scholarly journals Pharmacoinformatics: Development through History and Its Role in Pharmaceutical Industry

2019 ◽  
pp. 1-7
Author(s):  
Zaffar Ahmed Shaikh ◽  
Ali Orangzeb Panhwar ◽  
Kamlesh Kumar ◽  
Irfan Ahmed Solangi ◽  
Abida Parveen Panhwar
Keyword(s):  
Information Technology ◽  
Drug Discovery ◽  
Pharmaceutical Industry ◽  
Past Century ◽  
Great Role ◽  
Medical Field ◽  
Computer Data ◽  
The Past ◽  
The World ◽  
Over Time

Medicine has displayed miraculous developments during the past century or so. Credit goes to the emergence of scientific research methods. Research on the disease, its causes, effects, precaution, and especially cure has revolutionized the world. Man has been liberated from epidemics and other deadly diseases. All this would not have been possible, had there not been research and development in medication simultaneously. The pharmaceutical industry is an integral part of the medical field. A real boost was given to all kinds of research with the invention of the computer. Data saving, processing, and analysis were never easier. This paper aims at highlighting the great role and importance of Pharmacoinformatics in drug discovery. It also elucidates how drug discovery is done. A portion of it also targets how this science has evolved over time. The particular purpose is to trace the transformations that came with the introduction of Information Technology in this field.

The importance of synthetic chemistry in the pharmaceutical industry

Science ◽  
2019 ◽  
Vol 363 (6424) ◽  
pp. eaat0805 ◽  
Author(s):  
Kevin R. Campos ◽  
Paul J. Coleman ◽  
Juan C. Alvarez ◽  
Spencer D. Dreher ◽  
Robert M. Garbaccio ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Pharmaceutical Industry ◽  
Synthetic Methods ◽  
Past Century ◽  
Synthetic Chemistry ◽  
Drug Discovery And Development ◽  
The Past ◽  
New Concepts ◽  
The Face ◽  
Chemical Matter

Innovations in synthetic chemistry have enabled the discovery of many breakthrough therapies that have improved human health over the past century. In the face of increasing challenges in the pharmaceutical sector, continued innovation in chemistry is required to drive the discovery of the next wave of medicines. Novel synthetic methods not only unlock access to previously unattainable chemical matter, but also inspire new concepts as to how we design and build chemical matter. We identify some of the most important recent advances in synthetic chemistry as well as opportunities at the interface with partner disciplines that are poised to transform the practice of drug discovery and development.

Aftershocks

2017 ◽  
Author(s):  
Seva Gunitsky
Keyword(s):  
Twentieth Century ◽  
Regime Change ◽  
International System ◽  
Political Legitimacy ◽  
Great Powers ◽  
Past Century ◽  
The Past ◽  
Sudden Rise ◽  
The World ◽  
National Borders

Over the past century, democracy spread around the world in turbulent bursts of change, sweeping across national borders in dramatic cascades of revolution and reform. This book offers a new global-oriented explanation for this wavelike spread and retreat—not only of democracy but also of its twentieth-century rivals, fascism, and communism. The book argues that waves of regime change are driven by the aftermath of cataclysmic disruptions to the international system. These hegemonic shocks, marked by the sudden rise and fall of great powers, have been essential and often-neglected drivers of domestic transformations. Though rare and fleeting, they not only repeatedly alter the global hierarchy of powerful states but also create unique and powerful opportunities for sweeping national reforms—by triggering military impositions, swiftly changing the incentives of domestic actors, or transforming the basis of political legitimacy itself. As a result, the evolution of modern regimes cannot be fully understood without examining the consequences of clashes between great powers, which repeatedly—and often unsuccessfully—sought to cajole, inspire, and intimidate other states into joining their camps.

Variable oil and argumentative conflict in the Middle East

2020 ◽  
pp. 824
Author(s):  
Malik Daham Mata’ab
Keyword(s):  
Middle East ◽  
Past Century ◽  
Large Area ◽  
The Past ◽  
The World

Oil has formed since its discovery so far one of the main causes of global conflict, has occupied this energy map a large area of conflict the world over the past century, and certainly this matter will continue for the next period in our century..

scholarly journals Split-footed lacewings declined over time: indications from the morphological diversity of their antlion-like larvae

PalZ ◽  
2021 ◽  
Author(s):  
Gideon T. Haug ◽  
Carolin Haug ◽  
Serita van der Wal ◽  
Patrick Müller ◽  
Joachim T. Haug
Keyword(s):  
Morphological Diversity ◽  
Single Specimen ◽  
Burmese Amber ◽  
The Past ◽  
The World ◽  
Poor Group ◽  
Outline Analysis ◽  
Loss Of Diversity ◽  
Over Time ◽  
Antlion Larvae

AbstractNymphidae, the group of split-footed lacewings, is a rather species-poor group. Split-footed lacewings nowadays are restricted to Australasia, while fossil forms are also known from other areas of the world, indicating that the group was more species-rich and therefore likely diverse in the past. Split-footed lacewings have rather distinct larvae, roughly resembling antlion larvae, but differing from the latter especially with regard to the mandibles. Antlion larvae usually have three prominent teeth on each mandible, while at least extant larvae of split-footed lacewings only have a single prominent tooth per mandible. Fossils interpreted as larvae of split-footed lacewings are well known from amber from Myanmar (ca. 100 myr; Burmese amber) and by a single specimen from Baltic amber (about 40 myr). We here report additional fossil specimens from Myanmar amber, expanding the known record of fossil forms from six depicted specimens to 15. For the extant fauna, we could compile 25 larvae. We compare the diversity of shape of extant and fossil larvae through time using an outline analysis (based on elliptic Fourier transformation) of the head. The results of this analysis indicate that the morphological diversity, or disparity, of split-footed lacewing larvae was higher in the past than it is today. With this type of analysis, we can show a loss of diversity over time, without the necessity to identify the fossil larvae down to a narrow taxonomical range. A similar pattern has already been recognised in silky lacewings, Psychopsidae. This might indicate a general loss of diversity of lacewing larvae.

Number of Siblings in Childhood, Social Outcomes in Adulthood

2019 ◽  
Vol 41 (2) ◽  
pp. 212-234
Author(s):  
Joseph J. Merry ◽  
Donna Bobbitt-Zeher ◽  
Douglas B. Downey
Keyword(s):  
Conflict Management ◽  
Negative Association ◽  
Social Outcomes ◽  
Past Century ◽  
Adult Health ◽  
Growing Up ◽  
The Past ◽  
National Longitudinal Study ◽  
The World ◽  
The Relationship

In many parts of the world, fertility has declined in important ways in the past century. What are the consequences of this demographic change? Our study expands the empirical basis for understanding the relationship between number of siblings in childhood and social outcomes among adults. An important recent study found that for each additional sibling an individual grows up with, the likelihood of divorce as an adult declines by 3%. We expand this work by (a) determining whether the original pattern replicates in the National Longitudinal Study of Adolescent to Adult Health and (b) extending the analysis beyond divorce to consider whether growing up with siblings is related to prosocial adult behaviors (relationships with parents, friends, and views on conflict management with one’s partner). Our results confirm a negative association between number of siblings and divorce in adulthood. We find mixed results related to other prosocial adult behaviors.

The Writing and the Bronze: Commemoration as Historiography

2021 ◽  
pp. e20200042
Author(s):  
Alan Gordon
Keyword(s):  
Public Life ◽  
The Past ◽  
National Heritage ◽  
Physical Form ◽  
The World ◽  
Historic Monuments ◽  
Over Time

Historic monuments are the most public and recognized forms of commemoration. In Canada, as around the world, many monuments have come under fire recently for celebrating a vision of the past that is no longer palatable to large segments of the population. The heroes and events they enshrine have been denounced by many as tributes to racism, yet they are valued by others as aspects of our collective history and a celebration of our national heritage. Both these positions gloss over the complexity of the historical act of raising monuments and interpreting their historical meanings. Monuments in Canada, like all forms of commemoration, are reflections of the historiographical and methodological trends contemporary to the discipline of history at the time of their creation. Changes in methods and interpretations have thus also affected their meaning over time. Thus, monuments are not straightforward representations of history but, instead, layered expressions of historiography in physical form. Ascribing to them singular meanings obscures the complexity of the societies that constructed them and simplifies their connections to public life.

India and the World

2010 ◽  
Author(s):  
David M. Malone ◽  
C. Raja Mohan ◽  
Srinath Raghavan
Keyword(s):  
Foreign Policy ◽  
International Relations ◽  
Asian Country ◽  
Extensive Survey ◽  
The Past ◽  
External Relations ◽  
The World ◽  
Global Affairs ◽  
Indian Foreign Policy ◽  
Over Time

India has emerged as a leading voice in global affairs in the past two decades. Its fast-growing domestic market largely explains the ardour with which Delhi is courted by powers great and small. India is also becoming increasingly important to global geostrategic calculations, being the only Asian country with the heft to counterbalance China over time. Nevertheless, India’s foreign policy has been relatively neglected in the existing literature. ThisHandbook, edited by three widely recognized students of the topic, provides an extensive survey of India’s external relations. The authors include leading Indian scholars and commentators of the field and several outstanding foreign scholars and practitioners. They address factors in Indian foreign policy flowing from both history and geography and also discuss key relationships, issues, and multilateral forums through which the country’s international relations are refracted.

scholarly journals Writing in the World and Linguistics

2010 ◽  
Vol 36 (1) ◽  
pp. 61 ◽  
Author(s):  
Peter T. Daniels
Keyword(s):  
General Public ◽  
Past Century ◽  
The Past ◽  
The World ◽  
And Linguistics

It seems to me that the study of writing is about where the study of language was before the development of linguistics over the past century-and-a-bit. Everyone we know knows how to write, and therefore everyone we know thinks they know about writing. This paper looks at how writing has been presented to the general public, and how it has been treated in linguistics since the first real textbook of 1933.

Why blackseed can be the cure for all illnesses except death

2021 ◽  
Vol 9 (4) ◽  
pp. 75-80
Author(s):  
Rashid Bhikha ◽  
Keyword(s):  
Pharmacological Action ◽  
The Body ◽  
Past Century ◽  
Self Healing ◽  
The Past ◽  
The Bible ◽  
The World ◽  
Prevention And Treatment ◽  
Vast Range ◽  
Regular Intake

The use of plants to prevent and treat illnesses has been known since time immemorial. Blackseed has been used in different civilizations around the world for centuries. The curative properties of blackseed were mentioned in the Bible and further elaborated on by Prophet Mohammed (PBUH) as “Hold on to the use of blackseed, as it has a remedy for every illness except death”. Extensive research conducted over the past century into the phytochemistry of blackseed has identified many active ingredients and confirmed its pharmacological action in the treatment of a vast range of illness conditions across the different systems of the body, including the prevention and treatment of cancer, and optimum functioning of the immune system. Furthermore, the Tibb philosophical principles highlight the ability of the body’s inherent self-healing capacity, known as Physis, and the intricate functioning of the human body, based on the temperamental and humoral theory. This paper emphasizes the importance of Physis, and its role in the maintenance and restoration of health with the regular intake of blackseed, highlighting why blackseed can be a cure for all illnesses except death. Keywords: Blackseed, phytochemistry, pharmacological action, Tibb philosophical principles.

Drug Discovery

2018 ◽  
pp. 399-404
Author(s):  
S. Nassir Ghaemi
Keyword(s):  
Drug Discovery ◽  
Pharmaceutical Industry ◽  
Discovery Process ◽  
Drug Discovery Process ◽  
New Approach ◽  
The Past ◽  
Scientific Exploration ◽  
Clinical Indications ◽  
The Future ◽  
Clinical Diagnoses

Newer and better medications are obtained as part of the drug discovery process, which occurs mainly in the pharmaceutical industry. This process is hampered by excessive attention to marketing demands, as opposed to scientific exploration. It also is impaired by the psychiatric profession’s mistaken ideologies, whether psychoanalytic orthodoxy in the past or DSM beliefs of the present. Wrong clinical phenotypes impair finding new pharmacological mechanisms and targeting them well to the write clinical indications. Perhaps as a consequence, no treatments have been developed in the last few decades, since DSM-III, that are more effective than prior agents. Progress for the future in drug discovery will require not just better neurobiological work, but also a new approach to clinical diagnoses in psychiatry.

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