scholarly journals Importance of anatomopathological analysis and histopathological examination for the diagnosis of suspected cases of syphilitic aneurysm

2017 ◽  
Vol 16 (2) ◽  
pp. 242
Author(s):  
Pedro Pereira Tenório ◽  
Andréa Kedima Diniz Cavalcanti Tenório ◽  
Marcos André Araújo Duque ◽  
Mônica Modesto Araújo ◽  
Lenieé Campos Maia ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Descriptive Study ◽  
Diagnostic Tools ◽  
Histopathological Study ◽  
Histopathological Analysis ◽  
Sexually Transmitted ◽  
Longitudinal Striation ◽  
Tertiary Stage

<strong>Introduction</strong>: syphilis is a sexually transmitted disease caused by mycobacterium Treponema pallidum in which in its tertiary stage can lead to an aortic syphilitic aneurysm. Currently, such cases are rare because of the effectiveness of antibiotic therapy. <strong>Objective</strong>: we aimed to carry out an anatomopathological analysis and histopathological examination of three cases potentially suspicious of aortic syphilitic aneurysm on human corpses. Methods: It was a descriptive study which 03 anatomic specimens of aortas from cadavers with ages ranging from 50 to 91 years obtained in Service checklist of deaths during the period from 2014 to 2015. We performed an anatomopathological and histopathological analysis with the use of special dyes. <strong>Results</strong>: through the macroscopic evaluation it was observed in all cases a dilation corresponding to arch of aorta where the intima obtained an aspect of longitudinal striation, classic of syphilitic process. As for histopathological study on the tissues treatment with the staining batteries, it was demonstrated the presence of the dissecting hematoma in all cases, besides necrosis and absence characteristic of the inflammatory process. <strong>Conclusion</strong>: the anatomopathological and histopathological study are diagnostic tools which have specific characteristics and are directed to assist in preliminary diagnosis of suspected cases of aortic syphilitic aneurysm in necropsies.

scholarly journals Using Joinpoint Regression for the Analysis of Trends in Syphilis Incidence in Poland in the Years 1950–2017

2019 ◽  
Vol 60 (1) ◽  
pp. 7-18
Author(s):  
Marcin Milewski ◽  
Rafał Milewski ◽  
Gabriela Sokołowska ◽  
Anna Justyna Milewska
Keyword(s):  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Epidemiological Studies ◽  
Sexual Contact ◽  
Regression Method ◽  
Serological Response ◽  
Joinpoint Regression ◽  
Sexually Transmitted ◽  
The Impact ◽  
Splitting Time

Abstract Syphilis is a bacterial sexually transmitted disease (STD), whose main route of infection is through sexual contact. In order to diagnose syphilis, Treponema pallidum must be detected in the material sampled from a lesion and a blood test must be performed in order to detect serological response to syphilis. Since 1946, a statutory obligation to report all cases of syphilis has been in force in Poland, which is why data concerning the incidence is available. The aim of this paper is to analyse trends in syphilis incidence in the years 1950–2017 using Joinpoint Regression and to present the impact of prophylaxis and education of society on syphilis prevention. The Joinpoint Regression method indicated the splitting time points of the trend corresponding to real changes in incidence, which corroborates the purpose of using the method in question in epidemiological studies.

scholarly journals Sonographic appearance of syphilitic induration mimicking squamous cell carcinoma in the lower lip: a case report

2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Satomi Asai ◽  
Akihiro Kaneko ◽  
Tsukumi Matsuda ◽  
Noboru Takanashi ◽  
Mika Doi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Color Doppler ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Japanese Woman ◽  
Rapid Plasma Reagin ◽  
Lower Lip ◽  
Sexually Transmitted

Abstract Background Syphilis is a sexually transmitted disease caused by the spirochete Treponema pallidum. Recently, its incidence has been increasing worldwide. We encountered a young woman who presented with induration mimicking squamous cell carcinoma in the lower lip, without major medical conditions. Case presentation A 25-year-old Japanese woman presented with a 1-month history of a painless induration in her lower lip. Because squamous cell carcinoma was suspected, a preoperation work up was performed, including laboratory tests, an ultrasonographic examination, and a biopsy. The ultrasonography findings showed an oval-shaped 17 × 11 × 12 mm tumor-like lesion with heterogeneous internal echo and an indistinct border. A pressure test and color Doppler sonography revealed that the lesion was soft with a very abundant blood flow. These findings suggested the possibility of underlying inflammatory causes rather than a neoplastic tumor. Serology tests for syphilis, including the anti-Treponema pallidum antibody and reactive rapid plasma reagin tests, were positive. The biopsy revealed no malignancy. Finally, she was diagnosed as having primary syphilis and treated with amoxicillin for 28 days. The rapid plasma reagin value gradually decreased and the initial induration in her lower lip disappeared. Conclusion This case highlights the need for prompt examinations for possible underlying infective causes, such as syphilis, when seeing a painless induration with ulcer in the lip. Ultrasonography was helpful in the differential diagnosis of a tumor-like lesion and should be included in addition to syphilis serology tests, such as anti-Treponema pallidum antibody and rapid plasma reagin tests.

scholarly journals A rare case of tertiary syphilis spondylodiscitis of the upper cervical spine: Diagnostic and therapeutic complexity, review of literature

2020 ◽  
Author(s):  
Valerio Cipolloni ◽  
Luigi Aurelio Nasto ◽  
Luca Piccone ◽  
Domenico Alessandro Santagada ◽  
Virginia Sangiorgi ◽  
...  
Keyword(s):  
Cervical Spine ◽  
Rare Case ◽  
Osteolytic Lesion ◽  
Bone Lesion ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Bone Lesions ◽  
Upper Cervical Spine ◽  
Sexually Transmitted ◽  
Tertiary Syphilis

Syphilis is a sexually transmitted disease caused by the spirochetes Treponema pallidum. Syphilitic spinal lesions present as erosive bone lesions often simulating spondylodiscitis or cancer. In this article we describe a rare case of cervical osteolytic lesion from tertiary syphilis. A 45-year-old male with axial neck pain, without fever presented with an isolated osteolytic lesion at C3. Tuberculous spondylitis was initially suspected. A new CT and contrast enhanced MRI of the cervical spine and of the neck showed an extention of the bone lesion at C3 with bilateral lymphadenomegaly. To confirm the diagnosis of tertiary syphilis, US-guided biopsy of the lymph nodes was performed. The patient was treated with i.m. benzylpenicillin 2.4 MIU and the follow-up showed clinical and radiological resolution of the condition. The aim of this case report is to raise awareness of tertiary syphilis in the differential diagnosis of lytic lesions of the spine among the spinal community.

scholarly journals Characterization and Serologic Analysis of the Treponema pallidum Proteome

2010 ◽  
Vol 78 (6) ◽  
pp. 2631-2643 ◽  
Author(s):  
Melanie A. McGill ◽  
Diane G. Edmondson ◽  
James A. Carroll ◽  
Richard G. Cook ◽  
Ralph S. Orkiszewski ◽  
...  
Keyword(s):  
Gel Electrophoresis ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Immunoblot Analysis ◽  
Serum Samples ◽  
Syphilis Infection ◽  
Two Dimensional Gel Electrophoresis ◽  
Ionization Time ◽  
Sexually Transmitted ◽  
Human Sera

ABSTRACT Treponema pallidum subsp. pallidum is the causative agent of syphilis, a sexually transmitted disease characterized by widespread tissue dissemination and chronic infection. In this study, we analyzed the proteome of T. pallidum by the isoelectric focusing (IEF) and nonequilibrating pH gel electrophoresis (NEPHGE) forms of two-dimensional gel electrophoresis (2DGE), coupled with matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis. We determined the identity of 148 T. pallidum protein spots, representing 88 T. pallidum polypeptides; 63 of these polypeptides had not been identified previously at the protein level. To examine which of these proteins are important in the antibody response to syphilis, we performed immunoblot analysis using infected rabbit sera or human sera from patients at different stages of syphilis infection. Twenty-nine previously described antigens (predominantly lipoproteins) were detected, as were a number of previously unidentified antigens. The reactivity patterns obtained with sera from infected rabbits and humans were similar; these patterns included a subset of antigens reactive with all serum samples tested, including CfpA, MglB-2, TmpA, TmpB, flagellins, and the 47-kDa, 17-kDa, and 15-kDa lipoproteins. A unique group of antigens specifically reactive with infected human serum was also identified and included the previously described antigen TpF1 and the hypothetical proteins TP0584, TP0608, and TP0965. This combined proteomic and serologic analysis further delineates the antigens potentially useful as vaccine candidates or diagnostic markers and may provide insight into the host-pathogen interactions that occur during T. pallidum infection.

scholarly journals Imunopatogenesis Treponema pallidum dan Pemeriksaan Serologi

2014 ◽  
Vol 3 (3) ◽  
Author(s):  
Efrida Efrida ◽  
Elvinawaty Elvinawaty
Keyword(s):  
Clinical Symptoms ◽  
Early Stage ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
Major Health Problem ◽  
Sexually Transmitted ◽  
Tertiary Syphilis ◽  
History Of ◽  
Latent Syphilis

AbstrakSifilis adalah penyakit menular seksual yang sangat infeksius, disebabkan oleh bakteri berbentuk spiral, Treponema pallidum subspesies pallidum. Penyebaran sifilis di dunia telah menjadi masalah kesehatan yang besar dengan jumlah kasus 12 juta pertahun. Infeksi sifilis dibagi menjadi sifilis stadium dini dan lanjut. Sifilis stadium dini terbagi menjadi sifilis primer, sekunder, dan laten dini. Sifilis stadium lanjut termasuk sifilis tersier (gumatous, sifilis kardiovaskular dan neurosifilis) serta sifilis laten lanjut. Sifilis primer didiagnosis berdasarkan gejala klinis ditemukannya satu atau lebih chancre (ulser). Sifilis sekunder ditandai dengan ditemukannya lesi mukokutaneus yang terlokalisir atau difus dengan limfadenopati. Sifilis laten tanpa gejala klinis sifilis dengan pemeriksaan nontreponemal dan treponemal reaktif, riwayat terapi sifilis dengan titer uji nontreponemal yang meningkat dibandingkan dengan hasil titer nontreponemal sebelumnya. Sifilis tersier ditemukan guma dengan pemeriksaan treponemal reaktif, sekitar 30% dengan uji nontreponemal yang tidak reaktifKata kunci: sifilis, Treponema pallidum, serologiAbstractSyphilis is a sexually transmitted disease that is highly infectious, caused by a spiral -shaped bacterium, Treponema pallidum subspecies pallidum. The spread of syphilis in the world has become a major health problem and the common, the number of 12 million cases per year. Infectious syphilis is divided into early and late-stage syphilis. Early-stage syphilis is divided into primary, secondary, and early latent. Advanced stage of syphilis include tertiary syphilis (gumatous, cardiovascular syphilis, and neurosyphilis) and late latent syphilis. Primary syphilis is diagnosed by clinical symptoms of the discovery of one or more chancre (ulcer). Secondary syphilis is characterized by the finding of localized mucocutaneous lesions or with diffuse lymphadenopathy. Latent syphilis without clinical symptoms of syphilis with a nontreponemal and treponemal reactive examination, history of syphilis therapy in nontreponemal test titer increased compared with the results of previous nontreponemal titers. Tertiary syphilis is found guma with reactive treponemal examination, approximately 30% of the non- reactive nontreponemal testKeywords: syphilis, Treponema pallidum, serologi

scholarly journals Laboratory Examination of Syphilis

2021 ◽  
Vol 5 (3) ◽  
pp. 722-741
Author(s):  
M. Izazi Hari Purwoko ◽  
Mutia Devi ◽  
Suroso Adi Nugroho ◽  
Fitriani Fitriani ◽  
Raden Pamudji ◽  
...  
Keyword(s):  
Venereal Disease ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Clinical Manifestations ◽  
Rapid Test ◽  
Dark Field ◽  
Morphological Observation ◽  
Serologic Test ◽  
Sexually Transmitted ◽  
Antibody Absorption

Syphilis, is sexually transmitted disease caused by spirochete Treponema pallidum subsp.pallidum. It have many diverse clinical manifestations that occur in distinct stages. Early diagnosis and management are the main things to prevent transmission and complication. Direct test or morphological observation is the definitive diagnosis of syphilis. This can be done through animal inoculation test, dark field microscopy, direct fluorescence antibody (DFA), and nucleid acid amplification test (NAAT). While the indirect test is a nontreponemal serologic test consist of Wasserman test, venereal disease research laboratory (VDRL), toluidine red unheated serum test (TRUST), unheated serum reagin (USR), rapid plasma reagin (RPR) and treponemal serologic test, such as T. pallidum passive particle agglutination (TPPA), T. pallidum haemagglutination assay (TPHA), fluorescent treponemal antibody absorption (FTA-Abs), enzyme immunoassay (EIA) and rapid test. The algorithm of serologic test can be divided into traditional or reverse.

Syphilis (Treponema pallidum)

2018 ◽  
Author(s):  
Mark N. Gilroy ◽  
Juan C. Salazar
Keyword(s):  
Congenital Syphilis ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Public Health Problem ◽  
Adverse Outcomes ◽  
Global Public Health ◽  
Serological Screening ◽  
Sexually Transmitted

Syphilis, a chronic, sexually transmitted disease caused by the extracellular spirochete Treponema pallidum, has exhibited a remarkable resurgence in recent years. Despite the existence of inexpensive, easily administered, and highly effective antibiotic treatments, maternal and neonatal syphilis infections continue to be a major global public health problem. In addition to its potential to cause morbidity in the mother, untreated gestational syphilis (GS) can lead to serious adverse outcomes in the offspring, including stillbirth, prematurity, low birth weight, and neonatal death. Congenital syphilis (CS) is regarded as a missed opportunity during the antenatal care of the mother, resulting from socioeconomic, demographic, and behavioral factors that promote mother-to-child transmission (MTCT) of syphilis. This chapter emphasizes emerging concepts about screening aimed at controlling the ongoing epidemic, including serological screening of mother and infant, newer paradigms of “reverse screening,” clinical presentation, therapy, and long-term neurodevelopmental disabilities that must be a component of follow-up care.

scholarly journals Treponema pallidumNucleic Acid Amplification Testing To Augment Syphilis Screening among Men Who Have Sex with Men

2019 ◽  
Vol 57 (8) ◽  
Author(s):  
Matthew Golden ◽  
Meghan O’Donnell ◽  
Sheila Lukehart ◽  
Paul Swenson ◽  
Paul Hovey ◽  
...  
Keyword(s):  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Secondary Syphilis ◽  
23S Rrna ◽  
Serological Testing ◽  
Content Type ◽  
Sexually Transmitted ◽  
Syphilis Screening ◽  
Sex With Men ◽  
Latent Syphilis

ABSTRACTSyphilis rates in much of the world are now at their highest levels in almost three decades, and new approaches to controlling syphilis, including diagnostic tests with shorter window periods, are urgently needed. We compared the sensitivity of syphilis serological testing using the rapid plasma reagin (RPR) test with that of the combination of serological testing and an experimental 23S rRNATreponema pallidumreal-time transcription-mediated amplification (TMA) assay performed on rectal and pharyngeal mucosal swabs.T. pallidumPCR assays for thetpp47gene were performed on all TMA-positive specimens, as well as specimens from 20 randomly selected TMA-negative men. A total of 545 men who have sex with men (MSM) who were seen in a sexually transmitted disease clinic provided 506 pharyngeal specimens and 410 rectal specimens with valid TMA results. Twenty-two men (4%) were diagnosed with syphilis on the basis of positive RPR test results and clinical diagnoses, including 3 men with primary infections, 8 with secondary syphilis, 9 with early latent syphilis, 1 with late latent syphilis, and 1 with an unstaged infection. Two additional men were diagnosed based on positive rectal mucosal TMA assay results alone, and both also tested positive by PCR assay. At least 1 specimen was TMA positive for 12 of 24 men with syphilis (sensitivity, 50% [95% confidence interval [CI], 29 to 71%]). RPR testing and clinical diagnosis were 92% sensitive (95% CI, 73 to 99%) in identifying infected men. Combining mucosal TMA testing and serological testing may increase the sensitivity of syphilis screening in high-risk populations.

scholarly journals Present characteristics of symptomatic amebiasis due to Entamoeba histolytica in the east-southeast area of Tokyo

1997 ◽  
Vol 119 (3) ◽  
pp. 363-367 ◽  
Author(s):  
K. OHNISHI ◽  
M. MURATA
Keyword(s):  
Entamoeba Histolytica ◽  
Liver Abscess ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Sexual Practices ◽  
Bisexual Men ◽  
Male Homosexual ◽  
Sexually Transmitted ◽  
Male Patients ◽  
And Bisexual

Admitted medical records, from January 1988 to December 1995, of 28 symptomatic amebic patients who lived in the east-southeast area of Tokyo were studied retrospectively, in order to find the present characteristics of symptomatic amebiasis due to Entamoeba histolytica in this area. Categorized by disease, there were 14 cases of colitis, 9 cases of liver abscess, 4 cases of colitis with liver abscess, and 1 case of liver abscess with brain abscess. Patients consisted of 26 Japanese males, 0 Japanese females, 1 non-Japanese male and 1 non-Japanese female. The mean age of colitis patients and liver abscess patients was 55·4 years old and 41·3 years old, respectively. The presumed place of contraction was Japan in 64% of the patients. Forty-eight percent of male patients indicated that they engaged in homosexual or bisexual practices, and 36% of male patients who denied such sexual practices or did not answer the question had no history of marriage. Positive rate of serum titre for Treponema pallidum hemagglutination test (TPHA) and human immunodeficiency virus antibody was 42·9% and 0%, respectively. Sixty-seven percent of TPHA-positive patients indicated that they engaged in male homosexual or bisexual practices. Zymodeme patterns of E. histolytica isolated from 4 colitis patients were XIV in 1 case and II in 3 cases. Symptomatic amebiasis in the east-southeast area of Tokyo is a disease which predominantly afflicts males, especially those in their middle age, and most patients contract the disease in Japan. The high rates of patients who engaged in male homosexual or bisexual practices and the high rates of patients with positive TPHA suggest that amebiasis is likely to be sexually transmitted disease in homosexual and bisexual men in the east-southeast area of Tokyo, and zymodeme II may be the predominant type in symptomatic amebic colitis in this area.

scholarly journals Syphilis Fast Latex Agglutination Test, a Rapid Confirmatory Test

2001 ◽  
Vol 8 (4) ◽  
pp. 841-842 ◽  
Author(s):  
Martha B. Fears ◽  
Victoria Pope
Keyword(s):  
Point Of Care ◽  
Transmitted Disease ◽  
Treponema Pallidum ◽  
Latex Agglutination ◽  
Agglutination Test ◽  
Latex Agglutination Test ◽  
Confirmatory Test ◽  
Serum Samples ◽  
Sexually Transmitted ◽  
Particle Agglutination

ABSTRACT Using 255 serum samples with various reactivities, we evaluated the Syphilis Fast latex agglutination test (Syphilis Fast) against theTreponema pallidum particle agglutination test (TP-PA) for confirming a diagnosis of syphilis. We found 98.8% agreement between the Syphilis Fast and the TP-PA. The Syphilis Fast, however, had a couple of advantages over the TP-PA: the test takes only 8 min to perform and produces results that are easy to read. It appears to be a good confirmatory test for syphilis, especially for point-of-care clinics such as prenatal or sexually transmitted disease clinics.

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