The Effects of Intravenous Vitamin C on Stress Response Severity in Abdominal Hysterectomy Following Prolonged Fasting Time

Background: Inevitable prolonged fasting time before surgery leads to inflammatory reactions, surgery-related stress response, and consequently unfavorable outcomes; thus, developing strategies to mitigate these consequences is crucial. Objectives: In this study, we evaluated the effect of ascorbic acid on stress response reduction in abdominal hysterectomy following prolonged fasting time. Methods: Eligible women candidates for abdominal hysterectomy following prolonged fasting time were enrolled in the study and divided into 2 groups of vitamin C [group C; 1 g intravenously (IV) before surgery] and placebo (group P). Before induction of anesthesia, C-reactive protein (CRP), mean arterial pressure (MAP), heart rate (HR), and blood sugar (BS) were measured and compared between the 2 groups at 4-point times, 24 and 48 hours immediately after extubation. Results: Finally, the data of 80 patients were included for the final analysis. A statistically significant difference was observed between the 2 groups in terms of CRP and BS values in T1 CRP serum levels; at the end of the study, CRP values were 0.5 ± 0.55 and 0.92 ± 0.69 in groups C and P, respectively (P = 0.012), and BS levels were 124.12 ± 18.11 and 152.0 ± 17.36 in groups C and P, respectively (P = 0.0001). However, this significant difference was not observed at T2 regarding CRP (P = 0.145) and BS (P = 0.135), as well as at T3 regarding CRP (P = 0.282) and BS (P = 0.213). However, according to both CRP and BS values, the trend of changes from T0 to T3 was significant in the 2 groups (P < 0.0001). Hemodynamic parameters were not significantly different between the 2 groups. No adverse event was reported in the 2 groups. Conclusions: We found that ascorbic acid could induce short-term positive effects in abdominal hysterectomy following prolonged fasting time. Obviously, the optimal dosage, timing, and specific cases that benefit the most from this intervention should be investigated.

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COMPARISON OF ASCORBIC ACID CONTENT IN IMPORTED TOMATOES AND IN CULTIVARS GROWN IN NOVA SCOTIA

Canadian Journal of Plant Science ◽

10.4141/cjps87-047 ◽

1987 ◽

Vol 67 (1) ◽

pp. 331-335

Author(s):

HAK-YOON JU ◽

W. JOHN MULLIN

Keyword(s):

Ascorbic Acid ◽

Nova Scotia ◽

Vitamin C ◽

Acid Content ◽

Ascorbic Acid Content ◽

Fresh Weight ◽

Atlantic Region ◽

Significant Difference ◽

Cluster Location ◽

Greenhouse Tomatoes

The ascorbic acid (vitamin C) content of fresh imported field tomatoes and Nova Scotia greenhouse and field tomatoes was determined on a bi-weekly basis during the period of availability of each type of tomato to the Nova Scotia consumer in 1984. The average ascorbic acid contents of imported and Nova Scotia field and greenhouse tomatoes were 13.3, 16.7 and 17.7 mg 100 g−1 fresh weight, respectively. A study of nine recommended or promising field tomatoes for the Atlantic region showed significant differences in ascorbic acid content among the cultivars. The cultivar Quick Pick had the highest ascorbic acid content of 22.5 ± 1.5 mg 100 g−1, the cultivar Campbell 18 had the lowest content, 12.0 ± 2.9 mg 100 g−1. In Dombito greenhouse tomatoes the stage of maturity and the effect of cluster location were tested against ascorbic acid content. The lowest ascorbic acid content of 9.1 ± 1.0 mg 100 g−1 was found with the small green tomatoes while others from mature green to overripe contained 14.0–16.7 mg 100 g−1. Tomatoes from different cluster locations showed no significant difference in ascorbic acid content.Key words: Vitamin C, L-ascorbic acid, tomatoes

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Vitamin C In Neuropsychiatry

Serbian Journal of Experimental and Clinical Research ◽

10.1515/sjecr-2015-0021 ◽

2015 ◽

Vol 16 (2) ◽

pp. 157-161 ◽

Cited By ~ 1

Author(s):

Dragan M. Pavlović ◽

Merdin Š. Markišić ◽

Aleksandra M. Pavlović

Keyword(s):

Ascorbic Acid ◽

Vitamin C ◽

The Body ◽

Adult Brain ◽

Normal Brain ◽

Positive Effects ◽

Normal Brain Function ◽

High Concentrations ◽

High Doses ◽

The Brain

Abstract Vitamins are necessary factors in human development and normal brain function. Vitamin C is a hydrosoluble compound that humans cannot produce; therefore, we are completely dependent on food intake for vitamin C. Ascorbic acid is an important antioxidative agent and is present in high concentrations in neurons and is also crucial for collagen synthesis throughout the body. Ascorbic acid has a role in modulating many essential neurotransmitters, enables neurogenesis in adult brain and protects cells against infection. While SVCT1 enables the absorption of vitamin C in the intestine, SVCT2 is primarily located in the brain. Ascorbate deficiency is classically expressed as scurvy, which is lethal if not treated. However, subclinical deficiencies are probably much more frequent. Potential fields of vitamin C therapy are in neurodegenerative, cerebrovascular and affective diseases, cancer, brain trauma and others. For example, there is some data on its positive effects in Alzheimer’s disease. Various dosing regimes are used, but ascorbate is safe, even in high doses for protracted periods. Better designed studies are needed to elucidate all of the potential therapeutic roles of vitamin C.

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The comparison of techniques and methods for L-ascorbic acid determination in the fruits

Hemijska industrija ◽

10.2298/hemind111020016c ◽

2012 ◽

Vol 66 (4) ◽

pp. 553-558 ◽

Cited By ~ 1

Author(s):

Biljana Cvetkovic ◽

Radomir Malbasa ◽

Eva Loncar ◽

Zvonko Njezic ◽

Olivera Simurina ◽

...

Keyword(s):

Ascorbic Acid ◽

Acetic Acid ◽

Vitamin C ◽

Ascorbate Oxidase ◽

Local Market ◽

Acid Extraction ◽

Metaphosphoric Acid ◽

Significant Difference ◽

Ascorbic Acid Determination ◽

Acid Determination

Vitamin C is an essential vitamin for human nutrition; with the L-ascorbic acid (AA) being the active form of vitamin C. Hence, determination of the L-ascorbic acid in the natural and processed foods is very important. In the past, plenty of methods based on the reversible redox reaction of AA oxidation/DHA reduction were developed. Because of L-ascorbic acid instability in aqueous solutions, it is useful to analyze various types of extraction. The aim of this study is to compare three different methods and three different extractants for the L-ascorbic acid determination. Fruits (kiwi, lemon, orange, and grapefruit) were purchased from a local market. The L-ascorbic acid in these four samples was determined by the three different methods: the AOAC, the HPLC method with three different types of extractions, and the colorimetric method using ascorbate-oxidase. For the HPLC measurements, one part of the fruits was extracted with distilled water, the second with potassium hydrogen phosphate, and the third with 3% meta-phosphoric acid (MPA) in 8% acetic acid. The HPLC measurements of each sample were repeated three times, the AOAC titration was repeated five times, and in the calorimetric method three measurements were performed. The results were statistically evaluated related to sample basis. Statistical analysis shows that there is a significant difference between the results for all three methods of extraction for all samples, except for the grapefruit sample where no significant difference was observed between the results obtained after the buffer extraction (E2) and the metaphosphoric acid in acetic acid extraction (E3). Discriminative analysis for the HPLC determinations proves that there is a clear difference and defined border between the samples in relation to the methods of extraction during the HPLC determination.

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Total phenol, total flavonoid and ascorbic acid content of Iranian commercial orange juice

Journal of Food Safety and Hygiene ◽

10.18502/jfsh.v6i1.6022 ◽

2021 ◽

Author(s):

Hoda Ashari ◽

Naficeh Sadeghi ◽

Mohammad Reza Oveisi ◽

Mannan Hajimahmoodi

Keyword(s):

Ascorbic Acid ◽

Vitamin C ◽

Acid Content ◽

Orange Juice ◽

Ascorbic Acid Content ◽

Total Phenol ◽

Spectrometric Method ◽

Total Phenols ◽

Significant Difference ◽

Gallic Acid Equivalent

This study was designed to measure and compare the total phenols, flavonoids and vitamin C contents in four orange juice brands which are commercially available in Iran. Total phenols, flavonoids and ascorbic acid content of 100 samples from four different commercial brands were evaluated by the spectrometric method. The concentration of total phenol in commercial orange juice samples was between 28.39 and 114.20 mg gallic acid equivalent per liter (mg GAE/L). The measured range of total flavonoids was from 12.53 to 32.62 mg quercetin equivalent per liter (mg QE/L) and the content of ascorbic acid in the samples was between 29.95 and 93.08 mg/L. The results showed a significant difference between the four brand`s total phenols, flavonoids and vitamin C level (P< 0.05). According to the found variation among different studied brands, setting a determined amount for the measured parameters is suggested.

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PERFORMANSI PERTUMBUHAN DAN REPRODUKSI UDANG WINDU, Penaeus monodon YANG DIBERI PAKAN DENGAN PENAMBAHAN VITAMIN C DAN E

Jurnal Riset Akuakultur ◽

10.15578/jra.14.4.2019.233-242 ◽

2019 ◽

Vol 14 (4) ◽

pp. 233

Author(s):

Usman Usman ◽

Kamaruddin Kamaruddin ◽

Asda Laining ◽

Samuel Lante ◽

Bunga Rante Tampangallo

Keyword(s):

Ascorbic Acid ◽

Vitamin E ◽

Vitamin C ◽

Penaeus Monodon ◽

Hepatosomatic Index ◽

Hatching Rate ◽

Test Diet ◽

Tiger Shrimp ◽

Significant Difference ◽

Specific Growth Rates

Penelitian ini bertujuan mengevaluasi pengaruh penambahan vitamin C dan E dalam pakan terhadap performansi pertumbuhan dan reproduksi udang windu fase prematurasi. Dua pakan uji dengan perlakuan: penambahan vitamin C (mengandung ascorbic acid 406,1 mg/kg) dan vitamin E (mengandung 286,3 mg/kg) (PS), dan tanpa penambahan vitamin C dan E (PK). Hewan uji yang digunakan adalah udang windu fase prematurasi hasil budidaya berbobot awal 43,1±5,1 g untuk betina dan 41,9±4,4 g untuk jantan, dipelihara dalam 2 petak tambak beton berukuran 1000 m2 dengan kepadatan awal 100 ekor/tambak dan rasio udang jantan : betina adalah 4 : 6. Udang tersebut diberi pakan uji sebanyak 3% dari biomassa per hari selama 3 bulan di tambak. Selanjutnya udang dipindahkan ke bak pematangan gonad untuk mengevaluasi kinerja reproduksinya. Hasil penelitian menunjukan bahwa,laju pertumbuhan spesifik, total hemosit, jumlah sel sperma, gonada somatic indeks, dan hepatosomatic indeks cenderung lebih tinggi pada udang yang diberi pakan uji PS dibandingkan yang diberi pakan PK. Udang yang diberi pakan uji PS juga memiliki fekunditas, diameter telur, daya tetas telur, dan produksi nauplii yang cenderung lebih tinggi, meskipun secara statistik tidak berbeda nyata (P>0,05) di antara kedua perlakuan. Hasil penelitian ini menunjukkan penambahan vitamin C dan E dalam pakan cenderung meningkatkan performansi pertumbuhan dan reproduksi udang windu. This experiment was aimed to evaluate the effects of feed supplemented with vitamin C and E on the growth and reproductive performances of prematurated tiger shrimp. Two test diets were formulated as the treatments: diet with the addition of vitamin C (contain ascorbic acid of 406.1 mg/kg diet) and vitamin E (contain 286.3 mg/kg diet) (PS), and a diet without the addition of vitamin C and E (PK). The test shrimp were prematurated tiger shrimp with an average initial weight of 43.1 ± 5.1 g/ind. for females and 41.9 ± 4.4 g/ind. for males. The tiger shrimp were cultured in two of 1,000 m2 concrete ponds with a density of 100 ind./pond, and the ratio of male : female was 4 : 6. The shrimp were fed with the experimental diets at a rate of 3% of body weight/day for three months. The shrimp were then transferred to concrete tanks for reproductive evaluation. The results showed that the specific growth rates, total hemocytes, number of sperm cells, gonado-somatic index, and hepatosomatic index tended to be higher in the shrimp fed with the PS test diet compared to the shrimp fed with the PK test diet. The shrimp fed with the PS test diet had higher egg fecundity, egg diameter, hatching rate, and nauplii production compared to the shrimp fed with the PK test diet. However, the study found no significant difference (P>0.05) between the two treatments. The addition of vitamins C and E in the diet could improve the growth and reproductive performance of tiger shrimp.

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Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association

Nutrients ◽

10.3390/nu12020553 ◽

2020 ◽

Vol 12 (2) ◽

pp. 553

Author(s):

Maria Bogdan ◽

Andreea Daniela Meca ◽

Mihail Virgil Boldeanu ◽

Dorin Nicolae Gheorghe ◽

Adina Turcu-Stiolica ◽

...

Keyword(s):

Diabetes Mellitus ◽

Clinical Trials ◽

Ascorbic Acid ◽

Vitamin C ◽

Periodontal Disease ◽

Fruits And Vegetables ◽

Water Soluble ◽

Beneficial Effects ◽

Positive Effects ◽

Water Soluble Vitamin

Ascorbic acid (vitamin C) is an important water-soluble vitamin found in many fruits and vegetables. It has well-documented beneficial effects on the human body and is used as a supplement, alone or in combination with other vitamins and minerals. Over recent years, research has focused on possible new therapeutic actions in chronic conditions including periodontal disease (PD). We conducted a systematic review on clinical trials from four databases (PubMed, Clinical Trials, Cochrane, Web of Science) which measured plasmatic/salivary levels of ascorbic acid in PD–diabetes mellitus (DM) association. Six studies were included in our review, three of them analyzing patients with different grades of PD and DM who received vitamin C as a treatment (500 mg vitamin C/day for 2 months and 450 mg/day for 2 weeks) or as part of their alimentation (guava fruits), in combination with standard therapies and procedures. Decreased levels of vitamin C were observed in PD patients with DM but data about efficacy of vitamin C administration are inconclusive. Given the important bidirectional relationship between PD and DM, there is a strong need for more research to assess the positive effects of ascorbic acid supplementation in individuals suffering from both diseases and also its proper regimen for these patients.

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SUPPLEMENTAL VALUE OF ASCORBIC ACID DURING LATE GESTATION ON PIGLET SURVIVAL AND EARLY GROWTH

Canadian Journal of Animal Science ◽

10.4141/cjas83-077 ◽

1983 ◽

Vol 63 (3) ◽

pp. 683-687 ◽

Cited By ~ 5

Author(s):

E. R. CHAVEZ

Keyword(s):

Ascorbic Acid ◽

Vitamin C ◽

Late Gestation ◽

Dietary Vitamin ◽

Control Group ◽

Plasma Vitamin ◽

Significant Difference ◽

Vitamin C Supplementation ◽

Dietary Treatments ◽

Piglet Survival

Twenty-six pregnant sows were included in four different dietary treatments as follows: (1) Control group with no vitamin C supplementation; (2) vitamin-C-supplemented group receiving 1 g/day ascorbic acid provided in a gelatin capsule; or (3) vitamin-C-supplemented group receiving 1 g/day ascorbic acid in a powder form spread on the top of the pelleted meal; (4) as (3) but receiving 10 g/day ascorbic acid. Vitamin-C-supplemented sows in treatments 2 and 4 showed a significant (P < 0.05) increase in blood plasma vitamin C prefarrowing. Pregnant sows receiving 10 g/day vitamin C supplement showed a significantly (P < 0.05) higher concentration of this vitamin in the urine than either control or sows receiving 1 g/day vitamin C supplementation. Sows in treatment 4 showed a significantly higher (P < 0.05) vitamin C content in colostrum than control animals. During lactation, no significant difference in vitamin C content in milk was observed between control and animals receiving 10 g/day vitamin C supplement. The vitamin C content in the plasma of the piglets at birth indicated that supplementing vitamin C to the mothers, significantly (P < 0.05) increased the concentration of this vitamin in the newborn piglet compared to control animals. However, the piglet survival and growth up to weaning at 3 wk of age was not significantly affected by dietary vitamin C supplementation of the mothers' diet. Key words: Ascorbic acid, gestation, piglet survival, Vitamin C

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Role of serum Vitamin-C and lipid profile in cardiovascular diseases patients of Southern Rajasthan

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20194585 ◽

2019 ◽

Vol 7 (11) ◽

pp. 4003

Author(s):

Parul Dhanak ◽

Ashish Sharma ◽

Neha Sharma

Keyword(s):

Ascorbic Acid ◽

Vitamin C ◽

Lipid Profile ◽

Disease Risk ◽

Serum Vitamin ◽

Normal Diet ◽

Adult Men ◽

Chronic Disease Risk ◽

Significant Difference

Background: Vitamin C's functions as an antioxidant and as an enzyme cofactor are well established, but the ways in which these functions may modify chronic disease risk are less well established. The belief that vitamin C may benefit heart health has stemmed from multiple pieces of evidence and lines of reasoning. Thus, we took the objective of this study to evaluate the correlations of serum concentrations of trace elements including vitamin-C with lipid profile parameters of adult men in Southern Rajasthan.Methods: Present study was conducted in Cardiology and Biochemistry Department in GMCH, Udaipur during the year 2019. A total of 150 MI cases/controls were selected. Blood sample was collected by vein puncture using an aseptic technique. The blood was allowed to settle at 37ºC and then centrifuged at 3000 rpm for 15 min. Serum was then separated and stored at -20ºC until analysis. Vitamin C by NATELSON method on colorimeter.Results: The study cases had significantly higher lipid values than those of controls (p<0.001). In cases the vitamin-C levels were significantly low than the controls. There was significant difference in lipid levels among smokers and nonsmokers. When vitamin C levels were compared there was no statistically significant difference in their levels. There was no significant correlation between serum vitamin C levels and Lipids.Conclusions: The physical characteristics such as diet, residence, smokers, non-smokers, showed significant difference in the controls and cases. Women seemed to have higher proportion of lipid abnormality than men. It is concluded from this study that lower levels of ascorbic acid definitely increase the risk of cardiovascular disease and inclusion of ascorbic acid in the normal diet will control the level of lipids.

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Effects of dietary vitamin E and vitamin C supplementation on the level of α-tocopherol and L-ascorbic acid in muscle and on the antioxidative status and meat quality of pigs

Czech Journal of Animal Science ◽

10.17221/4012-cjas ◽

2011 ◽

Vol 50 (No. 4) ◽

pp. 175-184 ◽

Cited By ~ 7

Author(s):

R. Lahučký ◽

IBahelka ◽

K. Novotná ◽

K. Vašíčková

Keyword(s):

Ascorbic Acid ◽

Vitamin E ◽

Vitamin C ◽

Oxidative Stability ◽

Meat Quality ◽

Alpha Tocopherol ◽

Dietary Vitamin ◽

Control Group ◽

Drip Loss ◽

Positive Effects

In total thirty pigs (Slovak Meaty) defined by DNA based test as not susceptible to malignant hyperthermia (non-mutant on RYR1) were used in the experiment. Treatment consisted in supplementation of vitamin E (500 mg α-tocopherol/kg diet as α-tocopherol acetate) (group E) and the same doses of vitamin E plus vitamin C (200 mg L-ascorbic acid/kg diet) (group E + C) to finishing pigs for the last 30 days before slaughter. The higher dietary vitamin E level resulted in higher levels of α-tocopherol in fresh (24 h), chill-stored (5 days, 4°C), chill-stored and cooked (80°C) and frozen meat (3 months, –25°C), (P < 0.05). Higher dietary vitamin C resulted in higher levels L-ascorbic acid in fresh and chill-stored meat (P < 0.05) but no significant differences vs. control pigs were observed in cooked and frozen meats. Supplementation with vitamins E and C (group E + C) had positive effects on pH (45 min) (P = 0.06) and on drip loss (P < 0.05) values as compared to control group. The rate of oxidation (malondialdehyde-MDA production) by stimulation with Fe<sup>2+</sup>/ascorbate (incubation of muscle LD for 0 and 30 min) was higher in control group as compared to both experimental groups (P < 0.05). Positive effects of vitamin E on oxidative stability measured as thiobarbituric acid reactive substances (TBARS, MDA) were observed mainly in chill-stored meat (P < 0.05). Using TBARS method, no additional effect of vitamin C on oxidative stability of fresh, chill-stored, cooked and frozen meat was found. In conclusion, supplementation of the combination of vitamin E (500 mg α-tocopherol/kg diet) and vitamin C (200 mg L-ascorbic acid/kg diet) for 30 days before slaughter improved meat quality values (drip loss, pH), however, it seems to depend on the genetic background of animals (occurrence of mutation on RYR1). Oxidative stability of meat lipids measured as TBARS value can be improved by vitamin E supplementation to feed.  

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Efficacy of L-Ascorbic acid in the healing of extraction site after trans alveolar extraction of third molar teeth

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11ispl4.4261 ◽

2020 ◽

Vol 11 (SPL4) ◽

pp. 1179-1182

Author(s):

Subhashini Ramasubbu ◽

Shivangi Gaur ◽

Abdul Wahab P U ◽

Madhulaxmi Marimuthu

Keyword(s):

Wound Healing ◽

Ascorbic Acid ◽

Vitamin C ◽

Third Molar ◽

Mouth Opening ◽

Surgical Removal ◽

Significant Difference ◽

Tissue Flap ◽

Group B ◽

Soft Tissue Flap

Wound healing monitoring after every surgery is the most vital concern to deal with. The surgical removal of the teeth involves guttering of overlying bone, splitting the tooth (odontectomy), delivery of the tooth, irrigation of the socket, achieving haemostasis and closure of the soft tissue flap. This leads to big surgical insults resulting in post-operative inflammatory response like pain and swelling, difficulty in mouth opening, fever, etc. In some cases, other rare complications, including infection, nerve damage, have also been reported. The objective of this study is to evaluate the effects of submucosal injection of vitamin c (L-Ascorbic Acid) in wound healing after trans alveolar extraction of teeth. Thirty patients requiring trans alveolar extraction of teeth were included in this study. Patients were divided into two groups, Group S (Vit c) and Group B (Control). Healing of extraction socket was observed on 3rd and 7th post-operative days. The study group (Vitamin C) had better healing indices than the controls at 7th post-op day. There was no significant difference in 3rd post-op day. There was no significant reduction in pain on 3rd and 7th post-operative days. L-Ascorbic acid injection provides satisfactory post-operative healing following trans alveolar extraction of teeth. But it does not decrease the post-operative pain following surgery.

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