scholarly journals Frequency and Fetomaternal Outcome in COVID 19 Positive Pregnant Women

Author(s):  
Mehwish Younus ◽  
Urooj Naz ◽  
Aruna Kumari Hira ◽  
Sana Shahmir ◽  
Uroosa Naz ◽  
...  

Objective: To determine the frequency and outcome in pregnant women with COVID-19 infection. Study Design: This is a observational cohort study. Setting: Study carried out at Department of Obstetrics & Gynecology, Civil Hospital, Dow University of health sciences Karachi, from July 2020 to November 2021. Materials & Methods:  The study was conducted in a tertiary care hospital in Karachi. Women having COVID-19 positive status during any stage of their pregnancy having antenatal visits in our hospital were included in our study. Maternal demographics, race, maternal outcome, and neonatal complications were noted on a self-made Performa. Statistical analysis was done by SPSS version 21 and descriptive statistics with frequencies were mainly calculated. Results: During the defined time of 14 months, we had 143 women visiting antenatal outpatient department and were tested positive for COVID-19. Majority of the women were tested for COVID-19 due to symptoms like fever, flu, cough and diarrhea. The mean age of women in our study was found to be 30 ± 6.7 years. The most frequent maternal outcome with SARSCOV-2 was preterm delivery. Out of 143, 27 cases had emergency lower segment C-section.PCR testing of neonates was carried out and 8.39% (n=12) neonates tested positive for SARSCOV-2.  Conclusion: Infection with Covid-19 during pregnancy is associated with adverse pregnancy outcomes. Covid-19  infection can be transmitted to the fetus during pregnancy or childbirth. Neonatal has a high chance of being admitted to the ICU, and women also faces other complications of Covid 19, such as the risk of miscarriage and premature delivery.

Author(s):  
Eren Pek ◽  
Fatma Beyazit

Background: Although the choice of a particular method of birth delivery by the pregnant woman is a modern, complex and controversial subject all over the world, the rate of caesarean delivery has risen to nearly 50% in western countries. Apart from medical reasons, several non-medical factors are also involved in this choice, and they comprise the socioeconomic conditions, ethical/legal concerns and psychological and cultural characteristics of the patients and doctors. In this study, we aimed to evaluate the demographic and clinical characteristics of pregnant women who gave birth in a tertiary care hospital between October 2012 and June 2016.Methods: The patients’ charts of pregnant women who presented to the Canakkale Onsekiz Mart University hospital between October 2012 and June 2016 and who gave birth through either vaginal or caesarean delivery were retrospectively analysed. The patients’ age, delivery type, weeks of pregnancy at delivery, number of pregnancies and caesarean indications were recorded.Results: In this study, we retrospectively analysed 2012 pregnant women. The mean age of the pregnant women was 28.9 ±5.4 years. The mean gravida and parity of pregnant women were 1.9±1.0 and 1.5±0.7, respectively. Regardless of the delivery type, the mean pregnancy weeks were found to be 38.6±1.9 weeks. The mean pregnancy weeks of patients undergoing caesarean delivery were 38.4±1.8 weeks. The primary caesarean rates were 52.81%. The most common caesarean delivery indications were foetal distress, cephalopelvic disproportion and presentation anomalies.Conclusions: The steady increase in caesarean delivery rates has become a major cause of concern worldwide. The reasons for this phenomenon are mostly related to advanced age; foetal distress, especially one that is detected in continuous foetal monitoring; intrauterine growth retardation; presentation anomalies and multiple gestation. To avoid unnecessary caesarean births, mothers, especially nulliparous mothers, should be persuaded to undergo vaginal delivery.


2013 ◽  
Vol 20 (02) ◽  
pp. 214-219
Author(s):  
SHAHIDA SHAIKH ◽  
SALEEM AKHTER SHAIKHM ◽  
BASMA ZIA

Objective: To establish the frequency of bacterial vaginosis in asymptomatic pregnant women. Study design: Crossst Sectional Descriptive study. Setting: Private tertiary care hospital of Larkana. Period: 1 June 2011 to 31st December 2011. Materialand methods: 120 asymptomatic pregnant women at 14-28 weeks of gestation were included in this study after fulfilling selectioncriteria. A high vaginal swab stick was dipped into secretion through speculum and slides were made and sent to attached laboratory forclue cells. Vaginal PH was tested with PH paper (change in color noted). Whiff test was performed by adding two drops of KOH onposterior blade of speculum for fishy odour. The diagnosis of bacterial vaginosis was made with the help of Amsel’s criteria. Presence of>3 signs was labeled as bacterial vaginosis positive. Data analysis was done on statistical package of social science (SPSS version 13).Results: Although total 120 patients who were recruited in our study, all did not present with any symptom of vaginal discharge, but thefrequency of pregnant women having Bacterial Vaginosis was quite high. A total of 77 (64.1%) patients discovered positive for bacterialvaginosis, while only 43 (35.8%) patient’s samples were negative for bacterial vaginosis. The mean age of our patients was 28.56 ±3.71years, while mean gestational age was 24.65 ±2.34 weeks. Homogenous milky discharge was observed in total 65 (54.16 %) patients,while in rest of patients, we did not detect any discharge. Bacterial Vaginosis was more prevalent in women belonging to lowsocioeconomic group and who had low literacy rate. Conclusions: The frequency of bacterial vaginosis was found to be very high amongasymptomatic pregnant women. Timely diagnosis can be helpful in treating complications related with it.


Author(s):  
Geetanjali Kanwar ◽  
Shweta Rani Prasad ◽  
Rekha Ratnani

Background: Anemia in pregnancy is an important public health problem in developing countries like India. Anemia results in poor pregnancy outcome and also affects fetal outcome. The present study was conducted to asses maternal and fetal outcome in relation anemia. Aim and objectives of the study was to determine incidence, risk factors and maternal-fetal outcome of anemia in the admitted pregnant women attending obstetrics and gyanecology department, shanakarcharya institute of medical sciences, Bhilai.Methods: This is retrospective observational study conducted among pregnant women admitted in labor room over a period of one year after getting approval from the institutional ethical committee.Results: Out of total 1503 delivery during study period 675 patients were found to be anaemic which gives incidence of 44.5%. Most the pregnant women were moderately anaemic i.e. 50.96% followed by mild (45.04%) and severe (4%) repectively. Among the pregnant women most common type of anaemia is Iron deficiency anaemia (69.65%) followed by Sickle cell anaemia (15.4%). In the present study,90.4% of subject received oral iron, 26.9% received parenteral iron and 19.4% received blood transfusion. Common maternal outcome related to anemia found to be low birth weight (25.2%) followed by premature delivery (22.96%) and fetal outcome in anemic mother in the form of preterm (22.9%) followed by NICU admission (14.37%) and FGR (8.6%).Conclusions: Anemia being one of the most important cause of poor feto maternal outcome should be treated preconceptionaly. There is a need of health education programmes and adequate intake of iron rich diet during pregnancy, to be strengthened for safe maternal and foetal outcomes.


Author(s):  
Raheela Rani Junejo ◽  
Nousheen Memon ◽  
Nazia Memon ◽  
Ali Faraz Shaikh ◽  
Abdul Ghaffar Dars

Objective: To determine the severity of anemia among pregnant women and its impact on feto-maternal outcome at tertiary care Hospital. Materials and Methods: This was a cross-sectional study; conducted at gynae department of LUMHS; during 6 months from November 2019 to April 2020. Women with age >15 years, visited antenatal clinic and admitted for delivery and those who were admitted through emergency with labour pain and either of parity were included. A 3 ml fresh blood sample was taken from each woman and was sent immediately to the Hospital diagnostic laboratory for the assessment of haemoglobin level. Mothers having haemoglobin levels <11 g/dL, were considered as anemic. All the information regarding feto-maternal outcome, in terms of maternal and fetal complications including prolonged Hospital stays mortality were documented via self-made study proforma. Data analysis was done by using SPSS version 20. Results: Total 150 pregnant women were enrolled. Maternal mean age was 26.83+4.13 years and mean gestational age was 35.96+2.61 weeks. Most of the women utilized an unsatisfactory diet. Out of all, 83(55.3%) women underwent C-sections and 67(44.7%) underwent normal vaginal deliveries. majority of the women 90(60.0%) underwent blood transfusion. Maternal anemia was highly prevalent (90.7%). Moderate anemia was most common in 64(42.7%) women, followed by mild anemia among 39(26.0%) women, and 33(22.0%) women were severely anemic, while only 14(09.3%) were found with normal haemoglobin level. According to maternal and fetal outcomes, 02.7% women had acute kidney injury, 02.0% had blood transfusion reaction, pre-eclampsia was seen in 06.0% women, 04.7% women were admitted in ICU and mortality rate was 04.7%. Pre-term birth rate was 35.3%, ABG was seen in 26.7% of the cases, early neonatal death rate was 02.0%, neonatal intensive care unit (NICU) admission rate was 02.7% and intrauterine death was 15.3%. Conclusions: Severity of anemia observed to be highly prevalent in our population and found to be associated with adverse feto-maternal outcomes.


Author(s):  
Dr. Naveen Saxena ◽  
Dr. Anita Sharma ◽  
Dr. Ghanshyam Soni ◽  
Dr. Saurabh Sharma

Background: UTI’s are more common during pregnancy because of changes in the urinary tract and has been reported among 20% of the pregnant women with significant reason for hospital admission. It has several adverse outcomes not only on the mother but also on the fetus like chronic renal failure, pyelonephritis, preeclampsia, anemia, fetal mortality and premature delivery. Patients and methods: The aim of this study was to determine the prevalence and etiologyof UTI among 120 pregnant women attending the ANC of GMC Kotaduring the study period from January 2017 to June 2017.UTI was diagnosed by growth of at least 105 CFU/ml of a urinary tract pathogen in a culture of a midstream urine sample. The isolated bacteria were identified by biochemical tests. Results: Of the 120 urine samples examined in this study,34 (28.33%) were found to contain significant bacteriuria. Of the variables examined, Highest prevalence was observed in 21-25 years age group (50%), multipara (44.11%), and in 3rd trimester (55.88%). The bacterial pathogens isolated were most commonly Escherichia coli (55.88%), Klebsiella sps(20.6%), Pseudomonas sps(8.82%), Proteus sps(5.88%), Enterobacter sps(5.88%), Enterococcus sps(2.94%). Conclusion: The prevalence rate of urinary tract infection (UTI) during pregnancy is high. So it is important to do routine screening of all pregnant women for significant bacteriuria to reduce the complications on both maternal and fetal health. The study also recommends health education on personal sanitary hygiene.


Author(s):  
Md. Amirunnisa Begum ◽  
B. Krishna Sowmya ◽  
D. Shailendra

Background: Pregnancy is a physiological condition during which immune system is weakened. Therefore, most women are prone to develop infections during this period for which antimicrobials are prescribed. Drugs used during pregnancy may lead to teratogenicity. Therefore, this study was done with the following objectives: 1.to determine the type of infections encountered, 2.to assess the prescription profile of antimicrobials and 3.to assess FDA categories of antimicrobials used in pregnant women in a tertiary care center in Telangana, India.Methods: This was a prospective observational study conducted on pregnant women attending antenatal clinic (ANC) at Mediciti Institute of Medical Sciences (MIMS) from 1st January 2018 to 30th June 2018.Results: Out of a total of 165 cases enrolled, 57 (34.5%) cases were prescribed antimicrobials and 108 (65.5%) were treated symptomatically. The mean (SD) age of women who were prescribed antimicrobials was 22.9 (2.97) years. Of the conditions encountered, respiratory tract infections (RTIs) accounted for 31%, followed by urinary tract infections (UTIs) 26% and gastroenteritis 25%. Most prevalent infections which required antimicrobials prescription were UTIs (36.84%), followed by Gastroenteritis (17.54%). Majority of the antimicrobials prescribed were from Betalactams (40.34%), followed by Nitrofuranes (29.82%), Nitroimidazoles (17.54%) and Antifungals (8.77%). Antimicrobials prescription was more in the 3rd trimester (63.1%), followed by 2nd trimester (31.6%) and 1st trimester (5.3%). Majority of the antimicrobials were administered orally (75.44%), followed by injections (15.79%) and per vaginal route (8.77%). Antimicrobials were mostly prescribed from FDA Category B (96%).Conclusions: RTIs were the most common among the conditions encountered. However, UTIs were the leading cause for antimicrobial prescriptions. Antimicrobials prescription was more during 3rd trimester. Most antimicrobials prescribed were safe as they were from FDA Category B.


2021 ◽  
Vol 9 (3) ◽  
pp. 846-855
Author(s):  
Quratulain Ahsan ◽  
Jaweria Hassan ◽  
Tazeem Akhtar ◽  
Aasia Khan ◽  
Abid Malik

Purpose of the study: Antenatal depression is a significant predictor for postnatal depression, and pregnant women with depressive symptoms have an increased risk of frequent non-scheduled medical and emergency visits. The purpose of this study is to evaluate the antenatal depression and its related factors and effects of the COVID-19 pandemic on the frequency of antenatal visits. Methodology: A descriptive cross-sectional study was conducted from July to September 2020 with 220 pregnant women from the Gynae Outpatient Department at the Tertiary Care Hospital of Lahore. Women aged 18–45 years with no pregnancy-related complications were included. The Patient Health Questionnaire-9 tool was used to screen for antenatal depression, and a self-structured questionnaire was developed to explore depression-related factors. Main Findings: Antenatal depression prevalence was found very high among pregnant women during the second wave of Covid-19 and pandemic did not affect regular antenatal visits of women. Applications of this study: Mental disorders are associated with several individuals and societal factors, including feelings of insecurity and hopelessness, exposure to violence, physical ill health, and rapid social change. The existing pandemic situation, working from home, temporary unemployment, home-schooling of children, lack of contact and social support, it is important to look after mental and physical health especially women in pregnancy who can suffer from more severe mental health problems and can affect ANC visits that directly related to maternal and child health. Novelty/Originality of this study: Depression in pregnancy is associated with severe complications and prevents patients from taking an active role in their healthcare. Women with depressive symptoms have an increased risk of frequent non-scheduled antenatal care (ANC) visits and emergency healthcare visits for pregnancy-related emergencies especially in the 2nd wave of COVID-19. It was very important to study the factors related to antenatal depression during this pandemic. Counselling and awareness may improve the physical and mental health of pregnant women.


Author(s):  
Kavya Ananthathirtha ◽  
Pracheth Raghuveer

Background: It has been postulated that hyperhomocysteinemia may be associated with preeclampsia, as the vascular changes mediated by homocysteine are similar to the changes that occur in preeclampsia. In this context, the study was conducted to compare maternal serum levels of total homocysteine in preeclamptic and normotensive pregnant women attending a tertiary care hospital in Coimbatore, Tamil Nadu, India.Methods: A prospective case-control study was carried out in the inpatient wards and the outpatient department (OPD) of the Department of Obstetrics and Gynaecology (OBG) at a tertiary care hospital of Coimbatore, for one year from March 2015 to April 2016. Pregnant women with preeclampsia were considered as cases and women without any medical or other obstetric and fetal complications were selected as controls. A pre-designed and pre-tested proforma was used to collect the appropriate information. The assessments were conducted using standard procedures.Results: The study population comprised of 50 cases and equal number of controls. Around 28.0% of the cases had severe preeclampsia. The mean serum homocysteine values among cases was 13.87±4.01 µmol/L. The difference in the mean serum homocysteine level among cases and controls was statistically significant (p <0.001). However, there was no significant difference in the mean serum homocysteine levels among women with severe and mild preeclampsia (p=0.731).Conclusions: Maternal serum levels of total homocysteine were found to be significantly higher among preeclamptic women when compared to normotensive women. Thus, estimation of serum homocysteine levels among preeclamptic women may serve as a biomarker for identifying those at risk for complications.


Author(s):  
Bhagwan S. Yadav ◽  
Sharad K. Jain ◽  
Neelam A. Toppo ◽  
Chanchlesh Dehariya

Background: Pre-eclampsia is a multisystem disorder of pregnancy which is characterized by hypertension with proteinuria after 20 weeks of gestation in previously normotensive and non proteinuric pregnant women. Pre-eclampsia associated with intrauterine growth retardation, preterm birth, maternal and perinatal death. Serum creatinine and uric acid has been shown to play a significant role in the pathogenesis of the disease and often precede clinical manifestations. This study compares the serum creatinine and uric acid in pre -eclampsia case and normal pregnant women and to assess its role in pre-eclampsia.Methods: 158 patients of which 79 pre-eclampsia (cases) and 79 (controls) were selected randomly and were matched with their gestational age in patient who Attending ANC clinic at Department of Obstretics and Gynecology in March 2016 to August 2017. Lipid profile was estimated by the Randox imola is a compact fully automated clinical chemistry analyser.Results: Authors observed that pre-eclampsia is more common in young age pregnant women with low socioeconomic status with strenuous activities. The mean age was 24.51±3.707 years. The mean serum creatinine and urice acid value is analysed in pre-eclampia cases and compared with control group showing significantly increase (p<0.0001).Conclusions: Young age, nullyparity, low socio economic status specially labour occupation, with derangment of Serum creatinine in pregnant women were found to be more prone to develop pre-eclampsia. Proper history tacking, examination and estimation of serum creatinine and uric acid may be helpful for early diagnosis and management of pre–eclampsia in order to prevent fetal and maternal complications especially in nulliparous women.


Author(s):  
Kirtan Krishna ◽  
N. Shailaja ◽  
B. Shyamasundara Bhat ◽  
L. Krishna ◽  
Namrata .

Background: The aim of treatment of severe pre-eclampsia and eclampsia is to quickly bring about a smooth reduction in blood pressure to levels that are safe for both mother and baby but avoiding any sudden drops. There are not many studies comparing nifedipine and labetalol for this purpose. Authors conducted this study with the aim of comparing their efficacy in reducing maternal blood pressure.Methods: It was a cross over trial with 30 patients in each group conducted at a tertiary care hospital. 60 pregnant women were randomized to receive nifedipine (20mg loading dose followed by 10 mg tablet, orally, up to maximum of five doses) or  intravenous labetalol  (in an escalating dose regimen of 20, 40, 80, 80 and 80 mg)  every 20 minutes until the target blood pressure of 150/100 mmHg was achieved. Crossover treatment was affected if the initial treatment regimen was unsuccessful after 20 min of the last dose of the drug in the respective groups.Results: The mean time to achieve the target blood pressure was 32.0 ±18.64 minutes (mean ± SD) in nifedipine group as compared with 37.04 ± 16.36 minutes in those receiving labetalol (P = .002). In the nifedipine group 63.3% required only one dose compared to 36.6% in the labetalol group.  Only two women in the nifedipine group required maximum number of doses that is five doses. Cross over treatment was required by 10% of patients in the labetalol group and none in the nifedipine group.Conclusions: This study shows that oral nifedipine is more effective than intravenous labetalol in rapid control of hypertension in severe pre-eclampsia and eclampsia.


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