scholarly journals A REVIEW ON LASUNA (GARLIC): A BOON FOR WOMEN

2021 ◽  
Vol 10 (1) ◽  
pp. 13-16
Author(s):  
Preeti Agarwal ◽  
Kalpna Sharma ◽  
Anjali Verma ◽  
Hem Prakash
Keyword(s):  
Sedentary Lifestyle ◽  
Inflammatory Diseases ◽  
Scientific Evidence ◽  
Lifestyle Modifications ◽  
Estrogenic Effect ◽  
Gynecological Disorders ◽  
Quality Life ◽  
Healthy Family ◽  
Anti Inflammatory

Women are the important pillar for the overall development of the healthy family as well as society. In the present era, due to sedentary lifestyle modifications lots of gynecological disorders arises and affects the quality life of female. Ayurvedic classics described all gynecological disorders under the umbrella of Yonivyapadas & Artava Vikaras and for that Acharya Kashyapa describing Lasuna as Lasuna Rasayana like nectar for various female disorders. To find out classical references for use of Lasuna in various female disorders along with its review of recent research on effect of Lasuna in management of female disorders. Classical reference of Lasuna for female disorders find out majorly in Kashyap Samhita. Whereas various recent research suggest that Lasuna has hypolipidemic, antifungal, antibacterial, antispasmodic, anti-inflammatory, Phyto estrogenic effect that’s why it is very useful in PCOD, Pelvic inflammatory diseases, Dysmenorrhea, Infertility, PMS etc. Lasuna is certainly nectar for gynecological problems, which is mentioned in Ayurveda classics and significantly proved by modern scientific evidence also.

scholarly journals Efek Anti Inflamasi Enzim Bromelin Nanas Terhadap Osteoartritis

2017 ◽  
Vol 8 (3) ◽  
pp. 489 ◽  
Author(s):  
Andini Bakti Putri ◽  
Anita Anita
Keyword(s):  
Vascular Tissue ◽  
Inflammatory Diseases ◽  
Cell Damage ◽  
Scientific Evidence ◽  
Gastric Ulcers ◽  
Therapeutic Modalities ◽  
Therapeutic Benefits ◽  
Relieve Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

<p>Inflammation is a complex reaction of the body's immune system in the vascular tissue that causes the accumulation and activation of leukocytes and plasma proteins that occur during infection, poisoning or cell damage. Inflammation can be treated by using anti-inflammatory drugs such as NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) that serve as pain reliever, febrifuge, and anti-inflammatory. One of the most common chronic inflammatory diseases is osteoarthritis. Osteoarthritis is the most common form of arthritis in society,which has a major impact on public health problems. Currently there are many therapeutic modalities of both pharmacology and non-pharmacology for the management of osteoarthritis, therefore it is necessary to recommend effective treatment of osteoarthritis in Indonesia based on the latest scientific evidence. The use of NSAIDs that do not correspond to doses can cause side effects such as bleeding, gastric ulcers, worsening asthma symptoms and acute kidney failure. This is the health problem in Indonesia, especially for ordinary people who use NSAIDs with excessive doses, because they want to quickly relieve pain. Therefore, it is necessary to look for a safe anti-inflammatory drug and can reduce the pain caused to arthritis. <em>Ananascomosus</em> (pineapple) has long been used for various medical purposes. There are four different proteases in the pineapple, the two major enzymes in pineapple defined as bromelain’s stems and bromelain’s fruit. In the latest study there are various therapeutic benefits that have been proposed for bromelin, such as anti-inflammatory, reducing swelling, reducing pain, facilitating the digestive system, accelerating wound healing and acting as an anticoagulant.<strong></strong></p>

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

scholarly journals The CONFINE (Comorbidities and Outcome iN patients with chronic heart Failure: a study in INternal mEdicine units) study: a new epidemiologic observational study on heart failure in the internal medicine departments in Italy

2013 ◽  
pp. 57-64
Author(s):  
P. Biagi
Keyword(s):  
Internal Medicine ◽  
Heart Failure ◽  
Observational Study ◽  
Inflammatory Diseases ◽  
Correct Diagnosis ◽  
Cognitive Disorders ◽  
Epidemiological Data ◽  
Chronic Kidney Failure ◽  
Chronic Obstructive ◽  
Quality Life

BACKGROUND The burden of heart failure (HF) is enormous and its prevalence increases sharply with age. It has been estimated that heart failure affects up to 3% of the general population and 10% of the elderly. It contributes to hospital admission for most of them, mainly elder adults (admitted in internal medicine units) with more than one comorbidity, cognitive disorders, impairment and so on. Despite the increasing prevalence of heart failure, its exact incidence and prevalence remain largely unknown and probably underestimated due to a lack of accurate epidemiological data and difficulties associated with comorbidities and correct diagnosis: over 40% of recurrent hospitalization causes, either cardiac or extracardiac, cannot be determined due to the lack of data. AIM OF THE STUDY The objective of this study estimated the prevalence and the primary care burden associated with comorbidities in internal medicine units. METHOD The design: a longitudinal multicentric observational study using spot analysis three data sheets were filled in during the hospital stay according to three crucial moments: enrolment (“the index day”), admission and discharge. Will be analyzed the following primary outcomes: total and cardiovascular mortality, intensive unit care admission, recurrent cardiovascular disorders, length of stay, hospital readmission, changes in activities of daily living, need for care. Second outcomes: clinical, therapeutic, instrumental and laboratory changes during the admission process. Deep analysis of the following comorbidities will be also taken into account: acute and chronic kidney failure, anaemia, chronic obstructive pulmonary disease, muscle loss, nutritional status, cirrhosis of the liver, neoplasms, blood cell disorders, chronic inflammatory diseases. Further evalutation items: cognitive impairment, self-sufficiency and perception of quality life.

scholarly journals Thiophene-Based Compounds with Potential Anti-Inflammatory Activity

2021 ◽  
Vol 14 (7) ◽  
pp. 692
Author(s):  
Ryldene Marques Duarte da Cruz ◽  
Francisco Jaime Bezerra Mendonça-Junior ◽  
Natália Barbosa de Mélo ◽  
Luciana Scotti ◽  
Rodrigo Santos Aquino de Araújo ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Structural Characteristics ◽  
Tiaprofenic Acid ◽  
Inflammatory Activity ◽  
Drug Candidates ◽  
Biological Target ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Privileged Structures

Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are public health problems and represent major therapeutic challenges. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most prescribed clinical treatments, despite their severe side effects and their exclusive action in improving symptoms, without effectively promoting the cure. However, recent advances in the fields of pharmacology, medicinal chemistry, and chemoinformatics have provided valuable information and opportunities for development of new anti-inflammatory drug candidates. For drug design and discovery, thiophene derivatives are privileged structures. Thiophene-based compounds, like the commercial drugs Tinoridine and Tiaprofenic acid, are known for their anti-inflammatory properties. The present review provides an update on the role of thiophene-based derivatives in inflammation. Studies on mechanisms of action, interactions with receptors (especially against cyclooxygenase (COX) and lipoxygenase (LOX)), and structure-activity relationships are also presented and discussed. The results demonstrate the importance of thiophene-based compounds as privileged structures for the design and discovery of novel anti-inflammatory agents. The studies reveal important structural characteristics. The presence of carboxylic acids, esters, amines, and amides, as well as methyl and methoxy groups, has been frequently described, and highlights the importance of these groups for anti-inflammatory activity and biological target recognition, especially for inhibition of COX and LOX enzymes.

scholarly journals Curcumin and Freshwater Clam Extracts Alleviate the Progression of Osteoarthritis by Reducing Synovial Inflammation and Allowing Cartilage Regeneration

Processes ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 931
Author(s):  
Chiao-Hsu Ke ◽  
Chia-Hui Hsu ◽  
Yu-Ling Lin ◽  
Wei-Hsiang Huang ◽  
Hsin-Pei Weng ◽  
...  
Keyword(s):  
Scoring System ◽  
Inflammatory Diseases ◽  
Synergistic Effects ◽  
Symptomatic Relief ◽  
Cartilage Regeneration ◽  
Research Society ◽  
Infrapatellar Fat Pad ◽  
Freshwater Clam ◽  
Inflammatory Status ◽  
Anti Inflammatory

Osteoarthritis (OA) is a common degenerative disorder and is accompanied by numerous pain symptoms. With increased age, individuals develop a chronic inflammatory status, and pro-inflammatory cytokines as well as mediators contribute to the progression of OA. However, no desirable remedies have been completely able to inhibit OA progression or safely provide effective symptomatic relief. Natural component extracts or dietary-derived compounds are widely used for anti-inflammatory diseases. Curcumin and freshwater clam extract (FCE) have been proven as functional foods that are able to regulate immune systems. This study demonstrated that curcumin and FCE had synergistic effects on alleviating the progression of OA by assuaging inflammation and repairing the cartilage within the joints. After consumption of curcumin and FCE, the severity of synovitis was quantified by the infrapatellar fat pad inflammation scoring system and the Osteoarthritis Research Society International (OARSI) scoring system. Significant improvement and articular cartilage regeneration were noted. Moreover, once the inflammation within the joints was reduced, the animals redistributed their body weight on the OA-induced hindlimb. In summary, curcumin and FCE possess desirable anti-inflammatory and repair functions, suggesting their potential as alternative remedies in the management of OA or other inflammatory diseases.

scholarly journals IL-6 Is Not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium tuberculosis H37rv

Cells ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 9
Author(s):  
Kristina Ritter ◽  
Jan Christian Sodenkamp ◽  
Alexandra Hölscher ◽  
Jochen Behrends ◽  
Christoph Hölscher
Keyword(s):  
Immune Response ◽  
Inflammatory Diseases ◽  
Mycobacterial Infection ◽  
Minor Effect ◽  
Mycobacterium Tuberculosis H37rv ◽  
Th 17 ◽  
Anti Inflammatory ◽  
A Minor ◽  
Aerosol Infection ◽  
Deficient Mice

Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and autoimmune diseases are mediated by interleukin (IL)-6-induced T helper (TH) 17 cells, a TH17-directed anti-inflammatory therapy may be preferable to an IL-12-dependent TH1 inhibition in order to avoid reactivation of latent infections. To assess, however, the risk of inhibition of IL-6-dependent TH17-mediated inflammation, we examined the TH17 immune response and the course of experimental TB in IL-6- and T-cell-specific gp130-deficient mice. Our study revealed that the absence of IL-6 or gp130 on T cells has only a minor effect on the development of antigen-specific TH1 and TH17 cells. Importantly, these gene-deficient mice were as capable as wild type mice to control mycobacterial infection. Together, in contrast to its key function for TH17 development in other inflammatory diseases, IL-6 plays an inferior role for the generation of TH17 immune responses during experimental TB.

scholarly journals Nepetoidin B from Salvia plebeia R. Br. Inhibits Inflammation by Modulating the NF-κB and Nrf2/HO-1 Signaling Pathways in Macrophage Cells

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1208
Author(s):  
Mina Kim ◽  
Ji Yeong Kim ◽  
Hee Sun Yang ◽  
Jeong-Sook Choe ◽  
In Guk Hwang
Keyword(s):  
Defense Mechanisms ◽  
Inflammatory Diseases ◽  
Cell Damage ◽  
Treated Group ◽  
Raw 264.7 Cells ◽  
Resonance Spectroscopy ◽  
Raw 264.7 ◽  
Related Factor ◽  
Anti Inflammatory ◽  
Factor Α

Salvia plebeia has been used to treat a variety of inflammatory diseases, as well as colds and bronchitis. Macrophages have antioxidant defense mechanisms to cope with the intracellular reactive oxygen species (ROS) produced as part of the immune response. The nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase (HO)-1 pathway in inflamed macrophages is an appealing target due to its protective effect against ROS-induced cell damage. In this study, nepetoidin B (NeB) was first isolated from S. plebeia and identified by nuclear magnetic resonance spectroscopy. NeB reduced pro-inflammatory mediators (nitric oxide and prostaglandin E2) and cytokines (tumor necrosis factor-α, interleukin (IL)-6, and IL-1β) in LPS-activated RAW 264.7 cells by inhibiting the NF-κB signaling pathway. In the NeB-treated group, catalase and superoxide dismutase levels were significantly higher, and ROS expression decreased. By activating Nrf2 signaling, NeB enhanced HO-1 expression. Furthermore, when the cells were pretreated with tin protoporphyrin (an HO-1 inhibitor), the anti-inflammatory effects of NeB were reduced. Therefore, NeB may activate the Nrf2/ HO-1 pathway. These results reveal the NeB isolated from S. plebeia exerts anti-inflammatory effects by modulating NF-κB signaling and activating the Nrf2/HO-1 pathway in LPS-stimulated RAW 264.7 cells.

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