scholarly journals A REVIEW ON CLINICAL APPLICATION OF SUKRAKSHAYA AND KSHEENASUKRA LAKSHANAS WITH RESPECT TO ANDROGEN DEFICIENCY

2021 ◽  
Vol 12 (1) ◽  
pp. 146-149
Author(s):  
Duragappa Savantri ◽  
Madhava Diggavi
Keyword(s):  
Clinical Application ◽  
Gonadal Hormones ◽  
The Body ◽  
Androgen Deficiency ◽  
Pathological Conditions ◽  
Causative Factors ◽  
Living Organisms

Sukra is the essence of all Dhatus and responsible for the both Prakruta and Vikruta function on the Body in Physiological and Pathological conditions respectively. Androgens are the male gonadal hormones and maintain the male reproductive functions. Acharya Sushruta clears that Sukradhara kala is present in all living organisms and all over the body as like Circulating Androgens in the blood. The dysfunction of Sukra Dhatu will affect all over the body by means of Many Causative factors (Nidanas) or Secondary affection as a result of many systemic disorders. In Bruhatrayi and Laghutrayee explained Ksheena sukra lakshana and Sukrakshaya lakshana to understand Sukra dushti. Here sukra denotes Semen plus androgen. Hyper and hypo androgenic action cause many diseases and itself will get affect by the influence of many systemic disorders so one should meticulously to be evaluated in most of the diseases even other than infertility cases for Sukrakshaya and androgen deficiency.

The recommendations on diagnostics and treatment of male hypogonadism (deficit of testosterone). The project

2015 ◽  
Vol 61 (5) ◽  
pp. 60-71 ◽  
Author(s):  
Ivan Ivanovich Dedov ◽  
Galina Afanas'evna Mel'nichenko ◽  
Roman Viktorovich Rozhivanov ◽  
Dmitriy Gennadievich Kurbatov
Keyword(s):  
Serum Level ◽  
Clinical Symptoms ◽  
The Body ◽  
Male Hypogonadism ◽  
Androgen Deficiency ◽  
Pathological Changes ◽  
Pathological Conditions ◽  
Clinical Variants ◽  
Low Serum

Male hypogonadism is a condition in which the body doesn’t produce enough testosterone which results in its low serum level in combination with characteristic clinical symptoms and/or signs (see the description below) that can be observed in the patients presenting with pathological changes in testicles and/or hypophysis, such as Kleinfelter’s syndrome, and in men with idiopathic metabolic or iatrogenic disorders leading to androgen deficiency. The present recommendations does not cover the entire set of pathological conditions responsible for the development of hypogonadism (deficit of testosterone); rather, they are focused on its clinical variants that account for the majority of the cases of male hypogonadism.

The use of Body Surface Index as a Better Clinical Health indicators Compare to Body Mass Index and Body Surface Area for Clinical Application

2018 ◽  
pp. 131-136
Author(s):  
Shirazu I. ◽  
Theophilus. A. Sackey ◽  
Elvis K. Tiburu ◽  
Mensah Y. B. ◽  
Forson A.
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Clinical Application ◽  
Body Surface ◽  
Body Height ◽  
Health Indicators ◽  
The Body ◽  
Body Parameters ◽  
The Relationship ◽  
Individual Body

The relationship between body height and body weight has been described by using various terms. Notable among them is the body mass index, body surface area, body shape index and body surface index. In clinical setting the first descriptive parameter is the BMI scale, which provides information about whether an individual body weight is proportionate to the body height. Since the development of BMI, two other body parameters have been developed in an attempt to determine the relationship between body height and weight. These are the body surface area (BSA) and body surface index (BSI). Generally, these body parameters are described as clinical health indicators that described how healthy an individual body response to the other internal organs. The aim of the study is to discuss the use of BSI as a better clinical health indicator for preclinical assessment of body-organ/tissue relationship. Hence organ health condition as against other body composition. In addition the study is `also to determine the best body parameter the best predict other parameters for clinical application. The model parameters are presented as; modeled height and weight; modelled BSI and BSA, BSI and BMI and modeled BSA and BMI. The models are presented as clinical application software for comfortable working process and designed as GUI and CAD for use in clinical application.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

Healthy Gut, Healthy Brain: The Gut Microbiome in Neurodegenerative Disorders

2020 ◽  
Vol 20 (13) ◽  
pp. 1142-1153 ◽  
Author(s):  
Sreyashi Chandra ◽  
Md. Tanjim Alam ◽  
Jhilik Dey ◽  
Baby C. Pulikkaparambil Sasidharan ◽  
Upasana Ray ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Neurodegenerative Disorders ◽  
The Body ◽  
Therapeutic Approaches ◽  
Cns Disorders ◽  
Physiological Conditions ◽  
Pathological Conditions ◽  
The Central Nervous System ◽  
Present Understanding ◽  
Lateral Sclerosis

Background: The central nervous system (CNS) known to regulate the physiological conditions of human body, also itself gets dynamically regulated by both the physiological as well as pathological conditions of the body. These conditions get changed quite often, and often involve changes introduced into the gut microbiota which, as studies are revealing, directly modulate the CNS via a crosstalk. This cross-talk between the gut microbiota and CNS, i.e., the gut-brain axis (GBA), plays a major role in the pathogenesis of many neurodegenerative disorders such as Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS) and Huntington’s disease (HD). Objective: We aim to discuss how gut microbiota, through GBA, regulate neurodegenerative disorders such as PD, AD, ALS, MS and HD. Methods: In this review, we have discussed the present understanding of the role played by the gut microbiota in neurodegenerative disorders and emphasized the probable therapeutic approaches being explored to treat them. Results: In the first part, we introduce the GBA and its relevance, followed by the changes occurring in the GBA during neurodegenerative disorders and then further discuss its role in the pathogenesis of these diseases. Finally, we discuss its applications in possible therapeutics of these diseases and the current research improvements being made to better investigate this interaction. Conclusion: We concluded that alterations in the intestinal microbiota modulate various activities that could potentially lead to CNS disorders through interactions via the GBA.

scholarly journals Dealing with PET radiometabolites

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Krishna Kanta Ghosh ◽  
Parasuraman Padmanabhan ◽  
Chang-Tong Yang ◽  
Sachin Mishra ◽  
Christer Halldin ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Distribution Patterns ◽  
The Body ◽  
Analysis Process ◽  
Pet Tracer ◽  
Positron Emission ◽  
Structural Identity ◽  
Available Technology ◽  
Living Organisms ◽  
Entire Amount

Abstract Positron emission tomography (PET) offers the study of biochemical, physiological, and pharmacological functions at a cellular and molecular level. The performance of a PET study mostly depends on the used radiotracer of interest. However, the development of a novel PET tracer is very difficult, as it is required to fulfill a lot of important criteria. PET radiotracers usually encounter different chemical modifications including redox reaction, hydrolysis, decarboxylation, and various conjugation processes within living organisms. Due to this biotransformation, different chemical entities are produced, and the amount of the parent radiotracer is declined. Consequently, the signal measured by the PET scanner indicates the entire amount of radioactivity deposited in the tissue; however, it does not offer any indication about the chemical disposition of the parent radiotracer itself. From a radiopharmaceutical perspective, it is necessary to quantify the parent radiotracer’s fraction present in the tissue. Hence, the identification of radiometabolites of the radiotracers is vital for PET imaging. There are mainly two reasons for the chemical identification of PET radiometabolites: firstly, to determine the amount of parent radiotracers in plasma, and secondly, to rule out (if a radiometabolite enters the brain) or correct any radiometabolite accumulation in peripheral tissue. Besides, radiometabolite formations of the tracer might be of concern for the PET study, as the radiometabolic products may display considerably contrasting distribution patterns inside the body when compared with the radiotracer itself. Therefore, necessary information is needed about these biochemical transformations to understand the distribution of radioactivity throughout the body. Various published review articles on PET radiometabolites mainly focus on the sample preparation techniques and recently available technology to improve the radiometabolite analysis process. This article essentially summarizes the chemical and structural identity of the radiometabolites of various radiotracers including [11C]PBB3, [11C]flumazenil, [18F]FEPE2I, [11C]PBR28, [11C]MADAM, and (+)[18F]flubatine. Besides, the importance of radiometabolite analysis in PET imaging is also briefly summarized. Moreover, this review also highlights how a slight chemical modification could reduce the formation of radiometabolites, which could interfere with the results of PET imaging. Graphical abstract

scholarly journals Enzymes, Reacting with Organophosphorus Compounds as Detoxifiers: Diversity and Functions

2021 ◽  
Vol 22 (4) ◽  
pp. 1761
Author(s):  
Ilya Lyagin ◽  
Elena Efremenko
Keyword(s):  
Phylogenetic Analysis ◽  
Future Development ◽  
Organophosphorus Compounds ◽  
The Body ◽  
Chemical Transformations ◽  
Negative Consequences ◽  
Biological Targets ◽  
Oxidation Reduction ◽  
Structural Differences ◽  
Living Organisms

Organophosphorus compounds (OPCs) are able to interact with various biological targets in living organisms, including enzymes. The binding of OPCs to enzymes does not always lead to negative consequences for the body itself, since there are a lot of natural biocatalysts that can catalyze the chemical transformations of the OPCs via hydrolysis or oxidation/reduction and thereby provide their detoxification. Some of these enzymes, their structural differences and identity, mechanisms, and specificity of catalytic action are discussed in this work, including results of computational modeling. Phylogenetic analysis of these diverse enzymes was specially realized for this review to emphasize a great area for future development(s) and applications.

scholarly journals Circadian Deregulation as Possible New Player in Pollution-Induced Tissue Damage

Atmosphere ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 116
Author(s):  
Mascia Benedusi ◽  
Elena Frigato ◽  
Cristiano Bertolucci ◽  
Giuseppe Valacchi
Keyword(s):  
Cardiovascular Diseases ◽  
Air Pollutants ◽  
Environmental Stressors ◽  
Common Mechanism ◽  
Particulate Matters ◽  
Circadian Misalignment ◽  
Pathological Conditions ◽  
Peripheral Clocks ◽  
Living Organisms ◽  
Almost All

Circadian rhythms are 24-h oscillations driven by a hypothalamic master oscillator that entrains peripheral clocks in almost all cells, tissues and organs. Circadian misalignment, triggered by industrialization and modern lifestyles, has been linked to several pathological conditions, with possible impairment of the quality or even the very existence of life. Living organisms are continuously exposed to air pollutants, and among them, ozone or particulate matters (PMs) are considered to be among the most toxic to human health. In particular, exposure to environmental stressors may result not only in pulmonary and cardiovascular diseases, but, as it has been demonstrated in the last two decades, the skin can also be affected by pollution. In this context, we hypothesize that chronodistruption can exacerbate cell vulnerability to exogenous damaging agents, and we suggest a possible common mechanism of action in deregulation of the homeostasis of the pulmonary, cardiovascular and cutaneous tissues and in its involvement in the development of pathological conditions.

Extase scopique, sédimentation langagičre et inscription corporelle. Les images dans la civilisation contemporaine

PARADIGMI ◽  
2009 ◽  
pp. 71-83
Author(s):  
Jean-Jacques Wunenburger
Keyword(s):  
Key Words ◽  
The Body ◽  
Pathological Conditions ◽  
Image Informatics

- Linguistic Sedimentation, and Bodily Inscription At present, we are exposed to an excessive offer of images, which raises a problem of assimilation. Subjects are increasingly passive, in ways that can border on pathological conditions. Yet, it is not so much a question of condemning this situation as of finding a way of re-symbolizing images, saving them from mere contemplation and inserting them in a process of contextualisation. Such a process requires an understanding of the role of the body and of the incorporation of images along the lines of Bachelard's intuition of the "resisting" nature of images. This raises the possibility of an education to images suited to the present age.Key words: Alienation, Education, Embodiment, Image, Informatics, Symbolisation.Parole chiave: Alienazione, Educazione, Immagine, Incorporazione, Informatica, Simbolizzazione.

Some aspects of hemostasis in the tactics of the ophthalmologist. Literature review

2021 ◽  
pp. 265-270
Author(s):  
O.M. Stanishevskaya ◽  
◽  
M.A. Safronova ◽  
G.V. Bratko ◽  
I.Y. Efremova ◽  
...  
Keyword(s):  
Open Angle Glaucoma ◽  
Vascular Diseases ◽  
Laboratory Diagnosis ◽  
The Body ◽  
Vascular Pathology ◽  
Treatment Result ◽  
Important Place ◽  
Correct Orientation ◽  
Pathological Conditions ◽  
Wide Range

Disorders of hemostasis occupy an important place in the structure of vascular diseases and are one of the most frequent pathological conditions encountered in practical medicine. The hemostasis system is naturally the most vulnerable system of the body. Violations of its balance are found in a wide variety of physiological and pathological conditions of the body. It is not uncommon for the first debut of decompensation to lead to an ophthalmologist. In the practice of an ophthalmologist, there are diseases when it is necessary to pay close attention to thrombophilic conditions. Changes in the hemostatic system, affect a wide range of vascular diseases of the eyeball. Recognition of the type of thrombophilia and its timely laboratory diagnosis in patients with vascular diseases of the retina and optic nerve are important in achieving the best treatment results. Multidisciplinary approach to the treatment of vascular diseases of the eyeball and modern diagnostics, including the study of hemostasis, is necessary and relevant to achieve the best clinical and functional treatment result. Timely and correct orientation of patients in vascular pathology is extremely important due to the fact that concomitant systemic pathology can aggravate the course of the disease, therefore, the choice of treatment tactics for this category of patients should be carried out in conjunction with a therapist, cardiologist, hematologist and endocrinologist. Key words: hemostasis, thrombosis CVS, diabet, primary open-angle glaucoma thrombodynamica, cardiovascular pathology.

An overview on the concept of “Aam” and its significance as mentioned in Ayurvedic texts.

2020 ◽  
Vol 8 (01) ◽  
Author(s):  
Tejaswini Katare ◽  
Disha Sharma ◽  
Ganesh Puradkar ◽  
Arun Dudhamal
Keyword(s):  
Point Of View ◽  
The Body ◽  
Diagnosis And Treatment ◽  
Important Concept ◽  
Root Cause ◽  
Causative Factors ◽  
Undigested Food ◽  
Unhealthy Diet ◽  
Lack Of Exercise ◽  
All Diseases

Aam is an important concept described by Ayurvedic Acharyas which is responsible for many diseases. According to Ayurvedic point of view, all diseases are originated from aamdosh, vitiation of Agni i.e malfunction of Agni produces Aam. Aam is unripe, undigested food which is caused due to Agnimandya. Agnimandya produces aam and viceversa. We all know that all diseases are caused due to Agnimandya. Therefore as agnimandya and aam are the causative factors of each other, aam is the root cause of all diseases. Hence aam and agnimandya plays an important role in diagnosis and treatment of disease. Nowadays due to lack of exercise, unhygienic and unhealthy diet, incapability to obey the rules of sound body maintenance and increasing pollution results in agnimandya and aam production in the body and decrease in immunity resulting into various diseases. The concept of aam is the most important fundamental principal of Ayurveda in understanding the physio- pathology of the disease.

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