Biological Activities and Valuable Bioactive Compounds from Portuguese Medicinal Plants

Plants have been used as a source of medicine for the treatment of different diseases from thousands of years ago. There is numerous evidences are available for use of plants as a medicine in the treatment of diseases in Indian, Egyptian, Chinese, Greek and Roman system of medicine. Pharmacognosy is the study of medicines derived from natural sources, mainly from plants which may further lead to development of new drug. The exploration, extraction and screening of biological diversity such as herbs, spices, microbes and other natural resources is the worldwide activity in recent years. Phytochemicals are the naturally available bioactive compounds which are derived from different plant parts and are primarily responsible for biological activities. The most important chemical compounds which are present in the plants are alkaloids, phenols, saponins, carbohydrates, terpenoids, steroids, flavonoids and tannins etc.

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Phytochemicals: Extraction and Preliminary Investigation of Bioactive Compounds from Rumex Vesicarius and Terminalia Catappa Plant

Asian Journal of Engineering and Applied Technology ◽

10.51983/ajeat-2019.8.3.1131 ◽

2019 ◽

Vol 8 (3) ◽

pp. 21-24

Author(s):

Anandika Suryavanshi ◽

Anand Murari Saxena

Keyword(s):

Medicinal Plants ◽

Bioactive Compounds ◽

Metabolic Pathways ◽

Biological Activities ◽

Preliminary Investigation ◽

Terminalia Catappa ◽

Long Time ◽

Soxhlet Method ◽

Phytochemical Compounds

The present study was carried out for the determination of bioactive compounds from different extracts of Terminalia catappa and Rumex vesicarius. The plants are mines of several bioactive compounds also called as phytochemical compounds. These bioactive compounds are responsible for imparting such a potential medicinal property in the plants. The medicinal plant contains various types of bioactive compounds including phenols, alkaloids, terpenoids, tannins, glycosides, flavonoids etc. These bioactive compounds take part in various metabolic pathways and impart their effect. Terminalia catappa and Rumex vesicarius are such medicinal plants which are being used for medicinal purposes for long time. Both of them are rich source of potential bioactive compounds and hence carry out several biological activities effective for the treatment of various diseases. Hence the study focuses on determining the types of bioactive compounds they acquire. For this the leaves of T. catappa and dry stems of R. vesicarius were used for the extraction using different solvents with soxhlet method. The extract of different solvents was analyzed for the phytochemical test. The results obtained revealed that the type of solvents is crucial in determining the type of bioactive compounds to be present in extract. The results showed that ethanol and methanol are good solvent choice for extraction for these two plants. The results concludes that the presence of such potential and effective bioactive compounds in their extract makes them important medicinal plants and are hence employed for several researches and also used for treatment of various kinds of diseases.

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UJI TOKSISITAS EKSTRAK DAUN HYPERICUM LESCHENAULTII CHOISY DARI GUNUNG LAWU TERHADAP ARTEMIA SALINA L. SEBAGAI KANDIDAT ANTIKANKER

At-Taqaddum ◽

10.21580/at.v11i2.4448 ◽

2020 ◽

Vol 11 (2) ◽

pp. 168

Author(s):

Yudha Noviana ◽

Dwimei Ayudewandari Pranatami

Keyword(s):

Medicinal Plants ◽

Bioactive Compounds ◽

Brine Shrimp ◽

Leaf Extract ◽

Biological Activities ◽

Ethanol Extract ◽

Artemia Salina ◽

Brine Shrimp Lethality ◽

Rf Values ◽

Layer Chromatography

Mount Lawu is a biodiversity rich mountain, with the potensial of medicinal plants of various kinds including anticancer plants. Flora on the Mount Lawu that has potential for anticancer is Hypericum leschenaultii Choisy containing compounds hypericin. Hypericum has several biological activities such as a antioxidant, antitumor, and anticancer. The research aims to determine the potential of bioactive compounds and extracts of the leaves of H. leschenaultii from Mount Lawu and toxicity to Artemia salina Leach and profile Thin Layer Chromatography (TLC) it. Ethanol extract of the leaves of H. leschenaultii was tested toxicity with Brine Shrimp Lethality Test (BST) using a concentration of 400 µg/ml, 200 µg/ml, 100 µg/ml, 50 µg/ml, 25 µg/ml. The TLC profiles of bioactive compounds were determined by using spesific spray reagent. The results show the potential and toxicity of leaf extract of H. leschenaultii with LC values 175,77 µg/ml. TLC profile of bioactive compounds leaf extract of H. leschenaultiicontaining flavonoids with Rf values of 0,98 and terpenoid compounds with Rf value of 0,91; 0,95; 0,98. ==================================================Gunung Lawu merupakan gunung yang kaya akan keanekaragaman hayati, dengan potensi tumbuhan obat yang beragam, termasuk potensi tumbuhan sebagai antikanker. Adanya potensi tumbuhan sebagai sumber senyawa antikanker tersebut belum banyak diteliti dan digunakan sebagai pengobatan alternatif. Flora di Gunung Lawu yang potensial sebagai tumbuhan antikanker, yaitu Hypericum leschenaultii Choisy yang mengandung senyawa hypericin dan memiliki status keberadaan yang melimpah di Gunung lawu, sehingga sangat penting untuk diketahui manfaatnya agar dapat dimanfaatkan lebih luas. Hypericin memiliki beberapa aktivitas biologis seperti antioksidan, antitumor, dan antikanker. Penelitian ini bertujuan untuk mengetahui potensi senyawa bioaktif ekstrak daun H. leschenaultii dari Gunung Lawu sebagai antikanker dengan melihat toksisitasnya terhadap Artemia salina Leach serta profil Kromatografi Lapis Tipis (KLT) nya. Untuk mengetahui potensi sebagai tanaman antikanker maka ekstrak etanol daun H. leschenaultii diuji toksisitasnya dengan metode Brine Shrimp Lethality Test (BST). Dalam uji BST tersebut digunakan 5 konsentrasi esktrak etanol daun H. leschenaultii yaitu: 400 µg/ml, 200 µg/ml, 100 µg/ml, 50 µg/ml, 25 µg/ml. Kandungan senyawa bioaktif dideteksi dengan reagen semprot spesifik untuk mengetahui profil KLT-nya. Hasil penelitian menunjukkan potensi dan toksisitas ekstrak H. leschenaultii dengan nilai LC 175,77 µg/ml. Profil KLT senyawa bioaktif ekstrak daun H. leschenaultii mengandung senyawa flavonoid dengan nilai Rf 0,98 serta senyawa terpenoid dengan nilai Rf 0,91; 0,95; 0,98.

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Pharmacologically potentials of different substituted coumarin derivatives

10.31221/osf.io/w6hdg ◽

2019 ◽

Cited By ~ 1

Author(s):

Chem Int

Keyword(s):

Benzene Ring ◽

Bioactive Compounds ◽

Biological Activities ◽

Pharmacological Properties ◽

Coumarin Derivatives ◽

Wide Range ◽

Anti Oxidant ◽

Anti Inflammatory ◽

Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

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Extraction of Essential Oils from Medicinal Plants and their Utilization as Food Antioxidants

Current Pharmaceutical Design ◽

10.2174/1381612826666200121092018 ◽

2020 ◽

Vol 26 (5) ◽

pp. 519-541 ◽

Cited By ~ 3

Author(s):

Giovanna Ferrentino ◽

Ksenia Morozova ◽

Christine Horn ◽

Matteo Scampicchio

Keyword(s):

Chemical Composition ◽

Medicinal Plants ◽

Beneficial Effect ◽

Essential Oils ◽

Bioactive Compounds ◽

Antimicrobial Properties ◽

Food Products ◽

Human Diseases ◽

Present Review ◽

Green Technologies

Background: The use of essential oils is receiving increasing attention worldwide, as these oils are good sources of several bioactive compounds. Nowadays essential oils are preferred over synthetic preservatives thanks to their antioxidant and antimicrobial properties. Several studies highlight the beneficial effect of essential oils extracted from medicinal plants to cure human diseases such as hypertension, diabetes, or obesity. However, to preserve their bioactivity, the use of appropriate extraction technologies is required. Method: The present review aims to describe the studies published so far on the essential oils focusing on their sources and chemical composition, the technologies used for their recovery and their application as antioxidants in food products. Results: The review has been structured in three parts. In the first part, the main compounds present in essential oils extracted from medicinal plants have been listed and described. In the second part, the most important technologies used for extraction and distillation, have been presented. In detail, conventional methods have been described and compared with innovative and green technologies. Finally, in the last part, the studies related to the application of essential oils as antioxidants in food products have been reviewed and the main findings discussed in detail. Conclusions: In summary, an overview of the aforementioned subjects is presented by discussing the results of the most recent published studies.

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Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances for Drug Discovery

Current Pharmaceutical Design ◽

10.2174/1381612826666200928160357 ◽

2020 ◽

Vol 26 ◽

Author(s):

Kondeti Ramudu Shanmugam ◽

Bhasha Shanmugam ◽

Gangigunta Venkatasubbaiah ◽

Sahukari Ravi ◽

Kesireddy Sathyavelu Reddy

Keyword(s):

Herbal Medicine ◽

Medicinal Plants ◽

Bioactive Compounds ◽

Diabetes Management ◽

Therapeutic Potential ◽

Public Health Problem ◽

In Vivo Studies ◽

Major Public Health Problem

Background : Diabetes is a major public health problem in the world. It affects each and every part of the human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic research. Objectives: Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat diabetes in India and other countries. Methods: Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science, Pubmed and Google scholar. Data was analyzed and summarized in the review. Results and Conclusion: Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger, phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin, gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of bioactive compounds of medicinal plants in prevention and management of diabetes. Conclusion: Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against diabetes. However, further in vitro and in vivo studies are needed to validate these findings.

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The Antidiabetic Activity Of Bioactive Compounds Of Indian Medicinal Plants: A Meta Data Review

Bioscience Biotechnology Research Communications ◽

10.21786/bbrc/12.2/24 ◽

2019 ◽

Vol 12 (2) ◽

pp. 397-407

Author(s):

Anandika Suryavanshi ◽

A.M. Saxena

Keyword(s):

Medicinal Plants ◽

Bioactive Compounds ◽

Antidiabetic Activity ◽

Meta Data ◽

Indian Medicinal Plants

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Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽

10.3390/md19050241 ◽

2021 ◽

Vol 19 (5) ◽

pp. 241

Author(s):

Shaden A. M. Khalifa ◽

Eslam S. Shedid ◽

Essa M. Saied ◽

Amir Reza Jassbi ◽

Fatemeh H. Jamebozorgi ◽

...

Keyword(s):

Bioactive Compounds ◽

Biomedical Applications ◽

Large Scale ◽

Biological Activities ◽

Scale Production ◽

Pharmacological Activities ◽

Large Scale Production ◽

Marine Products ◽

Hiv 1 ◽

Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

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