Relationship between quality of life and physical fitness in adults with intellectual disabilities

Purpose People with intellectual disabilities have lower levels of physical fitness compared with peers without intellectual disability, because of the high levels of sedentary behaviour in this population. This study aims to know the relationship between quality of life and physical fitness in adults with intellectual disability. Design/methodology/approach Ninety-six adults with intellectual disability were assessed with quality of life questionnaire and physical fitness tests, which involve balance, muscle strength, flexibility and aerobic condition. Findings Adults with higher self-reported levels of quality of life reported higher levels of physical fitness in balance, muscular strength and flexibility. In contrast, in aerobic condition were not found significant correlations with self-reported quality of life. Originality/value These findings support the hypothesis that people with intellectual disability with lower levels of physical fitness could influence in their levels of quality of life. This insight is useful for improving treatments to improve physical fitness in this population.

Microfossil as proxy for palaeoclimate and palaeoceanography

Recent global warming has been addressed due to human activity that causes increased greenhouse gases. However, there are inherent uncertainties in the statement, one of them is the level of natural variability inherent in the climate system. Climate data from measuring instruments are not long enough to evaluate climate variability and current climate evolution. Therefore, we need climate data that has a long back span. To get adequate past climate data, we need natural phenomena which are climate dependent. This natural phenomenon provides a proxy record of the climate. This study of proxy data is the foundation of palaeoclimatology and paleoceanography. Microfossils (i.e., foraminifera, palynomorphs, nannofossils) which in geology are used as a standard tool in biostratigraphy for both age determination and paleoenvironment and correlation, can also be used as a proxy for obtaining paleoclimate and paleoceanography data. Using microfossil as a proxy to study past climate and paleoceanography, we need an understanding of the type of proxy data available and methods used in their analysis.In addition to the dating method (biostratigraphy), there are many climate and oceanography parameters that can be obtained from microfossil proxies such as: sea surface temperature (SST), sea surface salinity, (SST) climate (warm, cold, dry, wet), precipitation, productivity, oxygen content and organic carbon level, deep sea current and ventilation/upwelling, thermocline and mixed layer, variability deep water properties, CCD, bathymetry, sea level change and dissolution. The methods to obtain data fall into some categories e.g., faunal/floral displacement, morphology changes, transfer function/modern analog and isotopic content. Another method that can be used is observing microfossil assemblages and link them to ecological changes associated with climate change and its paleoceanography.A paleoclimate and paleoceanography study using microfossil proxies has been conducted in the Cendrawasih bay, Papua, Indonesia. The study shows that climate in the tropical west Pacific margin (Cendrawasih bay) during Late Pleistocene to Holocene shows high variability. There are nineteen climate changes occurred during Holocene. Early Holocene dated as ca. 11,800-year BP marked by rapid warming with SST differences to last glacial is about 4oC. Early to Middle Holocene (ca. 5960-year BP) marked by increasing temperature up to 2oC, interrupted by cooling at ca. 11230-, 8310- and 7120-years BP. At Middle Holocene temperature decreased rapidly and reached its peak at around ca. 3150-year BP. After cooling at ca. 3150-year BP, temperature increased and then decreased with its peak at ca. 1710-year BP. Since ca. 1710-year BP to Recent, temperature shows warming trend. SST from MAT indicates warming environment near to 1.5oC. The warming trend was interrupted by rapid cooling and warming at ca. 300-year BP. This last warming trend indicates that global warming had started before industrial era and rapid cooling, or warming can occur without anthropogenic gases influence. The typical Holocene climate of warm-wet, dry-cold reverse and become warm-dry, cold-wet during ca. 790-370-year BP and then reversed back to preceding state.Semi-restricted basin occurred since last glacial with anaerobic condition and estuarine circulation system. Warming during interstadial 1e-1a, causing reverse water circulation and basin become sub-aerobic with anti-estuarine circulation. A lot of terrestrial organic matter flow to the bay and increase acidity and carbonate dissolution. High sedimentation found occurred during glacial period especially at the end of glacial period. Rapid warming during late glacial to middle Holocene, rising relative sea level and the bay become more open marine with well oxygenated bottom water and high marine productivity. Warm temperature and deeper thermocline depth (~ 250 m) in west Pacific occurred up to ca. 5960-year BP. Decreasing Sea surface temperature at ca. 5960-year BP and drop of relative sea level causing sub-aerobic condition inside bay. The semi-restricted state with sub-aerobic condition occurred up to Recent.Distribution of Sphaeroidinella group in the tropical west Pacific shows strong correlation with thermocline depth and reflect El Niño frequency event. Early middle Holocene dominated by La Niña-like condition and since Middle Holocene (ca. 5960-year BP) frequent El Niño event began to occur.

Synthesis of Atmospherically Stable Zero-Valent Iron Nanoparticles (nZVI) for the Efficient Catalytic Treatment of High-Strength Domestic Wastewater

Here, we report the fabrication of nZVI by the wet chemical technique in the presence of ethanol using ferric iron and sodium borohydride as the reducing agents under ambient conditions. The obtained nZVI particles are mainly in a zero-valent oxidation state and do not undergo significant oxidation for several weeks. The structural and morphological parameters of nZVI were investigated by using UV, XRD, SEM, EDX, TEM, and DLS analysis. The optical nature, bandgap energy, and absorption edge were all revealed by the UV–visible spectrum. The phase development and crystallinity of nZVI particles were shown by the XRD pattern. The morphological investigation revealed that the nanoparticles were spherical with an average size of 34–110 nm by using ImageJ software, and the elemental analysis was analyzed using EDX. Furthermore, the catalytic treatment performance of domestic wastewater was evaluated in terms of pH, COD (chemical oxygen demand) solubilization, total solids (TS), volatile solids (VS), phosphorous, and total nitrogen (TN) reduction under aerobic and anaerobic operating conditions. The effluent was subjected to a process evaluation with a different range (100–500 mg/L) of nZVI dosages. The COD solubilization and suspended solids reduction were significantly improved in the anaerobic condition in comparison to the aerobic condition. Furthermore, the effect of nZVI on phosphorous (PO43−) reduction was enhanced by the electrons of iron ions. The high concentration of nZVI dosing has a positive impact on COD solubilization and phosphorous removal regardless of the aeration condition with 400 mg/L of nZVI dosage.

A hydrated 2,3-diaminophenazinium chloride as a promising building block against SARS-CoV-2

Phenazine scaffolds are the versatile secondary metabolites of bacterial origin. It functions in the biological control of plant pathogens and contributes to the producing strains ecological fitness and pathogenicity. In the light of the excellent therapeutic properties of phenazine, we have synthesized a hydrated 2,3-diaminophenazinium chloride (DAPH+Cl−·3H2O) through direct catalytic oxidation of o-phenylenediamine with an iron(III) complex, [Fe(1,10-phenanthroline)2Cl2]NO3 in ethanol under aerobic condition. The crystal structure, molecular complexity and supramolecular aspects of DAPH+Cl− were confirmed and elucidated with different spectroscopic methods and single crystal X-ray structural analysis. Crystal engineering study on DAPH+Cl− exhibits a fascinating formation of (H2O)2…Cl−…(H2O) cluster and energy framework analysis of defines the role of chloride ions in the stabilization of DAPH+Cl−. The bactericidal efficiency of the compound has been testified against few clinical bacteria like Streptococcus pneumoniae, Escherichia coli, K. pneumoniae using the disc diffusion method and the results of high inhibition zone suggest its excellent antibacterial properties. The phenazinium chloride exhibits a significant percentage of cell viability and a considerable inhibition property against SARS-CoV-2 at non-cytotoxic concentration compared to remdesivir. Molecular docking studies estimate a good binding propensity of DAPH+Cl− with non-structural proteins (nsp2 and nsp7-nsp-8) and the main protease (Mpro) of SARS-CoV-2. The molecular dynamics simulation studies attribute the conformationally stable structures of the DAPH+Cl− bound Mpro and nsp2, nsp7-nsp8 complexes as evident from the considerable binding energy values, − 19.2 ± 0.3, − 25.7 ± 0.1, and − 24.5 ± 0.7 kcal/mol, respectively.

Study of Coefficient of Variation, Heritability and Genetic Advance for Different Traits of Rice Genotypes Grown under Aerobic Condition

The field experiments with thirty genotypes were conducted during June to October month of kharif, 2018 and kharif, 2019, to assess extent of variability under aerobic condition. The genotypes were sown under dry direct seeded condition using randomized block design (RBD) with three replications. Each genotype was sown in single row of 5 m length with spacing of 20 cm between rows and 15 cm between plants. Data recorded for 22 characters including different morphological and quality traits from 5 randomly selected plants of each replication and mean data used for analysis. ANOVA revealed that the mean sum of squares were highly significant difference for most of the traits. The value of PCV was higher than GCV for all the twenty-two characters. However, maximum GCV and PCV were observed for root dry weight plant-1 (31.44% and 32.17%) followed grain yield plant-1 (29.97% and 31.03%), root volume (28.62% and 29.20%), root fresh weight plant-1 (28.51% and 29.08%), biological yield plant-1 (21.86% 22.50%) and number of grains panicle-1 (20.55% and 21.37%). Rest of the traits showed moderate and low GCV and PCV. High heritability and genetic advance were recorded for the traits viz., leaf length, number of tillers plant-1, number of grains panicle-1, 1000 seed weight, root length, root volume, root fresh weight plant-1, root dry weight plant-1, kernel length-breadth ratio, grain yield plant-1, biological yield plant-1 and harvest index. The information regarding different variability will provide direction to select high yielding genotypes under aerobic condition.

Redox sensing modulates the activity of ComE response regulator of Streptococcus mutans

Streptococcus mutans , a dental pathogen, encodes the ComDE two-component system comprised of a histidine kinase (ComD) and a response regulator (ComE). This system is necessary for production of bacteriocins and development of genetic competence. ComE interacts with its cognate promoters to activate the transcription of bacteriocin and competence related genes. Previous transcriptomic studies indicated that expressions of bacteriocin genes were upregulated in the presence of oxygen. To understand the relationship between the aerobic condition and bacteriocin expression, we analyzed the S. mutans ComE sequence and its close homologs. Surprisingly, we noticed the presence of cysteine (Cys) residues located at positions 200 and 229, which are highly conserved among the ComE homologs. Here we investigated the role of Cys residues of S. mutans ComE in the activation of bacteriocin transcription using the P nlmA promoter that expresses bacteriocin NlmA. We constructed both single mutants and double mutants by replacing the Cys residues with serine and performed complementation assays. We observed that the presence of Cys residues is essential for P nlmA activation. With purified ComE mutant proteins we found that ComE double mutants displayed a nearly two-fold lower association rate than wild-type ComE. Furthermore, ANS fluorescence studies indicated that the double mutants displayed wider conformation changes than wild-type ComE. Finally, we demonstrated that close streptococcal ComE homologs successfully activate the P nlmA expression in vivo . This is the first report suggesting that S. mutans ComE and its homologs can sense the oxidation status of the cell, a phenomenon similar to the AgrA system of Staphylococcus aureus but with different outcome. IMPORTANCE Streptococci are an important species that prefer to grow under anaerobic or microaerophilic environments. Studies have shown that streptococci growth in an aerobic environment generates oxidative stress responses by activating various defense systems including production of antimicrobial peptides called bacteriocins. This study highlights the importance of a two-component response regulator (ComE) that senses the aerobic environment and induces bacteriocin production in Streptococcus mutans , a dental pathogen. We believe increased bacteriocin secretion under aerobic conditions is necessary for survival and colonization of S. mutans in the oral cavity by inhibiting other competing organisms. Redox sensing by response regulator might be a wide-spread phenomenon, since two other ComE homologs from pathogenic streptococci that inhabit diverse environmental niches also perform a similar function.

Characterization of preparation for fat separators

Fats, oils and greases in waste water frequently cause serious environmental problems. A commercial preparation was tested for its ability to degrade oil and grease in wastewater. As substrates, two fats (lard and beef fat) and four oils (rape seed oil, sunflower oil, palm oil and olive oil) were chosen. The degradation ability of commercial preparation for different substrates was investigated by the determination of lipid degradation at pH 7, temperature 25 °C, aerobic condition and agitation at 160 rev/min for 14 days in Erlenmeyer flasks. Simultaneously, the lipolytic activity was spectrophotometrically determined at 420 nm. All tested substrates were degraded by the different rate to basic units (fatty acids). Rape seed oil and lard were decomposed by bacterial lipase from commercial preparation.

Non-microbial methane emissions from tropical rainforest soils under different conditions

Non-microbial methane (NM-CH4), emissions from soil might play a significant role in carbon cycling and global climate change. However, the production mechanisms and emission potential of soil NM-CH4 from tropical rainforest remain highly uncertain. In order to explore the laws and characteristics of NM-CH4 emission from tropical rainforest soils. Incubation experiments at different environmental conditions (temperatures, soil water contents, hydrogen peroxide) and for soils with different soil organic carbon (SOC) contents were conducted to investigate the NM-CH4 emission characteristics and its influence factors of soils (0-10cm) that collected from a tropical rainforest in Hainan, China. Incubation results illustrated that soil NM-CH4 release showed a linear increase with the incubation time in the first 24 hours at 70 °C, whereas the logarithmic curve increase was found in 192 h incubation. Soil NM-CH4 emission rates under aerobic condition were significantly higher than that of under anaerobic condition at first 24 h incubation. The increasing of temperature, suitable soil water contents (0–100%), and hydrogen peroxide significantly promoted soil NM-CH4 emission rates at the first 24 h incubation. However, excessive soil water contents (200%) inhibited soil NM-CH4 emissions. According to the curve simulated from the NM-CH4 emission rates and incubation time at 70 °C of aerobic condition, soil would no longer release NM-CH4 after 229 h incubation. The NM-CH4 emissions were positively corelated with SOC contents, and the average soil NM-CH4 emission potential was about 6.91 ug per gram organic carbon in the tropical mountain rainforest. This study revealed that soils in the tropical rainforest could produce NM-CH4 under certain environment conditions and it supported production mechanisms of thermal degradation and reactive oxygen species oxidation. Those results could provide a basic data for understanding the soil NM-CH4 production mechanisms and its potential in the tropical rainforest.