Serum Zinc Concentrations of Adults in an Outpatient Clinic and Risk Factors Associated With Zinc Deficiency

2020 ◽  
Vol 120 (11) ◽  
pp. 796
Author(s):  
Jen-Tzer Gau ◽  
Charles Ebersbacher ◽  
Tzu-Cheg Kao
Keyword(s):  
Risk Factors ◽  
Zinc Deficiency ◽  
Outpatient Clinic ◽  
Serum Zinc ◽  
Factors Associated ◽  
Zinc Concentrations

Association between serum zinc concentrations and metabolic risk factors among Chinese children and adolescents

2021 ◽  
pp. 1-31
Author(s):  
Qianrang Zhu ◽  
Yue Dai ◽  
Jingxian Zhang ◽  
Wei Xie ◽  
Hui Zuo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Density Lipoprotein ◽  
Serum Zinc ◽  
Negative Association ◽  
Metabolic Risk Factors ◽  
Chinese Children ◽  
Metabolic Risk ◽  
Zinc Concentrations ◽  
Chinese Children And Adolescents

Abstract Purpose Zinc plays an important role in metabolic processes in human organisms and is indispensable in many enzymatic processes. To date, few studies have assessed the association between serum zinc and metabolic risk factors in children and adolescents. The aim of the present study was to examine whether serum zinc concentrations was associated with metabolic risk factors in Chinese children and adolescents. Methods This study was a cross-sectional analysis of data from the 2016-2017 China National Nutrition and Health Surveillance for Children and Nursing in Jiangsu Province. A total of 3241 participants aged 6 -17years were included. Metabolic risk factors included fasting glucose (FG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), systolic blood pressure and diastolic blood pressure. Data were analyzed using multivariable linear regression and generalized additive models, which were adjusted for age, gender, high sensitive C-reactive protein, estimated glomerular filtration rate, body mass index and region of residence, to assess the associations of serum zinc concentrations with metabolic risk factors. Results We observed a negative association between serum zinc concentrations and FG (coefficient = -0.532; 95% CI: -0.569, -0.495; p< 0.001). Moreover, TC (coefficient = 0.175 ; 95% CI 0.127, 0.222; p< 0.001), HDL-C (coefficient = 0.137 ; 95% CI 0.082, 0.193; p< 0.001) and LDL-C (coefficient = 0.195 ; 95% CI 0.128, 0.263; p< 0.001) were found to be positively associated with zinc levels. A generalized additive model showed that the negative association between serum zinc and FG was weak at lower serum zinc concentrations, and was stronger with the increase in serum zinc concentrations. Additionally, a U-shaped association between serum zinc and TG was observed. Conclusions Serum zinc concentrations were associated with FG, TC, TG, HDL-C and LDL-C levels in Chinese children and adolescents. Lower levels of serum zinc were more likely related to a poor metabolic status.

Risk Factors Associated to Stroke in Patients With Pacemakers and Implantable Cardioverter Defibrillator at an Outpatient Clinic in the City of Salvador, Bahia, Brazil

CHEST Journal ◽  
2014 ◽  
Vol 145 (3) ◽  
pp. 83A
Author(s):  
Elieusa Sampaio ◽  
Roque Aras Júnior ◽  
José Alberto da Matta ◽  
Cristiano Macedo ◽  
Márcia Maria Oliveira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Implantable Cardioverter Defibrillator ◽  
Outpatient Clinic ◽  
Cardioverter Defibrillator ◽  
Factors Associated ◽  
The City

scholarly journals Serum zinc concentrations and characteristics of zinc deficiency/marginal deficiency among Japanese subjects

2020 ◽  
Vol 21 (6) ◽  
pp. 248-255
Author(s):  
Hirohide Yokokawa ◽  
Hiroshi Fukuda ◽  
Mizue Saita ◽  
Taiju Miyagami ◽  
Yuichi Takahashi ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Serum Zinc ◽  
Zinc Concentrations ◽  
Japanese Subjects

scholarly journals High Prevalence of Zinc Deficiency in Rural Nigerian Preschool Children: A Community-Based Cross-Sectional Study

2017 ◽  
Vol 24 (1) ◽  
pp. 31-39
Author(s):  
Amarabia N.E. Ibeawuchi ◽  
Alphonsus N. Onyiriuka ◽  
Philip O. Abiodun
Keyword(s):  
Zinc Deficiency ◽  
Rural Community ◽  
Zinc Concentration ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Community Based ◽  
Cross Sectional ◽  
Serum Zinc Concentration ◽  
High Prevalence ◽  
Zinc Concentrations

AbstractBackground and Aims: In Nigeria, community-based epidemiological data related to the prevalence of zinc deficiency in preschool children are scarce. We assessed the prevalence of zinc deficiency and the associated socio-demographic variables in children aged between 6 and 60 months, living in a Nigerian rural community.Materials and Methods: In this cross-sectional study, the serum zinc concentrations of 252 children aged between 6 and 60 months in a rural community in Nigeria were assessed, using atomic absorption spectrophotometry. The study population was selected by multistage random sampling and at least two children were selected from every household which had children in the study age group. The socio-demographic characteristics of the subjects were obtained, using an interviewer-administered questionnaire.Results: A total of 252 children were studied, 134 (53.2%) males and 118 (46.8%) females. The mean age was 32.7±17.0 months, similar for both sexes. Overall, 220 (87.3%) had low serum zinc concentrations (less than 7.65µmol/L). According to age, the highest mean serum zinc concentration was 5.43±3.52µmol/L in children aged between 6 and 12 months. Correlation between serum zinc concentration and family size or socio-economic status (SES) showed that the smaller the family size and the higher the SES, the higher the serum zinc concentration.Conclusions: The high prevalence of low serum zinc concentration indicates that zinc deficiency is a public health problem in our rural communities, requiring public health intervention.

scholarly journals Association of Zinc Deficiency with Development of CVD Events in Patients with CKD

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1680
Author(s):  
Shinya Nakatani ◽  
Katsuhito Mori ◽  
Tetsuo Shoji ◽  
Masanori Emoto
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Arterial Calcification ◽  
And Oxidative Stress

Deficiency of the micronutrient zinc is common in patients with chronic kidney disease (CKD). The aim of this review is to summarize evidence presented in literature for consolidation of current knowledge regarding zinc status in CKD patients, including those undergoing hemodialysis. Zinc deficiency is known to be associated with various risk factors for cardiovascular disease (CVD), such as increased blood pressure, dyslipidemia, type 2 diabetes mellitus, inflammation, and oxidative stress. Zinc may protect against phosphate-induced arterial calcification by suppressing activation of nuclear factor kappa light chain enhancer of activated B. Serum zinc levels have been shown to be positively correlated with T50 (shorter T50 indicates higher calcification propensity) in patients with type 2 diabetes mellitus as well as those with CKD. Additionally, higher intake of dietary zinc was associated with a lower risk of severe abdominal aortic calcification. In hemodialysis patients, the beneficial effects of zinc supplementation in relation to serum zinc and oxidative stress levels was demonstrated in a meta-analysis of 15 randomized controlled trials. Thus, evidence presented supports important roles of zinc regarding antioxidative stress and suppression of calcification and indicates that zinc intake/supplementation may help to ameliorate CVD risk factors in CKD patients.

scholarly journals Prevalência e Fatores de Riscos Associados à Síndrome Metabólica entre os Funcionários Atendidos no Ambulatório do SESI - Serviço Social da Indústria de Vitória da Conquista - BA / Prevalence and Risk Factors Associated with Metabolic Syndrome among Employees Attended at the SESI Outpatient Clinic – Industry Social Service of Vitória da Conquista - BA

2020 ◽  
Vol 14 (53) ◽  
pp. 1102-1115
Author(s):  
Higor Silva Dutra ◽  
Nádia Cristina Ferreira Chiachio
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Outpatient Clinic ◽  
Social Service ◽  
Factors Associated ◽  
Sindrome Metabolica

A síndrome metabólica tem se destacado como importante problema de saúde pública e é definida pelo aumento da pressão arterial, os distúrbios do metabolismo dos glicídios e lipídios e o excesso de peso, estes estão associados ao aumento da morbidade e mortalidade cardiovascular. A síndrome metabólica é também definida como a associação de pelo menos três dos seguintes fatores de risco, como, obesidade abdominal, hipertensão arterial, elevação dos triglicerídeos, elevados níveis de glicemia de jejum e baixos níveis de lipoproteína de alta densidade (HDL-c). Portanto, este trabalho teve como objetivo verificar os parâmetros antropométricos, hemodinâmicos e sócio comportamentais dos funcionários atendidos no ambulatório do SESI. Trata-se de uma pesquisa de delineamento transversal, de natureza descritiva com abordagem quantitativa, a coleta dos dados amostrais foi realizada com funcionários atendidos no ambulatório do Serviço Social da Indústria - SESI de Vitória da Conquista. A população do estudo foi constituída de 150 pacientes. Foram analisados o perfil metabólico e bioquímico, os parâmetros antropométrico, síndrome metabólica e por fim foi realizada a entrevista com os funcionários. Os resultados obtidos permitiram identificar que houve um predomínio do sexo masculino, sendo 122 indivíduos de 18 - 63 anos de idade. Em relação aos indivíduos que apresentaram Síndrome Metabólica com idades entre 24 e 48 anos, apenas 1 mulher e 14 homens continham respectivamente a doença. Quanto a associação da Síndrome Metabólica com as Comorbidades destaca-se um maior número de homens que tinham essas Comorbidade alteradas. Em relação aos parâmetros bioquímicos observou-se que a maioria dos homens tinham colesterol total, triglicerídeos e glicemia em jejum apresentaram alterados para estes parâmetros. Os principais fatores de risco associados à Síndrome Metabólica foram a hipertensão, o diabetes e a obesidade. Quanto a classificação do nível de atividade física a maioria dos participantes pratica atividade física. Conclui-se que há a necessidade de fortalecer as medidas de prevenção e ações de monitoramento de saúde dos portadores da Síndrome Metabólica, a fim de proporcionar melhor qualidade de vida à população e evitar os fatores de riscos e as Comorbidades associadas à essas doenças.

scholarly journals Low zinc levels at clinical admission associates with poor outcomes in COVID-19

2020 ◽  
Author(s):  
Marina Vogel-González ◽  
Marc Talló-Parra ◽  
Víctor Herrera-Fernández ◽  
Gemma Pérez-Vilaró ◽  
Miguel Chillón ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Randomized Clinical Trials ◽  
Serum Zinc ◽  
Zinc Content ◽  
Zinc Concentrations ◽  
Infected Cells ◽  
Poor Outcomes ◽  
Zinc Levels ◽  
Serum Zinc Levels

AbstractBackgroundBiomarkers to predict Coronavirus disease-19 (COVID-19) outcome early at infection are urgently needed to improve prognosis and treatment. Zinc balances immune responses and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with more severe COVID-19 outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression and thus might represent a useful biomarker.MethodsWe run a retrospective observational study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel we have studied SARS-CoV2 replication in the Vero E6 cell line modifying zinc concentrations.FindingsOur study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dl at admission correlated with worse clinical presentation, longer time to reach stability and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV2 infected cells.InterpretationSZC is a novel biomarker to predict COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency.FundingSpanish Ministry of Science and Innovation, “Maria de Maeztu” Programme for Units of Excellence in R&D and Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement of the Generalitat de Catalunya. Instituto Carlos III Fondos de Investigaciones Sanitarias (FIS), CIBER on Frailty and Healthy Ageing and FEDER funds

scholarly journals Adjusting plasma or serum zinc concentrations for inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

2020 ◽  
Vol 111 (4) ◽  
pp. 927-937 ◽  
Author(s):  
Christine M McDonald ◽  
Parminder S Suchdev ◽  
Nancy F Krebs ◽  
Sonja Y Hess ◽  
K Ryan Wessells ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
Serum Zinc ◽  
Population Level ◽  
Negative Association ◽  
Reproductive Age ◽  
Accurate Estimation ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Zinc Concentrations ◽  
Nationally Representative

ABSTRACT Background The accurate estimation of zinc deficiency at the population level is important, as it guides the design, targeting, and evaluation of nutrition interventions. Plasma or serum zinc concentration (PZC) is recommended to estimate zinc nutritional status; however, concentrations may decrease in the presence of inflammation. Objectives We aimed to assess the relation between PZC and inflammation in preschool children (PSC; 6–59 mo) and nonpregnant women of reproductive age (WRA; 15–49 y), and to compare different inflammation adjustment approaches, if adjustment is warranted. Methods Cross-sectional data from 13 nationally representative surveys (18,859 PSC, 22,695 WRA) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed. Correlation and decile analyses were conducted, and the following 3 adjustment methods were compared if a consistent negative association between PZC and C-reactive protein (CRP) or α-1-acid glycoprotein (AGP) was observed: 1) exclude individuals with CRP &gt; 5 mg/L or AGP &gt; 1 g/L; 2) apply arithmetic correction factors; and 3) use the BRINDA regression correction (RC) approach. Results In 6 of 12 PSC surveys, the estimated prevalence of zinc deficiency increased with increasing CRP deciles, and to a lesser extent, with increasing AGP deciles. In WRA, the association of PZC with CRP and AGP was weak and inconsistent. In the 6 PSC surveys in which adjustment methods were compared, application of RC reduced the estimated prevalence of zinc deficiency by a median of 11 (range: 4–18) percentage points, compared with the unadjusted prevalence. Conclusions Relations between PZC and inflammatory markers were inconsistent, suggesting that correlation and decile analyses should be conducted before applying any inflammation adjustments. In populations of PSC that exhibit a significant negative association between PZC and CRP or AGP, application of the RC approach is supported. At this time, there is insufficient evidence to warrant inflammation adjustment in WRA.

Use of Serum Zinc Concentration as an Indicator of Population Zinc Status

2007 ◽  
Vol 28 (3_suppl3) ◽  
pp. S403-S429 ◽  
Author(s):  
Sonja Y. Hess ◽  
Janet M. Peerson ◽  
Janet C. King ◽  
Kenneth H. Brown
Keyword(s):  
Zinc Deficiency ◽  
Zinc Concentration ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Interindividual Variation ◽  
Zinc Status ◽  
Dietary Zinc ◽  
Serum Zinc Concentration ◽  
Zinc Concentrations ◽  
Intervention Trials

Assessing the prevalence and severity of zinc deficiency in populations is critical to determine the need for and appropriate targeting of zinc intervention programs and to assess their effectiveness for improving the health and well-being of high-risk populations. However, there is very little information on the zinc status of populations worldwide due to the lack of consensus on appropriate biochemical indicators of zinc status. The objective of this review was to evaluate the use of serum zinc concentration as an indicator of population zinc status. We have reviewed the response of serum zinc concentration to dietary zinc restriction and zinc supplementation. In addition, we completed pooled analyses of nine zinc intervention trials in young children to assess the relations between serum zinc concentration of individuals before treatment and their responses to zinc supplementation. Also, in updated combined analyses of previously published data, we investigated the relation between the mean initial serum zinc concentration of a study population and their mean growth responses to zinc supplementation in randomized intervention trials among children. The results from depletion/repletion studies indicate that serum zinc concentrations respond appreciably to severe dietary zinc restriction, although there is considerable interindividual variation in these responses. There is also clear evidence that both individual and population mean serum zinc concentrations increase consistently during zinc supplementation, regardless of the initial level of serum zinc concentration. By contrast, an individual's serum zinc concentration does not reliably predict that person's response to zinc supplementation. Serum zinc concentration can be considered a useful biomarker of a population's risk of zinc deficiency and response to zinc interventions, although it may not be a reliable indicator of individual zinc status.

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