Performance of chicken broilers fed with diets substituted with mulberry leaf powder

The antiobesity molecular mechanisms of mulberry leave components were analyzed based on intestinal micro-ecology and metabolomics. An obesity model was established by feeding rats with a high-calorie diet. Rats were divided into seven groups: the obesity model control (MC), positive control (PC), mulberry leaf powder (MLP), mulberry leaf fiber (MLF), mulberry leaf polyphenols (MLPS), mulberry leaf fiber and polyphenols mixture (MLM), and normal control (NC), and fed daily for 6 consecutive weeks. The results demonstrated that the MLM group had the best efficiency on weight loss, indicating synergistic interactions between MLPS and MLF. The reduction of Firmicutes abundance, and the downstream Clostridiales, Lachnespiraceae, was a key pathway for the antiobesity effects. The increased abundances of Lactobacillus vaginalis and Lactobacillus gasseri might result in lipid metabolism disorder. The test groups regulated the amino acid and oligopeptides metabolic disorder tents to normal levels compared with the MC and NC groups.

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Mulberry Leaf Polyphenols and Fiber Induce Synergistic Antiobesity and Display a Modulation Effect on Gut Microbiota and Metabolites

Current Developments in Nutrition ◽

10.1093/cdn/nzaa063_052 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1654-1654

Author(s):

Qian Li ◽

Yuxiao Zou ◽

Sentai Liao

Keyword(s):

Weight Loss ◽

Lipid Metabolism ◽

Amino Acid ◽

Dietary Fiber ◽

High Energy ◽

Mulberry Leaf ◽

Model Control ◽

Significant Difference ◽

Leaf Powder ◽

Leaf Fiber

Abstract Objectives In this study we compared the antiobesity effects of mulberry leaf powder, dietary fiber, polyphenols, and a fiber/polyphenols mixture.Combining intestinal community modulation and metabolite analysis, we investigated the antiobesity effects and mechanisms of mulberry leaf components, detecting the interaction between mulberry leaf dietary fiber and polyphenol. Methods An obesity model was established by feeding rats with a high-calorie diet. Rats were divided into seven groups: the obesity model control (MC), positive control (PC), mulberry leaf powder (MLP), mulberry leaf fiber (MLF), mulberry leaf polyphenols (MLPS), mulberry leaf fiber and polyphenols mixture (MLM), and normal control (NC), and fed daily for 6 consecutive weeks.the 16S rRNA gene was sequenced using Illumina MiSeq.UPLC Triple TOF MS/MS system and Agilent 6890 N GC-MS were used to profile the urinary/fecal metabolites. Results The synergistic interaction between mulberry dietary fiber and polyphenols (MLM) in antiobesity was reported for the first time. The content of Firmicutes in the MC group was increased significantly. Except for the MLPS group, other test groups regulated the Firmicutes content to a normal level. Our study demonstrated that different components of mulberry leaves might achieve weight loss by reducing the amount of Lachnespiraceae. At the same time, the reduction Lactobacillus_vaginalis and Lactobacillus_gasseri species was closely related to the improvement of lipid metabolism profiles. In addition, the high energy diet induced feces and urine metabolic disorders in MC group with significant difference. The amino acid and oligopeptide metabolites were regulated to the NC level under the regulation of mulberry leaf components. Conclusions MLM group had the best efficiency on weight loss, indicating synergistic interactions between MLPS and MLF. The reduction of Firmicutes abundance, and the downstream Clostridiales, Lachnespiraceae, was a key pathway for the antiobesity effects. The increased abundances of Lactobacillus vaginalis and Lactobacillus gasseri might result in lipid metabolism disorder. The test groups regulated the amino acid and oligopeptides metabolic disorder tents to normal levels compared with the MC and NC groups. Funding Sources The Science & Technology Projects of Guangdong Province No.2017A050501022/No.2017A030310416.

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Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2007.04.170 ◽

2007 ◽

Vol 358 (3) ◽

pp. 751-756 ◽

Cited By ~ 40

Author(s):

Akiko Harauma ◽

Toshinori Murayama ◽

Kazuyuki Ikeyama ◽

Hideto Sano ◽

Hidenori Arai ◽

...

Keyword(s):

Apolipoprotein E ◽

Mulberry Leaf ◽

Leaf Powder ◽

Deficient Mice

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Effects of dietary supplement of mulberry leaf (Morus alba) on growth and meat quality in rabbits

Indian Journal of Animal Research ◽

10.18805/ijar.b-1006 ◽

2018 ◽

Author(s):

Q.R. Hou ◽

J. Zhang ◽

T. Chen ◽

W.G. Zhao ◽

L. Li

Keyword(s):

Meat Quality ◽

Average Daily Gain ◽

Carcass Characteristics ◽

B Value ◽

Feed Conversion ◽

Fat Percentage ◽

Leg Muscles ◽

Mulberry Leaf ◽

Leaf Powder ◽

Daily Gain

This research evaluated the effects of mulberry leaf in diet on growth and meat quality in rabbits. Five treatment diets were prepared by using a proportion of 0% (CK), 5% (ML5), 10% (ML10), 15% (ML15) and 20% (ML20) mulberry leaf powder (MLP), respectively. Results showed that average daily gain (ADG) in the ML20 group was significantly (P£ 0.05) lower than that in the CK, ML5 and ML10 treatments. Feed conversion ratio (FCR) in the ML20 treatment was significantly (P£ 0.05) higher than that in all other treatments. Most of the carcass characteristics had no significant differences among the five treatments (P>0.05), however, abdominal fat percentage in the four MLP treatments was significantly (P£ 0.05) lower than that in the CK. The L* and a* values in most of MLP treatment samples of longissimus dorsi and hind leg muscles were significantly increased, and the b* value significantly declined than those in the CK (P£ 0.05). Drip loss values in the ML10, ML15 and ML20 group were significantly (P£ 0.05) lower than those in the CK. Moisture, fat and ash contents in the higher MLP level treatments (ML15 and ML20) were significantly (P£ 0.05) lower than those in the CK. In conclusion, MLP for a certain proportion in diet (£ 15%)is greatly valuable for improvement of growth and meat appearance of rabbits, and a high proportion of MLP (e.g. ³ 20%) may impede growth of young rabbits.

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Quality and Antioxidant Properties of Cookies Supplemented With Mulberry Leaf Powder

Food Engineering Progress ◽

10.13050/foodengprog.2016.20.4.416 ◽

2016 ◽

Vol 20 (4) ◽

pp. 416-420 ◽

Cited By ~ 2

Author(s):

Jun Ho Lee ◽

Keyword(s):

Antioxidant Properties ◽

Mulberry Leaf ◽

Leaf Powder

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Process optimization of supercritical carbon dioxide (SC-CO2) extraction parameters for extraction of deoxynojirimycin (1-DNJ) from mulberry (Morus alba L.) leaves

Journal of Applied and Natural Science ◽

10.31018/jans.v8i1.807 ◽

2016 ◽

Vol 8 (1) ◽

pp. 405-411 ◽

Cited By ~ 1

Author(s):

V. Ramya ◽

Udaykumar Nidoni ◽

Sharangouda Hiregoudar ◽

C. T. Ramachandra ◽

J. Ashoka ◽

...

Keyword(s):

Carbon Dioxide ◽

Extraction Efficiency ◽

Extraction Yield ◽

Extraction Time ◽

Extraction Solvent ◽

Mulberry Leaf ◽

Leaf Powder ◽

Dynamic Extraction ◽

Extraction Parameters ◽

Carbon Dioxide Co2

In the present study, supercritical fluid extraction (SFE) technology was applied to extract deoxynojirimycin (1-DNJ) from mulberry leaf powder using carbon dioxide (CO2) as major extraction solvent with ethanol as cosolvent, and extraction parameters such as pressure (100, 150 and 200 bar), temperature (40, 50 and 60 Â°C) anddynamic extraction time (40, 60 and 80 min) were systematically investigated by full factorial design to obtain the optimum extraction efficiency and extraction yield. Under optimized conditions (pressure of 200 bar, temperature of 50 Â°C and dynamic extraction time of 80 min), DNJ enriched extract was obtained with high extraction efficiency (96.46 %) and extraction yield (13.41 %), enabling this product to use for nutraceutical purpose. The results indicated that SC-CO2 extraction is a promising and alternative process for recovering the bioactive compounds from mulberry leaves.

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Effect of Mulberry Leaf powder on reproductive performance, serum indexes and milk amino acid composition in lactating sows

Journal of Animal Physiology and Animal Nutrition ◽

10.1111/jpn.13668 ◽

2021 ◽

Author(s):

Can Yang ◽

XiaoWu Tang ◽

YangYang Duan ◽

JiaoYu Tang ◽

QingHai Tang ◽

...

Keyword(s):

Amino Acid ◽

Amino Acid Composition ◽

Acid Composition ◽

Reproductive Performance ◽

Mulberry Leaf ◽

Lactating Sows ◽

Leaf Powder

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Mulberry Leaf Reduces Oxidation and C-Reactive Protein Level in Patients with Mild Dyslipidemia

BioMed Research International ◽

10.1155/2013/787981 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 12

Author(s):

Pornanong Aramwit ◽

Ouppatham Supasyndh ◽

Tippawan Siritienthong ◽

Nipaporn Bang

Keyword(s):

Inflammatory Marker ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

C Reactive Protein ◽

Reactive Protein ◽

Mulberry Leaf ◽

Significant Difference ◽

Leaf Powder ◽

The Mean

C-reactive protein (CRP) is the inflammatory marker that could represent the inflammation in blood vessels resulted from dyslipidemia. The objective of this study was to evaluate the antioxidative activity of mulberry leaf powder using DPPH assay and the effect of mulberry leaf powder on lipid profile, CRP level, and antioxidative parameters in mild dyslipidemia patients. A within-subjects design was conducted and patients received three tablets of 280 mg mulberry leaf powder three times a day before meals for 12 weeks. Total of 25 patients were enrolled but one subject was excluded. After three months of mulberry leaf consumption, serum triglyceride and low-density lipoprotein (LDL) level were significantly reduced and more than half of all patients’ CRP levels decreased every month as well as the mean CRP level but no statistically significant difference was found. The average erythrocyte glutathione peroxidase activity of patients was increased but not at significant level; however, the mean serum 8-isoprostane level was significantly lower after mulberry treatment for 12 weeks. It can be concluded that mulberry leaf powder exhibited antioxidant activity and mulberry leaf powder has potential to decrease serum triglyceride, LDL, and CRP levels in mild dyslipidemia patients without causing severe adverse reactions.

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Effects of Dietary Mulberry Leaf Powder in Concentrate on the Rumen Fermentation and Ruminal Epithelium in Fattening Hu Sheep

Animals ◽

10.3390/ani9050218 ◽

2019 ◽

Vol 9 (5) ◽

pp. 218 ◽

Cited By ~ 5

Author(s):

Jialiang Ouyang ◽

Mengzhi Wang ◽

Qirui Hou ◽

Dan Feng ◽

Yu Pi ◽

...

Keyword(s):

Average Daily Gain ◽

Rumen Fermentation ◽

Nutrient Digestibility ◽

Neutral Detergent Fiber ◽

Control Treatment ◽

Rumen Epithelium ◽

Mulberry Leaf ◽

Significant Difference ◽

Leaf Powder ◽

Hu Sheep

Mulberry leaves have been used as a protein source in replacing concentrates of domestic animals, however, little is known about the relationship between supplementation level and the development of rumen epithelium. This experiment aimed to investigate the effects of different proportions of mulberry leaf powder (MLP) in dietary concentrate on rumen fermentation and rumen epithelium morphology in fattening Hu sheep. Forty three-month-old male Hu sheep with an initial body weight of 16.5 ± 0.6 kg (BW ± SD) were chosen and randomly divided into five treatments: 0% (control), 15% (T15), 30% (T30), 45% (T45) and 60% (T60) of MLP in concentrate, respectively. The results showed that the dry matter intake (DMI) and average daily gain (ADG) in treatments T15 and T30 have no significant difference with respect to the control treatment, but DMI and ADG in treatments T45 and T60 were lower than the control treatment (p < 0.05). The apparent digestibility of organic matter (OM) and neutral detergent fiber (NDF) increased linearly and quadraticly as MLP supplementation increased (p < 0.05). The concentration of ammonia (NH3-N) trended to decrease linearly with the increase of MLP supplementation (p < 0.1), whereas the microbial protein (MCP) concentration increased linearly as MLP supplementation increased (p < 0.05). In the results of rumen epithelium morphology, the width of stratum corneum was reduced, whereas the width of ruminal papillae increased (p < 0.05), and the width of stratum granulosum and stratum basale also increased as MLP increased. In summary, MLP supplementation could improve nutrient digestibility, the development of rumen papillae and stratum basale. However, high content MLP (45%–60%) supplementation decreased the growth and food intake performance of fattening Hu sheep. Therefore, 30% MLP is recommended to supplement in concentrate for fattening Hu sheep.

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