Remote reading: a shelf list analysis of an academic library’s juvenile collection

Purpose This study aims to detail an analysis project of a juvenile collection within an academic library. The analysis became a starting point for the development of a coherent collection policy, and for charting a path toward a better maintained, more used, more diverse, inclusive and representative collection. Design/methodology/approach The analysis was done by using a catalog-generated shelf list, which revealed specific details about the aged state of the collection and brought to light the lack of attention the collection has been getting in recent years. Findings The analysis of a collection of children’s books in an academic library revealed a collection long out of date and unable to serve the needs of our user population. Research limitations/implications This analysis is specific to academic institutions that have collections of children’s material. Originality/value The literature on juvenile collections in academic libraries is relatively sparse. This research details a social justice approach to building and maintaining juvenile collections in academic libraries.

Role of NF-κB in Ageing and Age-Related Diseases: Lessons from Genetically Modified Mouse Models

Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and environmental factors. It is manifested by a decline in the physiological functions of organisms and associated to the development of age-related chronic diseases and cancer development. It is considered that ageing follows a strictly-regulated program, in which some signaling pathways critically contribute to the establishment and maintenance of the aged state. Chronic inflammation is a major mechanism that promotes the biological ageing process and comorbidity, with the transcription factor NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) as a crucial mediator of inflammatory responses. This, together with the finding that the activation or inhibition of NF-κB can induce or reverse respectively the main features of aged organisms, has brought it under consideration as a key transcription factor that acts as a driver of ageing. In this review, we focused on the data obtained entirely through the generation of knockout and transgenic mouse models of either protein involved in the NF-κB signaling pathway that have provided relevant information about the intricate processes or molecular mechanisms that control ageing. We have reviewed the relationship of NF-κB and premature ageing; the development of cancer associated with ageing and the implication of NF-κB activation in the development of age-related diseases, some of which greatly increase the risk of developing cancer.

What about Phenol Formaldehyde (PF) Foam in Modern-Contemporary Art? Insights into the Unaged and Naturally Aged Material by a Multi-Analytical Approach

The ageing behavior of phenol formaldehyde (PF) foam, a material increasingly used in modern-contemporary art, was investigated by a multi-analytical approach. PF foams with open- and closed-cell structures were selected and analyzed in their unaged and naturally indoor-aged state by employing optical microscopy (OM) and fiber optical reflectance spectroscopy (FORS) for assessing their morphology and color alteration. Micro-Fourier transform infrared spectroscopy (μ-FTIR) was used for determining chemical changes and oxidation processes, and the acidity was monitored by pH measurements. The results clearly showed the extreme sensitivity of both open- and closed-cell PF foams to conditions typically found in indoor museums. OM indicated that the cells of the foams are prone to disrupt, and a tendency towards a red color shift was observed with FORS. μ-FTIR revealed the formation of quinone groups resulting from oxidation reactions. Finally, a slight decrease in the acidity was found by pH measurements.

Technological properties of Al—Mg—Si alloys during manufacturing of thin-walled tubular products using welding and reduction

The reasons for the appearance of cracks during the reduction of filling nozzles made by using welding from the Al—Mg—Si alloy bars are studied. It is found that the cause of fracture is the embrittlement of the alloy and the deterioration of its deformability in the heat-affected zone of welding. Recommendations for eliminate the deterioration of the deformability of the alloy during the intensification of the cooling of the welding zone are developed, which makes it possible to preserve the zone-aged state in the heat-affected zone.

Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6

Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy to treat many degenerative diseases. Accumulating evidence shows that the function of MSCs declines with age, thus limiting their regenerative capacity. Nonetheless, the underlying mechanisms that control MSC ageing are not well understood. We show that compared with bone marrow-MSCs (BM-MSCs) isolated from young and aged samples, NADH dehydrogenase (ubiquinone) iron-sulfur protein 6 (Ndufs6) is depressed in aged MSCs. Similar to that of Ndufs6 knockout (Ndufs6−/−) mice, MSCs exhibited a reduced self-renewal and differentiation capacity with a tendency to senescence in the presence of an increased p53/p21 level. Downregulation of Ndufs6 by siRNA also accelerated progression of wild-type BM-MSCs to an aged state. In contrast, replenishment of Ndufs6 in Ndufs6−/−-BM-MSCs significantly rejuvenated senescent cells and restored their proliferative ability. Compared with BM-MSCs, Ndufs6−/−-BM-MSCs displayed increased intracellular and mitochondrial reactive oxygen species (ROS), and decreased mitochondrial membrane potential. Treatment of Ndufs6−/−-BM-MSCs with mitochondrial ROS inhibitor Mito-TEMPO notably reversed the cellular senescence and reduced the increased p53/p21 level. We provide direct evidence that impairment of mitochondrial Ndufs6 is a putative accelerator of adult stem cell ageing that is associated with excessive ROS accumulation and upregulation of p53/p21. It also indicates that manipulation of mitochondrial function is critical and can effectively protect adult stem cells against senescence.

Thermal Expansion and Microstructure Behavior at Elevated Temperature of various {Ni, Co}-based Cast Superalloys

This paper aims to investigate the thermal expansion behavior, up to an elevated temperature, of superalloys based on nickel and cobalt with various proportions and designed to be strengthened by tantalum carbides. The as-cast microstructures of these superalloys and their evolutions at two very high temperatures were also of interest. All results are discussed by considering the Ni/Co repartition in the base element position. It appears that when the Ni content is higher than the Co one: 1/the thermal expansion is slower, 2/the as-cast microstructures as well as the ones stabilized at high temperature contain not only TaC but also chromium carbides, and 3/the hardness in as-cast or aged state is lower.

Study on Microstructure and Mechanical Properties of Al-Mg-Si-Cu Aluminium Alloy with High Ductility

A new type of Al-Mg-Si-Cu aluminium alloy with high ductility was studied in the present work. The microstructure features and mechanical properties of this alloy were systematically characterized by scanning electron microscopy (SEM), electron back-scatter Diffraction (EBSD), high resolution transmission electron microscopy (HRTEM) and tensile and fatigue test. The percentage of sub-grain boundary under forging and aging process reaches up to 72% which can be attributed to the suppression of recrystallization by the nano-sized AlMnCrSi dispersoids. The combination of mechanical properties of the new alloy product in aged state showed that the ductility keeps in the range of 15~18%, yield strength and tensile strength are 310MPa and 380MPa respectively, fatigue strength ranges from 130MPa to 135MPa. It presents more excellent properties than commercial 6061 alloy for the nano-sized AlMnCrSi dispersoids, initial-β” precipitates and high percentage of sub-grain boundary.

The environmental forming and productional functions of the haloxylon aphyllum in the Karnabchul desert

We have conducted investigation of the environmental function of the desert tree of black saxaul (Haloxylon aphyllum) in the Karnabchul desert. As a result, it was found that different age plants of black saxaul had different effects on the degree of illumination. The greatest influence on the intensity of solar radiation was exerted by the saxaul plant of the black middle-aged state, the least the old generative individuals. Saxaul black had a significant impact on the temperature of the air: in the daytime, especially in the period 13-16 h, reducing the temperature under the crown and on the edge of the crown, and at night increasing it in the same areas. It also had a noticeable effect on the temperature of the soil. The temperature of the soil surface under the crown at night is higher, and during the day the warming was slower than in the outer part of the saxaul crown. Under the influence of black saxaul and soil moisture changed. Under the saxaul crown soil moisture is significantly higher compared to the control (open natural pastures). The highest soil moisture was observed in the upper soil layers at the base of the saxaul trunk. As a result, under the environmental action of black saxaul more favorable hydrothermal conditions for the growth and development of natural wormwood-ephemeral vegetation under the protection of strips and adjacent areas of pastures are formed. The result of production activities chemotaxonomic postbestowal bands consists of two following components: production of fodder mass of the Haloxylon and fodder productivity of wormwood-ephemeral vegetation of natural pastures. By increasing the yield of natural pastures under the protection of pasture protection strips and the harvest of the black saxaul fodder productivity of desert pastures increases more than twice.

A combined characterization of clusters in naturally aged Al–Cu–(Li, Mg) alloys using small-angle neutron and X-ray scattering and atom probe tomography

A new methodology for the characterization of solute clusters leading to compositional fluctuations is presented and discussed. The methodology makes use of contrast variation arising from a combination of small-angle scattering using neutrons and X-rays, and adapts a model for solute correlation to extract the chemistry and length scale of clustered states after quench and after natural ageing. In three subsets of the Al–Cu system, Cu-rich clusters are reported for all cases. The presence of Mg strongly enhances Cu clustering in the naturally aged state and results in more than double the number of clusters in the complex Al–Cu–Li–Mg system. The results are compared with those obtained using atom probe tomography.