scholarly journals Potential of artificial intelligence to accelerate diagnosis and drug discovery for COVID-19

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12073
Author(s):  
Indira Mikkili ◽  
Abraham Peele Karlapudi ◽  
T. C. Venkateswarulu ◽  
Vidya Prabhakar Kodali ◽  
Deepika Sri Singh Macamdas ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Imaging Techniques ◽  
Learning Tools ◽  
Rt Pcr ◽  
Drug Molecules ◽  
Potential Applications ◽  
The Neural Networks ◽  
Polymerase Chain ◽  
The Internet Of Things

The coronavirus disease (COVID-19) pandemic has caused havoc worldwide. The tests currently used to diagnose COVID-19 are based on real time reverse transcription polymerase chain reaction (RT-PCR), computed tomography medical imaging techniques and immunoassays. It takes 2 days to obtain results from the RT-PCR test and also shortage of test kits creating a requirement for alternate and rapid methods to accurately diagnose COVID-19. Application of artificial intelligence technologies such as the Internet of Things, machine learning tools and big data analysis to COVID-19 diagnosis could yield rapid and accurate results. The neural networks and machine learning tools can also be used to develop potential drug molecules. Pharmaceutical companies face challenges linked to the costs of drug molecules, research and development efforts, reduced efficiency of drugs, safety concerns and the conduct of clinical trials. In this review, relevant features of artificial intelligence and their potential applications in COVID-19 diagnosis and drug development are highlighted.

scholarly journals Use of Machine Learning to Rapidly Predict Positivity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Using Basic Clinical Data

2020 ◽  
Author(s):  
Thomas Langer ◽  
Martina Favarato ◽  
Riccardo Giudici ◽  
Gabriele Bassi ◽  
Roberta Garberi ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Data ◽  
Laboratory Data ◽  
Learning System ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Long Time ◽  
Polymerase Chain

Abstract Objective: Reverse Transcription-Polymerase Chain Reaction (RT-PCR) for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) diagnosis currently requires quite a long time span. A quicker and more efficient diagnostic tool in emergency departments could improve management during this global crisis. Our maingoal was assessing the accuracy of artificial intelligence in forecasting the resultsof RT-PCR for SARS-COV-2, using basic information at hand in all emergencydepartments.Methods: This is a retrospective study carried out between February 22 and March 16 2020 in one of the main hospitals in Milan, Italy. We screened for eligibility all patients admitted with influenza-like symptoms tested for SARS-COV-2.Patients under 12 years old, with no leukocyte formula performed in the ED,were excluded. Input data through artificial intelligence were made up of a combination of clinical, radiological and routine laboratory data upon hospital admission.Results: Among 199 patients subject to study (median [interquartile range] age 65 [46-78] years; 127 [63.8%] men), 124 [62.3%] resulted positive to SARS-COV-2. The best Machine Learning System reached an accuracy of 91.4% with 94.1% sensitivity and 88.7% specificity.Conclusion: Our study suggests that properly trained artificial intelligence algorithms may be able to predict correct results in RT-PCR for SARS-COV-2, using basic clinical data. If confirmed,on a larger-scale study, this approach could have important clinical and organizational implications.

scholarly journals Machine Learning Prediction of SARS-CoV-2 Polymerase Chain Reaction Results with Routine Blood Tests

2020 ◽  
Author(s):  
Thomas Tschoellitsch ◽  
Martin Dünser ◽  
Carl Böck ◽  
Karin Schwarzbauer ◽  
Jens Meier
Keyword(s):  
Machine Learning ◽  
Polymerase Chain Reaction ◽  
Characteristic Curve ◽  
Cohort Analysis ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Blood Tests ◽  
Routine Blood ◽  
Machine Learning Model ◽  
Polymerase Chain

Abstract Objective The diagnosis of COVID-19 is based on the detection of SARS-CoV-2 in respiratory secretions, blood, or stool. Currently, reverse transcription polymerase chain reaction (RT-PCR) is the most commonly used method to test for SARS-CoV-2. Methods In this retrospective cohort analysis, we evaluated whether machine learning could exclude SARS-CoV-2 infection using routinely available laboratory values. A Random Forests algorithm with 1353 unique features was trained to predict the RT-PCR results. Results Out of 12,848 patients undergoing SARS-CoV-2 testing, routine blood tests were simultaneously performed in 1528 patients. The machine learning model could predict SARS-CoV-2 test results with an accuracy of 86% and an area under the receiver operating characteristic curve of 0.90. Conclusion Machine learning methods can reliably predict a negative SARS-CoV-2 RT-PCR test result using standard blood tests.

scholarly journals Anomaly Identification during Polymerase Chain Reaction for Detecting SARS-CoV-2 Using Artificial Intelligence Trained from Simulated Data

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 20
Author(s):  
Reynaldo Villarreal-González ◽  
Antonio J. Acosta-Hoyos ◽  
Jaime A. Garzon-Ochoa ◽  
Nataly J. Galán-Freyle ◽  
Paola Amar-Sepúlveda ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Big Data ◽  
Real Time ◽  
Binary Classification ◽  
Simulated Data ◽  
Classification Model ◽  
Rt Pcr ◽  
Simon Bolivar ◽  
Polymerase Chain ◽  
Available Information

Real-time reverse transcription (RT) PCR is the gold standard for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), owing to its sensitivity and specificity, thereby meeting the demand for the rising number of cases. The scarcity of trained molecular biologists for analyzing PCR results makes data verification a challenge. Artificial intelligence (AI) was designed to ease verification, by detecting atypical profiles in PCR curves caused by contamination or artifacts. Four classes of simulated real-time RT-PCR curves were generated, namely, positive, early, no, and abnormal amplifications. Machine learning (ML) models were generated and tested using small amounts of data from each class. The best model was used for classifying the big data obtained by the Virology Laboratory of Simon Bolivar University from real-time RT-PCR curves for SARS-CoV-2, and the model was retrained and implemented in a software that correlated patient data with test and AI diagnoses. The best strategy for AI included a binary classification model, which was generated from simulated data, where data analyzed by the first model were classified as either positive or negative and abnormal. To differentiate between negative and abnormal, the data were reevaluated using the second model. In the first model, the data required preanalysis through a combination of prepossessing. The early amplification class was eliminated from the models because the numbers of cases in big data was negligible. ML models can be created from simulated data using minimum available information. During analysis, changes or variations can be incorporated by generating simulated data, avoiding the incorporation of large amounts of experimental data encompassing all possible changes. For diagnosing SARS-CoV-2, this type of AI is critical for optimizing PCR tests because it enables rapid diagnosis and reduces false positives. Our method can also be used for other types of molecular analyses.

scholarly journals IMPROVING INTERNET OF THINGS PARKING SYSTEMS

2021 ◽  
Vol 19 (3) ◽  
pp. 163
Author(s):  
Dušan Bogićević
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Cloud Computing ◽  
Internet Of Things ◽  
Information Needs ◽  
Vehicle Classification ◽  
The Internet ◽  
Parking Space ◽  
Automated Systems ◽  
The Internet Of Things

Edge data processing represents the new evolution of the Internet and Cloud computing. Its application to the Internet of Things (IoT) is a step towards faster processing of information from sensors for better performance. In automated systems, we have a large number of sensors, whose information needs to be processed in the shortest possible time and acted upon. The paper describes the possibility of applying Artificial Intelligence on Edge devices using the example of finding a parking space for a vehicle, and directing it based on the segment the vehicle belongs to. Algorithm of Machine Learning is used for vehicle classification, which is based on vehicle dimensions.

A Survey on Intelligence Tools for Data Analytics

2021 ◽  
pp. 73-95
Author(s):  
Shatakshi Singh ◽  
Kanika Gautam ◽  
Prachi Singhal ◽  
Sunil Kumar Jangir ◽  
Manish Kumar
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Language Processing ◽  
Real Life ◽  
Learning Tools ◽  
The Core ◽  
Training Mode ◽  
Real Life Situation ◽  
Selection Of

The recent development in artificial intelligence is quite astounding in this decade. Especially, machine learning is one of the core subareas of AI. Also, ML field is an incessantly growing along with evolution and becomes a rise in its demand and importance. It transmogrified the way data is extracted, analyzed, and interpreted. Computers are trained to get in a self-training mode so that when new data is fed they can learn, grow, change, and develop themselves without explicit programming. It helps to make useful predictions that can guide better decisions in a real-life situation without human interference. Selection of ML tool is always a challenging task, since choosing an appropriate tool can end up saving time as well as making it faster and easier to provide any solution. This chapter provides a classification of various machine learning tools on the following aspects: for non-programmers, for model deployment, for Computer vision, natural language processing, and audio for reinforcement learning and data mining.

Isolation and Characterization of Mesenchymal Stem Cells from Chicken Liver

2020 ◽  
Vol 10 (1) ◽  
pp. 8-16
Author(s):  
Xibin Liu ◽  
Shuang Zhang ◽  
Weijun Guan ◽  
Dong Zheng
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Protein Markers ◽  
Multilineage Differentiation ◽  
Rt Pcr ◽  
Multipotent Stem Cells ◽  
Isolation And Characterization ◽  
Potential Applications ◽  
Polymerase Chain

Hepatic mesenchymal stem cells (HMSCs) are multipotent stem cells that is a vital part of the regeneration of hepatocytes after injury. In this study, HMSCs were isolated in embryonic livers from of 12-day-old chick embryo using collagenase, and the primary HMSCs were sub-cultured to passage. The protein markers of HMSCs, namely CD71, CD29 and CD44, were tested with immunofluorescence and Reverse Transcription-Polymerase Chain Reaction (RT-PCR). The proliferation of HMSCs in different passages was detected using growth curve, which shown a typically sigmoidal. And then, the pluripotent of HMSCs was analyzed, the results showed that HMSCs could directly induce to differentiate into neural-like cells, adipocytes, and osteoblasts. Our data illustrated that the chick HMSCs have same characteristics to those obtained from other species. The capacity of these cells for multilineage differentiation shows promise for many potential applications.

scholarly journals Management of Software-Defined Networking Powered by Artificial Intelligence

2021 ◽  
Author(s):  
Jehad Ali ◽  
Byeong-hee Roh
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Internet Of Things ◽  
Heterogeneous Networks ◽  
Software Defined Networking ◽  
Machine Learning Algorithms ◽  
The Internet ◽  
Underlying Network ◽  
And Control ◽  
The Internet Of Things

Separating data and control planes by Software-Defined Networking (SDN) not only handles networks centrally and smartly. However, through implementing innovative protocols by centralized controllers, it also contributes flexibility to computer networks. The Internet-of-Things (IoT) and the implementation of 5G have increased the number of heterogeneous connected devices, creating a huge amount of data. Hence, the incorporation of Artificial Intelligence (AI) and Machine Learning is significant. Thanks to SDN controllers, which are programmable and versatile enough to incorporate machine learning algorithms to handle the underlying networks while keeping the network abstracted from controller applications. In this chapter, a software-defined networking management system powered by AI (SDNMS-PAI) is proposed for end-to-end (E2E) heterogeneous networks. By applying artificial intelligence to the controller, we will demonstrate this regarding E2E resource management. SDNMS-PAI provides an architecture with a global view of the underlying network and manages the E2E heterogeneous networks with AI learning.

Fairness and Ethics in Artificial Intelligence-Based Medical Imagining

2022 ◽  
pp. 71-85
Author(s):  
Satvik Tripathi ◽  
Thomas Heinrich Musiolik
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Patient Care ◽  
Data Sharing ◽  
Ethical Issues ◽  
Medical Systems ◽  
Healthcare Facilities ◽  
The World ◽  
Potential Applications ◽  
Medical Imagining

Artificial intelligence has a huge array of current and potential applications in healthcare and medicine. Ethical issues arising due to algorithmic biases are one of the greatest challenges faced in the generalizability of AI models today. The authors address safety and regulatory barriers that impede data sharing in medicine as well as potential changes to existing techniques and frameworks that might allow ethical data sharing for machine learning. With these developments in view, they also present different algorithmic models that are being used to develop machine learning-based medical systems that will potentially evolve to be free of the sample, annotator, and temporal bias. These AI-based medical imaging models will then be completely implemented in healthcare facilities and institutions all around the world, even in the remotest areas, making diagnosis and patient care both cheaper and freely accessible.

The Machine Learning Embedded Method of Parameters Determination in the Constitutive Models and Potential Applications for Hydrogels

2021 ◽  
Vol 13 (01) ◽  
pp. 2150001 ◽  
Author(s):  
Shoujing Zheng ◽  
Zishun Liu
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Chemical Potential ◽  
Constitutive Models ◽  
Experimental Application ◽  
Potential Applications ◽  
The Neural Networks ◽  
Hydrogel Swelling ◽  
Embedded Method ◽  
Fitting Parameters

We propose a machine learning embedded method of parameters determination in the constitutional models of hydrogels. It is found that the developed logistic regression-like algorithm for hydrogel swelling allows us to determine the fitting parameters based on known swelling ratio and chemical potential. We also put forward the neural networks-like algorithm, which, by its own property, can converge faster as the layer deepens. We then develop neural networks-like algorithm for hydrogel under uniaxial load for experimental application purpose. Finally, we propose several machine learning embedded potential applications for hydrogels, which would provide directions for machine learning-based hydrogel research.

scholarly journals Technology and More-Than-Human Design

Design Issues ◽  
2020 ◽  
Vol 36 (4) ◽  
pp. 33-44 ◽  
Author(s):  
Elisa Giaccardi ◽  
Johan Redström
Keyword(s):  
Artificial Intelligence ◽  
Machine Learning ◽  
Internet Of Things ◽  
The Internet ◽  
User Centered Design ◽  
Human Centered Design ◽  
Design Methodologies ◽  
The Everyday ◽  
The Internet Of Things ◽  
User Centered

Are we reaching the limits of what human-centered and user-centered design can cope with? Developing new design methodologies and tools to unlock the potentials of data technologies such as the Internet of Things, Machine Learning and Artificial Intelligence for the everyday job of design is necessary but not sufficient. There is now a need to fundamentally question what happens when human-centered design is unable to effectively give form to technology, why this might be the case, and where we could look for alternatives.

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