scholarly journals Features of the second half of pregnancy in women with labor abnormalities

2021 ◽  
Vol 14 (6) ◽  
pp. 659-665
Author(s):  
U. G. Shokirova ◽  
S. P. Pakhomov ◽  
A. S. Ustyuzhina ◽  
A. V. Matrosova
Keyword(s):  
Laboratory Data ◽  
International Normalized Ratio ◽  
Study Data ◽  
Main Group ◽  
Individual Risk ◽  
Control Group ◽  
Systematic Analysis ◽  
Laboratory Parameters ◽  
Blood Biochemical ◽  
Labor Abnormalities

Aim: conduct a systematic analysis of pregnancy development, investigate clinical and laboratory data affecting development of labor abnormalities in women residing in the Belgorod region. Materials and Methods. From 2014 to 2018, 484 women were examined and divided into 2 groups: main group consisted of those who had childbirth complicated with labor abnormalities (n = 344), whereas control group consisted of women lacking complications during delivery (n = 140). The following methods were used in the study: questionnaires, general clinical methods, biochemical blood tests in pregnant and postpartum women, populational statistics as well as methods of standard and multivariate statistics. Results. In the second half of pregnancy in women with labor abnormalities revealed higher rate of moderate preeclampsia (34.30 ± 2.56 % vs. 10.71 ± 2.61%; p < 0.05), polyhydramnios (11.34 ± 1.71 % vs. 5.71 ± 1.96 %; p < 0.05), chronic intrauterine hypoxia (29.6 ± 2.46 % vs. 12.86 ± 2.83 %; p < 0.05), chronic utero-placental insufficiency (60.47 ± 2.64 % vs. 20.00 ± 3.38 %; p < 0.05), sexually transmitted infections (3.78 ± 1.03 % vs. 0.71 ± 0.71 %; p < 0.05), acute respiratory viral infection (8.72 ± 1.52 % vs. 3.57 ± 1.57 %; p < 0.05) as well as a combination of several types of pathology (8.72 ± 1.52 % vs. 13.57 ± 2.89 %; p < 0.05). Laboratory parameters in women with labor abnormalities compared with control antepartum group were noted to have significantly decreased count of red blood cells (3.89 ± 0.38×1012/L vs. 3.99 ± 0.40×1012/L; p = 0.006), eosinophils (0.95 ± 0.69×109/L vs. 1.20 ± 0.67×109/L; p = 0.026) and platelets (226.29 ± 62.71×109/L vs. 245.44 ± 60.32×109/L; p = 0.0003). Blood biochemical parameters in women with labor abnormalities vs. control group were featured with significantly decreased level of bilirubin (6.76 ± 3.16 μmol/L vs. 9.88 ± 3.60 μmol/L; p < 0.05) and alanine aminotransferase (13.94 ± 10.08 U/L vs. 19.41 ± 14.40 U/L; p = 0.004). Analyzing coagulation parameters in the main group showed significantly reduced fibrinogen level (4.30 ± 1.00 g/L) compared with control group (4.71 ± 1.14 g/L; p < 0.05) as well as elevated international normalized ratio (1.07 ± 0.11 vs. 1.03 ± 0.10; p = 0.001). Conclusion. Our study data found that pregnant women with labor abnormalities had altered clinical and laboratory parameters observed as early as in the second half of gestation, which may be used to calculate an individual risk of such labor complication.

scholarly journals Late results of embolization of a portal hepatic vein branches in patients, suffering extended hepatic tumors

2018 ◽  
Vol 85 (6) ◽  
pp. 18-20
Author(s):  
O. G. Kotenko ◽  
V. A. Kondratiuk ◽  
O. O. Korshak ◽  
D. O. Fedorov ◽  
O. V. Hrynenko ◽  
...  
Keyword(s):  
Hepatic Vein ◽  
Laboratory Data ◽  
Late Results ◽  
Main Group ◽  
Functional Adaptation ◽  
Control Group ◽  
Preoperative Embolization ◽  
Hepatic Tumors ◽  
Hepatic Volume ◽  
Synthetic Function

Objective. To analyze late results of preoperative  embolization of the portal hepatic vein branches (EPHVB) in patients, suffering extended hepatic tumors and extremely border-like small calculated residual hepatic volume(CRHV). Маterials and methods. From 2004 to 2014 yr the extended hepatic resection (HER) was performed in 285 patients, to whom EPHVB was applied (the main group), аnd in 353 patients as well, but without endovascular preparation (control group). In both groups dynamics of laboratory indices, structure of complications and lethality, late survival were studied. Results. In the main group a trustworthily lower rate of an acute hepatic insufficiency and connected with a lower postoperative lethality - accordingly 2.3 and 4.6%, comparing with a control group - 9.3 and 8.8%, were suggested. The laboratory data dynamics have witnessed a lesser intensiveness of postoperative hepatocytolysis and lesser degree of the hepatic synthetic function lowering in the main group, what have confirmed a better functional adaptation of hepatic residual in patients, to whom preoperative EPHVB was applied. Conclusion. Preoperative EPHVB permits to lower the postoperative complications and lethality rate in patients, suffering hepatic tumors, due to better functional adaptation of hepatic residual.

scholarly journals Efficiency of the combination of transdermal estrogens and a hormone-releasing intrauterine system for the correction of menopausal symptoms

2020 ◽  
Vol 69 (1) ◽  
pp. 37-44
Author(s):  
Irina N. Medvedevа ◽  
Kseniya S. Svyatchenko
Keyword(s):  
Hormonal Therapy ◽  
Biochemical Parameters ◽  
Test Group ◽  
Main Group ◽  
Menopausal Symptoms ◽  
Control Group ◽  
Two Phase ◽  
Good Tolerability ◽  
Blood Biochemical ◽  
Tablet Preparation

Hypothesis/aims of study. The aim of this study was to assess the efficiency of Mirena (levonorgestrel-releasing intrauterine system) combined with EstroGel (17-estradiol transdermal gel) being applied in the test group of peri- and postmenopausal women as menopausal hormonal therapy. Study design, materials and methods. The study involved 62 patients aged 42 to 55 years. The main group included 33 women who were prescribed Mirena in combination with EstroGel. The control group consisted of 29 women who were prescribed a combined two-phase tablet preparation containing micronized 17-estradiol as an estrogen component and dydrogesterone as a gestagen component. The condition of the patients was evaluated at the beginning of therapy and after 3, 6 and 12 months. Results. During therapy, patients in the main group decreased climacteric symptoms and improved lipid profile and blood biochemical parameters characterizing the hepatobiliary system. Patients in the control group had a comparable decrease in menopausal symptoms; however, there were changes in biochemical parameters, such as hypertriglyceridemia and a significant increase in bilirubin and transaminases, which required discontinuation of therapy. All the patients using Mirena in combination with EstroGel demonstrated good tolerability, efficiency of the therapy and no significant symptoms requiring its withdrawal. During the menopausal hormonal therapy, there were no cases of relapse of endometrial hyperplasia, growth of myomatous nodes and an increase in endometriosis prevalence. Patients in the control group during the first three months of therapy noted acyclic spotting, breast engorgement and tenderness, headaches, and exacerbation of cholelithiasis, which resulted in decreased adherence to therapy. Conclusion. The use of estrogen transdermally in combination with the intrauterine administration of levonorgestrel is an effective and safe method that helps to relieve menopausal symptoms and to improve the health and quality of life of women with extragenital pathology, endometrial and mammary gland hyperplastic processes, endometriosis, and menometrorrhagia.

scholarly journals The role of cholecalciferol in the pathogenesis of polycystic ovary syndrome

2021 ◽  
Vol 8 (1) ◽  
pp. 48-54
Author(s):  
Aigul T. Safi ◽  
Aigerim B. Ospanova ◽  
Svetlana Yu. Kalinchenko ◽  
Mekan R. Orazov
Keyword(s):  
Waist Circumference ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Laboratory Data ◽  
Density Lipoprotein ◽  
Main Group ◽  
Control Group ◽  
Nominal Data ◽  
Ovary Syndrome ◽  
Significant Difference

Objective to evaluate and compare clinical, anamnestic and laboratory data of patients with polycystic ovary syndrome (PCOS) and without syndrome, including the level of vitamin 25(OH) D3. Material and methods. In this work, 81 patients were examined, who, at the 1st stage of the study, were divided into two groups depending on the presence or absence of signs of PCOS. The main group included 51 patients with signs of PCOS. The control group included 30 healthy women without signs of PCOS, matched by sex and age with the main group. The main and control groups were compared by clinical and anamnestic data, including birth weight, by the presence of complications of pregnancy and childbirth in their mothers during their gestation, by the level of vitamin D. PCOS was verified on the basis of diagnostic criteria Rotterdam (2003) and International guidelines on PCOS (2018). Vitamin 25(OH)D3 was determined by mass spectrometry (ng/ml). At the 2nd stage of the study, the main group with PCOS was divided into 2 subgroups depending on the waist circumference (WT). Subsequently, the subgroups were compared with each other in the same parameters as at stage 1, as well as in the level of insulin, low-density lipoprotein (LDL), triglycerides (TG), anti-Mllerian hormone (AMH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). To reflect the statistical results, the parametric parameters of the Students t-test were applied for two independent samples with equal or different variance. For nominal data Pearsons Chi-test, when the means are not calculated and a test is carried out for the presence of a relationship between nominal variables. Results. There was no statistically significant difference in vitamin 25(OH)D3 levels in patients with and without PCOS. Statistically significant differences in vitamin 25(OH)D3 levels were found in women with PCOS, depending on the waist circumference (WT). In these subgroups, differences were also found in the level of insulin, LDL, TG. Conclusion. The values of the level of vitamin 25(OH)D3 do not differ in the groups of patients with PCOS and without PCOS, but significantly correlate with the metabolic profile of patients.

scholarly journals Characteristics of somatic dysfunctions in pregnant women with chronic pyelonephritis

2019 ◽  
pp. 42-55 ◽  
Author(s):  
E. N. Nenashkina ◽  
E. S. Tregubova ◽  
V. O. Belash
Keyword(s):  
Pregnant Women ◽  
Kidney Diseases ◽  
Laboratory Data ◽  
Pain Syndrome ◽  
Main Group ◽  
Chronic Pyelonephritis ◽  
Control Group ◽  
Lumbar Region ◽  
Thoracic Region ◽  
Pelvic Region

Introduction. Chronic pyelonephritis occupies one of the fi rst places in the structure of extragenital pathologies of pregnant women. The approach to the treatment of pyelonephritis in pregnancy consists in the use of both pharmacological and non-pharmacological methods of treatment. One of the non-medicamentous methods is osteopathic correction of somatic dysfunctions. However, the structure of these functional disorders is virtually unexplored.Goal of research — to describe somatic dysfunctions (SDs) in pregnant women with chronic pyelonephritis before and after osteopathic correction, as well as to defi ne its effect on the intensity of subjective indices.Materials and methods. A simple longitudinal randomized study conducted in 2016–2018 on the clinical basis of the St. Petersburg Institute of Osteopathy — LLC «Mokhov Institute of Osteopathy» included 120 pregnant women aged 25–45 years with a gestation period of 13–27 weeks. All pregnant women with chronic pyelonephritis were divided into two groups with the use of random number generator. The two groups of 30 people each were comparable in age, parity, presence of concomitant pathology and the duration of the disease. The main group received pharmacological and osteopathic treatment, the control group received only pharmacological treatment. In a similar way, a comparison group of women comparable in age and parity was formed. It included 60 pregnant women in the second trimester of pregnancy without clinical, instrumental and laboratory data of chronic kidney diseases; the patients of this group underwent dynamic observation. All patients were subjected to clinical obstetrical and osteopathic examination. The severity of the pain syndrome was assessed with the use of the visual analogue scale.Results. In the course of osteopathic diagnostics, the following dominant SDs have been revealed: in patients with chronic pyelonephritis, a global rhythmogenic disorder of the development of the cranial rhythmic impulse (GRD (C)) — 26,7 %, a global neurodynamic disorder (psycho-viscero-somatic) — 25 %, regional SDs: the lumbar region — 33,3 %, the pelvic region — 6,7 %, and the thoracic region — 5 %; in healthy pregnant women, GRD (C) — 6,7 %, GNDD (PVS) — 6,7 %, and regional SDs: the pelvic region — 28,3 %, the thoracic region — 23,3 % and the duramatral region — 26,7 %. As a result of osteopathic correction of SDs in patients with chronic pyelonephritis, there was a decrease in the total number of SDs (from 174 to 30) and a change in their structure (global before the treatment and local after the treatment). The severity of the pain syndrome in accordance with the VAS has also decreased from 29±3,16 to 11±0,79 points in the main group, whereas in the control group it has increased from 20±1,78 to 26±1,53.Conclusion. In pregnant women with chronic pyelonephritis, the majority of SDs manifest themselves at the global level, whereas in healthy pregnant women, most dysfunctions are regional. Osteopathic correction of SDs in complex therapy of pregnant women with chronic pyelonephritis signifi cantly contributes to the reduction of the pain syndrome according to the VAS compared with isolated traditional pharmacological therapy.

scholarly journals Features of coagulation hemostasis and anticoagulation system in patients with chronic heart failure due to ischemic heart disease

2015 ◽  
Vol 96 (5) ◽  
pp. 716-722 ◽  
Author(s):  
G Kh Mirsaeva ◽  
N N Mironchuk
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Heart Disease ◽  
International Normalized Ratio ◽  
Main Group ◽  
Functional Class ◽  
Control Group ◽  
General Group ◽  
Cofactor Activity ◽  
D Dimer

Aim. To study the features of coagulant and anticoagulant systems in patients with varoious functional classes of congestive heart failure secondary to coronary heart disease (according to New York Heart Association criteria) and to determine the most informative method for diagnosing the hemostasis disorders. Methods. 82 patients with congestive heart failure, who had previously survived myocardial infarction with Q-wave formation, and left ventricle ejection fraction (by Simpson) less than 50%, were included. Average age was 54.0 [50.0-64.0] years. Control group of 30 healthy people was formed. All patients were allocated to two groups. 1st group included patients with I-II functional class of congestive heart failure (n=57), 2nd group - patients with III-IV functional class of congestive heart failure (n=25). Activated partial thromboplastin time, prothrombin and fibrinogen levels, international normalized ratio, heparin cofactor activity of antithrombin, D-dimer level were measured in blood serum. Results. Only D-dimer level and heparin cofactor activity of antithrombin were changed in the main group compared to the controls. D-dimer level in patients of the general group was 0.2 [0.2-0.4] mg/L versus 0.2 [0.2-0.2] mg/L in control group (p=0.000064). There was no obvious deficit of heparin cofactor activity of antithrombin in patients with congestive heart failure, but the values were lower in the main group - 90.5 [82,7-100,4]% compared to the control group - 102 [90,0-104,0]% (p=0.0068). In subgroups, there were indicators (prothrombin, international normalized ratio, D-dimer) that changed according to the functional class. The lowest values of prothrombin were found in patients with III-IV functional class, the highest - in patients with I-II functional class. Indicators (prothrombin, INR, D-dimer) which changing with the growth of CHF FC were identified by separating the patients into subgroups. FC, the largest - in patients with FC I-II. Serum D-dimer level increased in accordance with congestive heart failure functional class (р1-2=0.0065). Conclusion. Congestive heart failure contributes to prothrombotic changes in hemostasis. The severity increases with increasing congestive heart failure functional class. D-dimer is the most sensitive marker of hemostasis activation at congestive heart failure. This parameter should be included in the routine hemostasis testing in patients with congestive heart failure.

scholarly journals Signs of connective tissue dysplasia in women with genital prolapse

2021 ◽  
Vol 15 (1) ◽  
pp. 32-40
Author(s):  
A. S. Ustyuzhina ◽  
M. A. Solodilova ◽  
A. V. Polonikov ◽  
S. P. Pakhomov ◽  
U. G. Shokirova
Keyword(s):  
Pelvic Organ Prolapse ◽  
Connective Tissue ◽  
Varicose Veins ◽  
Genital Prolapse ◽  
Pelvic Organ ◽  
Main Group ◽  
Control Group ◽  
Systematic Analysis ◽  
Healthy Women ◽  
Connective Tissue Dysplasia

Introduction. Despite a long history of the disease, genital prolapse still have not been definitively solved. A relevance of pelvic organ prolapse in women has been increasing in recent years largely due to a change in the quality of life and desire to sustain their youth. The number of studies pinpointing the cause of the disease in connective tissue dysplasia (CTD) has been increasing annually.Aim: to conduct a systematic analysis and determine most common signs of CTD in women with genital prolapse.Materials and methods. CTD criteria and the relationship with genital prolapse were analyzed. The study was conducted using questionnaires and including clinical studies examining residents of the Belgorod region (135 women). The main group included 91 patients who had signs of pelvic organ prolapse, and control group consisted of 44 healthy women. CTD intensity score proposed by T.Yu. Smolnova et al. (2003) was used to assess signs of dysplasia in women examined allowing to build up three groups in which each symptom was evaluated as severity score.Results. Asthenic constitution was noted in high percentage of women suffering from genital prolapse (16.70 ± 0.38 %) compared with healthy women (2.30 ± 0.15 %; p = 0.016). Mild bruising, increased tissue bleeding tended to rise in main vs. control group (16.50 ± 0.37 % in main group and 0.0 in control group; p = 0.016). Signs of varicose veins and hemorrhoids requiring no surgical treatment were found in 33.00 ± 0.47 % and 4.50 ± 0.21 % in main vs. control group (p = 0.0002), respectively. Genital prolapse and hernia in first-line relatives were recorded in 9.90 ± 0.30 % in main group (p = 0.031), women without signs of prolapse did not indicate prolapse in close relatives.Conclusion. Asthenic constitution, hernias, varicose veins and hemorrhoids, female pelvic and hernial prolapse in close female relatives, a tendency to mild bruising, skeletal anomalies, elastosis skin were among common CTD signs in women with genital prolapse.

scholarly journals Features the nutritional status of children with relapsing respiratory pathology

2019 ◽  
pp. 188-194
Author(s):  
N. A. Druzhinina ◽  
L. M. Nasibullina ◽  
D. R. Merzlyakova ◽  
R. Z. Akhmetshin ◽  
G. P. Shiryaeva ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Preventive Measures ◽  
Component Composition ◽  
Main Group ◽  
The Body ◽  
Control Group ◽  
Healthy Children ◽  
Laboratory Parameters ◽  
Respiratory Pathology ◽  
Nutritional Status Of Children

A survey of 182 children aged 5 to 9 years in the children’s sanatorium «Duslyk» Ufa. A survey of 182 children aged 5 to 9 years in the children’s sanatorium «Duslyk» Ufa.The main group included 101 children with relapsing respiratory pathology, the control group 81 healthy children. The article presents an analysis of the actual weekly diet of children at home, modern approaches to the study of nutritional status using clinical, biochemical, anthropometric, somatometric methods, bioimpedance measurements. The actual nutrition of children with relapsing respiratory pathology was characterized by an imbalance in the content of the main nutrients. A comprehensive assessment of nutritional status revealed malnutrition in children of the main group. The aim of the study was to assess the actual nutrition, the study of nutritional status, taking into account the clinical and laboratory parameters and the component composition of the body of children in the children’s sanatorium. The inclusion of an assessment of actual nutrition and nutritional status in the survey program will make it possible to timely identify malnutrition in children with relapsing respiratory pathology, purposefully carry out preventive measures.

Urinary Tract Infection in Adults: Ways of Optimization of Complex Therapy

2016 ◽  
pp. 18-25
Author(s):  
Iryna Shifris ◽  
Iryna Dudar ◽  
Olena Loboda ◽  
Viktor Krot ◽  
Eduard Krasyuk ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pathogenic Bacteria ◽  
Comparison Group ◽  
Main Group ◽  
Herbal Remedies ◽  
Control Group ◽  
Antibacterial Drug ◽  
Laboratory Parameters

The aim of the research: to study the efficacy of using Solidagoren in the complex treatment of the urinary tract infection (UTI). Materials and methods. The study involved patients (n=51) aged from 18 to 65 years. All patients were verified UTI. The patients were divided into two groups: the main group (n=30) were prescribed an antibacterial drug in combination with medicinal herbal remedies Solidagoren; comparison group (n=21) who underwent only antibacterial therapy. The patient group was representative in terms of demographic indicators, nosology of UTI, course of the disease before the study began. The duration of antibiotics depended on the clinical variant of UTI and the dynamics of the main clinical and laboratory parameters. The duration of treatment with the help of Solidagoren was 30 days for all patients. Clinical studies, complaints, data of objective status were assessed in dynamics three times: at the beginning of treatment, on the 4-th to 7-th day and on the 30-th day of observation. Bacteriological examination of urine was performed twice before treatment and on 17-20 day. Evaluation of the overall clinical efficacy was performed according to the dynamics of subjective and objective criteria for each patient. Results. According to the results of microbiological study the pathogenic bacteria identified in 100% of cases. Only 57 selected strains of conditionally pathogenic aerobic bacteria: in 45 patients in the form of monoculture, 6 patients in the form of microbe associations. Among the isolated strains, more than 70% were gram1negative bacteria, dominated by Escherichia coli (56,14%). Gram1positive cocks in the structure of pathogens of UTI were around 30%. It was found that patients in the comparison group normalization of laboratory values (leukocytosis, proteinuria, leukocyturia) were significantly slower than in the main group. Patients of the main group with symptoms such as lower back pain, dysuria, loss of appetite, weakness, already after 4-7 days of treatment bothered much less and this trend was observed for further observation. Eradication of the pathogen detected in 26 (86,7%) patients of the main group and only in 11 (52,3%) patients of the control group. Not established negative influence of the drug Solidagoren to the level of GFR. Conclusion. The results of the study found that the use of the drug Solidaire in the treatment of UTI has a positive influence on dynamics of clinical and laboratory parameters, was well tolerated, promotes rapid eradication of pathogens UTI.

scholarly journals Ozone therapy as a component of a comprehensive rehabilitation program for patients after polysegmental pneumonia associated with SARS-CoV2 infection

2021 ◽  
Vol 23 (6) ◽  
pp. 752-758
Author(s):  
I. B. Baranova ◽  
A. F. Gumeniuk ◽  
A. I. Semenenko ◽  
I. A. Iliuk ◽  
I. P. Osypenko
Keyword(s):  
Oxygen Saturation ◽  
Cost Effective ◽  
Integrated Approach ◽  
Rehabilitation Program ◽  
Main Group ◽  
Control Group ◽  
Ozone Therapy ◽  
Reactive Protein ◽  
Blood Biochemical ◽  
6 Minute Walk Test

Aim: to analyze the effectiveness of intravenous ozone therapy in long COVID-19 patients experienced community-acquired polysegmental pneumonia (associated with SARS-CoV2 infection). Materials and methods. The study involved 42 long COVID-19 individuals aged 41–82 years who underwent rehabilitation after community-acquired polysegmental pneumonia associated with SARS-CoV2 infection. The patients were examined and followed up subjectively (by the G. Borg and PCFS scales) and objectively (oxygen saturation, C-reactive protein, ferritin, D-dimer, urea and creatinine, 6-minute walk test). All patients received similar medicamentous therapy, and combined intravenous ozone therapy was additionally prescribed to the main group patients (n = 21): an alternate-day infusion of 200 ml ozonized saline at a concentration of 20 mg/ml and major autohemotherapy (100 ml ozonized saline at a concentration of 30 mg/ml mixed with 100 ml of the patient’s blood), 10 sessions per treatment course. Results. The integrated approach to the complex program of long COVID-19 treatment and rehabilitation for patients after pneumonia associated with SARS-CoV2 infection using intravenous ozone therapy has demonstrated its significant effectiveness based on the objective and subjective findings (P < 0.01). Twice as many patients in the main group (n = 18) achieved endpoints of the study (absence of dyspnea, normalization of blood biochemical markers and oxygen saturation levels, restoration of exercise tolerance) as compared to the control group (n = 9). Conclusions. The use of combined intravenous ozone therapy (alternating infusion of ozonized saline and ozonized saline mixed with the patient’s blood) in the rehabilitation program for patients after experienced community-acquired polysegmental pneumonia associated with SARS-CoV2 infection is pathogenetically substantiated, effective and cost-effective addition to complex health recovery tools.

The experience of using a bacteriophages-based complex antibacterial and analgesic drug in gel formulation in women who underwent various instrumental and diagnostic and treatment interventions

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (3) ◽  
pp. 42-48
Author(s):  
Alexander O. Vasilyev ◽  
Natalia A. Sazonova ◽  
Vladimir D. Melnikov ◽  
Amir F. Gabdullin ◽  
Andrei V. Zaitsev ◽  
...  
Keyword(s):  
Pathogenic Bacteria ◽  
Laboratory Data ◽  
Main Group ◽  
Control Group ◽  
Analgesic Drug ◽  
Antibacterial Drugs ◽  
Bacteriological Analysis ◽  
Topical Gel ◽  
Number Of Patients ◽  
Analysis Of Urine

During the spread of bacterial infections with extensive drug resistance, the potential of existing antibacterial drugs is significantly reduced. The medical community is seeking opportunities for the rational use of antibacterial drugs, the development of new drugs, as well as the use of alternative treatments for these infections. Aim. The objective of this study was to evaluate the effectiveness of the use of a complex antibacterial and analgesic drug based on bacteriophages in gel form during various instrumental studies and diagnostic procedures in order to minimize the risk of the urinary system infections complications. Materials and methods. The study included 235 women aged 18 to 75 years who underwent treatment at the Moscow State Clinical Hospital named after Spasokukotsky and in the clinic of urology of Moscow State University of Medicine and Dentistry from September 2019 to January 2020. During the manipulation, all patients of the main group (n=120) used a developed preparation based on bacteriophages, and in the control group (n=115), a topical gel based on chlorhexidine dihydrochloride and lidocaine hydrochloride was used. All patients before the manipulation, as well as 10 days after the manipulation, underwent bacteriological analysis of urine. Efficiency assessment was carried out on the basis of laboratory data obtained, as well as according to the visual analogue scale of the pain syndrome severity. Results. None of the patients in the main group showed intolerance, side effects and allergic reactions of the developed drug based on bacteriophages. Bacteriological analysis of urine received before manipulation in both groups showed the absence of clinically significant titers of pathogenic bacteria, while 1 week after manipulation the number of titers of pathogenic bacteria (104) was significantly higher in the control group (p0.04). In patients of the main group, the incidence of dysuria was lower compared with the control group (p0.05). Conclusion. The study showed good tolerance of the developed drug and its clinical effectiveness in reducing the number of symptomatic bacteriuria; severity of pain after undergoing manipulation was relatively lower in the main group of patients. Conducting multicenter studies with the inclusion of a larger number of patients in the future will reduce the economic costs associated with treating patients by reducing the number of cases of nosocomial infections and reducing postoperative time spent by patients in the hospital.

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