Analysis of the gestational period and perinatal outcomes in women after surgical treatment of the cervix

Background. The purpose was to conduct a comparative analysis of the course of pregnancy and perinatal outcomes in women who underwent treatment of the cervix using various organ preserving surgical methods. Material and methods. We examined 250 women of reproductive age who underwent excision or ablative treatment of the cervix before pregnancy. The subjects were divided into five groups depending on the cervix treatment method. The study used general clinical examination protocols outlined in the regulations № 417 and № 676 issued by the Ministry of Health of Ukraine. The results. The most frequent complications of pregnancy in the patients with cervical surgery were: threatened abortion, threatened of preterm birth, anemia, low placentation, placental dysfunction, and low levels of amniotic fluid. Childbirth complications in women who underwent excision or ablation treatment of the cervix before pregnancy predominantly consisted of labor abnormalities, premature amniotic sac rupture, fetal distress, tears of the cervix and perineum. Among the complications of the postpartum period, there were isolated cases of subinvolution of the uterus, lochiometers, metroendometritis, and lactostasis. There were no cases of intrapartum and early neonatal mortality among the newborns. Conclusions. Given the high frequency of gestational and postpartum complications in women after organ-sparing surgical treatment of the cervix, it is necessary to choose the least harmful approach. The lowest incidence of complications during pregnancy, intra and postnatal periods was observed in the women who underwent laser vaporization and radio-wave ablation.

Features of the second half of pregnancy in women with labor abnormalities

Aim: conduct a systematic analysis of pregnancy development, investigate clinical and laboratory data affecting development of labor abnormalities in women residing in the Belgorod region. Materials and Methods. From 2014 to 2018, 484 women were examined and divided into 2 groups: main group consisted of those who had childbirth complicated with labor abnormalities (n = 344), whereas control group consisted of women lacking complications during delivery (n = 140). The following methods were used in the study: questionnaires, general clinical methods, biochemical blood tests in pregnant and postpartum women, populational statistics as well as methods of standard and multivariate statistics. Results. In the second half of pregnancy in women with labor abnormalities revealed higher rate of moderate preeclampsia (34.30 ± 2.56 % vs. 10.71 ± 2.61%; p < 0.05), polyhydramnios (11.34 ± 1.71 % vs. 5.71 ± 1.96 %; p < 0.05), chronic intrauterine hypoxia (29.6 ± 2.46 % vs. 12.86 ± 2.83 %; p < 0.05), chronic utero-placental insufficiency (60.47 ± 2.64 % vs. 20.00 ± 3.38 %; p < 0.05), sexually transmitted infections (3.78 ± 1.03 % vs. 0.71 ± 0.71 %; p < 0.05), acute respiratory viral infection (8.72 ± 1.52 % vs. 3.57 ± 1.57 %; p < 0.05) as well as a combination of several types of pathology (8.72 ± 1.52 % vs. 13.57 ± 2.89 %; p < 0.05). Laboratory parameters in women with labor abnormalities compared with control antepartum group were noted to have significantly decreased count of red blood cells (3.89 ± 0.38×1012/L vs. 3.99 ± 0.40×1012/L; p = 0.006), eosinophils (0.95 ± 0.69×109/L vs. 1.20 ± 0.67×109/L; p = 0.026) and platelets (226.29 ± 62.71×109/L vs. 245.44 ± 60.32×109/L; p = 0.0003). Blood biochemical parameters in women with labor abnormalities vs. control group were featured with significantly decreased level of bilirubin (6.76 ± 3.16 μmol/L vs. 9.88 ± 3.60 μmol/L; p < 0.05) and alanine aminotransferase (13.94 ± 10.08 U/L vs. 19.41 ± 14.40 U/L; p = 0.004). Analyzing coagulation parameters in the main group showed significantly reduced fibrinogen level (4.30 ± 1.00 g/L) compared with control group (4.71 ± 1.14 g/L; p < 0.05) as well as elevated international normalized ratio (1.07 ± 0.11 vs. 1.03 ± 0.10; p = 0.001). Conclusion. Our study data found that pregnant women with labor abnormalities had altered clinical and laboratory parameters observed as early as in the second half of gestation, which may be used to calculate an individual risk of such labor complication.

Possibilities for predicting abnormal labor at the present stage

Hypothesis/aims of study. Labor abnormalities can lead to dangerous complications for both the mother and the fetus. There are currently no effective ways to prevent abnormal uterine contractile activity. Therefore, the timeliness of diagnosis, which largely determines labor outcome, depends on the effectiveness of assessing the likelihood of the development of abnormal labor. The aim of this study was to examine the possibilities for predicting abnormal labor progression at the present stage of the development of science. Study design, materials and methods. A systematic analysis and synthesis of the literature data presented by domestic and foreign authors in the period from 1985 to 2020. Conclusion. A comprehensive approach to assessing the likelihood of the development of abnormal labor will optimize the tactics of labor management, which in the long-term will reduce the frequency of surgical delivery.

Clinical evaluation of labor: an evidence- and experience-based approach

During labor mother and fetus are evaluated at intervals to assess their well-being and determine how the labor is progressing. These assessments require skillful physical diagnosis and the ability to translate the acquired information into meaningful prognostic decision-making. We describe a coordinated approach to the assessment of labor. Graphing of serial measurements of cervical dilatation and fetal station creates “labor curves,” which provide diagnostic and prognostic information. Based on these curves we recognize nine discrete labor abnormalities. Many may be related to insufficient or disordered contractile mechanisms. Several factors are strongly associated with development of labor disorders, including cephalopelvic disproportion, excess analgesia, fetal malpositions, intrauterine infection, and maternal obesity. Clinical cephalopelvimetry involves assessing pelvic traits and predicting their effects on labor. These observations must be integrated with information derived from the labor curves. Exogenous oxytocin is widely used. It has a high therapeutic index, but is easily misused. Oxytocin treatment should be restricted to situations in which its potential benefits clearly outweigh its risks. This requires there be a documented labor dysfunction or a legitimate medical reason to shorten the labor. Normal labor and delivery pose little risk to a healthy fetus; but dysfunctional labors, especially if stimulated excessively by oxytocin or terminated by complex operative vaginal delivery, have the potential for considerable harm. Conscientiously implemented, the approach to the evaluation of labor outlined in this review will result in a reasonable cesarean rate and minimize risks that may accrue from the labor and delivery process.

Gestational process and labour activity in women with different types of autonomic regulation

The objective: is to analyze the frequency of gestational complications and labor abnormalities in pregnant women with different types of autonomic regulation disorders. Materials and methods. 129 women were examined. The type of autonomic regulation was determined by recording the time and spectral parameters of heart rate variability by computer cardiointervalography with use of CardioLab Bebicard diagnostic system. The main group consisted of 66 pregnant women with established autonomic regulation disorders. 63 patients with a normal autonomic state, a balanced level of sympathetic and parasympathetic activity formed a control group. To assess the status of the mother-placenta-fetus, an ultrasound examination with doplerometry was performed. Results. A significant increase of the central regulatory activity in pregnant women with autonomic dysfunction was established. The cardiointervalography indicate a balanced activity of the autonomic nervous system in the control group. The gestational complications were significantly more frequent in women of the main group in the context of detected autonomic dysfunction than in the control group. Labor anomalies were more common in pregnant women of the main group. Women with high parasympathetic astivity noted an increased frequency of labor dystocia. In patients with a superiority of sympathetic and humoral regulation, an increased frequency of labour activity weakness was observed. The fast deliveries often determined in pregnant women with decreased activity of both departments of autonomic nervous system. The incidence of urgent caesarian deliveries was significantly higher in the main group, including due to the ineffectiveness of the medical correction of labor abnormalities. Conclusions. The cardiointervalography is informative for the diagnosis of autonomous regulation and adaptive disorders, which may be the prerequisites for the gestational complications and labor abnormalities development. Using the heart rate variability analys is in pregnant women will improve the early prediction of gestational pathology and pathological birth process, reduce the risk of obstetric and perinatal complications. Key words: heart rate variability, autonomic regulation, gestational complications, labor activity abnormalities.

Features of pregnancy and delivery in patients with pregnancy-induced hypertension

Pregnant women with hypertensive disorders have a high risk for premature birth and early delivery due to the increased severity of hypertension associated with low effect of treatment. Vaginal birth in patients with hypertensive disorders are often complicated by premature rupture of membranes, labor abnormalities, abnormal blood loss. Emergency abdominal delivery is performed together with complex intensive therapy. A common approach to the management of pregnancies with mild and moderate forms of hypertension is treatment associated with prolongation of pregnancy. Therapeutic and protective regimen in childbirth is created by phased long-term epidural analgesia. Indications for induced delivery - I-II degree of nephropathy in the absence of a positive therapeutic effect for 1-2 weeks. Regarding to severe forms of hypertensive disorders, many researchers tend to think of the need for early delivery, to avoid complications. At the same time, early delivery often leads to birth with premature fetus, which contributes to worsening of perinatal outcomes in patients with hypertensive disorders. Currently the possibility of conservative management of pregnant with hypertensive disorders at the gestation term of less than 32 weeks using glucocorticoids may significantly improve perinatal outcomes. Conservative management is only possible in large clinical settings with careful selection of patients. Currently, there are different approaches to the selection of methods and timing of delivery in hypertensive disorders. The optimal strategy is based on a differentiated approach that takes into account the severity of hypertensive disorders and the probability of complications for mother and fetus. At the same time, the diversity of the pathogenesis of hypertensive disorders determines the presence of different variants of its clinical manifestations, clinical course and complications, making it difficult to properly assess its severity.