽  
3D Printed ◽  
Timely Topic

Regarding the innovation of biomimetic cell culture scaffold, 3DPVS, namely 3D printed vibratory scaffold, has been proposed as a present-to-future novel product. It currently stands at the stage of conceptual development. Design studies on 3DPVS Concept Generation show high value, and one essential part inside this could dwell at establishing design methodological knowledge that has innovation merits. TRIZ with its tools has proven value on creation and design innovativeness while they have not yet been utilized for scaffold design at mature level. In this paper, we attempt to study and explore the design aspects of TRIZ and its most relevant tools on the context of 3DPVS, as well as preliminarily indicating a TRIZ-based methodology, which could tailor the design aspects of 3DPVS. It also, to some extent, fills a gap in scaffold engineering and TRIZ literature and provides a comprehensive overview of a timely topic.

scholarly journals A Systematic Study on Design Initiation of Conceptual 3DPVS

Biomimetics ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 31
Author(s):  
Yuan ◽  
Xing
Keyword(s):  
Conceptual Design ◽  
Conceptual Development ◽  
The Novel ◽  
Concept Generation ◽  
3D Scaffold ◽  
Concept Evaluation ◽  
3D Printed ◽  
The Difference ◽  
Novel Scaffold

An important product in biomedical and biomimetic engineering is the 3D scaffold, which mimics the real tissue in vitro to achieve the external cultivation of cells. The difference between the 3D scaffold and other biomimetic products lies in the fact that the former mimics the internal features of tissue, while the latter generally approximates the external traits of biological beings. In the field of scaffold engineering, the 3D printed vibratory scaffold, 3DPVS, has been proposed as a present-to-future novel scaffold product, and it currently stays at the stage of conceptual development. To achieve the novel design of the conceptual 3DPVS, a conceptual design process has been established by authors in their previous work, which contain three main stages, namely the design initiation, concept generation, and concept evaluation. In terms of design initiation, it is a ‘must-accomplish’ stage which generates outputs for both the subsequent concept generation and evaluation. Work of design initiation therefore is of significant value and it consists of several tasks; that is, conducting a thorough literature review, summarizing the fundamental issues preparing the general conceptual design, studying the multi-characterization of the 3DPVS, putting forward the potential base model(s), as well as indicating the ideality of the scaffold and establishing potential ideal model(s) for the 3DPVS. In this paper, design initiation will be chiefly focused upon these essential aspects to be discussed, work of which is expected to be useful in establishing a solid ground for future innovation work of the 3DPVS.

Control of cell growth on 3D-printed cell culture platforms for tissue engineering

2017 ◽  
Vol 105 (12) ◽  
pp. 3281-3292 ◽  
Author(s):  
Zhikai Tan ◽  
Tong Liu ◽  
Juchang Zhong ◽  
Yikun Yang ◽  
Weihong Tan
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Cell Growth ◽  
3D Printed

3D printing of cellular materials for advanced electrochemical energy storage and conversion

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7416-7432 ◽  
Author(s):  
Xiaocong Tian ◽  
Kun Zhou
Keyword(s):  
Energy Storage ◽  
3D Printing ◽  
Cellular Materials ◽  
Electrochemical Energy Storage ◽  
Energy Storage And Conversion ◽  
Comprehensive Overview ◽  
3D Printed ◽  
Electrochemical Energy

This article provides a comprehensive overview of 3D-printed cellular materials for advanced electrochemical energy storage and conversion applications.

scholarly journals A Non-Cytotoxic Resin for Micro-Stereolithography for Cell Cultures of HUVECs

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 246 ◽  
Author(s):  
Max Männel ◽  
Carolin Fischer ◽  
Julian Thiele
Keyword(s):  
Cell Culture ◽  
Ethylene Glycol ◽  
Umbilical Vein ◽  
Polymer Materials ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
3D Printed ◽  
Poly Ethylene ◽  
The Impact

Three-dimensional (3D) printing of microfluidic devices continuously replaces conventional fabrication methods. A versatile tool for achieving microscopic feature sizes and short process times is micro-stereolithography (µSL). However, common resins for µSL lack biocompatibility and are cytotoxic. This work focuses on developing new photo-curable resins as a basis for µSL fabrication of polymer materials and surfaces for cell culture. Different acrylate- and methacrylate-based compositions are screened for material characteristics including wettability, surface roughness, and swelling behavior. For further understanding, the impact of photo-absorber and photo-initiator on the cytotoxicity of 3D-printed substrates is studied. Cell culture experiments with human umbilical vein endothelial cells (HUVECs) in standard polystyrene vessels are compared to 3D-printed parts made from our library of homemade resins. Among these, after optimizing material composition and post-processing, we identify selected mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) methyl ethyl methacrylate (PEGMEMA) as most suitable to allow for fabricating cell culture platforms that retain both the viability and proliferation of HUVECs. Next, our PEGDA/PEGMEMA resins will be further optimized regarding minimal feature size and cell adhesion to fabricate microscopic (microfluidic) cell culture platforms, e.g., for studying vascularization of HUVECs in vitro.

scholarly journals 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy

2020 ◽  
Vol 212 (3) ◽  
pp. 107633 ◽  
Author(s):  
Florian Fäßler ◽  
Bettina Zens ◽  
Robert Hauschild ◽  
Florian K.M. Schur
Keyword(s):  
Electron Microscopy ◽  
Cell Culture ◽  
Specimen Preparation ◽  
Cryo Electron Microscopy ◽  
3D Printed

scholarly journals 3D Printing to Support the Shortage in Personal Protective Equipment Caused by COVID-19 Pandemic

Materials ◽  
2020 ◽  
Vol 13 (15) ◽  
pp. 3339 ◽  
Author(s):  
Mostapha Tarfaoui ◽  
Mourad Nachtane ◽  
Ibrahim Goda ◽  
Yumna Qureshi ◽  
Hamza Benyahia
Keyword(s):  
3D Printing ◽  
Medical Devices ◽  
Personal Protective Equipment ◽  
Health Concern ◽  
Protective Equipment ◽  
Global Public Health ◽  
Comprehensive Overview ◽  
3D Printed ◽  
Single Use ◽  
Tract Infections

Currently, the emergence of a novel human coronavirus disease, named COVID-19, has become a great global public health concern causing severe respiratory tract infections in humans. Yet, there is no specific vaccine or treatment for this COVID-19 where anti-disease measures rely on preventing or slowing the transmission of infection from one person to another. In particularly, there is a growing effort to prevent or reduce transmission to frontline healthcare professionals. However, it is becoming an increasingly international concern respecting the shortage in the supply chain of critical single-use personal protective equipment (PPE). To that scope, we aim in the present work to provide a comprehensive overview of the latest 3D printing efforts against COVID-19, including professional additive manufacturing (AM) providers, makers and designers in the 3D printing community. Through this review paper, the response to several questions and inquiries regarding the following issues are addressed: technical factors connected with AM processes; recommendations for testing and characterizing medical devices that additively manufactured; AM materials that can be used for medical devices; biological concerns of final 3D printed medical parts, comprising biocompatibility, cleaning and sterility; and limitations of AM technology.

scholarly journals Biocompatibility of Blank, Post-Processed and Coated 3D Printed Resin Structures with Electrogenic Cells

Biosensors ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 152
Author(s):  
Cacie Hart ◽  
Charles M. Didier ◽  
Frank Sommerhage ◽  
Swaminathan Rajaraman
Keyword(s):  
Cell Culture ◽  
3D Printing ◽  
Culture Vessel ◽  
Standard Cell ◽  
Post Processing ◽  
3D Printed ◽  
Processing Techniques

The widespread adaptation of 3D printing in the microfluidic, bioelectronic, and Bio-MEMS communities has been stifled by the lack of investigation into the biocompatibility of commercially available printer resins. By introducing an in-depth post-printing treatment of these resins, their biocompatibility can be dramatically improved up to that of a standard cell culture vessel (99.99%). Additionally, encapsulating resins that are less biocompatible with materials that are common constituents in biosensors further enhances the biocompatibility of the material. This investigation provides a clear pathway toward developing fully functional and biocompatible 3D printed biosensor devices, especially for interfacing with electrogenic cells, utilizing benchtop-based microfabrication, and post-processing techniques.

scholarly journals 3D printed microfluidic devices for cell culture

2021 ◽  
Vol 4 (s1) ◽  
Author(s):  
Marta Canta ◽  
Désirée Baruffaldi ◽  
Ignazio Roppolo ◽  
Annalisa Chiappone ◽  
Candido F. Pirri ◽  
...  
Keyword(s):  
Cell Culture ◽  
Microfluidic Device ◽  
Microfluidic Devices ◽  
3D Printed ◽  
Biomedical Field ◽  
Printed Materials

A successful application of the 3D printed materials in the biomedical field requires extensive studies to ensure their biocompatibility at every step of the process. Here, different components suitable for cell applications, including a microfluidic device, were 3D printed using common resins and a deep analysis of their biocompatibility and post printed protocols was conducted.

scholarly journals 3D printing – a key technology for tailored biomedical cell culture lab ware

2016 ◽  
Vol 2 (1) ◽  
pp. 105-108 ◽  
Author(s):  
Florian Schmieder ◽  
Joachim Ströbel ◽  
Mechthild Rösler ◽  
Stefan Grünzner ◽  
Bernd Hohenstein ◽  
...  
Keyword(s):  
Cell Culture ◽  
3D Printing ◽  
Ex Vivo ◽  
Vascular Perfusion ◽  
Laboratory Equipment ◽  
Key Technology ◽  
Cell Culture Systems ◽  
First Results ◽  
3D Printed

AbstractToday’s 3D printing technologies offer great possibilities for biomedical researchers to create their own specific laboratory equipment. With respect to the generation of ex vivo vascular perfusion systems this will enable new types of products that will embed complex 3D structures possibly coupled with cell loaded scaffolds closely reflecting the in-vivo environment. Moreover this could lead to microfluidic devices that should be available in small numbers of pieces at moderate prices. Here, we will present first results of such 3D printed cell culture systems made from plastics and show their use for scaffold based applications.

scholarly journals Breaking the Third Wall: Implementing 3D-Printing Technics to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 627
Author(s):  
Yoel Goldstein ◽  
Sarah Spitz ◽  
Keren Turjeman ◽  
Florian Selinger ◽  
Yechezkel Barenholz ◽  
...  
Keyword(s):  
Cell Culture ◽  
Cfd Simulation ◽  
Cost Effective ◽  
In Vitro Models ◽  
3D Print ◽  
Biological Compatibility ◽  
3D Printed ◽  
Organ On A Chip

The understanding that systemic context and tissue crosstalk are essential keys for bridging the gap between in vitro models and in vivo conditions led to a growing effort in the last decade to develop advanced multi-organ-on-a-chip devices. However, many of the proposed devices have failed to implement the means to allow for conditions tailored to each organ individually, a crucial aspect in cell functionality. Here, we present two 3D-print-based fabrication methods for a generic multi-organ-on-a-chip device: One with a PDMS microfluidic core unit and one based on 3D-printed units. The device was designed for culturing different tissues in separate compartments by integrating individual pairs of inlets and outlets, thus enabling tissue-specific perfusion rates that facilitate the generation of individual tissue-adapted perfusion profiles. The device allowed tissue crosstalk using microchannel configuration and permeable membranes used as barriers between individual cell culture compartments. Computational fluid dynamics (CFD) simulation confirmed the capability to generate significant differences in shear stress between the two individual culture compartments, each with a selective shear force. In addition, we provide preliminary findings that indicate the feasibility for biological compatibility for cell culture and long-term incubation in 3D-printed wells. Finally, we offer a cost-effective, accessible protocol enabling the design and fabrication of advanced multi-organ-on-a-chip devices.

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