scholarly journals Intense Impact of Health Alert Due to COVID-19 on Adherence of Moderate to Severe Psoriasis Patients to Hospital Therapy

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Luisa Martos-Cabrera ◽  
Alberto Calvo-Garcia ◽  
Beatriz Butron-Bris ◽  
Ana Reymundo ◽  
C. Santamaria ◽  
...  
Keyword(s):  
Biological Therapy ◽  
Certolizumab Pegol ◽  
Medication Possession Ratio ◽  
Income Quintile ◽  
Control Group ◽  
Dermatology Department ◽  
Paired Control ◽  
Chronic Skin ◽  
Observational Database Study ◽  
Chronic Skin Disease

Background: Psoriasis is a chronic skin disease in which lifelong treatment is required. Recently, we faced COVID-19 pandemic where adherence to a prescribed drug could have been affected. Objectives: We conduct a study to assess this statement. Methods: The study was performed in Dermatology Department with Pharmacy database in the Hospital Universitario de La Princesa. A retrospective observational database study was performed, including all psoriatic patients with a biological therapy prescription between March 13 and May 31, 2020, with a paired control group between March 13 and May 31, 2019. Medication possession ratio (MPR) was used to determine the adherence. Results: A total of 244 patients were included in the cohort and 228 in the control group. We observed a decrease in the percentage of adherent patients of 40.0% in COVID-19 period. Overall, MPR was lower in the 2020 period than in 2019. MPRs by treatment and drug family, with the exception of etanercept, certolizumab pegol, and guselkumab, were significantly lower between the 2019 and the 2020 period. Conclusions: Adherence to a prescribed drug can be affected by different factors such as age, sex, income quintile, or stress. We have demonstrated a deep impact on adherence because of the situation created by COVID-19 pandemic. These data are in contrast with previously reported results where adherence was slightly affected, probably due to the different epidemiological situation in different countries. Further efforts are needed to be done to mitigate COVID-19 pandemic influence on the therapeutic adherence.

scholarly journals Association between Psoriasis and Obesity

2018 ◽  
Vol 16 (2) ◽  
pp. 58-61
Author(s):  
Sumit Pandey ◽  
Smita Jha ◽  
Shyam Kumar B.K ◽  
Shyam Kumar B.K. ◽  
Kumar Pokharel
Keyword(s):  
College Teaching ◽  
Control Group ◽  
Medical College ◽  
Pasi Score ◽  
Prevalence Of Obesity ◽  
Study Population ◽  
Duration Of Disease ◽  
The Mean ◽  
Chronic Skin ◽  
Chronic Skin Disease

Background: Psoriasis is primarily a chronic skin disease, the course being punctuated by remissions and relapses. Research has shown that hypertension, obesity, heart failure and diabetes are significantly more common in patients with psoriasis. Obesity is associated with severe psoriasis and is reported about twice as frequently among psoriasis patients as in the general population. In recent years many reports have demonstrated an association between psoriasis and metabolic syndrome. Objectives: The aim of this study was to identify the prevalence of obesity in patients with psoriasis and compare it with that of non-psoriatic population. Material and Method: This study is a case control hospital based study conducted in the Department of Dermatology, Venereologyand Leprology of Nepalgunj Medical College Teaching Hospital, Kohalpur between May 2017 to October 2018.Total 56 cases of psoriasis and similar number of healthy age and sex matched controls were enrolled in the study after taking written consent. Detailed history and physical examination was performed with measurement of body mass index which was recorded. Statistical analysis was done using SPSS 20. Result: The results of the study which included 56 patients with psoriasis and 56 subjects without psoriasis. Among them 26 male and 30 female in study population and 25 male and 31 female in control group. The mean age was41.68±19.04 years in study population and 39.46 ±16.27 years in control group. Duration of disease ranged from 2 months to 360months and PASI score ranged from 4.4 to 28.2 with mean PASI score 11.02±5.4. BMI in cases ranged from 16.7 to 34.2 with mean24.3±4.3 and in controls it ranged from 15.5 to 29.1 with mean 21.9±3. Mean BMI was significantly higher in cases than controls. Conclusion: The result of this study supports the significantly higher prevalence of obesity in study population than control group.

Life course and family history in dermatitis artefact: a comparative study

2011 ◽  
Vol 26 (S2) ◽  
pp. 1660-1660
Author(s):  
Y. El Kissi ◽  
J. Mannai ◽  
N. Kenani ◽  
R. Nouira ◽  
B. Ben Hadj Ali
Keyword(s):  
Family History ◽  
Life Course ◽  
Medical Care ◽  
Psychiatric Disorders ◽  
Skin Disease ◽  
Suicide Attempts ◽  
Professional Activity ◽  
Dermatology Department ◽  
Chronic Skin ◽  
Chronic Skin Disease

IntroductionDermatitis artefact (DA) is a self-inflicted skin disease. The exploration of family history and life course of patients could help to better understand the pathogenesis of this disorder.ObjectiveTo compare family history and life course between patients with DA with patients with other chronic skin disease and siblings.Materials and methodsThirty female patients meeting DSM-IV criteria of DA were recruited in dermatology department of Farhat Hached hospital (Sousse, Tunisia).Controls consisted of 30 patients with chronic dermatitis, randomly selected and matched for age and disease duration. For each patient, one sister, the closest in age, was recruited to constitute the siblings group.ResultCompared with controls, DA patients had lower educational level (p < 10-3), less occupational activity (p = 0.002) and were more often single (p < 10-3). They reported more medical care or prolonged hospitalization in childhood (p = 0.013), more psychiatric disorders (p = 0.006) and more suicide attempts (p = 0.001).Compared with their sisters, patients with DA had fewer professional activity (p < 103), and were more often single (p < 10-3). They also had more medical history or prolonged hospitalizations during childhood (p = 0.006), more psychiatric disorders (p = 0.002) and more suicide attempts (p = 0.001).ConclusionCompared to their sisters and to patients with other chronic skin disease, DA patients were more often single, less often professionally active and had more medical care during childhood, psychiatric history and suicide attempts.

Depression, anxiety and quality of life in female patients with dermatitis artefact: a comparative study

2011 ◽  
Vol 26 (S2) ◽  
pp. 1661-1661
Author(s):  
Y. El Kissi ◽  
J. Mannai ◽  
N. Kenani ◽  
R. Nouira ◽  
B. Ben Hadj Ali
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Depression Scale ◽  
Mental Condition ◽  
Anxiety And Depression ◽  
Control Group ◽  
Dermatology Department ◽  
Chronic Skin ◽  
Impaired Quality

IntroductionPsychological profile and quality of life of patients suffering from Dermatitis artefact (DA) have never been assessed in a standardized and comparative way.ObjectiveTo compare anxiety, depression and quality of life in patients with DA and in patients with other chronic skin illnessMaterial and methodsThirty patients meeting DSM-IV criteria of Dermatitis artefact were recruited in dermatology department of Farhat Hached hospital (Sousse, Tunisia). Control group consisted of 30 patients with other chronic dermatitis, randomly selected and matched for age and disease duration. Anxiety and depression were assed using the Hospital Anxiety and Depression Scale (HAD-S). Quality of life was measured by the MOS 36-Item Short-Form Health Survey (SF-36).ResultsCompared with controls, patients with DA had an impaired quality of life (p < 10-3). They had lower scores in physical activity (p = 10-3), limitations due to physical condition (p = 0.024), physical pain (p < 10-3), perception of health (p < 10-3). They also had lower scores in vitality (p = 0.005), social dysfunction (p = 0.003), limitations due to mental condition (p < 10-3) and mental health (p < 10-3). Anxiety and depression scores showed no differences between DA patients and controls.ConclusionCompared to patients with other chronic dermatological conditions, patients suffering from DA had a more impaired quality of life, but they were no more depressed or anxious.

scholarly journals Association between Alcohol, Smoking and HLA-DQA1*0201 Genotype in Psoriasis

2004 ◽  
Vol 36 (9) ◽  
pp. 597-602 ◽  
Author(s):  
Guang-Yong Zheng ◽  
Sheng-Cai Wei ◽  
Tie-Liu Shi ◽  
Yi-Xue Li
Keyword(s):  
Control Group ◽  
Specific Primer ◽  
Reaction Sequence ◽  
Chain Reaction ◽  
Male Patients ◽  
Polymerase Chain ◽  
Chronic Skin ◽  
Few Data ◽  
Hla Dqa1 ◽  
Chronic Skin Disease

Abstract Psoriasis is a chronic skin disease triggered by genetic, environment or other risk factors such as infection, drugs, stress, moisture, alcohol, and smoking. A major psoriasis susceptibility locus at 6p21.3 has been identified. Further studies found that HLA-DQA1*0201 allele was associated with psoriasis. However, there were few data exploring an association between the environmental factors and susceptibility genes. In this study, the samples of 189 patients with psoriasis and 333 healthy controls were collected with their consent and were carried on analysis through polymerase chain reaction sequence-specific primer (PCR-SSP) method. The proportion of male psoriasis patients engaging in the smoking and alcohol was much higher than that of the control group (P<0.005). The HLA-DQA1*0201 allele was present at significantly higher frequency in the patients with psoriasis (OR=4.25, P<1.0×10−6). Association was found between smoking, alcohol and HLA-DQA1*0201 in male patients with psoriasis (OR>6.91, P<1.0×10−4).

Paracrystalline Aggregates of Psoriatic Keratin and Their Relation to Normal Keratin Structure

1985 ◽  
Vol 43 ◽  
pp. 680-681
Author(s):  
S. Trachtenberg ◽  
P.M. Steinert ◽  
B.L. Trus ◽  
A.C. Steven
Keyword(s):  
Cell Death ◽  
Stratum Corneum ◽  
Intermediate Filament ◽  
Skin Disease ◽  
Amorphous Matrix ◽  
Terminal Differentiation ◽  
Proteolytic Degradation ◽  
Horny Layer ◽  
Chronic Skin ◽  
Chronic Skin Disease

During terminal differentiation of vertebrate epidermis, certain specific keratin intermediate filament (KIF) proteins are produced. Keratinization of the epidermis involves cell death and disruption of the cytoplasm, leaving a network of KIF embedded in an amorphous matrix which forms the outer horny layer known as the stratum corneum. Eventually these cells are shed (desquamation). Normally, the processes of differentiation, keratinization, and desquamation are regulated in an orderly manner. In psoriasis, a chronic skin disease, a hyperkeratotic stratum corneum is produced, resulting in abnormal desquamation of unusually large scales. In this disease, the normal KIF proteins are diminished in amount or absent, and other proteins more typical of proliferative epidermal cells are present. There is also evidence of proteolytic degradation of the KIF.

Morphometric analysis of peroxisomes in hepatocytes of alcohol-fed rats

1989 ◽  
Vol 47 ◽  
pp. 1100-1101
Author(s):  
D.C. Dominguez ◽  
J.T. Ellzey
Keyword(s):  
Caloric Intake ◽  
Volume Density ◽  
Controlled Study ◽  
Control Group ◽  
Numerical Density ◽  
Cacodylate Buffer ◽  
Paired Control ◽  
Experimental Group ◽  
Liver Peroxisomes ◽  
Single Lesion

Peroxisomes which participate in 1ipid metabolism have been shown to be altered in several metabolic disorders and toxic conditions. In alcoholic liver disease, the single lesion most frequently found is lipid accumu1ation in hepatocytes. However, the mechanisms for this 1ipid accumu1ation are not clear. The occurrence of modifications of liver peroxisomes due to excess alcohol consumption has not been subjected to a controlled study. We utilized a combination of cytochemica1 and morphometrictechniques to study the size and number of liver peroxisomes in rats fed an alcohol-supplemented diet compared to those of matched-paired control animals.Male Sprague-Daw1ey rats (400-500 g) received a liquid diet. The experimental group (N = 5/group) was fed a diet containing 30% ethanol-derived calories (EDC) and the control group was fed an isocaloric diet to 30% EDC. A pair feeding procedure was employed to control for caloric intake. Small pieces of liver randomly selected, were fixed in 2.3% -glutaraldehyde in 0.1 M sodium cacodylate buffer, pH 7.2, incubated in a DAB medium and postfixed with. 2% aqueous osmium tetroxide. EM photographs were taken from sections of 3 tissue blocks from each sample (7,200X) with a Zeiss EM10-A (60 kV). With the use of a point counting method and a digital planimeter the volume density (Vv) and numerical density (Nv) were determined.

Adult-Onset Atopic Dermatitis: Presentations and Progress

2020 ◽  
Vol 24 (3) ◽  
pp. 267-272
Author(s):  
Airiss R. Chan ◽  
Vijay K. Sandhu ◽  
Aaron M. Drucker ◽  
Patrick Fleming ◽  
Charles W. Lynde
Keyword(s):  
Atopic Dermatitis ◽  
Immune Dysregulation ◽  
Upper Limbs ◽  
Adult Onset ◽  
Barrier Dysfunction ◽  
Childhood Onset ◽  
Exclusion Criteria ◽  
Body Regions ◽  
Chronic Skin ◽  
Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease characterized by barrier dysfunction and immune dysregulation that affects approximately 20% of children and 2-5% of adults worldwide. Traditionally, AD has been considered a disease of childhood with many cases resolving before adulthood. However, in recent years, the prevalence of adult AD is increasingly recognized to be substantial, but it is uncertain whether this increase is due to increased childhood-persistent or relapsed AD, or new adult-onset AD. This highlights a need for further investigation into the adult AD population and evaluation of phenotypes in the adult-onset cohort. In this literature review, we examine five studies focused on adult-onset AD phenotype, conducted between 2013 and 2017. The most commonly reported body regions affected in adult-onset AD were the hands, eyelids, neck, and flexural surfaces of the upper limbs. These vary from childhood-onset AD findings, which are less specific to body regions other than flexural areas. These findings have implications for diagnostic accuracy and treatment of AD, including considerations for therapeutic choices and inclusion and exclusion criteria in clinical trials.

Spectral and Cepstral Properties of Vowels as a Means for Characterizing Velopharyngeal Impairment in Children

1996 ◽  
Vol 33 (6) ◽  
pp. 507-512 ◽  
Author(s):  
Stéphane, Garnier ◽  
Stéphane, Gallego ◽  
Lionel Collet ◽  
Christian Berger-Vachon
Keyword(s):  
Discriminant Function ◽  
Discriminant Function Analysis ◽  
Function Analysis ◽  
Control Group ◽  
Bottom Up ◽  
Total Group ◽  
Spoken Words ◽  
Paired Control

This study investigated spectral differences in the phonation of vowels between a group of 21 children with velopharyngeal impairment and a paired control group of 42 subjects. The speech material was composed of the isolated vowels /a/, /i/ and /u/, a sustained vowel /a/, and four vowels included in spoken words: two nasals /in/ and /on/ in “dindon,” and two orals /a/ and /o/ in “gâteau.” A bottom-up discriminant function analysis indicated that the cepstrum coefficients and the linear-FFT were the most efficient tools in the test to classify the set of children. They were superior to the results obtained with the formant-representation of the vowels. The use of a perceptive scale (barks) did not improve the results. Discrimination over the total group showed percentages lower than those obtained when boys and girls were assessed separately. The best discriminating results were obtained with the /a/ of “gâteau” for the girls and with the isolated /i/ for the boys.

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