Controlling Microdroplet Inner Rotation by Parallel Carrier Flow of Sesame and Silicone Oils

We developed a method for passively controlling microdroplet rotation, including interior rotation, using a parallel flow comprising silicone and sesame oils. This device has a simple 2D structure with a straight channel and T-junctions fabricated from polydimethylsiloxane. A microdroplet that forms upstream moves into the sesame oil. Then, the largest flow velocity at the interface of the two oil layers applies a rotational force to the microdroplet. A microdroplet in the lower oil rotates clockwise while that in the upper oil rotates anti-clockwise. The rotational direction was controlled by a simple combination of sesame and silicone oils. Droplet interior flow was visualized by tracking microbeads inside the microdroplets. This study will contribute to the efficient creation of chiral molecules for pharmaceutical and materials development by controlling rotational direction and speed.

Localized Electroconvection at Ion-Exchange Membranes with Heterogeneous Surface Charge

Operating electrochemical membrane processes beyond the limiting current density bears the potential to decrease the investment cost of desalination plants significantly. However, while there are strategies for successfully reducing energy demand by shortening the plateau region, their influence on the formation of electroconvection is still unknown. This study demonstrates control over the electroconvective vortices' rotational direction and position using a surface patterning method. We compare the development of electroconvection at two membranes modified with patterns of different surface charges. We analyze the electroconvective vortex field's build-up, the vortices' rotational direction, and structural stability in the steady-state. Finally, we showcase the control possibilities by enforcing a specific structure along an asymmetric letter pattern. Such tailor-made patterns have the potential to diminish the plateau region's energy loss completely. Furthermore, the scale-up of these membranes to industrial processes will allow the economic operation in the overlimiting regime, significantly increasing their space-time yield.

Impact of Cold Weather on Setup Errors in Radiotherapy

Objective. To investigate the influence of cold weather on setup errors of patients with chest and pelvic disease in radiotherapy. Methods. The image-guided data of the patients were collected from the Radiotherapy Center of Cancer Hospital Affiliated to Guangxi Medical University from October 2020 to February 2021. During this period, the cold weather days were December 15, 16, and 17, 2020, and January 7 and 8, 2021. For body fixation in radiotherapy, an integrated plate and a thermoplastic mold were employed in 18 patients with chest disease, while an integrated plate and a vacuum pad were applied in 19 patients with pelvic disease. All patients underwent cone beam computed tomography (CBCT) scans in the first five treatments and once a week thereafter. The obtained data were registered to the planning CT image to get the setup errors of the patient in the translational direction including X, Y, and Z axes and rotational direction including RX, RY, and RZ. Then, the Mann–Whitney U test was performed. The expansion boundary values of the chest and pelvis were calculated according to the formula M PTV = 2.5 ∑ + 0.7 δ . Results. A total of 286 eligible results of CBCT scans were collected. There were 138 chest CBCT scans, including 26 taken in cold weather and 112 in usual weather, and 148 pelvic CBCT scans, including 33 taken in cold weather and 115 in usual weather. The X-, Y-, and Z-axis translational setup errors of patients with chest disease in the cold weather group were 0.16 (0.06, 0.32) cm, 0.25 (0.17, 0.52) cm, and 0.35 (0.21, 0.47) cm, respectively, and those in the usual weather group were 0.14 (0.08, 0.29) cm, 0.23 (0.13, 0.37) cm, and 0.18 (0.1, 0.35) cm, respectively. The results indicated that there was a statistical difference in the Z-axis translational error between the cold weather group and the usual weather group (U = 935.5; p = 0.005 < 0.05 ), while there was no statistical difference in the rotational error between the two groups. The external boundary values of X, Y, and Z axes in the cold weather group were 0.57 cm, 0.92 cm, and 0.99 cm, respectively, and those in the usual weather group were 0.57 cm, 0.78 cm, and 0.68 cm, respectively. There was no significant difference in the translational and rotational errors of patients with pelvic disease between the cold weather group and the usual weather group ( p < 0.05 ). The external boundary values of X, Y, and Z axes were 0.63 cm, 0.79 cm, and 0.68 cm in the cold weather group and 0.61 cm, 0.79 cm, and 0.61 cm in the usual weather group, respectively. Conclusion. The setup error of patients undergoing radiotherapy with their bodies fixed by an integrated plate and a thermoplastic mold was greater in cold weather than in usual weather, especially in the ventrodorsal direction.

Variable Neighborhood Strategy Adaptive Search for Optimal Parameters of SSM-ADC12 Aluminum Friction Stir Welding

In this study, we present a new algorithm for finding the optimal friction stir welding parameters to maximize the tensile strength of a butt joint made of the semisolid material (SSM) ADC12 aluminum. The welding parameters were rotational speed, welding speed, tool tilt, tool pin profile, and rotational direction. The method presented is a variable neighborhood strategy adaptive search (VaNSAS) approach. The process of finding the optimal friction stir welding parameters comprises five steps: (1) identifying the type and range of friction stir parameters using a literature survey; (2) performing experiments according to (1); (3) constructing a regression model using the response surface method optimizer (RSM optimizer); (4) using VaNSAS to find the optimal parameters for the model obtained from (3); and (5) confirming the results from (4) using the parameter levels obtained from (4) to perform real experiments. The computational results revealed that the tensile strength generated from VaNSAS was 3.67% higher than the tensile strength obtained from the RSM optimizer parameters. The optimal parameters obtained from VaNSAS were a rotation speed of 2200 rpm, a welding speed of 108.34 mm/min, a tool tilt of 1.23 Deg, a tool pin profile of a hexagon, and a rotational direction of clockwise.

Mutations in The Stator Protein PomA Affect Switching of Rotational Direction in Bacterial Flagellar Motor

The flagellar motor rotates bi-directionally in counter-clockwise (CCW) and clockwise (CW) directions. The motor consists of a stator and a rotor. Recent structural studies have revealed that the stator is composed of a pentameric ring of A subunits and a dimer axis of B subunits. The stator interacts with the rotor through conserved charged and neighboring residues, and the rotational power is generated by their interactions through a gear-like mechanism. The rotational direction is controlled by chemotaxis signaling transmitted to the rotor, with no evidence for the stator being involved. In this study, we found novel mutations that affect the switching of the rotational direction at the putative interaction site of the stator to generate rotational force. Our results highlight a novel aspect of flagellar motor function that appropriate switching of the interaction states between the stator and rotor is critical for controlling the rotational direction.

An analysis method of pressure characteristic for cylindrical intershaft gas film seal considering centrifugal expansion, rotor misalignment, and precession

To improve the weaknesses of large leakage and wear of dual-rotor intershaft labyrinth seal in aero-engines, the cylindrical gas film seal of metal rubber with a compliant feature is proposed to substitute this conventional seal. According to the dual-rotor operating condition, an analysis method of gas film pressure is presented considering the complex condition of rotor tilt, centrifugal expansion effect, and rotor circular precession. The characteristics of gas film pressure distribution are computed and comparisons are conducted in a complex operating state that the tilt rotor is in forward/backward circular precession under a homodromous/counter-rotating condition with/without the influence of centrifugal expansion. Besides, the formation mechanism of the gas film pressure caused by rotor rotational direction and circular precession direction is revealed. Also, the influence of rotor speed and seal ring speed on gas film pressure is analyzed when the rotor is tilted. The results indicate that for the dual-rotor cylindrical gas film seal with high rotating speed, the rotor tilt and centrifugal expansion effect have significant influence on the gas film pressure distribution, and the rotors’ rotational direction as well as rotor circular precession direction determines the maximum gas film pressure distribution area. The maximum pressure under a homodromous condition with backward precession is the highest; the maximum pressure under a homodromous condition with forward precession is the lowest. The former is 1.33% and 1.68% higher than the latter, respectively, with/without consideration of centrifugal expansion. The study method, which is generally suitable for the cylindrical gas film seal with single-rotor/dual-rotor, lays the foundation of performance analysis under complex operating conditions.

Coordinating directional switches in pigeon flocks: the role of nonlinear interactions

The mechanisms inducing unpredictably directional switches in collective and moving biological entities are largely unclear. Deeply understanding such mechanisms is beneficial to delicate design of biologically inspired devices with particular functions. Here, articulating a framework that integrates data-driven, analytical and numerical methods, we investigate the underlying mechanism governing the coordinated rotational flight of pigeon flocks with unpredictably directional switches. Particularly using the sparse Bayesian learning method, we extract the inter-agent interactional dynamics from the high-resolution GPS data of three pigeon flocks, which reveals that the decision-making process in rotational switching flight performs in a more nonlinear manner than in smooth coordinated flight. To elaborate the principle of this nonlinearity of interactions, we establish a data-driven particle model with two potential wells and estimate the mean switching time of rotational direction. Our model with its analytical and numerical results renders the directional switches of moving biological groups more interpretable and predictable. Actually, an appropriate combination of natures, including high density, stronger nonlinearity in interactions, and moderate strength of noise, can enhance such highly ordered, less frequent switches.

Atropisomeric Properties of 9-Methyl-1,4-benzodiazepin-2-ones

The atropisomeric and conformational properties of 1,4-benzodiazepin-2-ones were investigated by freezing the conformation with a methyl group at the C9 of 1,4-benzodiazepine. It was revealed that 1,4-benzodiazepin-2-ones exist only as a pair of enantiomers [(a1 R, a2 S) and (a1 S, a2 R)], which was confirmed by X-ray analysis. The absolute configuration of each atropisomer was deduced by comparing the [α]D and CD data with those of (–)-N-methoxycarbonylmethylated 9-methyl-5-phenyl-1,4-benzodiaepin-2-one derivative. It was elucidated that the corresponding N-methylated derivative showed similar CD spectra, although the rotational direction of [α]D was opposite to that of others.