Epidemiology, etiology, and treatment of denture stomatitis

Multiple factors are involved in the pathogenesis of denture stomatitis, which increases the risk of tissue infection and inflammation. These factors include poor oral hygiene, trauma secondary to poorly fitting prostheses, resin porosity, and bacterial plaque accumulation. Our present review discusses the epidemiology, etiology, and treatment of denture stomatitis based on data from current studies in the literature. The prevalence of denture stomatitis is significantly variable among the different studies, as previously discussed. However, the cumulative incidence of denture stomatitis among their participants ranged between 17-77%. These hugely variable rates have been attributed to the nature of data collection, diagnostic criteria, sample size, and patient demographics. Studies also show that the condition is more prevalent among elderly females. However, not many studies have reported this correlation, indicating the need for future studies. Candida albicans infection is the primary parameter in the etiology and pathogenesis of the condition. However, other factors related to the patient (like status of immunological response) and dentures (like hygiene) were also reported. Therefore, the management of denture stomatitis should be based on applying adequate interventions. Besides, using antifungal medications is also necessary to eradicate organism.

Influence of Pulse Characteristics On Turbocharger Radial Turbine

Due to the reciprocating engine, a pulsating flow occurs in the turbine turbocharger, which experiences conditions far from the continuous flow scenario. In this work, the effects of the characteristics of the mass flow pulse, parameterized through amplitude, frequency and temporal gradient, are decoupled and studied via unsteady Computational Fluid Dynamics calculations under on-engine operating conditions. Firstly, the model is validated based on comparisons with experimental data in steady flow conditions. Then, the effect of each parameter on exergy budget is assessed by considering a +/-10% variation with respect to a baseline pulse. The other factors defining the operating conditions (e.g. mass flow, shaft speed and inflow exergy) are kept the same as the baseline. The adopted approach enables to completely isolate the effects of each parameter in contrast with previous literature studies. Based on the results observed, pulse amplitude is identified as the primary parameter affecting the hot-side system response in terms of turbine performance, heat transfer and entropy generation, while frequency and temporal gradient show a smaller influence compared to it. As the pulse amplitude increases, the turbine work is reported to improve up to 9.4%. Smaller variations are observed for the frequency and temporal gradient analysis. With a 10% increase of the pulse frequency the turbine work is registered to improve by 5.0%, while the same percentage reduction of the temporal gradient leads to an increase of turbine work equal to 3.6%.

Donor–recipient matching in hand transplantation: a comparison of anthropometric measurements, 3-dimensional virtual models and printed epitheses

Donor–recipient matching in hand transplantation remains challenging. The usefulness of three-dimensional (3-D) virtual models and printed epitheses were compared with measurements on cadaveric extremities to evaluate the most accurate method of donor–recipient matching for allograft procurement. Ten anthropometric measurements were recorded from 12 human cadaveric upper extremities and matched to printed epitheses and 3-D virtual models. Five circumferential and two longitudinal measurements obtained an intra-class correlation of >0.75 with all three methods, with the Kaplan (0.973) and wrist circumferences (0.942) achieving the highest concordance. Measurement on cadaveric specimens was the most reliable method. Using different combinations of donor hand and recipient forearms, a series of 72 virtual transplantations were then created, and their compatibility rated by ten transplant surgeons. The results confirmed that anthropometric measurements, obtained directly from potential human donor limbs and based on wrist circumference as the primary parameter, provide the best and most clinically relevant donor–recipient match.

Nanoparticle-Based Therapies for Turning Cold Tumors Hot: How to Treat an Immunosuppressive Tumor Microenvironment

Nanotechnologies are rapidly increasing their role in immuno-oncology in line with the need for novel therapeutic strategies to treat patients unresponsive to chemotherapies and immunotherapies. The tumor immune microenvironment (TIME) has emerged as critical for tumor classification and patient stratification to design better treatments. Notably, the tumor infiltration of effector T cells plays a crucial role in antitumor responses and has been identified as the primary parameter to define hot, immunosuppressed, excluded, and cold tumors. Organic and inorganic nanoparticles (NPs) have been applied as carriers of new targeted therapies to turn cold or altered (i.e., immunosuppressed or excluded) tumors into more therapeutically responsive hot tumors. This mini-review discusses the significant advances in NP-based approaches to turn immunologically cold tumors into hot ones.

Non-Destructive Test on Granite Powder Concrete

This paper presents a definite exploratory investigation on penetrability qualities of granite powder (GP) concrete. The primary parameter researched in this investigation was M30 and M60 grades concrete with substitution of sand by GP of 0, 25,50 and 100 and concrete as fractional supplanting with super plasticiser, fly ash, slag and silica fume. The antacid arrangement utilized for present examination is the mix of sodium hydroxide and sodium silicate arrangement. The test example was 50 mm (thick) x 100 mm (diameter) cylinder shapes heat-relieved at 60°C in an oven. The variety was concentrated on the examples exposed to ambient air just as oven heat relieving. non-destructive tests on cylinders with the help of rebound hammer for a time of 28, 56, 90, 180 and 365 days. The test outcomes show that the substitution of rock and incomplete substitution of admixtures display better execution

Determining Suitable Thermal Regimes for Early Instar Redclaw Juveniles, Cherax quadricarinatus (von Martens, 1868) (Decapoda, Parastacidae), for a Proposed Nursery Phase

Modern, intensified aquaculture typically involves three production phases; hatchery, nursery, and grow-out. For redclaw crayfish aquaculture however, such delineation has been ill-defined. Farming of redclaw was initiated based on the putative beneficial physical and biological attributes of the species, which suggested production methods would be relatively simple. The simple approach proved to be inefficient and only partially effective, which hindered industry development. Hatchery technology now exists to supply seed stock for grow-out, but hatchery production is variable, and the performance of hatchery reared juveniles is inconsistent. A nursery phase has been proposed between hatchery production and grow-out of approximately 3 weeks duration, sufficient to allow 2 or more moults. An important primary parameter in the proposed nursery phase is the thermal regime that will support optimum survival and growth. This study quantified the effect of temperature on the growth and survival of redclaw juveniles for a 22-day nursery phase. Temperature had a statistically significant effect on the survival of juveniles, whereby, the high temperatures were associated with high mortality, and the lower temperature treatments were associated with very low mortality. Survival was 98 to 100% for craylings held at temperatures between 18°C and 22°C, and between 0% and 6% for craylings at temperature treatments of 25°C to 32°C. Mortalities within treatments between 25°C and 30°C, primarily occurred from day six to day eleven, corresponding with the initiation of moulting. Change of mass of crayfish was significantly higher with increasing temperature between 18°C and 22°C and at individual weights that suggest they had completed a moult. This study suggests a water temperature of 22°C is optimal for survival and growth in a nursery phase.

Current and Voltage Harmonics Analysis in Green Building Case Study in Universitas Muhammadiyah Yogyakarta

This paper described research to investigate Total Harmonic Distortion (THD) on a supposedly green building; Admission Building in Universitas Muhammadiyah Yogyakarta. Observation was done for seven days involving peak and non-peak hours including workdays and off days. Data sampling was recorded 24 hours with one-hour interval for primary parameter data including voltage, current, power factor and frequency on each phase in three phases system. Secondary data calculated to find voltage and current THD and finally to evaluate the loss of money due to power loss as the result of harmonic and unbalance load. Investigation indicated that the building has not met the IEEE 512-2014 standard for Total Harmonic Distortion. National electricity company, PLN (Perusahaan Listrik Negara) as Government Company, has made regulation about tariff and standard. Electricity tariff in Indonesia has been divided into categories based on user, commercial, social, or housing. Based on this tariff, loss of cost was calculated. Cost due to electricity loss in the building was not high since the building has good electricity installation as green building. Total Harmonic distortion reduction was recommended using single tune order 5 filter.

Engaging Pathology Residents in Clinical Chemistry: The Essential Ingredient Is a Committed Teacher

Background Pathology residents are thought to show a lack of interest in clinical chemistry, therefore potentially graduating from training programs unprepared to function as laboratory directors and clinical consultants. Methods A structured program of tutorials based primarily on Henry’s textbook, supplemented by recent review articles; a question bank of about 600 questions to emphasize key concepts; requirement for performing and presenting quality improvement projects; participation in on-site CAP inspections; review of reference laboratory test requests; and involving residents in scholarly activity have resulted in sustained, transferable, and significant improvements in engagement, knowledge, competence, and examination scores. Results The primary parameter for measuring change in resident competence and engagement were improvements in resident in-service examination (RISE) scores, publications in peer-reviewed journals, and receipt of awards. The revised program produced significant improvement in RISE scores in clinical chemistry, over and above the improvements in the general residency program. The residents were authors on 12 publications in peer-reviewed PubMed listed journals in the 5-year period since revision in the clinical chemistry curriculum compared to no publications in clinical chemistry in the 5-year period before the new curriculum. Over the past 2 years, 6 of the 11 publications by graduating residents were in clinical chemistry, and 6 of 7 awards for research were garnered by residents engaged in clinical chemistry investigations. All of the residents passed their clinical pathology boards on first attempt since the change compared to 2 failures in the prior 5-year period. Conclusions The structured program described here is important as a template that could be adopted by any pathology training program. The question bank developed by this program is a valuable and transferable aid. However, success of such a program is dependent on the commitment of a knowledgeable, dedicated, and passionate teacher.