scholarly journals RANDOMIZED CONTROL TRIAL ON ERANDAMULA GHANAVATI WITH NASYA IN MANYAGRAHA WITH SPECIAL REFERENCE TO CERVICAL SPONDYLOSIS

2021 ◽  
Vol 12 (6) ◽  
pp. 20-25
Author(s):  
Sunil Solanke ◽  
Prakash Kabra
Keyword(s):  
Cervical Spine ◽  
Randomized Control Trial ◽  
Cervical Spondylosis ◽  
Group Discussion ◽  
The Elderly ◽  
Control Group ◽  
Trial Group ◽  
Effect Of Therapy ◽  
Randomized Control ◽  
And Control

Background: Cervical spondylosis is defined as degenerative changes occurring in the discs and cervical spine. Stating these changes is to be almost universal in the elderly. Cervical Spondylosis correlated with Manyagraha in Ayurvedic perspective. Aim: Aim of the study was to evaluate the effect of Erandamula Ghanavati and Anu Taila Nasya in Manyagraha. Methods: The Group in which Erandamula Ghanavati and Anutaila Nasya were given to patients was termed as Trial Group. The Group in which Panchatikta Ghrita Guggulu and Anutaila Nasya were given to patients was termed as Control Group. During this study 104 patients out of 150 were equally divided into Trial and Control Group by lottery method and comparative study was done. Statistical analysis was done using appropriate tests. Results: Erandamula Ghanavati along with Anu Taila Nasya has reduces symptoms of Manyagraha. Total effect of therapy is more in Trial group as compared to the Control Group. Discussion: As stated by Charak Erandamula is best Vatahara drug. Its Rasa, Virya and Vipak are helpful to alleviate Vata. Erandamula having Snigdha, Madhuraproperties is going to be beneficial in Dhatukshayajanya Vatavyadhi. Conclusion: Erandamula Ghanavati along with Anu Taila Nasya has beneficial for patients of Manyagraha.

scholarly journals Early Use of Corticosteroid May Prolong SARS-CoV-2 Shedding in Non-Intensive Care Unit Patients with COVID-19 Pneumonia: A Multicenter, Single-Blind, Randomized Control Trial

Respiration ◽  
2021 ◽  
pp. 1-11
Author(s):  
Xiao Tang ◽  
Ying-Mei Feng ◽  
Ji-Xiang Ni ◽  
Jia-Ying Zhang ◽  
Li-Min Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Randomized Control Trial ◽  
Corticosteroid Treatment ◽  
Clinical Deterioration ◽  
Control Group ◽  
Number Of Patients ◽  
Early Use ◽  
Randomized Control ◽  
And Control ◽  
Single Blind

<b><i>Background:</i></b> There is still no clinical evidence available to support or to oppose corticosteroid treatment for coronavirus disease 2019 (COVID-19) pneumonia. <b><i>Objective:</i></b> To investigate the efficacy and safety of corticosteroid given to the hospitalized patients with COVID-19 pneumonia. <b><i>Methods:</i></b> This was a prospective, multicenter, single-blind, randomized control trial. Adult patients with COVID-19 pneumonia who were admitted to the general ward were randomly assigned to either receive methylprednisolone or not for 7 days. The primary end point was the incidence of clinical deterioration 14 days after randomization. <b><i>Results:</i></b> We terminated this trial early because the number of patients with COVID-19 pneumonia in all the centers decreased in late March. Finally, a total of 86 COVID-19 patients underwent randomization. There was no difference of the incidence of clinical deterioration between the methylprednisolone group and control group (4.8 vs. 4.8%, <i>p</i> = 1.000). The duration of throat viral RNA detectability in the methylprednisolone group was 11 days (interquartile range, 6–16 days), which was significantly longer than that in the control group (8 days [2–12 days], <i>p</i> = 0.030). There were no significant differences between the 2 groups in other secondary outcomes. Mass cytometry discovered CD3<sup>+</sup> T cells, CD8<sup>+</sup> T cells, and NK cells in the methylprednisolone group which were significantly lower than those in the control group after randomization (<i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> From this prematurely closed trial, we found that the short-term early use of corticosteroid could suppress the immune cells, which may prolong severe acute respiratory syndrome coronavirus 2 shedding in patients with COVID-19 pneumonia. <b><i>Trial Registration:</i></b> ClinicalTrials.gov, NCT04273321.

scholarly journals Efficacy of Single Pre-Operative Dose of Glucocorticoid (125mg of Solumedrol Intravenous) in Terms of Seroma Formation in Patients Undergoing Mastectomy with Axillary Clearance For Breast Cancer: A Randomized Control Trial

2020 ◽  
pp. 1-5
Author(s):  
Aliya Ishaq ◽  
Abida Parveen ◽  
Aliya Ishaq ◽  
Mariya Ishaq ◽  
Muhammad Jamshaid Hussain Khan ◽  
...  
Keyword(s):  
Single Dose ◽  
Randomized Control Trial ◽  
Removal Rate ◽  
Fluid Collection ◽  
Study Groups ◽  
Seroma Formation ◽  
Control Group ◽  
Drain Removal ◽  
Randomized Control ◽  
And Control

Objective: The study aimed to determine the efficacy of single dose of glucocorticoid (125 mg of Solumedrol intravenous) in terms of seroma formation after mastectomy in patient with carcinoma of breast. Study Design: Randomized control trial. Place and Duration of Study: Study was conducted in the Department of General Surgery, Liaquat National Hospital Karachi, Pakistan from july 1 to dec 31, 2010. Patients and Methods: Patients were randomly divided in two groups (study and control) each group consisting of 30 patients. Randomization was done by opening of a sealed envelope which had a slip bearing the name of study medication (solumederol or saline as placebo) to be administered. The study group received a single dose of inj 125mg solumedrol IV half an hour prior to surgery by resident scrub in surgery. A similar procedure was applied to the control group and patients in controlled group were administered an equal volume of saline intravenously. After drain removal patients in both groups were observed for a duration of 2 weeks for sermoa formation. Detection of seroma formation was based on clinical grounds by absence of any fluid collection at mastectomy bed as detected by manual palpation. SPSS 10 was used for analysis. Results: Seroma formation was observed in 66.7% (40/60) women 2 weeks post drain removal. Rate of seroma formation was significantly low in study groups than control groups (33.3% vs. 100%; p=0.0001). Conclusion: Single dose of steroid is efficacious in reducing the post mastectomy seroma formation.

scholarly journals Effects of Muscle Energy Technique in Patients with Tension Type Headache; A Randomized Control Clnicial Trial

2021 ◽  
Author(s):  
Rabia Sohail ◽  
Huma Riaz ◽  
Muhammad Akhtar ◽  
Asim Raza ◽  
Kinza Shabbir ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Range Of Motion ◽  
Tension Type Headache ◽  
Control Group ◽  
Muscle Energy Technique ◽  
Randomized Control ◽  
Muscle Energy ◽  
Type Headache ◽  
And Control ◽  
Experimental Group

Abstract Background: Tension type headache is claimed to be one of top ten disabling conditions in the world. The purpose of the study was to determine the effects of muscle energy technique on pain, range of motion at cervical spine and disability related to tension type headache. Methods: A randomized control trial was conducted on 48 participants of both genders whose age was 18 to 40 years with complain of tension type at Rehabilitation and Injury Management Department of Medcare International Hospital Gujranwala, from July to December 2019. Participants were randomly selected and allocated into two groups (experimental and control group). The experimental group received both muscle energy technique and myofascial release technique on trapezius and sternocleidomastoid of both sides. The intervention was applied for 6 weeks (3 sessions per week). Assessments were done at baseline, 4th week and 6th week. Numeric pain rating scale (NPRS), Headache disability inventory (HDI), headache impact test (HIT) and cervical range of motion with the help of Inclinometer were tools for assessment. Data analysis was done using SPSS (version 21). Results: The mean age of experimental group was 26.5±5.42 and control group was 27.7±5.70. The experimental group was shown significant improvement in terms of pain and flexion and side flexion range of motion with p-value ≤0.05. Conclusion: It is concluded that muscle energy technique is effective treatment for tension type headache; it is associated to decreased range of motion at cervical spine and disability related to TTH. Trial registration: IRCT20190121042445N2, Registered 07-02-2021.

scholarly journals Prevention of Oculocardiac Reflex by Premedication With Low Dose I/V Ketamine during Strabismus Surgery

2021 ◽  
Vol 15 (10) ◽  
pp. 2652-2655
Author(s):  
Mehreen Akram ◽  
Iqra Mushtaq ◽  
Rafia Kousar
Keyword(s):  
Randomized Control Trial ◽  
Low Dose ◽  
Nmda Receptor Antagonist ◽  
Strabismus Surgery ◽  
Control Group ◽  
Case Report Form ◽  
Trial Methodology ◽  
Oculocardiac Reflex ◽  
Randomized Control ◽  
And Control

Background: OCR commonly occurs during strabismus surgery, producing bradycardia, arrhythmias and even cardiac arrest after manipulation of orbital structures. Ketamine is NMDA receptor antagonist and acts as an analgesic. Aim: To determine the effect of ketamine premedication on prevention of OCR during strabismus surgery. Study design: Randomized control trial Methodology: 60 patients were randomly divided into two groups i.e., Ketamine 0.75mg/kg (Group K) and control (Group C). Group K patients were premedicated with 0.75mg/kg ketamine while Group C patients did not receive any premedication. Heart rate and ECG were observed 30 sec before and continuously after traction on extraocular muscles was applied upto end of surgery for bradycardia and arrhythmias. Percentage change in HR and presence of arrhythmias was documented. All the data was collected using case report form and analyzed using SPSS version 15. Results: In Group C, 15(50%) cases had arrhythmias while in Group K, only 4(13.33%) cases had arrhythmias. Mean HR in Group C was 118.77±6.92/min and in Group K was 101.57±15.65/min. In Group C, oculocardiac reflex was present in 23(76.7%) cases and in Group K, OCR was present in 6 (20%) cases and prevented in 24 (80%) cases. Conclusion: Premedication with 0.75mg/kg IV ketamine significantly reduces the occurrence of oculocardiac reflex during strabismus surgery. Keywords: Ketamine, Oculocardiac Reflex, Premedication, Prevention, Strabismus

The Impact of a Foot-Toe Orthosis on Dynamic Balance: An Exploratory Randomized Control Trial

2020 ◽  
Vol 29 (7) ◽  
pp. 871-878
Author(s):  
Adam Kelly ◽  
Justin Stanek
Keyword(s):  
Randomized Control Trial ◽  
Daily Living ◽  
Dynamic Balance ◽  
Intervention Group ◽  
Control Group ◽  
Control Groups ◽  
Balance Test ◽  
Randomized Control ◽  
And Control ◽  
The Impact

Context: The influence of custom and over-the-counter foot orthoses on dynamic balance has been investigated in the past. However, there has not been an exploration of the use of a foot-toe orthosis for improving balance. The ability of clinicians to influence balance could have important implications for injury prevention and rehabilitation. Objective: To determine the impact of a foot-toe orthosis on dynamic balance in healthy, young adults. Design: Randomized control trial. Setting: Athletic training laboratory. Participants: In total, 64 healthy, recreationally active participants aged 18–29 years were randomly allocated to one of the following groups: the foot-toe orthosis and laboratory-issued shoe group, the laboratory-issued shoe only (SO) group, or the control group. Interventions: Subjects in the intervention group wore the foot-toe orthosis and laboratory-issued shoe with activities of daily living for 4 weeks. Subjects in the SO intervention group wore the laboratory-issued shoe with activities of daily living for 4 weeks. Participants in the control group did not receive any intervention. Main Outcome Measures: The instrumented version of the Star Excursion Balance Test, known as the Lower Quarter Y-Balance Test, was used to quantify the dynamic balance at baseline and follow-up. Reaches were normalized for leg length. Results: There were statistically significant differences in postintervention scores on the Lower Quarter Y-Balance Test for both the dominant (P = .03, effect size = 0.84; 95% confidence interval, 0.25 to 1.43) and nondominant (P = .002, effect size = 0.74; 95% confidence interval, 0.15 to 1.32) legs when comparing dynamic balance scores of the foot-toe orthosis and laboratory-issued shoe group with the SO and control groups. No significant differences were observed when comparing dynamic balance between the SO and control groups. Conclusions: A 4-week intervention with a foot-toe orthosis and laboratory-issued shoe resulted in improved dynamic balance in a healthy young adult population. These findings suggest a novel intervention for increasing balance.

scholarly journals Use of Lubricant at Meatus and Circumcision Site in Younger Children Prevent Post Circumcision Meatal Stenosis : A Randomized Control Trial

2013 ◽  
Vol 5 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Susankar Kumar Mondal ◽  
Md Ansar Ali ◽  
Md Kausar Alam ◽  
Kaniz Hasina ◽  
Abdur Rabban Talukder ◽  
...  
Keyword(s):  
Randomized Control Trial ◽  
Study Groups ◽  
Late Complications ◽  
Control Group ◽  
Petroleum Jelly ◽  
Control Groups ◽  
Topical Medication ◽  
Meatal Stenosis ◽  
Randomized Control ◽  
And Control

Background: Circumcision is the most common surgical procedure performed in boys through out the world. Meatal stenosis is one of its late complications. Objective: The aim of the present study is to see the effectiveness of use of lubricants vaseline-petrelium jelly) during arumcision meatal stenosis. Methodology: A randomized control trial was performed, in which two groups of boys younger than two years old underwent circumcision according to dissection (sleeve) method. The parents in the study groups were strictly instructed to use petroleum jelly on the meatus and circumcision site at every morning or after each diaper change where necessary for three months. On the other hand parents in the control group were instructed not to use any lubricants or topical medication on the same site. The boys were followed up regularly and evaluated for meatal stenosis, bleeding and infection. Results: A total of 120 boys were recruited & in each group comprised of 60 boys. None of the boys in the study group develop meatal stenosis , but 6(10%) in the control group develop meatal stenosis (p< 0.05 ). Infection of the circumcision site was seen in 1 (0.6%) and 3 (5%) children in the lubricant and control groups, respectively (p<0.05) and bleeding was seen in 3 (5.0%) and 6(10.0%) respectively. Conclusion: Based on the findings of this study, it seems logical to use a lubricant jelly for prevention of post circumcision meatal stenosis and other complications. DOI: http://dx.doi.org/10.3329/jssmc.v5i1.16204 J Shaheed Suhrawardy Med Coll, 2013;5(1):35-38

scholarly journals The Survey of Effectiveness of Group Counseling with Cognitive – Behavioural Method in Reducing Mother’s Stress of Child with Mental Retardation under 6 Years Old Under Cover of Khorramabad Province Welfare Organization (2012)

2013 ◽  
Vol 4 (2) ◽  
pp. 391
Author(s):  
Azarinvand, Abrahim ◽  
Gorjee, Yosef ◽  
Sadrepooshan, Najmeh ◽  
Esmaili, Ghasem
Keyword(s):  
Mental Retardation ◽  
Group Counseling ◽  
Repeated Measurements ◽  
Cognitive Behavioral ◽  
Control Group ◽  
Trial Group ◽  
Significant Difference ◽  
Group 15 ◽  
Behavioral Method ◽  
And Control

<p>The aim of this study was to investigate the effectiveness of group counseling with cognitive – behavioral method in reducing mother’s stress of child with mental retardation less than 6 years old covered of Khorramabad province welfare organization (2012). The statistical society of this study consisted of 52 mothers of child with mental retardation who their children had file in the welfare office. 30 persons were selected by simple random sampling and were divided into two groups including trial group (15 persons) and control group (15 persons).</p><p>The method of study was quasi – experimental way with control group and random trial and data gathering tool such as Friedrich, Greenberg and Crink resources and stress questionnaire. To perform the study; the first step was pretest trial and control group and then 10 group counseling sessions with cognitive- behavioral method had hold among trial group. The control group’s mothers did not receive any counseling. Then, it established post – testing of both group again and another test provided to following – up step for two weeks after test.</p><p>The result of variance analysis with repeated measurements showed that, there is significant difference in percentage1 level between control and trial groups post – test and follow – up scores, so, the first hypothesis of this study had approved upon group counseling efficacy with cognitive – behavioral method in reducing mother’s stress of child with mental retardation. In addition, these results showed that group counseling with cognitive – behavioral method has been established significant reduction in percentage 1 level physical and emotional symptoms of trial groups’ mothers, but it did not find the significant difference in the cognitive symptoms.</p>

EFFECT OF ACCUPRESSURE PEN ON DISTANCE VARIABLE IN SCIATICA PATIENTS -A RANDOMIZED CONTROL TRIAL

2021 ◽  
pp. 28-31
Author(s):  
Urja S. Vaidya ◽  
Roshani S. Patel
Keyword(s):  
Randomized Control Trial ◽  
Stride Length ◽  
Step Length ◽  
Control Group ◽  
Exclusion Criteria ◽  
Parametric Test ◽  
Group A ◽  
Randomized Control ◽  
Experimental Group ◽  
Distance Variable

Background: Sciatica is a radiating pain which is treated with manual accupressure and after a time electro accupressure came into introduction. Aim And Objective: Aim: To nd out the effectiveness of accupressure pen to improve the distance variable To nd out the effect of Objective: accupressure pen on pain and distance variable in sciatica patient To compare the experimental group to the control group On the basis of Method: inclusion and exclusion criteria 30 participants were selected. They were treated with electro accupressure pen for 3 alternative days / week for 3 weeks, after that re-assessment was taken with NPRS, Slump and Distance variables. The data was analyzed using SPSS Version Results: 21.Parametric test was used .In Group A improvement was seen Accupressure Conclusions: pen is effective to reduce pain and improve step length and stride length in Sciatica Patients

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