Efficacy of Three-Dimensional Transvaginal Sonography in Diagnosis of Uterine Cavity Abnormalities Among Infertile Women: A Cross-Sectional Study

Background and Aim: Uterine anatomical pathologies play important roles in causing female infertility. This study was conducted to survey the efficiency of hysteroscopy and vaginal sonography in detecting the intrauterine pathologies in infertile women. Methods: This cross-sectional study was conducted on all the infertile women referring to the Endometriosis Research Center between December 22, 2013 and August 22, 2015. Forty five women were recruited and the data on the examinations of uterine lesions were analyzed by transvaginal sonography (TVS), hysteroscopy, and pathology as the standard test. Data analysis was conducted by SPSSv16 using t-test and Mann-Whitney test, and the sensitivity and specificity were measured with reference to the standard test. Findings: For diagnosing polyp, endometrial hyperplasia, and myoma, TVS showed the 75%, 25%, and 85.71% sensitivity, respectively, and specificity of 92.30%, 92.30%, and 56.97% respectively. For them, hysteroscopy showed the 60%, 75%, and 75.71% sensitivity respectively, and specificity of 71.65%, 30.92%, and 56.97% respectively. Conclusion: According to the findings of this study, the sensitivity of TVS and hysteroscopic findings in diagnosing uterine pathologies is relatively high, but the sensitivity of TVS was low to diagnosis of endometrial hyperplasia.

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The Relationships Between Serum DHEA-S and AMH Levels in Infertile Women: A Retrospective Cross-Sectional Study

Journal of Clinical Medicine ◽

10.3390/jcm10061211 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1211

Author(s):

Li-Te Lin ◽

Kuan-Hao Tsui

Keyword(s):

Generalized Linear Models ◽

Large Scale ◽

Linear Models ◽

Positive Association ◽

Cross Sectional Study ◽

Dehydroepiandrosterone Sulphate ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

The Relationship

The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established. Therefore, we performed a large-scale cross-sectional study to investigate the association between serum DHEA-S and AMH levels. The study included a total of 2155 infertile women aged 20 to 46 years who were divided into four quartile groups (Q1 to Q4) based on serum DHEA-S levels. We found that there was a weak positive association between serum DHEA-S and AMH levels in infertile women (r = 0.190, p < 0.001). After adjusting for potential confounders, serum DHEA-S levels positively correlated with serum AMH levels in infertile women (β = 0.103, p < 0.001). Infertile women in the highest DHEA-S quartile category (Q4) showed significantly higher serum AMH levels (p < 0.001) compared with women in the lowest DHEA-S quartile category (Q1). The serum AMH levels significantly increased across increasing DHEA-S quartile categories in infertile women (p = 0.014) using generalized linear models after adjustment for potential confounders. Our data show that serum DHEA-S levels are positively associated with serum AMH levels.

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In-House, Open-Source 3D-Software-Based, CAD/CAM-Planned Mandibular Reconstructions in 20 Consecutive Free Fibula Flap Cases: An Explorative Cross-Sectional Study With Three-Dimensional Performance Analysis

Frontiers in Oncology ◽

10.3389/fonc.2021.731336 ◽

2021 ◽

Vol 11 ◽

Author(s):

Lucas M. Ritschl ◽

Paul Kilbertus ◽

Florian D. Grill ◽

Matthias Schwarz ◽

Jochen Weitz ◽

...

Keyword(s):

Open Source ◽

Dimensional Analysis ◽

Open Source Software ◽

Three Dimensional ◽

Cross Sectional Study ◽

Sectional Study ◽

Free Fibula Flap ◽

Cross Sectional ◽

Cad Cam ◽

Free Fibula

BackgroundMandibular reconstruction is conventionally performed freehand, CAD/CAM-assisted, or by using partially adjustable resection aids. CAD/CAM-assisted reconstructions are usually done in cooperation with osteosynthesis manufacturers, which entails additional costs and longer lead time. The purpose of this study is to analyze an in-house, open-source software-based solution for virtual planning.Methods and MaterialsAll consecutive cases between January 2019 and April 2021 that underwent in-house, software-based (Blender) mandibular reconstruction with a free fibula flap (FFF) were included in this cross-sectional study. The pre- and postoperative Digital Imaging and Com munications in Medicine (DICOM) data were converted to standard tessellation language (STL) files. In addition to documenting general information (sex, age, indication for surgery, extent of resection, number of segments, duration of surgery, and ischemia time), conventional measurements and three-dimensional analysis methods (root mean square error [RMSE], mean surface distance [MSD], and Hausdorff distance [HD]) were used.ResultsTwenty consecutive cases were enrolled. Three-dimensional analysis of preoperative and virtually planned neomandibula models was associated with a median RMSE of 1.4 (0.4–7.2), MSD of 0.3 (-0.1–2.9), and HD of 0.7 (0.1–3.1). Three-dimensional comparison of preoperative and postoperative models showed a median RMSE of 2.2 (1.5–11.1), MSD of 0.5 (-0.6–6.1), and HD of 1.5 (1.1–6.5) and the differences were significantly different for RMSE (p < 0.001) and HD (p < 0.001). The difference was not significantly different for MSD (p = 0.554). Three-dimensional analysis of virtual and postoperative models had a median RMSE of 2.3 (1.3–10.7), MSD of -0.1 (-1.0–5.6), and HD of 1.7 (0.1–5.9).ConclusionsOpen-source software-based in-house planning is a feasible, inexpensive, and fast method that enables accurate reconstructions. Additionally, it is excellent for teaching purposes.

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RELATIONSHIP BETWEEN DEPRESSION, ANXIETY AND STRESS WITH QUALITY OF LIFE OF INFERTILE COUPLES

10.36106/ijsr/9628314 ◽

2020 ◽

pp. 1-3

Author(s):

Jisha M. ◽

Dr Assuma Beevi.T. M.

Keyword(s):

Quality Of Life ◽

Cross Sectional Study ◽

Social Effects ◽

Anxiety And Depression ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Stress Scale ◽

Infertile Couples

Introduction: Psychological and social effects of infertility may cause decline in the quality of life of infertile couples. A cross sectional study was conducted among 100 infertile couples, to find out the association between level of stress, anxiety and depression with their quality of life. Materials and methods: Data was collected using demographic and fertility information questionnaire, depression anxiety and stress scale (DASS-42) and fertility quality of life (fertiQol-malayalam). Results: Infertile couples experiences higher levels of depression, anxiety and stress and it is more among women,(depression-(15.36 +_ 9.23), stress(16.3+-7.52) anxiety (9.36+_6.33) than men (depression(12.52+_10.30 )(P=0.030), stress(12.84+_ 7.94 )(P=0-002 ) anxiety(7.50+_5-55). Levels of depression, anxiety and stress have significant negative relation with their quality of life. Infertile women has significantly lower quality of life (P= 0.002) than men. Conclusion: Interventions, to reduce depression, anxiety and stress among infertile couples may be helpful to improve their quality of life.

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AMH and AMHR2 Polymorphisms and AMH Serum Level Can Predict Assisted Reproduction Outcomes: A Cross-Sectional Study

Cellular Physiology and Biochemistry ◽

10.1159/000373961 ◽

2015 ◽

Vol 35 (4) ◽

pp. 1401-1412 ◽

Cited By ~ 17

Author(s):

Carla Peluso ◽

Fernando L.A. Fonseca ◽

Guilherme G. Gastaldo ◽

Denise M. Christofolini ◽

Emerson Barchi Cordts ◽

...

Keyword(s):

Serum Level ◽

Assisted Reproduction ◽

Controlled Ovarian Hyperstimulation ◽

Cross Sectional Study ◽

Human Reproduction ◽

Ovarian Hyperstimulation ◽

Sectional Study ◽

Cross Sectional ◽

Infertile Women ◽

Assisted Reproductive Treatment

Background: In human assisted reproduction, the ovarian response to exogenous recombinant Follicle-stimulating Hormone (FSH) therapy is variable and difficult to predict. The standard protocol of ovarian hyperstimulation can result in satisfactory response; however, an unsatisfactory response necessitates FSH dose adjustment or results in ovarian hyperstimulation syndrome (OHSS). Polymorphisms in AMH and AMHR2 genes appear to affect hormone biological activities, thus affecting follicle recruitment and development, leading to infertility. We aimed to evaluate AMH and AMHR2 polymorphisms in infertile women, and correlate those findings with AMH, FSH and estradiol serum level response to controlled ovarian hyperstimulation (COH), as well as assisted reproduction outcomes. Methods: A cross-sectional study comprising 186 infertile women that underwent one cycle of high complexity assisted reproductive treatment. Blood samples were collected and a TaqMan assay was used for AMH G146T/rs10407022 and AMHR2 A-482G/rs2002555, A10G/rs11170555, C1749G/rs2071558 and G4952A/rs3741664 genotyping, and FSH, estradiol and AMH levels were measured. The findings were correlated to human reproduction outcomes. Results: AMH rs10407022 and AMHR2 rs2002555 polymorphisms were not associated with hormonal measurements, whereas AMHR2 rs11170555 and rs3741664 were positively associated with AMH, estradiol and FSH levels. The genotype distribution of AMH and AMHR2 genes according to Controlled Ovarian Hyperstimulation did not show a positive association. However, an association with AFC, degree of oocyte maturation (allele G of AMHR2 rs2071558) the number of embryos produced (alleles T and G of AMH rs10407022 and AMHR2 rs2002555, respectively) and frozen embryo (allele G of AMHR2 rs11170555) were found to be statistically associated. Considering COH, serum AMH and AFC were a positive predictor to OHSS. Regarding serum AMH and assisted reproduction outcomes, a positive correlation with all variables studied was found. Comparing AFC and AMH as predictors of human reproduction outcomes, the AFC was less effective than serum AMH. Considering pregnancy rates, no marker was positively associated. Conclusion: AMHR2 polymorphisms were associated with estradiol, AMH and FSH measurements, as well as number and quality of embryos, while AMH polymorphisms was associated with number of embryos produced. Serum AMH was correlated with nearly all variables analyzed in assisted reproductive treatment, demonstrating that it represents a better biomarker of OHSS and human reproduction outcomes compared to AMH and AMHR2 polymorphisms.

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Comparative Evaluation of Saline Infusion Sonohysterography and Hysterolaparoscopy for Diagnosis of Uterine Cavity Abnormalities and Tubal Patency in Infertility: A One Year Cross- sectional Study

Journal of SAFOG with DVD ◽

10.5005/jp-journals-10006-1081 ◽

2010 ◽

Vol 2 (2) ◽

pp. 133-135 ◽

Cited By ~ 1

Author(s):

Hema Dhumale ◽

BR Desai ◽

Yeshita Pujar ◽

Bhavana Sherigar ◽

Shobana Patted

Keyword(s):

Predictive Value ◽

Uterine Cavity ◽

Cross Sectional Study ◽

Saline Infusion ◽

Research Centre ◽

Sectional Study ◽

Cross Sectional ◽

Tubal Patency ◽

One Year ◽

Saline Infusion Sonohysterography

ABSTRACT Objective To compare the diagnostic efficacy of saline infusion sonohysterography (SIS) with hysterolaparoscopy in evaluation of uterine cavity and tubal patency. Methods This prospective one year cross-sectional study was conducted at the assisted reproduction center (ARC), KLES Dr Prabhakar Kore Hospital and Medical Research Centre, Belgaum. A total of 60 patients underwent SIS for evaluation of uterine cavity and tubal patency. Subsequently all patients underwent hysterolaparoscopy with chromopertubation (CPT). Results of SIS and hysterolaparoscopy with chromopertubation were compared. Results For evaluation of uterine cavity, when compared with hysteroscopy, SIS had a sensitivity of 97.8%, specificity of 88.8%, positive predictive value (PPV) of 97.8% and negative predictive value (NPV) of 88.8%. For evaluation of tubal patency when SIS was compared to laparoscopy with CPT, SIS had a sensitivity of 83.3%, specificity of 82.9%, PPV of 42.9% and NPV of 97.5%. Conclusion Saline infusion sonohysterography is a noninvasive, simple, easy and cost-effective procedure. SIS is more sensitive and specific for evaluation of uterine cavity as compared to evaluation of tubal patency.

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Validity of The Fertility Quality of Life (FertiQol) Questionnaire in Indonesian Infertile Women

KnE Medicine ◽

10.18502/kme.v1i1.642 ◽

2017 ◽

Vol 1 (1) ◽

pp. 202

Author(s):

Muhammad D. Priangga ◽

Gita Pratama ◽

Mila Maidarti ◽

Achmad K. Harzif ◽

Budi Wiweko

Keyword(s):

Quality Of Life ◽

Statistical Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Validity And Reliability ◽

Cross Sectional ◽

Infertile Women ◽

The Mean ◽

Preliminary Study

IntroductionInfertility in Indonesia has an estimated prevalence as high as 22.3%, with the nature of the problem and its treatment could be devastating, it could affect quality of life and vice versa influence successful of the treatment. The Fertility Quality of Life (FertiQol) Questionnaire was specifically designed for infertility couples and has been demonstrated to have good properties. Studies in several countries has showed consistency in validity and reliability of the questionnaire. Precedently there has been no published study about Fertiqol in Indonesia, this preliminary study is to measure validity and reliability of FertiQol questionnaire among Indonesian infertility women. Material & MethodsThis is a cross-sectional study, a written Fertiqol Questionnaire Indonesian version (www.Fertiqol.org) were distribute to Infertility clinic in Cipto Mangunkusumo General Hospital, total of 129 women completed the questionnaire. Statistical analysis used SPSS version 23.0. The questionnaire were tested for validity with Pearson’s correlation with two tailed and Cronbach α coefficient for reliability. ResultsFertiQol were completed by 129 women with infertility problem. The mean of total FertiQol score was 70.49±11.44, score for emotional, mind/body, relational, environment and tolerability was respectively 63.79±18.86; 66.05±18.22; 75.19.±15.11; 68.99±18.63; 75.64±16.55; 66.23±19.17. Reliability of Fertiqol was high (Cronbach a > 0.70) with every item of questionnaires was valid ( r> 0.1729). ConclusionThis study showed that FertiQol Indonesian version are valid and reliable in measured quality of life among infertility women in Indonesia.

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Effect of flip-flops on lower limb kinematics during walking: a cross-sectional study using three-dimensional gait analysis

Irish Journal of Medical Science (1971 -) ◽

10.1007/s11845-016-1421-y ◽

2016 ◽

Vol 185 (2) ◽

pp. 493-501 ◽

Cited By ~ 7

Author(s):

T. Sharpe ◽

A. Malone ◽

H. French ◽

D. Kiernan ◽

T. O’Brien

Keyword(s):

Gait Analysis ◽

Lower Limb ◽

Three Dimensional ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Limb Kinematics ◽

Lower Limb Kinematics

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VAGINAL SONOGRAPHY a HYSTEROSCOPY

The Professional Medical Journal ◽

10.29309/tpmj/2009.16.03.2873 ◽

2009 ◽

Vol 16 (03) ◽

pp. 432-437

Author(s):

MASOMEH ASGHARNIA ◽

Zahra Mohammad Tabar ◽

MARZIEH MEHRAFZA ◽

Mary am Shakiba ◽

MONA OUDI ◽

...

Keyword(s):

Sensitivity And Specificity ◽

Uterine Cavity ◽

Cross Sectional Study ◽

Therapeutic Modality ◽

Histological Evaluation ◽

Complete Evaluation ◽

Cross Sectional ◽

Predictive Values ◽

Infertile Women ◽

Sensitivity Specificity

B a c k g r o u n d : Hysteroscopy is a valuable diagnostic and therapeutic modality in the management of infertility. A i m : To evaluatethe consistency of hysteroscopy based on a histopathological report from endometrial specimens for intrauterine disorders. Materials andMethods: This is a cross-sectional study. The study included 115 infertile patients. All were admitted for investigation of infertile women beforeassisted reproduction in Mehr infertility institute between 2006 and 2007 hysteroscopy, and histological evaluation of endometrial biopsyperformed.We compared the efficacy of hysteroscopy in the diagnosis of benign intrauterine pathology in infertile women in whom the diagnosiswas confirmed by histologic studies. The women had a complete evaluation with preoperative hysteroscopy, and histological analysis of uterinecavity specimens. Sensitivity, specificity, predictive and negative predictive values were calculated for hysteroscopy considering the histologicalstudy as 100%. Results: Sensitivity and specificity of sonography in diagnosing the polyp were stated 81 % and 64% respectively. Sensitivityand specificity of hysteroscopy showed of polyps revealed 85% and 84% respectively. The results indicated that Sensitivity and specificity ofsonography in diagnosing the myoma were 25% and 98% respectively. Sensitivity and specificity of hysteroscopy in diagnosing the myomawere expressed 50% and 93% respectively. C o n c l u s i o n : Hysteroscopy is a safe and rapid direct visualisation of the uterine cavity. We believeit should be replaced by the diagnostic hysteroscopy as a first line infertility investigation.

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Investigating Hysteroscopy Implementation in Infertile Women Candidate With a Normal Uterine Cavity for Laparoscopy in Hysterosalpingography

International Journal of Women s Health and Reproduction Sciences ◽

10.15296/ijwhr.2019.13 ◽

2018 ◽

Vol 7 (1) ◽

pp. 79-84

Author(s):

Maliheh Amirian ◽

Anis Darvish Mohammadabad ◽

Negar Morovatdar ◽

Leili Hafizi

Keyword(s):

Diagnostic Laparoscopy ◽

False Negative ◽

Uterine Cavity ◽

Cross Sectional Study ◽

P Value ◽

Cross Sectional ◽

Endometrial Polyps ◽

Infertile Women ◽

Submucous Myoma ◽

Age Range

Objectives: Endometrial pathologies inside the cavity can occur simultaneously with gestational unpleasant consequences but are not always capable of being diagnosed by the hysterosalpingography (HSG). This study aimed to examine the value of performing diagnostic hysteroscopy beside diagnostic laparoscopy among infertile women with normal uterine cavities in HSG. Materials and Methods: A total of 103 infertile women with normal uterine cavities in the HSG and within the age range of 18-40 who referred to Imam Reza hospital for laparoscopy during 2016-2017 were included in this cross-sectional study. Hysteroscopy was performed simultaneously with diagnostic laparoscopy. Then, the existence of uterine pathologies like endometrial polyps, submucous myoma, and uterine endometrial adhesions and their relationship with the patient’s age, infertility type and duration, and cycle time were evaluated. A P value less than 0.05 was considered statistically significant. Results: Overall, 64 patients (63.1 %) had a normal uterine cavity in the hysteroscopy while 39 of them had an abnormal uterine cavity, the HSG false negative cases of whom were reported 37.9%. The pathologies found in the hysteroscopy were endometrial polyp (16 cases), submucous myoma (1 case), uterine septum (6 cases), asherman syndrome (7 cases), bicornuate uterus (4 cases), polyp + asherman (3 cases), polyp + submucous myoma (1 case), and septum + submucous myoma (1 case). Patients’ age, type of infertility, and menstruation time during performing hysteroscopy made no particular difference in diagnosing pathologies of the uterine cavity in the hysteroscopy. Conclusions: Based on the findings, conducting hysteroscopy in infertile women who are candidates of laparoscopy and have normal uterine cavities in HSG can result in recognizing some cases of uterine pathologies which influence the outcomes of future pregnancies is not dependent upon the patient’s age, menstruation time, type and duration of infertility, and result of laparoscopy.

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