scholarly journals Association between Peripheral Blood Inflammatory Markers, Endothelial Dysfunction Markers, and Depression

2020 ◽  
Author(s):  
Olga Vladimirovna Vorob’eva ◽  
Victoria Vyacheslavovna Fateeva ◽  
Ksenia Vladimirovna Nikulina ◽  
Kristina Konstantinovna Khacheva ◽  
Gulnara Rinatovna Khakimova ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Peripheral Blood ◽  
Inflammatory Markers

Endothelial Dysfunction and Inflammatory Markers of Vascular Disease

2020 ◽  
Vol 19 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Sevket Balta
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Disease ◽  
Inflammatory Markers ◽  
Vascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Non Invasive ◽  
Von Willebrand ◽  
The Relationship ◽  
Willebrand Factor

: Vascular diseases are the main reason for morbidity and mortality worldwide. As we know, the earlier phase of vascular diseases is endothelial dysfunction in humans, the endothelial tissues play an important role in inflammation, coagulation, and angiogenesis, via organizing ligand-receptor associations and the various mediators’ secretion. We can use many inflammatory non-invasive tests (flowmediated dilatation, epicedial fat thickness, carotid-intima media thickness, arterial stiffness and anklebrachial index) for assessing the endothelial function. In addition, many biomarkers (ischemia modified albumin, pentraxin-3, E-selectin, angiopoietin, endothelial cell specific molecule 1, asymmetrical dimethylarginine, von Willebrand factor, endothelial microparticles and endothelial progenitor cells) can be used to evaluate endothelial dysfunction. We have focused on the relationship between endothelial dysfunction and inflammatory markers of vascular disease in this review.

scholarly journals Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1037
Author(s):  
Patricia Ruiz-Limon ◽  
Maria L. Ladehesa-Pineda ◽  
Clementina Lopez-Medina ◽  
Chary Lopez-Pedrera ◽  
Maria C. Abalos-Aguilera ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Axial Spondyloarthritis ◽  
Endothelial Injury ◽  
In Vitro Studies ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Endothelial dysfunction (ED) is well known as a process that can lead to atherosclerosis and is frequently presented in radiographic axial spondyloarthritis (r-axSpA) patients. Here, we investigated cellular and molecular mechanisms underlying r-axSpA-related ED, and analyzed the potential effect of peripheral blood mononuclear cells (PBMCs) in promoting endothelial injury in r-axSpA. A total of 30 r-axSpA patients and 32 healthy donors (HDs) were evaluated. The endothelial function, inflammatory and atherogenic profile, and oxidative stress were quantified. In vitro studies were designed to evaluate the effect of PBMCs from r-axSpA patients on aberrant endothelial activation. Compared to HDs, our study found that, associated with ED and the plasma proatherogenic profile present in r-axSpA, PBMCs from these patients displayed a pro-oxidative, proinflammatory, and proatherogenic phenotype, with most molecular changes noticed in lymphocytes. Correlation studies revealed the relationship between this phenotype and the microvascular function. Additional in vitro studies confirmed that PBMCs from r-axSpA patients promoted endothelial injury. Altogether, this study suggests the relevance of r-axSpA itself as a strong and independent cardiovascular risk factor, contributing to a dysfunctional endothelium and atherogenic status by aberrant activation of PBMCs. Lymphocytes could be the main contributors in the development of ED and subsequent atherosclerosis in this pathology.

scholarly journals Choline Treatment Activates NLRP3 Inflammasome Formation and Leads to Endothelial Dysfunction in Mice

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 44-44
Author(s):  
Saisudha Koka ◽  
Goverdhan Puchchakayala ◽  
Krishna Boini
Keyword(s):  
Endothelial Dysfunction ◽  
Tight Junction ◽  
Real Time ◽  
Nlrp3 Inflammasome ◽  
Real Time Pcr ◽  
Inflammatory Markers ◽  
Carotid Arteries ◽  
Pcr Analysis ◽  
Tight Junction Proteins ◽  
Junction Proteins

Abstract Objectives Choline and other trimethylamine-containing nutrients are metabolized by gut microbiota into Trimethylamine N-oxide (TMAO), which is involved in the pathogenesis of various cardiovascular diseases. The present study was designed to investigate the relation between dietary choline and endothelial dysfunction in mice. Methods Nlrp3 +/+ and Nlrp3 −/− mice were treated with 3% choline chloride in drinking water for 6 months. Plasma concentration of TMAO levels were measured after the treatment. Cardiac and endothelial dysfunction were monitored using echocardiography. Vascular permeability was measured by Evans blue dye perfusion. Confocal microscopy was used to detect the co-localization of Nlrp3 inflammasome components. Caspase-1 activity was measured by colorimetric assay and IL-1β production was measured using ELISA. Western blotting was used to measure tight-junction proteins. Real time PCR analysis was used to determine the TLR-4 and inflammatory markers (ICAM and VCAM) in the carotid arteries of the mice. Results Choline treatment significantly increased plasma TMAO levels in all the groups. Choline treated Nlrp3+/+ mice showed significant impairment in endothelial function and had increased vascular hyper-permeability, enhanced Nlrp3 activation and decreased expression of tight junction proteins like ZO2, VE-cadherin and occludin expression in carotid arteries compared to choline treated Nlrp3−/− mice. Caspase-1 activity and IL-1β production was significantly enhanced in choline treated Nlrp3+/+ mice but not in Nlrp3−/- mice. Real time PCR analysis showed that TLR-4 and inflammatory markers (ICAM & VCAM) were significantly increased in carotid arteries of choline treated Nlrp3+/+ mice compared to Nlrp3−/− mice. Conclusions Our results suggest that chronic choline treatment induced endothelial dysfunction via activation of Nlrp3 inflammasome and other inflammatory markers. Funding Sources NIH - NHLBI, AHA.

The peripheral blood inflammatory markers may predict response to nivolumab for advanced renal cell carcinoma

2019 ◽  
Vol 18 (1) ◽  
pp. e2094-e2095
Author(s):  
D. Ikarashi ◽  
R. Kato ◽  
Y. Kato ◽  
M. Kanehira ◽  
R. Takata ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Peripheral Blood ◽  
Renal Cell ◽  
Inflammatory Markers ◽  
Advanced Renal Cell Carcinoma

scholarly journals Comparative effects of estrogen, raloxifene and tamoxifen on endothelial dysfunction, inflammatory markers and oxidative stress in ovariectomized rats

Life Sciences ◽  
2015 ◽  
Vol 124 ◽  
pp. 101-109 ◽  
Author(s):  
Aline Zandonadi Lamas ◽  
Izabela Facco Caliman ◽  
Polyana Lima Meireles Dalpiaz ◽  
Antônio Ferreira de Melo ◽  
Glaucia Rodrigues Abreu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Inflammatory Markers ◽  
Ovariectomized Rats ◽  
And Oxidative Stress

Increased Inflammatory Markers and Endothelial Dysfunction are Associated with Variant Angina

2007 ◽  
Vol 37 (1) ◽  
pp. 27 ◽  
Author(s):  
Sook Hee Cho ◽  
In Hyae Park ◽  
Myung Ho Jeong ◽  
Seon Ho Hwang ◽  
Nam Shik Yun ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Inflammatory Markers ◽  
Variant Angina

scholarly journals Peripheral blood mitochondrial DNA content in relation to circulating metabolites and inflammatory markers: A population study

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0181036 ◽  
Author(s):  
Judita Knez ◽  
Vannina G. Marrachelli ◽  
Nicholas Cauwenberghs ◽  
Ellen Winckelmans ◽  
Zhenyu Zhang ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Population Study ◽  
Dna Content ◽  
Peripheral Blood ◽  
Inflammatory Markers ◽  
Mitochondrial Dna Content
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