A diagnostic analysis of MONEX-1979 onset vortex over the Arabian Sea

Based on MONEX-,1979 data over the Arabian Sea, the paper analyses observationally the structure, development and movement of a vortex which formed during onset of the monsoon around mid-June near the coast of Kerala developed into a cyclonic storm at mid-sea and moved towards the coast of Oman to die out there Heat budget computations bring out the differential behaviour of the different quadrants of the disturbance and appear to highlight the contrasting features between the northwestern and the other quadrants in regard to vertical. distributions of diabatic heating, local temperature tendency thermal advection and adiabatic heating or cooling. The study reveals an interaction of the vortex with two eastward-propagating subtropical westerly troughs which might have contributed significantly to its explosive development (decay) through warm (cold) advection. Both barotropic and baroclinic energy conversions appear to supply energy to the storm; though there appears to be a dominance of one over the other at different stages of development and at different heights. It seems likely that condensation heating also contributed to development of the storm.

CriTER-A: A Novel Temperature-Dependent Noncoding RNA Switch in the Telomeric Transcriptome of Chironomus riparius

The telomeric transcriptome of Chironomus riparius has been involved in thermal stress response. One of the telomeric transcripts, the so-called CriTER-A variant, is highly overexpressed upon heat shock. On the other hand, its homologous variant CriTER-B, which is the most frequently encoded noncoding RNA in the telomeres of C. riparius, is only slightly affected by thermal stress. Interestingly, both transcripts show high sequence homology, but less is known about their folding and how this could influence their differential behaviour. Our study suggests that CriTER-A folds as two different conformers, whose relative proportion is influenced by temperature conditions. Meanwhile, the CriTER-B variant shows only one dominant conformer. Thus, a temperature-dependent conformational equilibrium can be established for CriTER-A, suggesting a putative functional role of the telomeric transcriptome in relation to thermal stress that could rely on the structure–function relationship of the CriTER-A transcripts.

Vocalic Intrusions in Consonant Clusters in Child-Directed vs. Adult-Directed Speech

In this paper, we investigate a prosodic-phonetic feature in child-directed speech within a dynamic, complex, interactive theoretical framework. We focus on vocalic intrusions, commonly occurring in Norwegian word initial consonant clusters. We analysed child-directed speech from nine Norwegian-speaking mothers to their children, aged 2;6, 4, and 6 years, and compared the incidence and duration of vocalic intrusions in initial consonant clusters in these data with those in adult-directed speech and child speech. When viewed overall, vocalic intrusion was found to be similar in incidence in child- and adult-directed speech. However, closer examination revealed differential behaviour in child-directed speech for certain conditions. Firstly, a difference emerged for one particular phonetic context: While vocalic intrusions in /Cr/ clusters are frequent in adult-directed speech, their presence is near-categorical in child-directed speech. Secondly, we found that the duration of vocalic intrusions was longer in child- than in adult-directed speech, but only when directed to 2;6-year-olds. We argue that vocalic intrusions in child-directed speech may have both a bonding as well as a didactic function, and that these may vary according to the age of the child being addressed.

Alterations of the Platelet Proteome in Lung Cancer: Accelerated F13A1 and ER Processing as New Actors in Hypercoagulability

In order to comprehensively expose cancer-related biochemical changes, we compared the platelet proteome of two types of cancer with a high risk of thrombosis (22 patients with brain cancer, 19 with lung cancer) to 41 matched healthy controls using unbiased two-dimensional differential in-gel electrophoresis. The examined platelet proteome was unchanged in patients with brain cancer, but considerably affected in lung cancer with 15 significantly altered proteins. Amongst these, the endoplasmic reticulum (ER) proteins calreticulin (CALR), endoplasmic reticulum chaperone BiP (HSPA5) and protein disulfide-isomerase (P4HB) were significantly elevated. Accelerated conversion of the fibrin stabilising factor XIII was detected in platelets of patients with lung cancer by elevated levels of a F13A1 55 kDa fragment. A significant correlation of this F13A1 cleavage product with plasma levels of the plasmin–α-2-antiplasmin complex and D-dimer suggests its enhanced degradation by the fibrinolytic system. Protein association network analysis showed that lung cancer-related proteins were involved in platelet degranulation and upregulated ER protein processing. As a possible outcome, plasma FVIII, an immediate end product for ER-mediated glycosylation, correlated significantly with the ER-executing chaperones CALR and HSPA5. These new data on the differential behaviour of platelets in various cancers revealed F13A1 and ER chaperones as potential novel diagnostic and therapeutic targets in lung cancer patients.

Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species

Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, is becoming increasingly important in virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a suitable intermediate host in animal viruses-generated human pandemics is highly topical. However, studies on host jumping involving plant viruses have been focused on shifting intra-species, leaving aside the putative role of “bridge hosts” in facilitating interspecies crossing. Here, we take advantage of several VPg mutants, derived from a chimeric construct of the potyvirus Plum pox virus (PPV), analyzing its differential behaviour in three herbaceous species. Our results showed that two VPg mutations in a Nicotiana clevelandii-adapted virus, emerged during adaptation to the bridge-host Arabidopsis thaliana, drastically prompted partial adaptation to Chenopodium foetidum. Although both changes are expected to facilitate productive interactions with eIF(iso)4E, polymorphims detected in PPV VPg and the three eIF(iso)4E studied, extrapolated to a recent VPg:eIF4E structural model, suggested that two adaptation ways can be operating. Remarkably, we found that VPg mutations driving host-range expansion in two non-related species, not only are not associated with cost trade-off constraints in the original host, but also improve fitness on it.

Business Performance in The Post-Startup Phase: The Case of LATAM For-Profit Ventures Participating in Accelerator Programs

This study aims at a more systematic understanding of the critical factors, based on Sharir & Lerner’s (2006) framework, that exert influence over the probabilities of performance development of For-Profit Ventures participating in accelerator programs worldwide, and specifically in the LATAM Region. Using an Ordinal Logit Regression Model on secondary data from a multipurpose survey over a sample of startups in more than 170 countries, the positive effects of such factors were first tested, and differential behaviour was sought, in ventures operating in the LATAM Region. Even though most of the factors accounted for in the framework were validated in the general sample and their effects were quantified, differential behaviour due to socio-economic and geographic conditions was found in the region; the most striking result revolved around the statistically confirmed notion that LATAM ventures have learned to operate in underprivileged conditions. Conclusions are drawn in support of harmonized for-profit entrepreneurship promotional programs and the adoption of standardized impact measurement criteria in order to improve the access to outside-funds. This argument raises ample academic and practical possibilities for investigating the impact of socio-economic and cultural influences on the efficacy of entrepreneurial support mechanisms. This study contributes to the literature by providing more empirical research about performance development in newly created for-profit ventures and the effectiveness of global accelerator programs.

Virus Host Jumping Can Be Boosted by Adaptation to a Bridge Plant Species

Understanding biological mechanisms that regulate emergence of viral diseases, in particular those events engaging cross-species pathogens spillover, are becoming increasingly important in Virology. Species barrier jumping has been extensively studied in animal viruses, and the critical role of a suitable intermediate host in animal viruses-generated human pandemics is highly topical. However, studies on host jumping involving plant viruses have been focused on shifting intra-species, leaving aside the putative role of “bridge hosts” in facilitating interspecies crossing. Here, we take advantage of several VPg mutants, derived from a chimeric construct of the potyvirus Plum pox virus (PPV), analysing its differential behaviour in three herbaceous species. Our results showed that two VPg mutations in a Nicotiana clevelandii-adapted virus, emerged during adaptation to the bridge-host Arabidopsis thaliana, drastically prompted partial adaptation to Chenopodium foetidum. Although, both changes are expected to facilitate productive interactions with eIF(iso)4E, polymorphims detected in PPV VPg and the three eIF(iso)4E studied, extrapolated to a recent VPg:eIF4E structural model, suggested that two adaptation ways can be operating. Remarkably, we found that VPg mutations driving host-range expansion in two non-related species, not only are not associated with cost trade-off constraints in the original host, but also improve fitness on it.

Efficient MILP Modelings for Sboxes and Linear Layers of SPN ciphers

Mixed Integer Linear Programming (MILP) solvers are regularly used by designers for providing security arguments and by cryptanalysts for searching for new distinguishers. For both applications, bitwise models are more refined and permit to analyze properties of primitives more accurately than word-oriented models. Yet, they are much heavier than these last ones. In this work, we first propose many new algorithms for efficiently modeling any subset of Fn2 with MILP inequalities. This permits, among others, to model differential or linear propagation through Sboxes. We manage notably to represent the differential behaviour of the AES Sbox with three times less inequalities than before. Then, we present two new algorithms inspired from coding theory to model complex linear layers without dummy variables. This permits us to represent many diffusion matrices, notably the ones of Skinny-128 and AES in a much more compact way. To demonstrate the impact of our new models on the solving time we ran experiments for both Skinny-128 and AES. Finally, our new models allowed us to computationally prove that there are no impossible differentials for 5-round AES and 13-round Skinny-128 with exactly one input and one output active byte, even if the details of both the Sbox and the linear layer are taken into account.

Sensitivity of Gene Sets to miRNA Regulation: A Cell-Based Probabilistic Approach

Mature microRNAs (miRNAs) are small, non-coding RNA molecules that function by base-pairing with mRNAs. In multicellular organisms, miRNAs lead to mRNA destabilization and translation arrest. Importantly, the quantities and stichometry of miRNAs/mRNAs determine the miRNA regulation characteristics of specific cells. In this study, we used COMICS (Competition of miRNA Interactions in Cell Systems), a stochastic computational iterative framework to characterize genes by their sensitivity and robustness to miRNA regulation. We monitor the cell state by quantifying the retention level for all mRNAs, at the end of 100,000 simulation iterations. In HeLa cells, we partitioned all genes to five classes according to their decay rates. We show that the largest class (69% of genes) is apparently resistant to miRNA regulation. We created in silico perturbations using overexpressing of all major miRNAs (248 types) at various levels relative to the basal level (x1 to x1000). We further classified genes according to the differential behaviour for any pair of conditions of miRNA expression profile. Based on such measure (OvereXpression Ratio, OXR), we identified a small number of gene sets that are especially sensitive to OXR. Our results expose an overlooked quantitative dimension for set of genes and miRNA regulation in living cells.