Model-Based Enterprise Continuous Improvement

The enterprise reengineering based on enterprise modelling is usually carried out within the framework of conventional projects. This leads to relatively long projects that are not compatible with a highly variable economic environment. The objective of the evolution management presented here is to use enterprise modelling and all the benefits it brings in a framework that allows for more continuous improvement than is generally observed. The proposed architecture is made up of three levels: a strategic level based on performance measurement, a tactical level that manages system migration and is based on enterprise models, and an operational level consisting of managing a portfolio of evolution projects. Together, these allow a shorter set of projects to be carried out, while remaining coherent and aligned with the company’s strategy. This approach puts enterprise modelling methods and continuous improvement/Lean management approaches into perspective, allowing complementarities and opening up interesting perspectives concerning enterprise re-engineering methods.

Live-Cell Microscopy Reveals That Human T Cells Primarily Respond Chemokinetically Within a CCL19 Gradient That Induces Chemotaxis in Dendritic Cells

The ability to study migratory behavior of immune cells is crucial to understanding the dynamic control of the immune system. Migration induced by chemokines is often assumed to be directional (chemotaxis), yet commonly used end-point migration assays are confounded by detecting increased cell migration that lacks directionality (chemokinesis). To distinguish between chemotaxis and chemokinesis we used the classic “under-agarose assay” in combination with video-microscopy to monitor migration of CCR7+ human monocyte-derived dendritic cells and T cells in response to a concentration gradient of CCL19. Formation of the gradients was visualized with a fluorescent marker and lasted several hours. Monocyte-derived dendritic cells migrated chemotactically towards the CCL19 gradient. In contrast, T cells exhibited a biased random walk that was largely driven by increased exploratory chemokinesis towards CCL19. This dominance of chemokinesis over chemotaxis in T cells is consistent with CCR7 ligation optimizing T cell scanning of antigen-presenting cells in lymphoid tissues.

Neutron: an attention-based neural decompiler

Decompilation aims to analyze and transform low-level program language (PL) codes such as binary code or assembly code to obtain an equivalent high-level PL. Decompilation plays a vital role in the cyberspace security fields such as software vulnerability discovery and analysis, malicious code detection and analysis, and software engineering fields such as source code analysis, optimization, and cross-language cross-operating system migration. Unfortunately, the existing decompilers mainly rely on experts to write rules, which leads to bottlenecks such as low scalability, development difficulties, and long cycles. The generated high-level PL codes often violate the code writing specifications. Further, their readability is still relatively low. The problems mentioned above hinder the efficiency of advanced applications (e.g., vulnerability discovery) based on decompiled high-level PL codes.In this paper, we propose a decompilation approach based on the attention-based neural machine translation (NMT) mechanism, which converts low-level PL into high-level PL while acquiring legibility and keeping functionally similar. To compensate for the information asymmetry between the low-level and high-level PL, a translation method based on basic operations of low-level PL is designed. This method improves the generalization of the NMT model and captures the translation rules between PLs more accurately and efficiently. Besides, we implement a neural decompilation framework called Neutron. The evaluation of two practical applications shows that Neutron’s average program accuracy is 96.96%, which is better than the traditional NMT model.

ECMWF's data archive and dissemination services migration to the Bologna Data Center.

<div>CMWF is the European Centre for Medium-Range Weather Forecasts. We are both a research institute and a 24/7 operational service, producing global numerical weather predictions and other data for our Member and Co-operating States and the broader community. The Centre has one of the largest supercomputer facilities and meteorological data archives in the world.</div><div> </div><div>ECMWF is about to migrate his 400+ PB of data to his new data centre in Bologna while continuing its operations. We will present and discuss challenges and opportunities that this migration offers in terms of evolution of operation practices.</div><div>The planning, the evolution, and the transition periods of the ECMWF Data Handling System migration to Bologna will be presented.</div><div> </div><div>The migration must occur while preserving ECMWF’s product generation and archive services, ensuring appropriate levels of quality of service. The planning and testing of a continuity plan of operations for operational forecasts, member states time critical suites, Copernicus suites (ERA5, CAMS C3S seasonal and alike), and research suites will be presented. This continuity plan of operation relies on the full identification and traceability of the data flow involves during critical operations. Indeed, it is not economically viable to keep the 400 PB online during all the migration period.</div><div> </div><div> <div>A completely redesigned data services deployment and testing mechanism will be use in the Bologna Data Center. Automation will be paramount in this context as the need is to redeploy entirely and from scratch all our services. This journey will be presented, and challenges inherent to software defined infrastructure and services will be discussed.</div> </div>

Beloved Land, Beloved Family: The Role of Welfare in Timorese Migration to England

Timor-Leste’s long history of colonisation and occupation has posed significant welfare challenges for the small, half-island nation nestled between Asia and the Pacific. Since independence in 2002, a budding pattern of migration has emerged, with increasing numbers of Timorese living and working in the United Kingdom. This chapter seeks to understand how the welfare concerns of these migrants shape their decisions about geographical mobility and vice versa. Analysing semi-structured interviews and overt participant observation conducted in England in 2017 and drawing on an extended version of the welfare resource environment framework, it explores the role of market, state and family-based welfare provisions in this migration trend. It finds that Timorese migrants in England utilise migration – and the market and state-based welfare provisions it brings – in service of their own, family-based social protection system. Migration between welfare contexts allows increased access to new and varied sources of welfare, valued for how they support a family-based framework founded on interdependence, relationships with others and responsibility. By querying the mobility of Timorese migrants in England in light of their welfare concerns, this chapter elucidates the culturally embedded ways in which migrants and their families piece together unique protection packages.

AN OPEN SOURCE MAIL SERVER MIGRATION EXPERIENCE: IREDMAIL

Servers are systems that set up to run for years, but it may be necessary to migrate to a new, better server when they have completed their lifetime or become inadequate. In this study, the open-source iRedMail e-mail server has been successfully migrated to another high-capacity physical server which uses an open-source CentOS operation system. Migration is a process that every step has to be very well planned. However, although planning is well done, unexpected errors may occur. For this reason, it is also essential to choose migration time. The experience gained as a result of the study is a guide for the new ones.

Live-cell microscopy reveals that human T cells primarily respond chemokinetically within a CCL19 gradient that induces chemotaxis in dendritic cells

The ability to study migratory behavior of immune cells is crucial to understanding the dynamic control of the immune system. Migration induced by chemokines is often assumed to be directional (chemotaxis), yet commonly used endpoint migration assays are confounded by detecting increased cell migration that lacks directionality (chemokinesis).To distinguish between chemotaxis and chemokinesis we used the classic “under-agarose assay” in combination with video-microscopy to monitor migration of CCR7+ human monocyte-derived dendritic cells and T cells in response to a concentration gradient of CCL19. The formation of the gradients was visualized with a fluorescent marker and lasted several hours.Monocyte-derived dendritic cells migrated chemotactically towards the CCL19 gradient. In contrast, T cells exhibited a biased random walk that was primarily driven by increased exploratory chemokinesis towards CCL19. This dominance of chemokinesis over chemotaxis in T cells is consistent with CCR7 ligation optimizing T cell scanning of antigen-presenting cells in lymphoid tissues.

Device-device communication stability of leadless anti-tachycardia pacemaker and subcutaneous implantable cardioverter defibrillator over 18 months

Background A novel modular cardiac rhythm management (mCRM) therapy approach is evaluated in this study: the performance of an anti-tachycardia pacing enabled leadless pacemaker (LP) commanded by a subcutaneous-ICD (S-ICD) via wireless, intra-body, device-device communication (DDC). Objectives To investigate long-term DDC performance of linked S-ICD to LP (mCRM System) and factors that impact DDC performance. Methods The mCRM System was implanted in 37 canine subjects: 33 with an S-ICD and an LP; 4 with an S-ICD and 2 LPs. The S-ICD was implanted using a Parsonnet pouch in the first 8 subjects. Communication thresholds were measured in three postures up to 18 months. Percent tissue encapsulation of the LP was measured at necropsy and ranged from 6% to 100% (mean: 62%). S-ICD system migration was evaluated radiographically at implant vs. at necropsy in two planes (anterior-posterior and left lateral) and evaluated 0–3 scale: none, minimal, moderate, significant. Communication thresholds were evaluated at 0 vs. 3 days using a t-test and 3 days through 18 months using a linear regression analysis. A repeated measures generalized linear model (GLM) was used to evaluate if test posture, percent tissue encapsulation of the LP, Parsonnet pouch use, or S-ICD system migration (no/ minimal migration vs. moderate/significant migration) were significant predictors of DDC performance at the subject's termination time point. Results DDC was successful for each tested posture and time point for all subjects (n=37), with 355 tests in Left Lateral (LL), 371 tests in Dorsal (D), and 355 tests in Right Lateral (RL). Follow up data are available up to 18 months for 19 subjects at the time of this abstract; additional follow-up data will be added to the analysis for presentation. Communication thresholds decreased between 0 days and 3 days (LL P<0.01, D P<0.01, RL P<0.05) and did not change significantly from 3 days through 18 months (LL P=0.90, D P=0.83, RL P=0.83). The GLM showed that there is no significant difference in communication thresholds for test posture (P=0.24 LL vs. D, P=0.24 RL vs. D), percent tissue encapsulation of the LP (P=0.63), Parsonnet pouch use (P=0.65), or S-ICD system migration (P=0.95). Conclusion Longitudinal studies demonstrate low and stable communication thresholds of a novel mCRM system over time for all three tested postures, regardless of factors such as LP encapsulation, Parsonnet pouch use, or S-ICD system migration. Device Communication Threshold Stability Funding Acknowledgement Type of funding source: Private company. Main funding source(s): Boston Scientific