The novel coronavirus and its possible treatment by vaccines, therapeutics and drug delivery systems: Current status and future perspectives

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 54-61 ◽  
Author(s):  
Madhurya Kadavakollu ◽  
Veera Venkata Satyanarayana Reddy Karri ◽  
Kuppusamy Gowthamarajan ◽  
Arun Radhakrishnan ◽  
Dhanabal Palanisamy ◽  
...  
Keyword(s):  
Virus Disease ◽  
World Health ◽  
Current Status ◽  
The Novel ◽  
Future Perspectives ◽  
Epidemic Disease ◽  
Wuhan City ◽  
Corona Virus ◽  
Novel Coronavirus ◽  
Health Organization

In the mid-end of December 2019, several cases of pneumonia outbreak of unknown cause and etiology were identified in Wuhan City of Hubei province in China, a city with a population of over 11 million.Till date(April 2020) around 1,051,635 confirmed cases of coronavirus disease 2019(COVID-19) and 56,985 confirmed deaths have been reported according to COVID-19 Situation Report – 75 by WHO. On 7th January 2020, the causative agent was identified and named consequently as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by the Chinese Centre for Disease Control and Prevention (CCDC) from throat swab samples. Later, on 12th January 2020, this coronavirus was named as 2019-novel coronavirus (2019-nCoV) by World Health Organization (WHO) and in 11th February 2020,it has been declared the epidemic disease caused by SARS-CoV-2 as Corona Virus Disease 2019(COVID-19) as it is spreading rapidly from its origin in Wuhan City to the rest of the world. In this context, the current review provides a landscape of the novel Corona Virus including its origin, transmission, epidemiology, drugs and vaccines in clinical trials for better understanding to the reads and peoples the status and future perspectives of this pandemic disease

scholarly journals A Review on Automatic Covid-19 Lung Infection Detection from Different Imaging Techniques

2021 ◽  
Vol 9 (VII) ◽  
pp. 3850-3856
Author(s):  
Sangeeta Singh
Keyword(s):  
World Health Organization ◽  
Virus Disease ◽  
Imaging Techniques ◽  
World Health ◽  
The Novel ◽  
Corona Virus ◽  
The World ◽  
Health Organization ◽  
High Level ◽  
Precision Rate

Corona Virus Disease-2019 commonly known as COVID-19 which has been defined by the Novel Corona Virus. It is a family of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and was first detected during respiratory outbreak. It was first reported to the World Health Organization on December 31, 2019. On January 30, 2020, the World Health Organization declared the COVID-19 eruption a global health emergency. As of 27-May-2021 169,095,283 confirmed cases have been reported in the world and 2, 73, 67, 935 cases in India. It is required to identify the infection with high precision rate but there are lots of deficiency in the diagnosing system that may resulted false alarm rate. Initially it could be detected through throat saliva but now it can also be identified thought the impairment in lungs from computerized tomographical imaging technique. This paper reviewed various researches over COVID-19 diagnosis approach as well as the syndrome in respiratory organs. There are so many imaging techniques through which lungs impairments can be detected that may diagnose COVID-19 with high level of accuracy. CT scan image is the best alternative for diagnosing COVID-19.

scholarly journals Sosialisasi bahaya dan upaya pencegahan infeksi corona virus disease (COVID-19) di Kelurahan Koja, Jakarta Utara

2020 ◽  
Vol 1 (2) ◽  
pp. 37-40
Author(s):  
Khariri Khariri
Keyword(s):  
Preventive Measures ◽  
Virus Disease ◽  
International Health ◽  
World Health ◽  
Wuhan City ◽  
The Public ◽  
Corona Virus ◽  
District Government ◽  
Health Organization ◽  
Almost All

Corona virus Disease (COVID-19) began with a report on December 31, 2019, in Wuhan City of China about pneumonia cluster cases that have not yet been identified. The number of COVID-19 cases has increased and has spread to almost all. The World Health Organization (WHO) has stated that COVID-19 is an international health problem and established as a pandemic. COVID-19 case in Indonesia was first reported on March 2, 2020, and spread in 34 provinces in Indonesia. Treatment and vaccination for the prevention of COVID-19 are still in the process of research. So far preventive measures such as maintaining distance, wearing masks, improving the immune system, and hand hygiene are expected to break the chain of transmission of COVID-19. The COVID-19 socialization aims to provide adequate information to the public about the dangers and efforts to prevent COVID-19 that can be carried out by individuals and the community. The socialization was held in Koja Village, North Jakarta on March 8, 2020. The activity was carried out by the Regional Management of Keluarga Alumni Universitas Gadjah Mada (KAGAMA) DKI Jakarta in collaboration with the Health Sub-Department and the Koja District Government, North Jakarta. The main part of the activity is the delivery of COVID-19 material followed by interactive discussions between participants and resource persons. Individual and community prevention efforts are very important in reducing the number of cases and breaking the chain of transmission so that cases do not increase.

scholarly journals Immunity Boosting measures during COVID– 19

2020 ◽  
Vol 6 (2) ◽  
pp. 40-42
Author(s):  
Tuba Tanveer ◽  
Keyword(s):  
Preventive Measures ◽  
Daily Practice ◽  
World Health ◽  
The Novel ◽  
Global Level ◽  
Human Race ◽  
Corona Virus ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Disease Epidemics

Viral pneumonia outbreak in Wuhan, China, in 2019 was observed and a novel coronavirus was identified as the cause of this outbreak. COVID-19 was the official term given by the World Health Organization and announced this on February 11, 2020 publicly. Corona virus spreads through person to person contact. The novel corona virus has taken a few months to sweep the globe, there are certain questions that are impossible to fathom as the disease rages. As the vaccine for Covid-19 is not yet discovered, the virus is being controlled from spreading worldwide through numerous strategies. Therefore, noticing the virulence of this virus several preventive measures have been taken at a global level to protect the human race. One of the effective measures in controlling the spread of respiratory disease epidemics is maintaining social distance and, therefore, can be used as a way to reduce its spread. Improving the immune power of a person is another crucial measure adopted to obviate its spread. AYUSH system of medicine is performing a central role in the contribution of meliorating the immune system of a person. Variety of herbal combinations have proven to perform the same function. The very first and easy way to boost the immunity and kill the virus, is to drink warm water throughout the day. It is further also advised to take steam once a day. 30 minutes of daily practice of Yogasana, Pranayama and meditation contributes in boosting immunity. Also using Dhaniya, Haldi, Jeera and Lahsun in cooking helps. It is also advised to use Half teaspoon Haldi with 150 ml of Hot milk, once or twice a day. Consuming Chyavanprash 10 mg in the morning is equally helpful.

scholarly journals Impact of Lockdown on Chain Break of Pandemic COVID-19: The Current Status and Forecast

2020 ◽  
Author(s):  
P. Siva Prasad ◽  
P. Hari Prasad
Keyword(s):  
Present Situation ◽  
World Health ◽  
Current Status ◽  
Online Database ◽  
Significant Elevation ◽  
Epidemic Disease ◽  
Wuhan City ◽  
Worldwide Population ◽  
Health Organization ◽  
The Impact

Abstract Coronavirus disease 2019 (COVID-19) is an outbreak of epidemic disease origin in Wuhan city, China. The virus transmits rapidly in worldwide and the rate of fatality also elevated by passing each day. But, action taken by World Health Organization failed to stop outbreak of COVID-19. Wuhan city in China has controlled the pandemic disease with lockdown strategy and present all other countries also followed the same strategy for a month. Hence, present study has been designed to observe the impact of lockdown on COVID-19 in worldwide population and future prophecy with present circumstances. Online database ( www.channelnewsasia.com) was used to ensure that number of COVID-19 cases, death and recovery are recorded in the period of 20 days lockdown (6th - 26th April 2020) in worldwide and as well as country wise population. The data shows significant elevation of COVID-19 cases was observed since 71447, on Feb 18th to 1.3 million by 6th April and then to 2.96 million by 26th April 2020 in worldwide. The fatality rate of COVID-19 were shown to be increased from 2.48% on Feb 18th to 5.51% by 6th April and then to 6.95% on 26th April 2020 in worldwide. We have found increased morbidity (2.21 folds) and fatality (6.95%) of COVID-19 in worldwide and country wise population. In fact lockdown might help to reduce register new cases, but not made zero. However, present situation demands continuation of lockdown and social distance should be maintained with strict rules otherwise probabilities are more to reach unimaginable number of cases in coming days.

Novel corona virus-2019 (SARS CoV-2)

2020 ◽  
Vol 10 (1) ◽  
pp. 1-13
Author(s):  
Dwarakesh B ◽  
Ananda Deepak V ◽  
Asifa Nikhat M ◽  
Bhaskar Reddy K ◽  
Brito Raj S
Keyword(s):  
Virus Disease ◽  
Large Family ◽  
World Health ◽  
The Novel ◽  
Health Crisis ◽  
Medical Practitioners ◽  
Corona Virus ◽  
The People ◽  
Serious Infection ◽  
Health Organization

Among disparate infectious diseases viral infection in particular challenges survival of mankind across the globe. By superseding those events, 2019 novel (CoVID-19) or SARS-CoV-2 has become a new human health crisis threatening the world. Corona viruses (CoV) are large family of viruses that affects birds and mammals. In humans, Corona virus can cause respiratory tract infection ranging from the common cold to more serious infection such as SARS (Severe acute respiratory syndrome), MERS (Middle East Respiratory Syndrome) and CoVID-19 (Corona Virus Disease 2019) which can also become lethal. The Novel corona virus (CoVID-19) originated in 2019, is a novel virus which has not been identified in humans since past. At present, the source of CoVID-19 is not known. Although the infection is presumed to be in origin, person to person transmission is evident. Many supportive and symptomatic therapies where being carried out by the Medical practitioners as per the instructions of World Health Organization (WHO) with a hypothesis and there is no evidence that it works against CoVID-19. best to lower the current crises of infection is prevention and many measures that boosts the immunity are following by the people as directed by the Ministry of AYUSH.

scholarly journals Novel Coronavirus Disease (COVID-19): An Update

2020 ◽  
Vol 22 (1-2) ◽  
pp. 93-98
Author(s):  
Niranjan Nayak ◽  
SK Rai
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
World Health Organization ◽  
Social Distance ◽  
Virus Disease ◽  
Hand Washing ◽  
World Health ◽  
Corona Virus ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Wet Market

At present, a novel Corona Virus called Severe Acute Respiratory Syndrome corona virus (SARS-Cov-2) has caused pandemic infection. This virus has been thought to be of zoonotic origin specially originating from bats. This Virus originated from wet market in Wuhan, China in December 2019. A small cluster of Pneumonia cases that occured in Wuhan in December 2019 was named COVID-19 (Corona Virus Disease) by World Health Organization (WHO). The Covid-19 is still on the rise across the globe. As there is no treatment available for the SARS-Cov-2, it is important to mantain social distance, practice frequent hand-washing and use mask.

scholarly journals The review of COVID-19 and the current progress in intervention and diagnostics

2021 ◽  
Vol 292 ◽  
pp. 03075
Author(s):  
Chunyun Chen ◽  
Xi Chen ◽  
Liwei Guo ◽  
Kanghui Zou
Keyword(s):  
Genome Structure ◽  
World Health ◽  
The Novel ◽  
Control Methods ◽  
Wuhan City ◽  
The Public ◽  
Medical Institutions ◽  
Important Challenge ◽  
Novel Coronavirus ◽  
Health Organization

COVID-19 was first reported in Wuhan city of Hubei Province of China in December 2019, becoming a pandemic declared by the world health organization. This article is a review of the novel coronavirus disease (COVID-19). It typically informs the genome structure of the SARS-CoV-2 and its pathogenic mechanisms, concludes a series of non-pharmaceutical control methods, and focuses on several testing measures. The inventions of the disease treatments remain an important challenge to all medical institutions while a series of medications have been brought to the public.

scholarly journals Histopathology and Pathogenesis of Coronavirus disease 2019 (COVID-19)

2020 ◽  
Vol 2 (3) ◽  
pp. 230-234
Author(s):  
Nikolaos Chrysanthakopoulos ◽  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Immune Responses ◽  
Good Prognosis ◽  
Multiple Organ ◽  
World Health ◽  
The Novel ◽  
Angiotensin Converting Enzyme 2 ◽  
Corona Virus ◽  
Novel Coronavirus ◽  
Health Organization

A severe pandemic of CoronaVirus disease 2019 (COVID-19), according to World Health Organization (WHO), appeared in China in December 2019, and spread rapidly. The majority of the patients had mild symptoms and good prognosis after recovery; however some patients developed severe inflammatory reaction and passed away from multiple organ complications. The novel coronavirus, Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a beta-coronavirus and is similar with the Severe Acute Respiratory Syndrome Corona Virus 1 (SARS-CoV-1) and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). SARS-CoV-2 and -1 have the same host receptor, the angiotensin-converting enzyme 2 (ACE2). The pathogenesis of SARS-CoV-2 infection in humans remains unclear. The immune response is essential to control and reduce SARS-CoV-1 and -2 infections, however, irregular and exaggerated immune responses may lead to the immunopathology of the disease and the lung lesions. This article presents the immunological features of SARS-CoV-2 infection and its potential pathogenesis based on the recent observations of the International literature.

scholarly journals Immune System Enriching Micronutrients: Essential Ingredient for Wellbeing in COVID-19

2020 ◽  
Vol 1 (supplement) ◽  
pp. 4
Author(s):  
Shizma Junejo ◽  
Mehreen Lateef ◽  
Eme Paul Eze
Keyword(s):  
Immune System ◽  
Virus Disease ◽  
Significant Loss ◽  
World Health ◽  
The Novel ◽  
Omega 3 ◽  
Global Pandemic ◽  
Nutrition Intake ◽  
Novel Coronavirus ◽  
Health Organization

The World Health Organization (WHO) on March 11, 2020, has declared the novel coronavirus (COVID-19) onset a global pandemic. Consequently, there has been noticeable economic adversity globally and a significant loss of life. A strong functioning immune system is crucial for adequate defense against pathogenic organisms. The intricacy of the interplay between nutrition and immunology is wide ranging. In the context of novel corona virus disease, competent immune system requires adequate supply of essential nutrients including vitamin C, D, E, A, B6, B12, folateandtraceelements,includingzinc,iron,selenium,magnesium,copper to support innate and adaptive immune systems. Other nutrients such as omega-3 fatty acids also support immune system effectively, specifically by helping to resolve the inflammatory response. Deficiencies or suboptimal status in micronutrients negatively affects immune function and can decrease resistance to infections. AlthoughmuchremainstobeknownaboutCOVID-19,itisimportantthat,toavertthelikelihoodof being infected with COVID-19, nutrition intake targeted towards boosting immune system is indispensable.

scholarly journals Average Mortality Rate of COVID-19 in Iran

2020 ◽  
Author(s):  
Sajjad Baber
Keyword(s):  
Mortality Rate ◽  
World Health Organization ◽  
Virus Disease ◽  
Hubei Province ◽  
World Health ◽  
Wuhan City ◽  
Corona Virus ◽  
The World ◽  
Health Organization

Background: Corona virus disease was first reported in Wuhan City, Hubei province, China. Soon the corona virus disease has spread to many countries. World health organization has described the situation as Pandemic. By 12 March 2020, corona virus disease has affected 125 countries around the world. Corona virus was first confirmed in Iran on 19 February 2020. Objective: The aim of writing this small article is to determine the mortality rate of corona virus disease in different cities of Iran. This article will give readers an idea of different ways to control spread of corona virus disease in Iran. Methods: Author has collected the data of daily confirmed cases from different diagnostic centers and hospitals across the country from 19 February 2020 to 1 April 2020. Results: Mortality rate of corona virus disease is roughly 4%. Conclusions: Mortality rate could rise if COVID 19 infection is not controlled.

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