Redox Balance Affects Fish Welfare

The article presents in an experiment obtained principal results based on repeated low-level inhalation exposures of laboratory animals (white rats, outbred) to nickel oxide nanoparticles with a diameter of (23 ± 5) nm, 4 hours a day, 5 times a week for up to 10 months in a «nose only» installation. It was shown that non-specific body reactions to the action of NiO NPs include: diverse manifestations of systemic toxicity with a particularly pronounced influence on liver and kidney function, redox balance, damage to some areas of brain tissue, associated with proven movement of the nanoparticles themselves from the nasal mucosa along the olfactory tract; some cytological signs of probable development for allergic syndrome; paradoxically low severity of pulmonary pathology by pneumoconiotic type explained by a small chronic delay of nanoparticles in the lungs; the genotoxic effect of the organismal level, even at those low levels of chronic exposure, at which systemic toxicity is rather poorly. Along with that, NiO NPs also induce phase-stimulation of erythropoiesis, which is relatively specific for the toxic nickel effects.

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Redox State in Atrial Fibrillation Pathogenesis and Relevant Therapeutic Approaches

Current Medicinal Chemistry ◽

10.2174/0929867324666170718130408 ◽

2019 ◽

Vol 26 (5) ◽

pp. 765-779 ◽

Cited By ~ 3

Author(s):

Alexios S. Antonopoulos ◽

Athina Goliopoulou ◽

Evangelos Oikonomou ◽

Sotiris Tsalamandris ◽

Georgios-Angelos Papamikroulis ◽

...

Keyword(s):

Atrial Fibrillation ◽

Clinical Studies ◽

Redox State ◽

Redox Balance ◽

Therapeutic Approaches ◽

Critical Determinant ◽

Electrophysiological Properties ◽

Antioxidant Agents ◽

Clinical Benefits

Background: Myocardial redox state is a critical determinant of atrial biology, regulating cardiomyocyte apoptosis, ion channel function, and cardiac hypertrophy/fibrosis and function. Nevertheless, it remains unclear whether the targeting of atrial redox state is a rational therapeutic strategy for atrial fibrillation prevention. Objective: To review the role of atrial redox state and anti-oxidant therapies in atrial fibrillation. Method: Published literature in Medline was searched for experimental and clinical evidence linking myocardial redox state with atrial fibrillation pathogenesis as well as studies looking into the role of redoxtargeting therapies in the prevention of atrial fibrillation. Results: Data from animal models have shown that altered myocardial nitroso-redox balance and NADPH oxidases activity are causally involved in the pathogenesis of atrial fibrillation. Similarly experimental animal data supports that increased reactive oxygen / nitrogen species formation in the atrial tissue is associated with altered electrophysiological properties of atrial myocytes and electrical remodeling, favoring atrial fibrillation development. In humans, randomized clinical studies using redox-related therapeutic approaches (e.g. statins or antioxidant agents) have not documented any benefits in the prevention of atrial fibrillation development (mainly post-operative atrial fibrillation risk). Conclusion: Despite strong experimental and translational data supporting the role of atrial redox state in atrial fibrillation pathogenesis, such mechanistic evidence has not been translated to clinical benefits in atrial fibrillation risk in randomized clinical studies using redox-related therapies.

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Effect of Propagation Method and Ploidy Level of Various Rootstocks on the Response of the Common Clementine (Citrus clementina Hort. ex Tan) to a Mild Water Deficit

Agriculture ◽

10.3390/agriculture10080321 ◽

2020 ◽

Vol 10 (8) ◽

pp. 321 ◽

Cited By ~ 1

Author(s):

Julie Oustric ◽

Radia Lourkisti ◽

Stéphane Herbette ◽

Raphaël Morillon ◽

Gilles Paolacci ◽

...

Keyword(s):

Water Deficit ◽

Ploidy Level ◽

Fruit Size ◽

Redox Balance ◽

Fruit Production ◽

Photosynthetic Parameters ◽

Trifoliate Orange ◽

Antioxidant Efficiency ◽

Diploid Genotype ◽

Propagation Methods

Current climatic upheavals reduce water availability which impacts the growth and fruit quality of plants. In citrus crops, scion/rootstock combinations are used to ensure high fruit production and quality and a stress tolerance/resistance. Our objective was to assess the effect on the clementine scion (C) under natural mild water deficit of (i) polyploid rootstocks by comparing the allotetraploid FlhorAG1 (C/4xFLs; trifoliate orange + Willowleaf mandarin) with its diploid parents, trifoliate orange (C/2xTOs), and Willowleaf mandarin (C/2xWLs), and with a diploid genotype used as reference (Carrizo citrange, C/2xCCs), (ii) rootstock propagation methods by comparing trifoliate orange seedling (C/2xTOs) with cutting (C/2xTOc). A mild water deficit observed under orchard conditions during the summer period (July–August) induced a significant change in yield (except in C/2xTOs), fruit size, and quality. C/2xCCs, C/2xTOs, and C/2xWLs appeared less affected by water deficit as indicated by their lower reduction of predawn leaf water potential (Ψpd), relative water content (RWC), transpiration (E), and photosynthetic parameters (Pnet and gs). Their greater redox balance was probably due to their better antioxidant efficiency. Seedling rootstocks lead to a better adaptation of clementine scions to water deficit than cutting or allotetraploid rootstock. Improving the tolerance to water deficit requires taking into consideration the rootstock genotype, propagation method, and ploidy level.

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Regulation of redox balance in cancer and T cells

Journal of Biological Chemistry ◽

10.1074/jbc.tm117.000257 ◽

2017 ◽

Vol 293 (20) ◽

pp. 7499-7507 ◽

Cited By ~ 42

Author(s):

Hyewon Kong ◽

Navdeep S. Chandel

Keyword(s):

T Cells ◽

Redox Balance

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Redox Imbalance in T Cell-Mediated Skin Diseases

Mediators of Inflammation ◽

10.1155/2010/861949 ◽

2010 ◽

Vol 2010 ◽

pp. 1-9 ◽

Cited By ~ 30

Author(s):

Saveria Pastore ◽

Liudmila Korkina

Keyword(s):

Oxidative Stress ◽

Atopic Dermatitis ◽

Contact Dermatitis ◽

Skin Diseases ◽

Redox Balance ◽

Inflammatory Disorder ◽

Chronic Inflammatory Disorder ◽

Physical Chemical ◽

Chemical Oxidants ◽

Beneficial Outcome

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

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Mitochondrial Sirtuins in Reproduction

Antioxidants ◽

10.3390/antiox10071047 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1047

Author(s):

Giovanna Di Emidio ◽

Stefano Falone ◽

Paolo Giovanni Artini ◽

Fernanda Amicarelli ◽

Anna Maria D’Alessandro ◽

...

Keyword(s):

Stress Responses ◽

Metabolic Pathways ◽

Redox Balance ◽

Antioxidant Defenses ◽

Metabolic Abnormalities ◽

Female Reproduction ◽

Mitochondrial Dysfunctions ◽

Early Embryos ◽

The Relationship

Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions contribute to altering the redox balance and predispose to aging and metabolic alterations. The sirtuin family is composed of seven members and three of them, SIRT3-5, are housed in mitochondria. They catalyze NAD+-dependent deacylation and the ADP-ribosylation of mitochondrial proteins, thereby modulating gene expression and activities of enzymes involved in oxidative metabolism and stress responses. In this context, mitochondrial sirtuins (mtSIRTs) act in synergistic or antagonistic manners to protect from aging and aging-related metabolic abnormalities. In this review, we focus on the role of mtSIRTs in the biological competence of reproductive cells, organs, and embryos. Most studies are focused on SIRT3 in female reproduction, providing evidence that SIRT3 improves the competence of oocytes in humans and animal models. Moreover, SIRT3 protects oocytes, early embryos, and ovaries against stress conditions. The relationship between derangement of SIRT3 signaling and the imbalance of ROS and antioxidant defenses in testes has also been demonstrated. Very little is known about SIRT4 and SIRT5 functions in the reproductive system. The final goal of this work is to understand whether sirtuin-based signaling may be taken into account as potential targets for therapeutic applications in female and male infertility.

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De novo adult acute myeloid leukemia patients’ display at diagnosis functional deregulation of redox balance correlated with molecular subtypes and overall survival

Morphologie ◽

10.1016/j.morpho.2019.10.002 ◽

2019 ◽

Vol 103 (342) ◽

pp. 69 ◽

Cited By ~ 1

Author(s):

Julie Mondet ◽

Caroline Lo Presti ◽

Catherine Garrel ◽

Kristina Skaare ◽

Clara Mariette ◽

...

Keyword(s):

Overall Survival ◽

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

De Novo ◽

Molecular Subtypes ◽

Redox Balance ◽

Acute Myeloid

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Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells

Cancer Gene Therapy ◽

10.1038/s41417-021-00326-4 ◽

2021 ◽

Author(s):

Tatsunori Suzuki ◽

Takahiro Kishikawa ◽

Tatsuyuki Sato ◽

Norihiko Takeda ◽

Yuki Sugiura ◽

...

Keyword(s):

Gene Mutation ◽

Biological Effects ◽

Redox Balance ◽

Metabolic Reprogramming ◽

Ductal Adenocarcinoma ◽

Early Event ◽

Autophagic Flux ◽

Nutritional Interventions ◽

Mutational Activation ◽

Almost All

AbstractMutational activation of the KRAS gene occurs in almost all pancreatic ductal adenocarcinoma (PDAC) and is the earliest molecular event in their carcinogenesis. Evidence has accumulated of the metabolic reprogramming in PDAC, such as amino acid homeostasis and autophagic flux. However, the biological effects of KRAS mutation on metabolic reprogramming at the earlier stages of PDAC carcinogenesis are unclear. Here we report dynamic metabolic reprogramming in immortalized human non-cancerous pancreatic ductal epithelial cells, in which a KRAS mutation was induced by gene-editing, which may mimic early pancreatic carcinogenesis. Similar to the cases of PDAC, KRAS gene mutation increased the dependency on glucose and glutamine for maintaining the intracellular redox balance. In addition, the intracellular levels of amino acids were significantly decreased because of active protein synthesis, and the cells required greater autophagic flux to maintain their viability. The lysosomal inhibitor chloroquine significantly inhibited cell proliferation. Therefore, metabolic reprogramming is an early event in carcinogenesis initiated by KRAS gene mutation, suggesting a rationale for the development of nutritional interventions that suppress or delay the development of PDAC.

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