Digitalisasi sebagai upaya adaptif industri pasar modal di era disruption: dampak pada eksistensi WPPE di masa pandemi Covid-19

This research is based on the number of securities companies that have begun to focus on the phenomenon of their business on online services, both online account opening and online trading media transactions as an effort to adapt to the current disruption. The research was conducted with a qualitative approach, by triangulating research data. Not all data were obtained in full due to limited access obtained by researchers. From the results of the study, there was an increase in the number of investors in the capital market during the COVID-19 pandemic. On the other hand, there is a decrease in the number of securities companies that are members of the stock exchange, as well as the WPPE licensed brokerage profession which is facing serious challenges due to this phenomenon.

Urban Zoning for Sustainable Tourism: A Continuum of Accommodation to Enhance City Resilience

While governments around the world are embarking on the path to recovery from the COVID-19 crisis, sustainable tourism planning is crucial, in particular in the hospitality sector, which enhances the resilience of destinations. However, many destination management models overlook the role of urban zoning. Little is known about the impacts of land-use zoning on the hospitality and property industries, especially with the current disruption of short-term peer-to-peer accommodation like Airbnb. Euclidean zoning, also known as effects-based planning, has long been criticised in destination management for its exclusionary nature and lack of flexibility. With exclusionary zoning, property owners may only be able to use their land sub-optimally, and cities will be less efficient in responding to market changes in short-term and long-term accommodation demands, but planning intentions can be better controlled, and the property supply can be more stable. Taking Hong Kong as a noteworthy case, this study puts forward a conceptual framework that enables comparison of a novel zoning approach with the traditional zoning approach. This novel zoning approach encompasses both the short- and long-term rental sectors as a continuum of accommodation, ranging from hotels and serviced apartments to Airbnb and rental housing units under a unified regulatory and planning regime to enhance the switching options value. This novel zoning system can gear up the tourism sector with the rapid growth of the sharing economy and aligns with sustainable tourism to ensure long-term socioeconomic benefits to related stakeholders. We extract the data of Airbnb listings to construct the first Airbnb ADR Index (ADRI) by Repeat-sales method, and the results support our Switching Option Hypothesis.

Plasma sheet thinning due to loss of near-Earth magnetotail plasma

A one-dimensional (1-D) model for thinning of the Earth's plasma sheet (Chao et al., Planet. Space Sci., vol. 25, 1977, p. 703) according to the current disruption (CD) model of auroral breakup is extended to two dimensions. A rarefaction wave, which is a signature component of the CD model, is generated with an initial disturbance. In the 1-D gas model, the rarefaction wave propagates tailward at sound velocity and is assumed to cause thinning. Extending to a two-dimensional (2-D) gas model of a simplified plasma sheet configuration, the rarefaction wave is weakened, and the thinning ceases to propagate. Extending further to a 2-D plasma model by adding magnetic field into the lobes, the rarefaction wave is quickly lost in the plasma sheet recompression, but the plasma sheet thinning is still present. It propagates at a slower velocity than a 1-D model suggests, behind a wave train of pulses of increased pressure generated by the thinning process itself. This shows that the dynamics of plasma sheet thinning may be dominated by sheet–lobe interactions that are absent from the 1-D model and may not support the behaviour assumed by the CD model.

Impact of Blockchain on E-Commerce

The current disruption has created many challenges for all businesses in the short run, but it has created many opportunities in the long time. By helping in crisis and recovery, blockchain can play a prominent role in accelerating post-crisis digital transformation initiatives. Trade has become more efficient, more inclusive, and less costly through blockchain. These innovative technologies in the fourth industrial revolution are transforming the world by making the processes more inclusive and efficient.

Sports Medicine Considerations During the COVID-19 Pandemic

The outbreak of the novel coronavirus (COVID-19) has resulted in upward of 14 million confirmed cases and >597,000 deaths worldwide as of July 19, 2020. The current disruption in sports activities caused by COVID-19 presents a challenge to physicians, coaches, and trainers in discerning best practices for a safe return to sport. There is a distinct need to develop and adopt consistent measures for resumption of sports activities, including training and competition, in a way that places the health and well-being of athletes at the forefront while also protecting coaches, allied staff, and spectators. This article provides an overview of the effects of COVID-19 in the athletic population and presents considerations for training during the pandemic, as well as guidelines for return to sports as restrictions are lifted.

Polar substorm on 7 December 2015: preonset phenomena and features of auroral breakup

Comprehensive analysis of a moderate 600 nT substorm was performed using simultaneous optical observations inside the auroral oval and in the polar cap, combined with data from satellites, radars, and ground magnetometers. The onset took place near the poleward boundary of the auroral oval that is not typical for classical substorms. The substorm onset was preceded by two negative excursions of the interplanetary magnetic field (IMF) Bz component, with a 1 min interval between them, two enhancements of the antisunward convection in the polar cap with the same time interval, and 15 min oscillations in the geomagnetic H component in the auroral zone. The distribution of the pulsation intensity along meridian has two local maxima, namely at the equatorial and poleward boundaries of the auroral oval, where pulsations occurred in the out-of-phase mode resembling the field line resonance. At the initial stage, the auroral breakup developed as the auroral torch stretched and expanded poleward along the meridian. Later it took the form of the large-scale coiling structure that also distinguishes the considered substorm from the classical one. Magnetic, radar, and the Active Magnetosphere and Planetary Electrodynamics Response Experiment (AMPERE) satellite data show that, before the collapse, the coiling structure was located between two field-aligned currents, namely downward at the poleward boundary of structure and upward at the equatorial boundary. The set of GEOTAIL satellites and ground data fit to the near-tail current disruption scenario of the substorm onset. We suggest that the 15 min oscillations might play a role in the substorm initiation.

Learning in the time of COVID-19: capitalizing on the opportunity presented by the pandemic

PurposeThis paper addresses the current disruption in the educational status quo ante that has been caused by the worldwide outbreak of COVID-19. Its purpose is to suggest how practicing educators, their professional associations and the university-based researchers with whom they partner might capitalize on the unanticipated opportunity to impact education policy that the pandemic presents.Design/methodology/approachThe author draws upon his own preparation and experiences – first as a long-time practitioner in the elementary and secondary school setting, then as a university professor – to offer insights and suggestions to practicing educators, their professional associations and the university-based researchers with whom they partner.FindingsDespite the unexpected challenges that the COVID-19 pandemic has presented to educators – challenges to which educators around the globe have risen admirably – the current crisis also affords practicing educators, their professional associations and the university-based researchers with whom they partner to change the status quo ante for the better.Originality/valueThe particular value of this piece is twofold: its analysis of the impact of this unanticipated crisis upon education by an author who has served both in the elementary/secondary setting and at the university level, and its assertion that educators must avail themselves of this once-in-a-lifetime opportunity to change the educational status quo ante for the better.

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

The human ether-a-go-go-related voltage-gated cardiac ion channel (commonly known as hERG) conducts the rapid outward repolarizing potassium current in cardiomyocytes (IKr). Inadvertent blockade of this channel by drug-like molecules represents a key challenge in pharmaceutical R&D due to frequent overlap between the structure-activity relationships of hERG and many primary targets. Building on our previous work, together with recent cryo-EM structures of hERG, we set about to better understand the energetic and structural basis of promiscuous blocker-hERG binding in the context of Biodynamics theory. We propose a two-step blocker binding process consisting of: Diffusion of a single fully solvated blocker copy into a large cavity lined by the intracellular cyclic nucleotide binding homology domain (the initial capture step). Occupation of this cavity is a necessary but insufficient condition for ion current disruption.Translocation of the captured blocker along the channel axis (the IKr disruption step), such that: The head group, consisting of a quasi-linear moiety, projects into the open pore, accompanied by partial de-solvation of the binding interface.One tail moiety packs along a kink between the S6 helix and proximal C-linker helix adjacent to the intra-cellular entrance of the pore, likewise accompanied by mutual de-solvation of the binding interface (noting that the association barrier is comprised largely of the total head + tail group de-solvation cost).Blockers containing a highly planar moiety that projects into a putative constriction zone within the closed channel become trapped upon closing, as do blockers terminating prior to this region.A single captured blocker molecule may associate and dissociate from the pore many times before exiting the CNBHD cavity.Lastly, we highlight possible flaws in the current hERG safety index (SI) and propose an alternate in vivo-relevant strategy factoring in: Benefit/risk.The predicted arrhythmogenic fractional hERG occupancy (based on action potential simulations of the undiseased human ventricular cardiomyocyte).Alteration of the safety threshold due to underlying disease.Risk of exposure escalation toward the predicted arrhythmic limit due to patient-to-patient pharmacokinetic variability, drug-drug interactions, overdose, and use for off-label indications in which the hERG safety parameters may differ from their on-label counterparts.

Polar substorm on 7 December 2015: pre-onset phenomena and features of auroral breakup

Comprehensive analysis of a moderate 600-nT substorm was performed with using simultaneous optical observations inside the auroral oval and in the polar cap, combined with data from satellites, radars, and ground magnetometers. The onset took place near the poleward boundary of the auroral oval that is not typical for classical substorms. The substorm onset was preceded by two negative excursions of the IMF Bz component with 15-min interval between them, two enhancements of the antisunward convection in the polar cap with the same repetition period, and 15-minute oscillations in geomagnetic H-component in the auroral zone. The distribution of the pulsation intensity along meridian has two local maxima – at equatorial and poleward boundaries of the auroral oval where pulsations occurred in the out-of-phase mode resembling the field-line resonance. At initial stage, the auroral breakup developed as auroral torch stretching and expanding poleward along the meridian. Some later it took a form of the large-scale coiling structure that also distinguishes the considered substorm from classical one. Magnetic, radar and AMPERE satellite data show that before the collapse the coiling structure was located between two field-aligned currents: downward at poleward boundary of structure and upward at equatorial boundary. The set of GEOTAIL satellite and ground data fits to the near-tail current disruption scenario of the substorm onset. We suggest that the 15-min oscillations might play a role in the substorm initiation.