scholarly journals A Review on Multifunctional Excipients with Regulatory Considerations

2021 ◽  
pp. 189-201
Author(s):  
Arti Swami ◽  
Prajakta Chavan ◽  
Shivani Chakankar ◽  
Amol Tagalpallewar
Keyword(s):  
High Speed ◽  
Drug Application ◽  
Review Article ◽  
Drug Formulation ◽  
Active Ingredients ◽  
Time Saving ◽  
The Cost ◽  
New Drug Application ◽  
Development Methods ◽  
Very High

The practice of multifunctional excipients is gaining more and more attention as it simplifies the process of drug formulation by substituting the necessity of using mixture of many excipients. The multifunctional excipients are the class of excipients which includes pre-–processed and co-processed excipients and it provides added functionalities to the formulation. Functionality of an excipient is a useful property which helps in manufacturing and improves quality as well as applicability of the material. Researchers have identified that single component excipients may not always give the required results during development and manufacturing of definite API, hence they are concentrating to develop multifunctional excipients which will have improved quality that will fulfil the requirements of the formulation experts in terms of cost. The cost of new excipient development is very high as it demands toxicity studies, hence the industry is now focusing on co-processing of approved materials. The demand for directly compressible co-processed excipients has also increased due to the availability of high-speed tableting machines, time saving in Abbreviated New Drug Application (ANDA), simplified validation and stability of active ingredients. The intention of this review article is to highlight applicability and increasing attention focusing the benefits of co-processed excipients. Their advantages over conventional blend of excipients include development methods, testing and also highlighting their regulatory consideration.

Research on Structure and Model of E-Commerce Based on Web Mining

2010 ◽  
Vol 143-144 ◽  
pp. 338-342
Author(s):  
Xu Hao
Keyword(s):  
Data Mining ◽  
Knowledge Discovery ◽  
High Speed ◽  
Web Mining ◽  
Data Sets ◽  
Individual Data ◽  
Specific Domain ◽  
Transaction Data ◽  
The Cost ◽  
Very High

As one of the key applied forms on Internet, E-commerce has been growing at a very high speed in China in recent years. Starting from the perspective that E-commerce consumers pursue low price while retailers try to decrease the cost. Data mining is a form of knowledge discovery essential for solving problems in a specific domain. Individual data sets may be gathered and studied collectively for purposes other than those for which they were originally created. Data mining is most commonly used in attempts to induce association rules from transaction data.

Vertical Axis Wind Turbine for Generation of Electricity through Highway Windmill

2015 ◽  
Vol 7 (02) ◽  
pp. 99-104 ◽  
Author(s):  
Shweta Singh ◽  
Sarita Singh
Keyword(s):  
Wind Turbine ◽  
Electromagnetic Induction ◽  
High Speed ◽  
Electrical Energy ◽  
Vertical Axis ◽  
Vertical Axis Wind Turbine ◽  
Night Time ◽  
Left Hand ◽  
The Cost ◽  
Very High

In this paper our effective approach is to harness electrical energy from the highway by using of vertical axis wind turbine. The smart windmill consists of a stationary shaft which is mounted on the ball bearing on the top and bottom end of the shaft The curvy darrieus blades are connected to the two ends of bearing which is able to rotate on its own axis. The dynamo is connected to the either upper part or lower part of the wind turbine which works on Fleming’s left hand rule of Electromagnetic induction. In highway both at day as well as at night time vehicles will be moving at very high speed. By this method the overall cost per unit of energy produces is less than the cost of new coal, natural gas and its installation. So the implementation can be made easier than any other methods.

scholarly journals EL2 CHANGES IN JAPANESE ACADEMIC CLINICAL TRIALS AND FRAMEWORKS FOR PLANNING CLINICAL TRIALS

2019 ◽  
Vol 1 (Supplement_2) ◽  
pp. ii4-ii4
Author(s):  
Kenichi Nakamura
Keyword(s):  
Clinical Trials ◽  
Public Funding ◽  
Drug Application ◽  
Scientific Validity ◽  
The Social ◽  
Social Scientific ◽  
The Cost ◽  
Scientific Value ◽  
New Drug Application ◽  
Research Budget

Abstract After the enforcement of the Japanese Clinical Trials Act, the number of investigator-initiated registration-directed trials (IIRDT, Chiken) is increasing while the number of non-registration academic trials is decreasing. Pharmaceutical companies tend to make an investment in IIRDT because the data derived from IIRDT can be utilized for new drug application for PMDA, which means the goals and return are clear for industries. On the other hand, the reason of the decrease of non-registration academic trials is the burden of cost and procedures specified in the Clinical Trials Act. In order to start academic trials, certain amount of research budget is indispensable due to the cost for certified review board and clinical trial insurance. Also, even minor changes of site information in jRCT should be submitted to certified review board and the hospital directors of all participating sites, which is one of the most serious burden for investigators. Confirmation of COI declaration in participating sites is another burden for investigators/sites. Under these circumstances, the number of non-registration academic trials will be decreasing for the time being. In the Clinical Trials Act era, investigators must prepare some budget to start clinical trials. In order to obtain public funding, social/scientific value and scientific validity are substantially important. To express the social value sufficiently, the purpose of the trial should focus not on the researcher’s interest but on the contribution for patients. In terms of scientific validity, the framework of PICO is useful; PICO means Patient, Intervention, Control and Outcome. Utilization of this framework and the consistency of these four factors are essential to make the trial design sound.

Structural changes in silicon-on-insulator material during post-implantation annealing

1986 ◽  
Vol 44 ◽  
pp. 736-737
Author(s):  
C. O. Jung ◽  
S. J. Krause ◽  
S.R. Wilson
Keyword(s):  
Integrated Circuits ◽  
Oxide Layer ◽  
High Speed ◽  
Structural Changes ◽  
Device Fabrication ◽  
Silicon On Insulator ◽  
High Quality ◽  
Radiation Hardened ◽  
Post Implantation ◽  
Very High

Silicon-on-insulator (SOI) structures have excellent potential for future use in radiation hardened and high speed integrated circuits. For device fabrication in SOI material a high quality superficial Si layer above a buried oxide layer is required. Recently, Celler et al. reported that post-implantation annealing of oxygen implanted SOI at very high temperatures would eliminate virtually all defects and precipiates in the superficial Si layer. In this work we are reporting on the effect of three different post implantation annealing cycles on the structure of oxygen implanted SOI samples which were implanted under the same conditions.

ANALISA PERBANDINGAN DALAM RANGKA PEMILIHAN BEBERAPA IP UPSTREAM PROVIDER DI PT. INDOSAT

2018 ◽  
Vol 4 (1) ◽  
pp. 57
Author(s):  
Yuli Anwar ◽  
Dahlar .
Keyword(s):  
Business Strategy ◽  
High Speed ◽  
Human Life ◽  
Sustainable Growth ◽  
The Internet ◽  
Network Service Provider ◽  
High Speed Data ◽  
Telecommunications Services ◽  
The Cost ◽  
Internet Network

Abstract. One of the advances in information technology that now has changed the outlook and human life, business process and business strategy of an institution is the internet. The internet is a very large networks that connected to computers and serves throughout the world in one centralized network. With the internet we can access data and information anytime and anywhere.    As one provider of high-speed data communications services and the pioneer of the internet network service provider in Indonesia that provides integrated services, as well as one of the pioneer development of internet services that provide extensive services in the building and apply it throughout Indonesia. Indosat ready to seize opportunities for sustainable growth of business spectrum are still sprawling Indonesia.    Therefore, Indosat continues to focus on the development of increased efforts to provide the best service for customers of Indosat. Indosat will continue to develop and expand network coverage and a larger investment that the company will achieve excellence in the field of integrated telecommunications services.    Ranking by region of the IP Providers can be seen by grouping IP Providers, and management over IP Providers prefer to choose providers based on where it orginates as an example for the region of the U.S if it will be preferred providers that come from U.S. providers.With the commencement of the internet network optimization start early in 2008 with the selection of the appropriate IP Upstream Provider criteria, it is up to date according to data obtained from Indosat, seen any significant changes to the cost of purchasing capacity of the IP Upstream.    Based on the data obtained that until Q3 or September 2008, the number of IP Upstream Providers that previously there were 20 to 10 IP Upstream Provider, IP Transit Price total decrease of 11% to the price of IP Transit Price / Mbps there is a decrease of 78%, while from the capacity bandwith an increase of 301% capacity from 2008.

YSS HAP72

Alloy Digest ◽  
2019 ◽  
Vol 68 (10) ◽  
Keyword(s):  
Wear Resistance ◽  
High Temperature ◽  
Powder Metallurgy ◽  
Tool Steel ◽  
High Speed ◽  
High Wear Resistance ◽  
Bend Strength ◽  
Temperature Performance ◽  
Very High

Abstract YSS HAP72 is a powder metallurgy high-speed tool steel with a very high wear resistance. This datasheet provides information on composition, hardness, and bend strength. It also includes information on high temperature performance. Filing Code: TS-779. Producer or source: Hitachi Metals America Ltd.

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