The Hardiness Profile of Islamic Boarding School Student in Indonesian

The primary goal of this study is to evaluate the hardiness profile of students in Islamic boarding schools and determine whether or not hardiness has a practical impact on students through Islamic boarding schools, with the top indicators being challenge, control, and commitment. Every shift brings with it a new set of challenges, which can be challenging to adjust to. This research employs quantitative methods to demonstrate this. For the 2020/2021 academic year, student boarding school students in Jakarta served as the study's subject population. As a result, 76 participants were chosen at random using a purposive selection method. It is possible to get data using the santri hardiness instrument as the method of gathering information. The hypothetical mean approach is utilized in this study to determine the optimal score, the minimal score, the standard deviation, and the theoretical mean. The score range is obtained in order to determine the category, which will be as follows: X 129.3 indicates a high category, 103.7 129.3 indicates a medium category, and X 103.7 indicates a low category. It is possible to conclude from these estimates that the hardiness profile of boarding school kids falls into the middle category. The result is that most students have attitudes and skills that are not yet optimal for coping with life difficulties in Islamic boarding schools.

The Wisdom Acquired During Emergencies Scale – Development and Validity

The COVID-19 pandemic and its related lockdown restrictions had repercussions on health status, psychological states of mind, and emotion regulation. Attitudes towards these restrictions, beliefs, emotions and behaviours could be wise, as in the acceptance of, and adaptation to, these constraints. On the other hand, they could be unwise, as in the rejection of rules and limitations, denial of the consequences, irrational beliefs, self-accusation, rage and general intolerance. This study aims to introduce the development and validation of the 25-item Wisdom Acquired During Emergencies Scale (WADES). It is a measure to assess the wisdom and self-regulation that are needed to cope with unexpected and unpredictable emergency situations. On the basis of a preliminary study (N1=212 Italian adults), a multiple-choice scale of 52 items was developed. In the reliability study (N2=1777), items were scaled, analysed according to the optimal score technique and selected to provide a final and reliable version (Cronbach’s α=0.83). The validity study (N3=1,345, N4=1,445, N5= 878) provided correlations with established scales measuring, for example, traditional wisdom, emotion regulation, empathy, post-traumatic growth, collectivism, conscientiousness and satisfaction with life. The results confirmed that high scores on the WADES are associated with the ability to regulate emotions, control impulses and develop goals in emotional situations, to tolerate current difficulties, while developing new attitudes, values and behaviours, entailing changes in self-perception and relationships. It was thus confirmed that high WADES scores indicate a higher degree of acquired wisdom.

Risk-Score Based Strategy to Minimize Antibiotic Exposure in Children With Sickle Cell Disease and Fever

Severe bacterial infections (SBI) have become less frequent in children with sickle cell disease (SCD) in the last decades. However, because of their potential risk of SBI, they usually receive empirical therapy with broad-spectrum antibiotics when they develop fever and are hospitalized in many cases. We performed a prospective study including 79 SCD patients with fever [median age 4.1 (1.7–7.5) years, 78.5% males; 17 of the episodes were diagnosed with SBI and 4 of them were confirmed] and developed a risk score for the prediction of SBI. The optimal score included CRP > 3 mg/dl, IL-6 > 125 pg/ml and hypoxemia, with an AUC of 0.91 (0.83–0.96) for the prediction of confirmed SBI and 0.86 (0.77–0.93) for possible SBI. We classified the patients in 3 groups: low, intermediate and high risk of SBI. Our risk-score based management proposal could help to safely minimize antibiotic treatments and hospital admissions in children with SCD at low risk of SBI.

Neighborhood Intervention Consistency: Measuring Confidence for Knowledge Graph Link Prediction

Link prediction based on knowledge graph embeddings (KGE) has recently drawn a considerable momentum. However, existing KGE models suffer from insufficient accuracy and hardly evaluate the confidence probability of each predicted triple. To fill this critical gap, we propose a novel confidence measurement method based on causal intervention, called Neighborhood Intervention Consistency (NIC). Unlike previous confidence measurement methods that focus on the optimal score in a prediction, NIC actively intervenes in the input entity vector to measure the robustness of the prediction result. The experimental results on ten popular KGE models show that our NIC method can effectively estimate the confidence score of each predicted triple. The top 10% triples with high NIC confidence can achieve 30% higher accuracy in the state-of-the-art KGE models.

Service selection in a marketplace: a multi-perspective solution

Most of the current research work on web service selection only considered the selection problem from the perspective of one party – service consumers. A service marketplace serves many parties including service consumers and providers. Thus, it is important to consider multiple parties. In this thesis, we propose a service selection model considering the benefits of multiple parties: consumers, providers and the marketplace. The model ranks services based on not only how much these services satisfy the user requirements but also how much the requests can be distributed to different providers and the revenue gain in the marketplace. We design different objective functions, then combine into a QoS-Plus-PF objective function. The results show that proposed model could achieve a high degree of satisfaction of user requests (i.e., 0.61% to 5.26% worse than the optimal score), and meanwhile have the capability of promoting more diversified set of services (i.e., 48.95% promotion percentage).

Service selection in a marketplace: a multi-perspective solution

Most of the current research work on web service selection only considered the selection problem from the perspective of one party – service consumers. A service marketplace serves many parties including service consumers and providers. Thus, it is important to consider multiple parties. In this thesis, we propose a service selection model considering the benefits of multiple parties: consumers, providers and the marketplace. The model ranks services based on not only how much these services satisfy the user requirements but also how much the requests can be distributed to different providers and the revenue gain in the marketplace. We design different objective functions, then combine into a QoS-Plus-PF objective function. The results show that proposed model could achieve a high degree of satisfaction of user requests (i.e., 0.61% to 5.26% worse than the optimal score), and meanwhile have the capability of promoting more diversified set of services (i.e., 48.95% promotion percentage).

Reproducibility of the Edinburgh Postnatal Depression Scale during the Postpartum Period

Objective This study was aimed to evaluate the efficacy of the Edinburgh Postnatal Depression Scale (EPDS) in the immediate postpartum period, which we defined as between 3 and 24 hours postpartum for the purpose of this research. This is such that if it can predict scores obtained at the postpartum visit, it will be an opportunity to access psychiatric services for the patient that may otherwise be more difficult to access in the outpatient setting. Study Design Longitudinal observational study, which included an analysis of 848 consecutive participants screened with the EPDS in the hospital and at the 6-week postpartum visit. Results Receiver-operating characteristic (ROC) curve suggested >3 at delivery as a more optimal score to predict depression at the postpartum visit with sensitivity 76.5% and specificity 65.9%. The commonly accepted EPDS cutoff value of >9 was far less sensitive at 28.8% but reasonably specific at 93.2% for predicting elevated scores (>9) 6 weeks postpartum. In subgroup analysis, only a prior mental health disorder was found to be predictive of elevated scores at the postpartum visit (relative risk: 1.97, 95% confidence interval: 1.17–3.32, p = 0.01). Conclusion The EPDS, originally designed to screen for postpartum depression (PPD) in the outpatient setting, does not predict the development of PPD, as determined by the EPDS (validated at the 6-week postpartum time interval) when administered during hospitalization shortly after delivery. Key Points

Client-care provider interaction during labour and birth as experienced by women: Respect, communication, confidentiality and autonomy

Introduction Respectful Maternity Care is important for achieving a positive labour and birth experience. Client-care provider interaction—specifically respect, communication, confidentiality and autonomy—is an important aspect of Respectful Maternity Care. The aim of this study was twofold: (1) to assess Dutch women’s experience of respect, communication, confidentiality and autonomy during labour and birth and (2) to identify which client characteristics are associated with experiencing optimal respect, communication, confidentiality and autonomy. Methods Pregnant women and women who recently gave birth in the Netherlands were recruited to fill out a validated web-based questionnaire (ReproQ). Mean scores per domain (scale 1–4) were calculated. Domains were dichotomised in non-optimal (score 1, 2,3) and optimal client-care provider interaction (score 4), and a multivariable logistic regression analysis was performed. Results Of the 1367 recruited women, 804 respondents completed the questionnaire and 767 respondents completed enough questions to be included for analysis. Each domain had a mean score above 3.5. The domain confidentiality had the highest proportion of optimal scores (64.0%), followed by respect (53.3%), communication (45.1%) and autonomy (36.2%). In all four domains, women who gave birth at home with a community midwife had a higher proportion of optimal scores than women who gave birth in the hospital with a (resident) obstetrician or hospital-based midwife. Lower education level, being multiparous and giving birth spontaneously were also significantly associated with a higher proportion of optimal scores in (one of) the domains. Discussion This study shows that on average women scored high on experienced client-care provider interaction in the domains respect, communication, confidentiality and autonomy. At the same time, client-care provider interaction in the Netherlands still fell short of being optimal for a large number of women, in particular regarding women’s autonomy. These results show there is still room for improvement in client-care provider interaction during labour and birth.

MBCL-18. ANALYSIS OF DNA METHYLATION PROFILES OF PEDIATRIC MEDULLOBLASTOMAS: EXPERIENCE AT THE BAMBINO GESÙ CHILDREN’S HOSPITAL

BACKGROUND Medulloblastoma is the most frequent malignant brain tumor in children, still resulting fatal in about one third of affected patients. An accurate diagnosis is essential for correct therapeutic stratification. The DNA methylation profile (DMP) is a combination of changes in DNA methylation and genetic features that reflect the cell of tumor origin. DMP contributed to classify Medulloblastoma into four subgroups: WNT, SHH, Group 3/4 (the latter recently further subdivided into 8 subclasses). Each Methylation is associated with different genetic, demographic and clinical characteristics. We report our experience on Medulloblastoma molecular classification based on DMP. MATERIALS AND METHODS 54 Medulloblastoma patients (28 males, 26 females) were selected. The DMP analysis was carried out via IlluminaEPICarrays. The results were obtained using the brain tumor classifier (Capper, 2018). RESULTS In all cases the DMP allowed to classify the neoplasm, with an optimal score, in a defined methylation class. 10 WNTs, 15 SHHs, 10 Group 3, 19 Group 4 were found. Groups 3/4 were further refined based on the new consensus (Sharma 2019) in group I (n = 1); group II (n = 5); group III (n = 2); group IV (n = 4); group V (n = 3); group VI (n = 2); group VII (n = 6); group VIII (n = 7). CONCLUSIONS This study carried out the first classification of Medulloblastomas diagnosed in Italy through DMP, demonstrating its high reproducibility, precision and accuracy. The molecular classification improves diagnostic accuracy and provides further information that can guide personalized treatment.

A Score to differentiate Takotsubo syndrome from non-ST-elevation myocardial nfarction in women at the bedside

ObjectiveA score to distinguish Takotsubo syndrome (TS) from acute coronary syndrome would be useful to facilitate appropriate patient investigation and management. This study sought to derive and validate a simple score using demographic, clinical and ECG data to distinguish women with non-ST elevation myocardial infarction (NSTEMI) from NSTE-TS.MethodsThe derivation cohort consisted of women with NSTE-TS (n=100) and NSTEMI (n=100). Logistic regression was used to derive the score using ECG values available on the postacute ward round on day 1 post-hospital admission. The score was then temporally validated in subsequent consecutive patients with NSTE-TS (n=40) and NSTEMI (n=70).ResultsThe five variables in the score and their relative weights were: T-wave inversion in ≥6 leads (+3), recent stress (+2), diabetes (−1), prior cardiovascular disease (−2) and ST-depression in any lead (−3). When calculated using ECG values obtained at admission, discrimination between conditions was very good (area under the curve (AUC) 0.87 95% CI 0.83 to 0.92). The optimal score cut-point of ≥1 to predict NSTE-TS had 73% sensitivity and 90% specificity. When applied to the validation cohort at admission, AUC was 0.82 (95% CI 0.75 to 0.90) and positive and negative predictive values were 78% and 81%, respectively. On day 1 post-admission, AUC was 0.92 (95% CI 0.87 to 0.97), with positive and negative predictive values of 77% and 91%, respectively.ConclusionThis NSTE-TS score is easy to use and may prove useful in clinical practice to distinguish women with NSTE-TS from NSTEMI. Further validation in external cohorts is needed.